{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:12:07Z","timestamp":1782832327905,"version":"3.54.5"},"reference-count":38,"publisher":"Impact Journals, LLC","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2024,9,15]]},"DOI":"10.18632\/aging.206070","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T14:08:21Z","timestamp":1725631701000},"page":"12239-12251","source":"Crossref","is-referenced-by-count":1,"title":["MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression"],"prefix":"10.18632","volume":"16","author":[{"given":"Chun","family":"Tseng","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan"},{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"},{"name":"Spine Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Orthopedic Surgery, China Medical University Beigang Hospital, Yunlin, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan"},{"name":"Department of Leisure Industry Management, National Chin-Yi University of Technology, Taichung, Taiwan"},{"name":"Department of Biomedical Sciences National Chung Cheng University, Chiayi, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsien","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"},{"name":"Spine Center, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"},{"name":"Spine Center, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pang-Hsuan","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chin","family":"Fong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan"},{"name":"Spine Center, China Medical University Hospital, Taichung, Taiwan"},{"name":"Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ni","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renn-Chia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Chung Shan Medical University Hospital, Taichung, Taiwan"},{"name":"School of Medicine, Chung Shan Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.3390\/cancers12082130","article-title":"Molecular Biology of Osteosarcoma.","volume":"1","author":"Rutkowski","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2","doi-asserted-by":"publisher","first-page":"1006622","DOI":"10.3389\/fonc.2023.1006622","article-title":"Systematic review of craniofacial osteosarcoma regarding different clinical, therapeutic and prognostic parameters.","volume":"1","author":"Weber","year":"2023","journal-title":"Front Oncol"},{"key":"3","doi-asserted-by":"publisher","first-page":"1123065","DOI":"10.3389\/fcell.2023.1123065","article-title":"The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications.","volume":"1","author":"Chen","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"4","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1007\/s11914-023-00803-9","article-title":"Advances in Osteosarcoma.","volume":"2","author":"Heymann","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"5","doi-asserted-by":"publisher","first-page":"4344","DOI":"10.3390\/cimb45050276","article-title":"Cellular and Genetic Background of Osteosarcoma.","volume":"4","author":"Ivkovi\u0107","year":"2023","journal-title":"Curr Issues Mol Biol"},{"key":"6","doi-asserted-by":"publisher","first-page":"3100","DOI":"10.1093\/nar\/gkv168","article-title":"An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex.","volume":"4","author":"Williams","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"7","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s10555-014-9518-0","article-title":"Role of MTA2 in human cancer.","volume":"3","author":"Fuqua","year":"2014","journal-title":"Cancer Metastasis Rev"},{"key":"8","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/s41419-021-03729-1","article-title":"MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1\/MEK3\/p38\/YB1 axis.","volume":"1","author":"Hsieh","year":"2021","journal-title":"Cell Death Dis"},{"key":"9","doi-asserted-by":"publisher","first-page":"6716","DOI":"10.7150\/jca.35626","article-title":"Metastasis-associated protein 2 regulates human hepatocellular carcinoma metastasis progression through modulating p38MAPK\/MMP2 pathways.","volume":"1","author":"Hsieh","year":"2019","journal-title":"J Cancer"},{"key":"10","doi-asserted-by":"publisher","first-page":"5577","DOI":"10.7314\/apjcp.2014.15.14.5577","article-title":"Short-hairpin RNA-mediated MTA2 silencing inhibits human breast cancer cell line MDA-MB231 proliferation and metastasis.","volume":"1","author":"Jin","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"key":"11","doi-asserted-by":"publisher","first-page":"4199","DOI":"10.1158\/0008-5472.CAN-20-1158","article-title":"Metastasis-Associated Protein 2 Represses NF-\u03baB to Reduce Lung Tumor Growth and Inflammation.","volume":"8","author":"Pullamsetti","year":"2020","journal-title":"Cancer Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.3390\/cancers11121851","article-title":"MTA2 as a Potential Biomarker and Its Involvement in Metastatic Progression of Human Renal Cancer by miR-133b Targeting MMP-9.","volume":"1","author":"Tsai","year":"2019","journal-title":"Cancers (Basel)"},{"key":"13","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1111\/cas.14778","article-title":"MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E-Twist feedback loop.","volume":"11","author":"Shan","year":"2021","journal-title":"Cancer Sci"},{"key":"14","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1111\/jop.12941","article-title":"Repression of metastasis-associated protein 2 for inhibiting metastasis of human oral cancer cells by promoting the p-cofilin-1\/ LC3-II expression.","volume":"4","author":"Hsieh","year":"2019","journal-title":"J Oral Pathol Med"},{"key":"15","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fonc.2018.00024","article-title":"Multifaceted Role of the Urokinase-Type Plasminogen Activator (uPA) and Its Receptor (uPAR): Diagnostic, Prognostic, and Therapeutic Applications.","volume":"8","author":"Rabbani","year":"2018","journal-title":"Front Oncol"},{"key":"16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3390\/cells9010040","article-title":"Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin.","volume":"9","author":"Gomariz","year":"2019","journal-title":"Cells"},{"key":"17","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1002\/ijc.22487","article-title":"Accurate discrimination of pancreatic ductal adenocarcinoma and chronic pancreatitis using multimarker expression data and samples obtained by minimally invasive fine needle aspiration.","volume":"12","author":"Mitas","year":"2007","journal-title":"Int J Cancer"},{"key":"18","doi-asserted-by":"publisher","first-page":"e23841","DOI":"10.1097\/MD.0000000000023841","article-title":"Prognostic role of urokinase plasminogen activator in hepatocellular carcinoma: A protocol for systematic review and meta analysis.","volume":"9","author":"Chen","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1177\/172460081002500209","article-title":"Identification of a novel biomarker signature associated with risk for bone metastasis in patients with renal cell carcinoma.","volume":"2","author":"Mourah","year":"2010","journal-title":"Int J Biol Markers"},{"key":"20","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s11060-019-03161-8","article-title":"Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1.","volume":"14","author":"Parat","year":"2019","journal-title":"J Neurooncol"},{"key":"21","doi-asserted-by":"publisher","first-page":"e0133592","DOI":"10.1371\/journal.pone.0133592","article-title":"Progression of Osteosarcoma from a Non-Metastatic to a Metastatic Phenotype Is Causally Associated with Activation of an Autocrine and Paracrine uPA Axis.","volume":"1","author":"Saunders","year":"2015","journal-title":"PLoS One"},{"key":"22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1475-2867-14-27","article-title":"The impact of COX-2 on invasion of osteosarcoma cell and its mechanism of regulation.","volume":"1","author":"Lou","year":"2014","journal-title":"Cancer Cell Int"},{"key":"23","doi-asserted-by":"publisher","first-page":"404810","DOI":"10.1155\/2012\/404810","article-title":"MAPK\/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions.","volume":"201","author":"Lee","year":"2012","journal-title":"Sarcoma"},{"key":"24","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.3892\/or.2016.5054","article-title":"Metastasis-associated protein is a predictive biomarker for metastasis and recurrence in gastric cancer.","volume":"3","author":"Kusunoki","year":"2016","journal-title":"Oncol Rep"},{"key":"25","doi-asserted-by":"publisher","first-page":"262","DOI":"10.7150\/jca.77402","article-title":"MTA2 is one of 14 Transcription factors predicting recurrence free survival in gastric cancer and promotes cancer progression by targeting MCM5.","volume":"1","author":"Xie","year":"2023","journal-title":"J Cancer"},{"key":"26","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.omtn.2020.04.009","article-title":"Transcriptional Suppression of miR-7 by MTA2 Induces Sp1-Mediated KLK10 Expression and Metastasis of Cervical Cancer.","volume":"2","author":"Hsieh","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"27","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.2147\/OTT.S96518","article-title":"Upregulation of metastasis-associated gene 2 promotes cell proliferation and invasion in nasopharyngeal carcinoma.","volume":"9","author":"Zhang","year":"2016","journal-title":"Onco Targets Ther"},{"key":"28","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3389\/fonc.2016.00024","article-title":"Mechanistic Insights into Molecular Targeting and Combined Modality Therapy for Aggressive, Localized Prostate Cancer.","volume":"6","author":"Bristow","year":"2016","journal-title":"Front Oncol"},{"key":"29","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.3390\/cancers13081838","article-title":"Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy.","volume":"1","author":"Waisman","year":"2021","journal-title":"Cancers (Basel)"},{"key":"30","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.cellsig.2017.01.020","article-title":"RhoA\/ROCK pathway mediates leptin-induced uPA expression to promote cell invasion in ovarian cancer cells.","volume":"3","author":"Panjehpour","year":"2017","journal-title":"Cell Signal"},{"key":"31","doi-asserted-by":"publisher","first-page":"48889","DOI":"10.18632\/oncotarget.16522","article-title":"TIPE3 protein promotes breast cancer metastasis through activating AKT and NF-\u03baB signaling pathways.","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"32","doi-asserted-by":"publisher","first-page":"21903","DOI":"10.1038\/srep21903","article-title":"Simultaneous knockdown of uPA and MMP9 can reduce breast cancer progression by increasing cell-cell adhesion and modulating EMT genes.","volume":"6","author":"Basu","year":"2016","journal-title":"Sci Rep"},{"key":"33","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.7150\/jca.84687","article-title":"ANP32A Knockdown Attenuates the Malignant Biological Behavior of Colorectal Cancer Cells by Suppressing Epithelial-mesenchymal Transition and ERK Activation.","volume":"1","author":"Wang","year":"2023","journal-title":"J Cancer"},{"key":"34","doi-asserted-by":"publisher","first-page":"216398","DOI":"10.1016\/j.canlet.2023.216398","article-title":"EMP3 as a key downstream target of miR-663a regulation interferes with MAPK\/ERK signaling pathway to inhibit gallbladder cancer progression.","volume":"57","author":"Liu","year":"2023","journal-title":"Cancer Lett"},{"key":"35","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.3390\/cancers13133181","article-title":"Lipocalin-2 Inhibits Osteosarcoma Cell Metastasis by Suppressing MET Expression via the MEK-ERK Pathway.","volume":"1","author":"Yang","year":"2021","journal-title":"Cancers (Basel)"},{"key":"36","first-page":"1147","article-title":"Ras\/Raf\/MEK\/ERK pathway is associated with lung metastasis of osteosarcoma in an orthotopic mouse model.","volume":"3","author":"Walsh","year":"2011","journal-title":"Anticancer Res"},{"key":"37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence.","volume":"27","author":"Chambard","year":"2010","journal-title":"FEBS J"},{"key":"38","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3390\/ph14030260","article-title":"Potential Antimetastatic Effect of Timosaponin AIII against Human Osteosarcoma Cells through Regulating the Integrin\/FAK\/Cofilin Axis.","volume":"1","author":"Lin","year":"2021","journal-title":"Pharmaceuticals (Basel)"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T16:12:53Z","timestamp":1726848773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":38,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,9,15]]}},"alternative-id":["206070","39248711"],"URL":"https:\/\/doi.org\/10.18632\/aging.206070","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]}}}