{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:56:50Z","timestamp":1780617410829,"version":"3.54.1"},"reference-count":41,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.206138","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:17:38Z","timestamp":1730294258000},"source":"Crossref","is-referenced-by-count":2,"title":["OSBPL2 inhibition leads to apoptosis of cochlea hair cells in age-related hearing loss by inhibiting the AKT\/FOXG1 signaling pathway"],"prefix":"10.18632","author":[{"given":"Meina","family":"Li-Yang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, The First People\u2019s Hospital of Changzhou, Jiangsu 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The First People\u2019s Hospital of Changzhou, Jiangsu 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First People\u2019s Hospital of Changzhou, Jiangsu 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"You","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, The First People\u2019s Hospital of Changzhou, Jiangsu 213003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/s41419-022-04774-0","article-title":"Downregulation of REST in the cochlea contributes to age-related hearing loss via the p53 apoptosis pathway.","volume":"1","author":"Lv","year":"2022","journal-title":"Cell Death Dis"},{"key":"2","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/S0140-6736(05)67423-5","article-title":"Presbycusis.","volume":"36","author":"Mills","year":"2005","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"publisher","first-page":"1240587","DOI":"10.3389\/fncom.2023.1240587","article-title":"The effect of hearing impairment and social participation on depressive symptoms in older adults: a cross-lagged analysis.","volume":"1","author":"Shi","year":"2023","journal-title":"Front Comput Neurosci"},{"key":"4","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.heares.2006.06.004","article-title":"Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss.","volume":"22","author":"Tanokura","year":"2007","journal-title":"Hear Res"},{"key":"5","doi-asserted-by":"publisher","first-page":"E33","DOI":"10.1002\/lary.24898","article-title":"No association between apolipoprotein E or N-acetyltransferase 2 gene polymorphisms and age-related hearing loss.","volume":"12","author":"Payton","year":"2015","journal-title":"Laryngoscope"},{"key":"6","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1093\/geronb\/gbac118","article-title":"Why Are Old-Age Disabilities Decreasing in Sweden and Denmark? Evidence on the Contribution of Cognition, Education, and Sensory Functions.","volume":"7","author":"Fors","year":"2023","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"7","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3892\/ijmm.2017.3004","article-title":"Otoprotective effects of ethosuximide in NOD\/LtJ mice with age-related hearing loss.","volume":"4","author":"Zheng","year":"2017","journal-title":"Int J Mol Med"},{"key":"8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.heares.2009.10.009","article-title":"Age-related loss of spiral ganglion neurons.","volume":"26","author":"Ohlemiller","year":"2010","journal-title":"Hear Res"},{"key":"9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3389\/fcell.2017.00021","article-title":"Signaling and Transcription Factors during Inner Ear Development: The Generation of Hair Cells and Otic Neurons.","volume":"5","author":"Giraldez","year":"2017","journal-title":"Front Cell Dev Biol"},{"key":"10","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/s41419-019-1386-7","article-title":"Pasireotide protects mammalian cochlear hair cells from gentamicin ototoxicity by activating the PI3K-Akt pathway.","volume":"1","author":"Petkovic","year":"2019","journal-title":"Cell Death Dis"},{"key":"11","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1007\/s10565-021-09596-y","article-title":"The DNA methylation inhibitor RG108 protects against noise-induced hearing loss.","volume":"3","author":"He","year":"2021","journal-title":"Cell Biol Toxicol"},{"key":"12","doi-asserted-by":"publisher","first-page":"760422","DOI":"10.3389\/fncel.2021.760422","article-title":"Autophagy Regulates the Survival of Hair Cells and Spiral Ganglion Neurons in Cases of Noise, Ototoxic Drug, and Age-Induced Sensorineural Hearing Loss.","volume":"1","author":"Yang","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"13","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41419-019-1858-9","article-title":"Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity.","volume":"1","author":"Cao","year":"2019","journal-title":"Cell Death Dis"},{"key":"14","doi-asserted-by":"publisher","first-page":"e149626","DOI":"10.1172\/jci.insight.149626","article-title":"Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling.","volume":"7","author":"Cao","year":"2022","journal-title":"JCI Insight"},{"key":"15","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/gim.2014.90","article-title":"Identification of OSBPL2 as a novel candidate gene for progressive nonsyndromic hearing loss by whole-exome sequencing.","volume":"1","author":"Cao","year":"2015","journal-title":"Genet Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1080\/15548627.2022.2040891","article-title":"OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin.","volume":"1","author":"Jung","year":"2022","journal-title":"Autophagy"},{"key":"17","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3390\/antiox12020233","article-title":"IGF-1 Controls Metabolic Homeostasis and Survival in HEI-OC1 Auditory Cells through AKT and mTOR Signaling.","volume":"1","author":"Varela-Nieto","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"18","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.3390\/antiox10091497","article-title":"Role of Oxidative Stress in the Senescence Pattern of Auditory Cells in Age-Related Hearing Loss.","volume":"1","author":"S\u00e1nchez-Rodr\u00edguez","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"19","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/kjm2.12632","article-title":"CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B.","volume":"3","author":"Hou","year":"2023","journal-title":"Kaohsiung J Med Sci"},{"key":"20","doi-asserted-by":"publisher","first-page":"644","DOI":"10.7150\/ijbs.25272","article-title":"MiR-152-5p as a microRNA passenger strand special functions in human gastric cancer cells.","volume":"1","author":"Li","year":"2018","journal-title":"Int J Biol Sci"},{"key":"21","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1002\/ar.23798","article-title":"Reducing-Autophagy Derived Mitochondrial Dysfunction during Resveratrol Promotes Fibroblast-Like Synovial Cell Apoptosis.","volume":"30","author":"Chen","year":"2018","journal-title":"Anat Rec (Hoboken)"},{"key":"22","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1080\/15548627.2016.1196318","article-title":"Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells.","volume":"1","author":"Chen","year":"2016","journal-title":"Autophagy"},{"key":"23","doi-asserted-by":"publisher","first-page":"e9737","DOI":"10.7717\/peerj.9737","article-title":"Transcriptomic analysis highlights cochlear inflammation associated with age-related hearing loss in C57BL\/6 mice using next generation sequencing.","volume":"8","author":"Zheng","year":"2020","journal-title":"PeerJ"},{"key":"24","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.redox.2017.04.031","article-title":"The role of sodium hydrosulfide in attenuating the aging process via PI3K\/AKT and CaMKK\u03b2\/AMPK pathways.","author":"Kong","year":"2017","journal-title":"Redox Biol"},{"key":"25","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuropharm.2018.10.021","article-title":"The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells.","volume":"14","author":"Yu","year":"2019","journal-title":"Neuropharmacology"},{"key":"26","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s00018-019-03291-2","article-title":"Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea.","volume":"7","author":"Zhang","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1523\/JNEUROSCI.2897-10.2011","article-title":"FoxG1 promotes the survival of postmitotic neurons.","volume":"3","author":"D\u2019Mello","year":"2011","journal-title":"J Neurosci"},{"key":"28","doi-asserted-by":"publisher","first-page":"1026056","DOI":"10.3389\/fnhum.2022.1026056","article-title":"Spontaneous head-movements improve sound localization in aging adults with hearing loss.","volume":"1","author":"Valzolgher","year":"2022","journal-title":"Front Hum Neurosci"},{"key":"29","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrm3999","article-title":"Live to die another way: modes of programmed cell death and the signals emanating from dying cells.","volume":"1","author":"Steller","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"30","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3892\/etm.2023.11793","article-title":"UCHL1 regulated by Sp1 ameliorates cochlear hair cell senescence and oxidative damage.","volume":"2","author":"Chen","year":"2023","journal-title":"Exp Ther Med"},{"key":"31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s13023-015-0238-5","article-title":"OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67).","volume":"1","author":"N\u00fcrnberg","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"32","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jgg.2019.06.006","article-title":"OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia.","volume":"4","author":"Dai","year":"2019","journal-title":"J Genet Genomics"},{"key":"33","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10162-015-0508-x","article-title":"Increased Sensitivity to Noise-Induced Hearing Loss by Blockade of Endogenous PI3K\/Akt Signaling.","volume":"1","author":"Sha","year":"2015","journal-title":"J Assoc Res Otolaryngol"},{"key":"34","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1002\/1873-3468.13482","article-title":"Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway.","volume":"59","author":"Ma","year":"2019","journal-title":"FEBS Lett"},{"key":"35","doi-asserted-by":"publisher","first-page":"e30790","DOI":"10.1371\/journal.pone.0030790","article-title":"AKT signaling mediates IGF-I survival actions on otic neural progenitors.","volume":"7","author":"Sanchez-Calderon","year":"2012","journal-title":"PLoS One"},{"key":"36","doi-asserted-by":"publisher","first-page":"e0121599","DOI":"10.1371\/journal.pone.0121599","article-title":"All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.","volume":"1","author":"Bodmer","year":"2015","journal-title":"PLoS One"},{"key":"37","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1002\/dvdy.20839","article-title":"Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear.","volume":"23","author":"Fritzsch","year":"2006","journal-title":"Dev Dyn"},{"key":"38","doi-asserted-by":"publisher","first-page":"614954","DOI":"10.3389\/fcell.2020.614954","article-title":"The Role of FoxG1 in the Inner Ear.","volume":"8","author":"Chai","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"39","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jsbmb.2007.03.012","article-title":"FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor.","volume":"10","author":"Wolf","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"40","doi-asserted-by":"publisher","first-page":"101364","DOI":"10.1016\/j.redox.2019.101364","article-title":"The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.","volume":"2","author":"Kong","year":"2020","journal-title":"Redox Biol"},{"key":"41","doi-asserted-by":"publisher","first-page":"4341","DOI":"10.1080\/15548627.2021.1916194","article-title":"FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway.","volume":"1","author":"Kong","year":"2021","journal-title":"Autophagy"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206138","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T13:17:40Z","timestamp":1730294260000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":41,"alternative-id":["206138"],"URL":"https:\/\/doi.org\/10.18632\/aging.206138","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]}}}