{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:45:15Z","timestamp":1792035915306,"version":"4.4.0"},"reference-count":97,"publisher":"Impact Journals, LLC","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2024,10,15]]},"DOI":"10.18632\/aging.206124","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T17:39:49Z","timestamp":1728063589000},"page":"12697-12725","source":"Crossref","is-referenced-by-count":15,"title":["A new model and precious tool to study molecular mechanisms of macrophage aging"],"prefix":"10.18632","volume":"16","author":[{"given":"R\u00e9my","family":"Smith","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS UMR 8256 Biological Adaptation and Ageing (B2A), INSERM U1164, Institut de Biologie Paris Seine (IBPS), Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e9vin","family":"Bassand","sequence":"additional","affiliation":[{"name":"INSERM U1148, Laboratory for Vascular and Translational Sciences (LVTS), Universit\u00e9 Sorbonne Paris Nord, Bobigny 93000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Dussol","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS UMR 8256 Biological Adaptation and Ageing (B2A), INSERM U1164, Institut de Biologie Paris Seine (IBPS), Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Piesse","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS, Institut de Biologie Paris Seine (IBPS), Plate-forme Ing\u00e9nierie des Prot\u00e9ines et Synth\u00e8se Peptidique, Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Duplus","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS UMR 8256 Biological Adaptation and Ageing (B2A), INSERM U1164, Institut de Biologie Paris Seine (IBPS), Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"El Hadri","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, CNRS UMR 8256 Biological Adaptation and Ageing (B2A), INSERM U1164, Institut de Biologie Paris Seine (IBPS), Paris 75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy.","volume":"2","author":"van Deursen","year":"2015","journal-title":"Nat Med"},{"key":"2","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence.","volume":"90","author":"De Benedictis","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"3","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span.","volume":"2","author":"Weyand","year":"2019","journal-title":"Nat Med"},{"key":"4","doi-asserted-by":"publisher","first-page":"3261","DOI":"10.1038\/s41467-018-05800-6","article-title":"Resolution of chronic inflammatory disease: universal and tissue-specific concepts.","volume":"9","author":"Neurath","year":"2018","journal-title":"Nat Commun"},{"key":"5","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.2174\/138161209789058110","article-title":"An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging.","volume":"1","author":"Miquel","year":"2009","journal-title":"Curr Pharm Des"},{"key":"6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-021-00646-9","article-title":"Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention.","volume":"6","author":"Ju","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"7","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo.","volume":"9","author":"Pereira-Smith","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"8","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells.","volume":"8","author":"d\u2019Adda di Fagagna","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.molmed.2010.03.003","article-title":"Inflammatory networks during cellular senescence: causes and consequences.","volume":"1","author":"Campisi","year":"2010","journal-title":"Trends Mol Med"},{"key":"10","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/cei.12876","article-title":"The convergence of senescence and nutrient sensing during lymphocyte ageing.","volume":"18","author":"Akbar","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"11","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.1172\/JCI75051","article-title":"p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8T cells.","volume":"12","author":"Akbar","year":"2014","journal-title":"J Clin Invest"},{"key":"12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/08830189509056697","article-title":"Introduction: the reshaping of the immune system with age.","volume":"1","author":"Cossarizza","year":"1995","journal-title":"Int Rev Immunol"},{"key":"13","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2174\/138161210790883840","article-title":"Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches.","volume":"1","author":"Pini","year":"2010","journal-title":"Curr Pharm Des"},{"key":"14","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s00281-020-00806-z","article-title":"The interplay between immunosenescence and age-related diseases.","volume":"4","author":"Bauer","year":"2020","journal-title":"Semin Immunopathol"},{"key":"15","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1172\/JCI22475","article-title":"Ink4a\/Arf expression is a biomarker of aging.","volume":"11","author":"Sharpless","year":"2004","journal-title":"J Clin Invest"},{"key":"16","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.","volume":"6","author":"Campisi","year":"2008","journal-title":"PLoS Biol"},{"key":"17","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cell.2014.10.039","article-title":"Geroscience: linking aging to chronic disease.","volume":"15","author":"Schadt","year":"2014","journal-title":"Cell"},{"key":"18","doi-asserted-by":"publisher","first-page":"e202010162","DOI":"10.1083\/jcb.202010162","article-title":"Similarities and interplay between senescent cells and macrophages.","volume":"22","author":"Gil","year":"2021","journal-title":"J Cell Biol"},{"key":"19","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1073\/pnas.1818313116","article-title":"Cells exhibiting strong p16promoter activation in vivo display features of senescence.","volume":"11","author":"Sharpless","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"20","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/jcp.1041510324","article-title":"Biochemical events accompanying macrophage activation and the inhibition of colony-stimulating factor-1-induced macrophage proliferation by tumor necrosis factor-alpha, interferon-gamma, and lipopolysaccharide.","volume":"15","author":"Hamilton","year":"1992","journal-title":"J Cell Physiol"},{"key":"21","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.18632\/aging.100991","article-title":"Aging of mice is associated with p16(Ink4a)- and \u03b2-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.","volume":"8","author":"Gudkov","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"22","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cmet.2020.05.002","article-title":"Defined p16Senescent Cell Types Are Indispensable for Mouse Healthspan.","volume":"3","author":"Bulavin","year":"2020","journal-title":"Cell Metab"},{"key":"23","doi-asserted-by":"publisher","first-page":"1960","DOI":"10.3389\/fimmu.2017.01960","article-title":"Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?","volume":"8","author":"Franceschi","year":"2018","journal-title":"Front Immunol"},{"key":"24","doi-asserted-by":"publisher","first-page":"101422","DOI":"10.1016\/j.arr.2021.101422","article-title":"Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?","volume":"7","author":"Monti","year":"2021","journal-title":"Ageing Res Rev"},{"key":"25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2020.12.003","article-title":"The impact of ageing on monocytes and macrophages.","volume":"23","author":"Chambers","year":"2021","journal-title":"Immunol Lett"},{"key":"26","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.cmet.2013.09.010","article-title":"Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.","volume":"1","author":"Ingram","year":"2013","journal-title":"Cell Metab"},{"key":"27","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/s41590-020-0646-0","article-title":"Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly.","volume":"2","author":"Gilroy","year":"2020","journal-title":"Nat Immunol"},{"key":"28","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.18632\/aging.101268","article-title":"p16(Ink4a) and senescence-associated \u03b2-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli.","volume":"9","author":"Gollnick","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"29","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.ccell.2023.05.006","article-title":"Senescent alveolar macrophages promote early-stage lung tumorigenesis.","volume":"4","author":"Baker","year":"2023","journal-title":"Cancer Cell"},{"key":"30","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.ccell.2023.05.004","article-title":"Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer.","volume":"4","author":"Gonzalez-Meljem","year":"2023","journal-title":"Cancer Cell"},{"key":"31","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.chom.2017.03.002","article-title":"Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.","volume":"2","author":"Davidson","year":"2017","journal-title":"Cell Host Microbe"},{"key":"32","doi-asserted-by":"publisher","first-page":"4697","DOI":"10.4049\/jimmunol.169.9.4697","article-title":"Cutting edge: impaired Toll-like receptor expression and function in aging.","volume":"16","author":"Sambhara","year":"2002","journal-title":"J Immunol"},{"key":"33","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1111\/j.1532-5415.2007.01300.x","article-title":"Toll-like receptors in older adults.","volume":"5","author":"Shaw","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1365-2249.2008.03658.x","article-title":"Ageing is associated with diminished apoptotic cell clearance in vivo.","volume":"15","author":"Walsh","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"35","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1016\/j.celrep.2018.02.071","article-title":"Telomere Dysfunction Disturbs Macrophage Mitochondrial Metabolism and the NLRP3 Inflammasome through the PGC-1\u03b1\/TNFAIP3 Axis.","volume":"2","author":"Shi","year":"2018","journal-title":"Cell Rep"},{"key":"36","doi-asserted-by":"publisher","first-page":"6118","DOI":"10.1046\/j.1432-1327.2000.01703.x","article-title":"Thioredoxin reductase as a pathophysiological factor and drug target.","volume":"26","author":"M\u00fcller","year":"2000","journal-title":"Eur J Biochem"},{"key":"37","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1089\/ars.2008.2379","article-title":"Thioredoxin-1 and endothelial cell aging: role in cardiovascular diseases.","volume":"1","author":"Haendeler","year":"2009","journal-title":"Antioxid Redox Signal"},{"key":"38","doi-asserted-by":"publisher","first-page":"40310","DOI":"10.1074\/jbc.M503644200","article-title":"Extracellular human thioredoxin-1 inhibits lipopolysaccharide-induced interleukin-1beta expression in human monocyte-derived macrophages.","volume":"28","author":"Rouis","year":"2005","journal-title":"J Biol Chem"},{"key":"39","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1161\/ATVBAHA.112.249334","article-title":"Thioredoxin-1 promotes anti-inflammatory macrophages of the M2 phenotype and antagonizes atherosclerosis.","volume":"3","author":"Rouis","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"40","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1161\/CIRCULATIONAHA.117.027612","article-title":"Human Plasma Thioredoxin-80 Increases With Age and in ApoEMice Induces Inflammation, Angiogenesis, and Atherosclerosis.","volume":"13","author":"Rouis","year":"2017","journal-title":"Circulation"},{"key":"41","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12020-020-02389-z","article-title":"Thioredoxin-1 attenuates atherosclerosis development through inhibiting NLRP3 inflammasome.","volume":"7","author":"Zhang","year":"2020","journal-title":"Endocrine"},{"key":"42","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/cvr\/cvy183","article-title":"A thioredoxin-mimetic peptide exerts potent anti-inflammatory, antioxidant, and atheroprotective effects in ApoE2.Ki mice fed high fat diet.","volume":"11","author":"El Hadri","year":"2019","journal-title":"Cardiovasc Res"},{"key":"43","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence.","volume":"12","author":"Gil","year":"2018","journal-title":"J Clin Invest"},{"key":"44","first-page":"639","article-title":"The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.","volume":"1","author":"Tyner","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"45","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis.","volume":"35","author":"van Deursen","year":"2016","journal-title":"Science"},{"key":"46","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1182\/blood.V75.1.4","article-title":"Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF.","volume":"7","author":"Dinarello","year":"1990","journal-title":"Blood"},{"key":"47","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1128\/MCB.21.3.721-730.2001","article-title":"The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR.","volume":"2","author":"Saklatvala","year":"2001","journal-title":"Mol Cell Biol"},{"key":"48","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10555-010-9220-9","article-title":"Senescent cells as a source of inflammatory factors for tumor progression.","volume":"2","author":"Desprez","year":"2010","journal-title":"Cancer Metastasis Rev"},{"key":"49","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1152\/physiol.00029.2013","article-title":"Matrix metalloproteinase-9: Many shades of function in cardiovascular disease.","volume":"2","author":"Lindsey","year":"2013","journal-title":"Physiology (Bethesda)"},{"key":"50","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/s41423-021-00791-9","article-title":"Metabolism of tissue macrophages in homeostasis and pathology.","volume":"1","author":"Sancho","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"51","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.celrep.2018.10.092","article-title":"A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.","volume":"2","author":"O\u2019neill","year":"2018","journal-title":"Cell Rep"},{"key":"52","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1083\/jcb.201004096","article-title":"Clearance of apoptotic cells: implications in health and disease.","volume":"18","author":"Ravichandran","year":"2010","journal-title":"J Cell Biol"},{"key":"53","doi-asserted-by":"publisher","first-page":"16018","DOI":"10.1038\/npjamd.2016.18","article-title":"Macrophages in age-related chronic inflammatory diseases.","volume":"2","author":"Manabe","year":"2016","journal-title":"NPJ Aging Mech Dis"},{"key":"54","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/j.1474-9726.2012.00851.x","article-title":"Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function.","volume":"1","author":"Crowe","year":"2012","journal-title":"Aging Cell"},{"key":"55","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1179\/096805103125001586","article-title":"Macrophage recognition of zymosan particles.","volume":"9","author":"Underhill","year":"2003","journal-title":"J Endotoxin Res"},{"key":"56","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1038\/s41591-018-0092-9","article-title":"Senolytics improve physical function and increase lifespan in old age.","volume":"2","author":"Verzosa","year":"2018","journal-title":"Nat Med"},{"key":"57","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.exger.2014.03.005","article-title":"The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4.","volume":"5","author":"Haendeler","year":"2014","journal-title":"Exp Gerontol"},{"key":"58","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.bbrc.2010.01.026","article-title":"Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts.","volume":"39","author":"Rai","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"59","doi-asserted-by":"publisher","first-page":"e1005212","DOI":"10.1371\/journal.pgen.1005212","article-title":"Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress.","volume":"1","author":"Koumenis","year":"2015","journal-title":"PLoS Genet"},{"key":"60","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2016.02.024","article-title":"Tissue-Resident Macrophage Ontogeny and Homeostasis.","volume":"4","author":"Guilliams","year":"2016","journal-title":"Immunity"},{"key":"61","doi-asserted-by":"publisher","first-page":"22637","DOI":"10.1038\/srep22637","article-title":"Age-associated metabolic dysregulation in bone marrow-derived macrophages stimulated with lipopolysaccharide.","volume":"6","author":"Bowdish","year":"2016","journal-title":"Sci Rep"},{"key":"62","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing.","volume":"50","author":"van Deursen","year":"2014","journal-title":"Nature"},{"key":"63","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1101\/gad.9.8.935","article-title":"p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.","volume":"9","author":"Jacks","year":"1995","journal-title":"Genes Dev"},{"key":"64","doi-asserted-by":"publisher","first-page":"3830","DOI":"10.1161\/01.CIR.0000148681.01282.89","article-title":"Absence of p21Waf1\/Cip1\/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis.","volume":"11","author":"Chan","year":"2004","journal-title":"Circulation"},{"key":"65","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling.","volume":"2","author":"Engeland","year":"2022","journal-title":"Cell Death Differ"},{"key":"66","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1084\/jem.147.4.1253","article-title":"Proliferative capacity of mouse peritoneal macrophages in vitro.","volume":"14","author":"Schlesinger","year":"1978","journal-title":"J Exp Med"},{"key":"67","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2172-14-6","article-title":"Characterization of murine macrophages from bone marrow, spleen and peritoneum.","volume":"1","author":"Harris","year":"2013","journal-title":"BMC Immunol"},{"key":"68","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","article-title":"Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response.","volume":"1","author":"von Zglinicki","year":"2012","journal-title":"Aging Cell"},{"key":"69","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1089\/ars.2020.8048","article-title":"Senescence in Post-Mitotic Cells: A Driver of Aging?","volume":"3","author":"Miwa","year":"2021","journal-title":"Antioxid Redox Signal"},{"key":"70","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.4049\/jimmunol.2100284","article-title":"Radiation-Induced Macrophage Senescence Impairs Resolution Programs and Drives Cardiovascular Inflammation.","volume":"20","author":"Guo","year":"2021","journal-title":"J Immunol"},{"key":"71","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1474-9726.2006.00199.x","article-title":"Senescence-associated beta-galactosidase is lysosomal beta-galactosidase.","volume":"5","author":"Hwang","year":"2006","journal-title":"Aging Cell"},{"key":"72","doi-asserted-by":"publisher","first-page":"81099","DOI":"10.18632\/oncotarget.12752","article-title":"Is senescence-associated \u03b2-galactosidase a marker of neuronal senescence?","volume":"7","author":"Sikora","year":"2016","journal-title":"Oncotarget"},{"key":"73","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1101\/gad.859201","article-title":"Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions.","volume":"1","author":"Wright","year":"2001","journal-title":"Genes Dev"},{"key":"74","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence.","volume":"19","author":"Campisi","year":"2011","journal-title":"J Cell Biol"},{"key":"75","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1111\/febs.15327","article-title":"Glycolysis - a key player in the inflammatory response.","volume":"28","author":"Mittelbrunn","year":"2020","journal-title":"FEBS J"},{"key":"76","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1.","volume":"49","author":"Tong","year":"2013","journal-title":"Nature"},{"key":"77","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1074\/jbc.M115.676817","article-title":"Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression.","volume":"29","author":"Hiller","year":"2016","journal-title":"J Biol Chem"},{"key":"78","doi-asserted-by":"publisher","first-page":"101147","DOI":"10.1016\/j.redox.2019.101147","article-title":"Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide - A divergent role for glycolysis.","volume":"2","author":"Immenschuh","year":"2019","journal-title":"Redox Biol"},{"key":"79","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1038\/s41467-017-02092-0","article-title":"Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels.","volume":"8","author":"McVicar","year":"2017","journal-title":"Nat Commun"},{"key":"80","doi-asserted-by":"publisher","first-page":"e3000599","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development.","volume":"1","author":"Schilling","year":"2020","journal-title":"PLoS Biol"},{"key":"81","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1101\/gad.17276711","article-title":"Control of the senescence-associated secretory phenotype by NF-\u03baB promotes senescence and enhances chemosensitivity.","volume":"2","author":"Lowe","year":"2011","journal-title":"Genes Dev"},{"key":"82","doi-asserted-by":"publisher","first-page":"e1005741","DOI":"10.1371\/journal.pcbi.1005741","article-title":"A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence.","volume":"1","author":"Scharffetter-Kochanek","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"83","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","article-title":"Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP).","volume":"2","author":"Kaarniranta","year":"2012","journal-title":"Cell Signal"},{"key":"84","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","article-title":"Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty.","volume":"5","author":"Keller","year":"2000","journal-title":"Annu Rev Med"},{"key":"85","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.jaci.2010.11.050","article-title":"Interleukins, from 1 to 37, and interferon-\u03b3: receptors, functions, and roles in diseases.","volume":"12","author":"Schaffartzik","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"86","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cyto.2014.05.024","article-title":"Interleukin-6 and its receptors: a highly regulated and dynamic system.","volume":"7","author":"Garbers","year":"2014","journal-title":"Cytokine"},{"key":"87","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1080\/15321819.2011.601781","article-title":"Cytokine serum profile in a group of Sicilian nonagenarians.","volume":"3","author":"Lio","year":"2012","journal-title":"J Immunoassay Immunochem"},{"key":"88","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00005-015-0377-3","article-title":"Inflammaging and Anti-Inflammaging: The Role of Cytokines in Extreme Longevity.","volume":"6","author":"Basile","year":"2016","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"89","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/j.cell.2008.03.039","article-title":"Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.","volume":"13","author":"Peeper","year":"2008","journal-title":"Cell"},{"key":"90","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.cell.2008.03.038","article-title":"Chemokine signaling via the CXCR2 receptor reinforces senescence.","volume":"13","author":"d\u2019Adda di Fagagna","year":"2008","journal-title":"Cell"},{"key":"91","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1016\/s0047-6374(01)00322-0","article-title":"Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages.","volume":"12","author":"Brock","year":"2001","journal-title":"Mech Ageing Dev"},{"key":"92","first-page":"262","article-title":"The impact of glial activation in the aging brain.","volume":"1","author":"Lynch","year":"2010","journal-title":"Aging Dis"},{"key":"93","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/acel.12223","article-title":"Aging impairs peritoneal but not bone marrow-derived macrophage phagocytosis.","volume":"1","author":"Fitzgerald","year":"2014","journal-title":"Aging Cell"},{"key":"94","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1189\/jlb.0803389","article-title":"Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression.","volume":"7","author":"Kovacs","year":"2004","journal-title":"J Leukoc Biol"},{"key":"95","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.","volume":"53","author":"van Deursen","year":"2016","journal-title":"Nature"},{"key":"96","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-021-03547-7","article-title":"An aged immune system drives senescence and ageing of solid organs.","volume":"59","author":"Dong","year":"2021","journal-title":"Nature"},{"key":"97","doi-asserted-by":"publisher","first-page":"e158450","DOI":"10.1172\/JCI158450","article-title":"Cellular senescence: a key therapeutic target in aging and diseases.","volume":"13","author":"Zhu","year":"2022","journal-title":"J Clin Invest"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T13:48:50Z","timestamp":1729518530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":97,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,10,15]]}},"alternative-id":["206124","39373702"],"URL":"https:\/\/doi.org\/10.18632\/aging.206124","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]}}}