{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:44:53Z","timestamp":1791571493149,"version":"4.3.4"},"reference-count":34,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2025,5,30]]},"DOI":"10.18632\/aging.206244","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T15:17:27Z","timestamp":1746112647000},"page":"1139-1147","source":"Crossref","is-referenced-by-count":5,"title":["Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets"],"prefix":"10.18632","volume":"17","author":[{"given":"Kasumi","family":"Hattori","sequence":"first","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"},{"name":"Department of Neurology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"},{"name":"Department of Neurology, Matsumura General Hospital, Fukushima 970-8516, Japan"},{"name":"Department of Neurology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Yamachi","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichi","family":"Tezuka","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syoko","family":"Yokota","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingen","family":"Misaka","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizu","family":"Hidema","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenju","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Maejima","sequence":"additional","affiliation":[{"name":"Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000489263","article-title":"The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication.","volume":"10","author":"Shimomura","year":"2018","journal-title":"Neuroendocrinology"},{"key":"2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000371636","article-title":"Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas.","volume":"10","author":"Yada","year":"2015","journal-title":"Neuroendocrinology"},{"key":"3","doi-asserted-by":"publisher","first-page":"8599","DOI":"10.1038\/s41598-017-09318-7","article-title":"Impact of sex, fat distribution and initial body weight on oxytocin\u2019s body weight regulation.","volume":"7","author":"Shimomura","year":"2017","journal-title":"Sci Rep"},{"key":"4","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1159\/000538792","article-title":"Systemic Co-Administration of Low-Dose Oxytocin and Glucagon-Like Peptide 1 Additively Decreases Food Intake and Body Weight.","volume":"11","author":"Shimomura","year":"2024","journal-title":"Neuroendocrinology"},{"key":"5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.2337\/diab.30.2.112","article-title":"Oxytocin infusion increases plasma insulin and glucagon levels and glucose production and uptake in the normal dog.","volume":"3","author":"Hampshire","year":"1981","journal-title":"Diabetes"},{"key":"6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3181\/00379727-182-42312","article-title":"Oxytocin increases extrapancreatic glucagon secretion and glucose production in pancreatectomized dogs.","volume":"18","author":"Saudek","year":"1986","journal-title":"Proc Soc Exp Biol Med"},{"key":"7","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/0196-9781(84)90109-8","article-title":"Modulation of insulin and glucagon secretion from the perfused rat pancreas by the neurohypophysial hormones and by desamino-D-arginine vasopressin (DDAVP).","volume":"5","author":"Fawcett","year":"1984","journal-title":"Peptides"},{"key":"8","doi-asserted-by":"publisher","first-page":"129811","DOI":"10.1016\/j.bbagen.2020.129811","article-title":"Development and characterisation of novel, enzymatically stable oxytocin analogues with beneficial antidiabetic effects in high fat fed mice.","volume":"186","author":"Moffett","year":"2021","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"9","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/sj.bjp.0706383","article-title":"Selectivity of d[Cha4]AVP and SSR149415 at human vasopressin and oxytocin receptors: evidence that SSR149415 is a mixed vasopressin V1b\/oxytocin receptor antagonist.","volume":"14","author":"Arban","year":"2005","journal-title":"Br J Pharmacol"},{"key":"10","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1085\/jgp.201411222","article-title":"Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2\/SUR1 but not Kir6.2\/SUR2A KATP channels: a mechanistic study.","volume":"14","author":"Ashcroft","year":"2014","journal-title":"J Gen Physiol"},{"key":"11","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1172\/JCI45680","article-title":"Dynamics of insulin secretion and the clinical implications for obesity and diabetes.","volume":"12","author":"Minami","year":"2011","journal-title":"J Clin Invest"},{"key":"12","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/dom.12995","article-title":"\u03b2-Cell signalling and insulin secretagogues: A path for improved diabetes therapy.","volume":"1","author":"Takahashi","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"13","doi-asserted-by":"publisher","first-page":"693","DOI":"10.2337\/dbi22-0030","article-title":"KATP Channels and the Metabolic Regulation of Insulin Secretion in Health and Disease: The 2022 Banting Medal for Scientific Achievement Award Lecture.","volume":"7","author":"Ashcroft","year":"2023","journal-title":"Diabetes"},{"key":"14","doi-asserted-by":"publisher","first-page":"170206","DOI":"10.1016\/j.peptides.2019.170206","article-title":"Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.","volume":"12","author":"Gribble","year":"2020","journal-title":"Peptides"},{"key":"15","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1210\/endo-123-4-2009","article-title":"Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach.","volume":"12","author":"Nielsen","year":"1988","journal-title":"Endocrinology"},{"key":"16","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1111\/jdi.14001","article-title":"Stimulatory effect of imeglimin on incretin secretion.","volume":"1","author":"Ogawa","year":"2023","journal-title":"J Diabetes Investig"},{"key":"17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.pharmthera.2009.11.001","article-title":"Glycaemic control in type 2 diabetes: targets and new therapies.","volume":"12","author":"Barnett","year":"2010","journal-title":"Pharmacol Ther"},{"key":"18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1080\/19382014.2021.1889941","article-title":"Evidence for the existence and potential roles of intra-islet glucagon-like peptide-1.","volume":"1","author":"Light","year":"2021","journal-title":"Islets"},{"key":"19","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1038\/s41598-020-59799-2","article-title":"Intra-islet GLP-1, but not CCK, is necessary for \u03b2-cell function in mouse and human islets.","volume":"1","author":"Davis","year":"2020","journal-title":"Sci Rep"},{"key":"20","doi-asserted-by":"publisher","first-page":"26488","DOI":"10.1074\/jbc.270.44.26488","article-title":"Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.","volume":"27","author":"Steiner","year":"1995","journal-title":"J Biol Chem"},{"key":"21","doi-asserted-by":"publisher","first-page":"32810","DOI":"10.1074\/jbc.272.52.32810","article-title":"Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1.","volume":"27","author":"Halban","year":"1997","journal-title":"J Biol Chem"},{"key":"22","first-page":"18827","article-title":"Proglucagon processing in porcine and human pancreas.","volume":"26","author":"Orskov","year":"1994","journal-title":"J Biol Chem"},{"key":"23","doi-asserted-by":"publisher","first-page":"149","DOI":"10.4161\/isl.2.3.11396","article-title":"Intraislet production of GLP-1 by activation of prohormone convertase 1\/3 in pancreatic \u03b1-cells in mouse models of \u00df-cell regeneration.","volume":"2","author":"Hara","year":"2010","journal-title":"Islets"},{"key":"24","doi-asserted-by":"publisher","first-page":"3262","DOI":"10.1007\/s00125-012-2716-9","article-title":"A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.","volume":"5","author":"Tinti","year":"2012","journal-title":"Diabetologia"},{"key":"25","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.cmet.2019.08.009","article-title":"Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.","volume":"3","author":"Drucker","year":"2019","journal-title":"Cell Metab"},{"key":"26","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s00125-005-1680-z","article-title":"A genetic and physiological study of impaired glucose homeostasis control in C57BL\/6J mice.","volume":"4","author":"Cox","year":"2005","journal-title":"Diabetologia"},{"key":"27","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1042\/bj2760169","article-title":"Mechanisms of the stimulation of insulin release by oxytocin in normal mouse islets.","volume":"27","author":"Henquin","year":"1991","journal-title":"Biochem J"},{"key":"28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1530\/JOE-11-0094","article-title":"Processing of proglucagon to GLP-1 in pancreatic \u03b1-cells: is this a paracrine mechanism enabling GLP-1 to act on \u03b2-cells?","volume":"21","author":"White","year":"2011","journal-title":"J Endocrinol"},{"key":"29","doi-asserted-by":"publisher","first-page":"e126742","DOI":"10.1172\/jci.insight.126742","article-title":"\u03b2 Cell tone is defined by proglucagon peptides through cAMP signaling.","volume":"4","author":"Campbell","year":"2019","journal-title":"JCI Insight"},{"key":"30","doi-asserted-by":"publisher","first-page":"13468","DOI":"10.1073\/pnas.0600655103","article-title":"Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1).","volume":"10","author":"Kieffer","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"31","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1007\/s00125-011-2080-1","article-title":"Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus--an adaptive response to hyperglycaemia?","volume":"5","author":"Karlsen","year":"2011","journal-title":"Diabetologia"},{"key":"32","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1210\/en.2005-0402","article-title":"Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells.","volume":"14","author":"Dhanvantari","year":"2005","journal-title":"Endocrinology"},{"key":"33","doi-asserted-by":"publisher","first-page":"16096","DOI":"10.1073\/pnas.0505312102","article-title":"Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice.","volume":"10","author":"Nishimori","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"34","doi-asserted-by":"publisher","first-page":"2259","DOI":"10.1523\/JNEUROSCI.5593-08.2009","article-title":"Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice.","volume":"2","author":"Nishimori","year":"2009","journal-title":"J Neurosci"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T21:43:55Z","timestamp":1749246235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,30]]}},"alternative-id":["206244","40317718"],"URL":"https:\/\/doi.org\/10.18632\/aging.206244","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]}}}