{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:57:27Z","timestamp":1781881047602,"version":"3.54.5"},"reference-count":28,"publisher":"Impact Journals, LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"DOI":"10.18632\/aging.206216","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T16:23:10Z","timestamp":1741105390000},"source":"Crossref","is-referenced-by-count":2,"title":["Recurrent falls as the presentations of Gitelman syndrome in an octogenarian"],"prefix":"10.18632","author":[{"given":"Chien-Yao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Geriatrics and Gerontology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan"},{"name":"Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan"},{"name":"Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA"},{"name":"Department of Geriatrics and Gerontology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang-Han","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ter","family":"Chao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei 100, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan"},{"name":"Graduate Institute of Toxicology, National Taiwan University College of Medicine, Taipei 100, Taiwan"},{"name":"Graduate Institute of Medical Education and Bioethics, National Taiwan University College of Medicine, Taipei 100, Taiwan"},{"name":"Division of Nephrology, Department of Internal Medicine, Min Sheng General Hospital, Taoyuan City 330, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hua","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, National Defense Medical Center, Taipei 104, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2025,3,4]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.2174\/092986707780831050","article-title":"Hypokalemia: a practical approach to diagnosis and its genetic basis.","volume":"1","author":"Halperin","year":"2007","journal-title":"Curr Med Chem"},{"key":"2","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.kint.2016.09.046","article-title":"Gitelman syndrome: consensus and guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.","volume":"9","author":"Vargas-Poussou","year":"2017","journal-title":"Kidney Int"},{"key":"3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000447366","article-title":"Genetic Features of Chinese Patients with Gitelman Syndrome: Sixteen Novel SLC12A3 Mutations Identified in a New Cohort.","volume":"4","author":"Chen","year":"2016","journal-title":"Am J Nephrol"},{"key":"4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/ejhg.2011.189","article-title":"Novel NCC mutants and functional analysis in a new cohort of patients with Gitelman syndrome.","volume":"2","author":"Hoefsloot","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2147\/TCRM.S150483","article-title":"Two mutations in the thiazide-sensitive NaCl co-transporter gene in a Romanian Gitelman syndrome patient: case report.","volume":"1","author":"Mozos","year":"2018","journal-title":"Ther Clin Risk Manag"},{"key":"6","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.2147\/IJGM.S308246","article-title":"Three Novel Homozygous Mutations of theGene in a Gitelman Syndrome Patient.","volume":"1","author":"Lu","year":"2021","journal-title":"Int J Gen Med"},{"key":"7","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1681\/ASN.2010090907","article-title":"Spectrum of mutations in Gitelman syndrome.","volume":"2","author":"Rigothier","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"8","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1291\/hypres.27.327","article-title":"A high prevalence of Gitelman's syndrome mutations in Japanese.","volume":"2","author":"Iwai","year":"2004","journal-title":"Hypertens Res"},{"key":"9","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1093\/ndt\/gfn619","article-title":"Heterozygous mutations of the sodium chloride cotransporter in Chinese children: prevalence and association with blood pressure.","volume":"2","author":"Lin","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/ng.118","article-title":"Rare independent mutations in renal salt handling genes contribute to blood pressure variation.","volume":"4","author":"Lifton","year":"2008","journal-title":"Nat Genet"},{"key":"11","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1046\/j.1523-1755.2001.059002710.x","article-title":"Gitelman's syndrome revisited: an evaluation of symptoms and health-related quality of life.","volume":"5","author":"Simon","year":"2001","journal-title":"Kidney Int"},{"key":"12","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.amjmed.2017.01.023","article-title":"Identification of the Causes for Chronic Hypokalemia: Importance of Urinary Sodium and Chloride Excretion.","volume":"13","author":"Lin","year":"2017","journal-title":"Am J Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1159\/000245172","article-title":"Hypokalaemia in the elderly.","volume":"1","author":"Judge","year":"1968","journal-title":"Gerontol Clin (Basel)"},{"key":"14","first-page":"861","article-title":"Hypokalemia: are elderly females more vulnerable?","volume":"8","author":"Corcoran","year":"1993","journal-title":"J Natl Med Assoc"},{"key":"15","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1053\/j.ajkd.2003.10.018","article-title":"Intrafamilial phenotype variability in patients with Gitelman syndrome having the same mutations in their thiazide-sensitive sodium\/chloride cotransporter.","volume":"4","author":"Halperin","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"16","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1046\/j.1523-1755.2003.00730.x","article-title":"A novel mutation in the chloride channel gene, CLCNKB, as a cause of Gitelman and Bartter syndromes.","volume":"6","author":"Nakhoul","year":"2003","journal-title":"Kidney Int"},{"key":"17","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1681\/ASN.V541112","article-title":"Influence of gender on renal thiazide diuretic receptor density and response.","volume":"5","author":"Fanestil","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"18","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.amepre.2018.04.035","article-title":"The Potential to Reduce Falls and Avert Costs by Clinically Managing Fall Risk.","volume":"5","author":"Lee","year":"2018","journal-title":"Am J Prev Med"},{"key":"19","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.maturitas.2020.10.021","article-title":"Risk factors for recurrent falls in older adults: A systematic review with meta-analysis.","volume":"14","author":"Liu-Ambrose","year":"2021","journal-title":"Maturitas"},{"key":"20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0022-510x(80)90125-2","article-title":"Neuronal changes of hypokalemic myopathy. A light-and electron-microscopic study on muscle biopsy.","volume":"4","author":"Imada","year":"1980","journal-title":"J Neurol Sci"},{"key":"21","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.bone.2019.07.029","article-title":"Chronic prolonged hyponatremia and risk of hip fracture in elderly patients with chronic kidney disease.","volume":"12","author":"Ayus","year":"2019","journal-title":"Bone"},{"key":"22","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/jbmr.2306","article-title":"Thiazide-sensitive Na+ -Cl-cotransporter (NCC) gene inactivation results in increased duodenal Ca2+ absorption, enhanced osteoblast differentiation and elevated bone mineral density.","volume":"3","author":"Lin","year":"2015","journal-title":"J Bone Miner Res"},{"key":"23","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1093\/ndt\/16.11.2250","article-title":"Severe hyponatraemia and hypouricaemia in Gitelman's syndrome.","volume":"1","author":"Lameire","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"24","doi-asserted-by":"publisher","first-page":"F756","DOI":"10.1152\/ajprenal.1999.277.5.F756","article-title":"Thiazide induces water absorption in the inner medullary collecting duct of normal and Brattleboro rats.","volume":"27","author":"Magaldi","year":"1999","journal-title":"Am J Physiol"},{"key":"25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3390\/cells8020139","article-title":"An Early Decrease in Release of Aquaporin-2 in Urinary Extracellular Vesicles After Cisplatin Treatment in Rats.","volume":"8","author":"Ikeda","year":"2019","journal-title":"Cells"},{"key":"26","doi-asserted-by":"publisher","first-page":"472","DOI":"10.2215\/CJN.00940111","article-title":"Localization of tubular adaptation to renal sodium loss in Gitelman syndrome.","volume":"7","author":"Moulin","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"27","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1093\/qjmed\/hcg157","article-title":"Risk factors for thiazide-induced hyponatraemia.","volume":"9","author":"Li","year":"2003","journal-title":"QJM"},{"key":"28","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1136\/pgmj.62.728.449","article-title":"Significance of the measurement of uric acid fractional clearance in diuretic induced hyponatraemia.","volume":"6","author":"Rosin","year":"1986","journal-title":"Postgrad Med J"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T16:23:11Z","timestamp":1741105391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,4]]},"references-count":28,"alternative-id":["206216"],"URL":"https:\/\/doi.org\/10.18632\/aging.206216","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,4]]}}}