{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:55:07Z","timestamp":1778612107435,"version":"3.51.4"},"reference-count":22,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.206152","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T15:58:33Z","timestamp":1731599913000},"source":"Crossref","is-referenced-by-count":1,"title":["Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression"],"prefix":"10.18632","author":[{"given":"Samuel R.","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Hematology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA"},{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA"},{"name":"UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Mitin","sequence":"additional","affiliation":[{"name":"Sapere Bio, Research Triangle Park, Raleigh-Durham-Chapel Hill, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa L. Ayer","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Clinical Sciences, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew B.","family":"Smitherman","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Hematology\/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA"},{"name":"Department of Pharmaceutical and Clinical Sciences, College of Pharmacy and Health Sciences, Campbell University, Buies Creek, NC 27506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus A.","family":"Carden","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"},{"name":"Cogent Biosciences, Waltham, MA 02451, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1182\/blood-2009-07-233700","article-title":"Improved survival of children and adolescents with sickle cell disease.","volume":"11","author":"Buchanan","year":"2010","journal-title":"Blood"},{"key":"2","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1182\/blood-2018-10-880575","article-title":"Decreased median survival of adults with sickle cell disease after adjusting for left truncation bias: a pooled analysis.","volume":"13","author":"Ataga","year":"2019","journal-title":"Blood"},{"key":"3","doi-asserted-by":"publisher","first-page":"E115","DOI":"10.1002\/ajh.25405","article-title":"A multi-institutional comparison of younger and older adults with sickle cell disease.","volume":"9","author":"Telen","year":"2019","journal-title":"Am J Hematol"},{"key":"4","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1182\/blood-2018-03-818161","article-title":"How I treat the older adult with sickle cell disease.","volume":"13","author":"Howard","year":"2018","journal-title":"Blood"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-140854","article-title":"Functional Assessment in Younger and Older Adults with Sickle Cell Disease.","volume":"13","author":"Strouse","year":"2020","journal-title":"Blood"},{"key":"6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1177\/15353702211068522","article-title":"Sickle cell disease as an accelerated aging syndrome.","volume":"24","author":"Hyacinth","year":"2022","journal-title":"Exp Biol Med (Maywood)"},{"key":"7","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1182\/blood-2017-05-783233","article-title":"Increased risk of leukemia among sickle cell disease patients in California.","volume":"13","author":"Wun","year":"2017","journal-title":"Blood"},{"key":"8","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1177\/0141076816651037","article-title":"Risk of individual malignant neoplasms in patients with sickle cell disease: English national record linkage study.","volume":"10","author":"Goldacre","year":"2016","journal-title":"J R Soc Med"},{"key":"9","doi-asserted-by":"publisher","first-page":"2707","DOI":"10.3324\/haematol.2020.265462","article-title":"Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease.","volume":"10","author":"El Nemer","year":"2021","journal-title":"Haematologica"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-145919","article-title":"Age-Associated Decline in Blood Parameters in Individuals with Sickle Cell Disease.","volume":"13","author":"Ataga","year":"2021","journal-title":"Blood"},{"key":"11","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.cell.2017.05.015","article-title":"Senescence in Health and Disease.","volume":"16","author":"Sharpless","year":"2017","journal-title":"Cell"},{"key":"12","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.tcb.2020.07.002","article-title":"A Senescence-Centric View of Aging: Implications for Longevity and Disease.","volume":"3","author":"Demaria","year":"2020","journal-title":"Trends Cell Biol"},{"key":"13","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41586-021-03547-7","article-title":"An aged immune system drives senescence and ageing of solid organs.","volume":"59","author":"Dong","year":"2021","journal-title":"Nature"},{"key":"14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1474-9726.2009.00489.x","article-title":"Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging.","volume":"8","author":"Sharpless","year":"2009","journal-title":"Aging Cell"},{"key":"15","doi-asserted-by":"publisher","first-page":"dju057","DOI":"10.1093\/jnci\/dju057","article-title":"Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.","volume":"10","author":"Alston","year":"2014","journal-title":"J Natl Cancer Inst"},{"key":"16","doi-asserted-by":"publisher","first-page":"4975","DOI":"10.1002\/cncr.33112","article-title":"Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16and frailty.","volume":"12","author":"Muss","year":"2020","journal-title":"Cancer"},{"key":"17","doi-asserted-by":"publisher","first-page":"5732","DOI":"10.21037\/tcr.2020.03.39","article-title":"p16 a biomarker of aging and tolerance for cancer therapy.","volume":"9","author":"Shachar","year":"2020","journal-title":"Transl Cancer Res"},{"key":"18","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1182\/bloodadvances.2023011188","article-title":"Characterizing epigenetic aging in an adult sickle cell disease cohort.","volume":"8","author":"Knisely","year":"2024","journal-title":"Blood Adv"},{"key":"19","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.3390\/cells9102159","article-title":"Characterization of Hematopoiesis in Sickle Cell Disease by Prospective Isolation of Stem and Progenitor Cells.","volume":"9","author":"Bouhassira","year":"2020","journal-title":"Cells"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaa082","article-title":"Effects of Breast Cancer Adjuvant Chemotherapy Regimens on Expression of the Aging Biomarker, p16INK4a.","volume":"4","author":"Speca","year":"2020","journal-title":"JNCI Cancer Spectrum"},{"key":"21","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1002\/ajh.27024","article-title":"\"Severity\" in adult sickle cell disease.","volume":"9","author":"Gladwin","year":"2023","journal-title":"Am J Hematol"},{"key":"22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.ebiom.2016.08.029","article-title":"Chemotherapy and Stem Cell Transplantation Increase p16Expression, a Biomarker of T-cell Aging.","volume":"1","author":"Sharpless","year":"2016","journal-title":"EBioMedicine"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T15:58:34Z","timestamp":1731599914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":22,"alternative-id":["206152"],"URL":"https:\/\/doi.org\/10.18632\/aging.206152","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,14]]}}}