{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T21:08:06Z","timestamp":1779484086145,"version":"3.53.1"},"reference-count":55,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2026,2,12]]},"DOI":"10.18632\/aging.206383","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T20:55:52Z","timestamp":1779483352000},"page":"593-604","source":"Crossref","is-referenced-by-count":0,"title":["Systemic cancer risk profile in neovascular age-related macular degeneration: insights into shared aging-related mechanisms from a nationwide population-based study"],"prefix":"10.18632","volume":"18","author":[{"given":"Hyeong Min","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Konkuk University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Ophthalmology, Konkuk University Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonjong","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Data Science, Hanmi Pharm. Co., Ltd., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Data Science, Hanmi Pharm. Co., Ltd., Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungwoo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Konkuk University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Ophthalmology, Konkuk University Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyewon","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Konkuk University College of Medicine, Seoul, Republic of Korea"},{"name":"Department of Ophthalmology, Konkuk University Medical Center, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1158\/1055-9965.EPI-16-0759","article-title":"The Association between Age-Related Macular Degeneration and Renal Cell Carcinoma: A Nested Case-Control Study.","volume":"2","author":"Keizman","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1093\/annonc\/mdx402","article-title":"Risk of age-related macular degeneration in patients with prostate cancer: a nationwide, population-based cohort study.","volume":"2","author":"Lin","year":"2017","journal-title":"Ann Oncol"},{"key":"3","doi-asserted-by":"publisher","first-page":"902","DOI":"10.3390\/ijerph15050902","article-title":"Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population.","volume":"1","author":"Lin","year":"2018","journal-title":"Int J Environ Res Public Health"},{"key":"4","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1136\/bjo-2023-323874","article-title":"Association between age-related macular degeneration and risk of incident cancer.","volume":"10","author":"Park","year":"2024","journal-title":"Br J Ophthalmol"},{"key":"5","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1001\/jama.2020.5576","article-title":"Current Perspective on Age-Related Macular Degeneration.","volume":"32","author":"Chakravarthy","year":"2020","journal-title":"JAMA"},{"key":"6","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/S0140-6736(22)02609-5","article-title":"Age-related macular degeneration.","volume":"40","author":"Guymer","year":"2023","journal-title":"Lancet"},{"key":"7","first-page":"2237","article-title":"Incidence and progression rates of age-related maculopathy: the Rotterdam Study.","volume":"4","author":"Klaver","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.preteyeres.2016.04.003","article-title":"Risk factors and biomarkers of age-related macular degeneration.","volume":"5","author":"Lambert","year":"2016","journal-title":"Prog Retin Eye Res"},{"key":"9","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1016\/s0161-6420(95)30846-9","article-title":"Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study.","volume":"10","author":"Mitchell","year":"1995","journal-title":"Ophthalmology"},{"key":"10","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis.","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"key":"11","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1001\/archopht.125.9.1241","article-title":"Age-related macular degeneration and cancer mortality in the atherosclerosis risk in communities study.","volume":"12","author":"Cheung","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"12","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nrc3627","article-title":"VEGF targets the tumour cell.","volume":"1","author":"Goel","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"13","doi-asserted-by":"publisher","first-page":"e136655","DOI":"10.1172\/JCI136655","article-title":"The vascular landscape of human cancer.","volume":"13","author":"Kahn","year":"2021","journal-title":"J Clin Invest"},{"key":"14","doi-asserted-by":"publisher","first-page":"4423","DOI":"10.1038\/s41598-022-08492-7","article-title":"Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients.","volume":"1","author":"Shahidatul-Adha","year":"2022","journal-title":"Sci Rep"},{"key":"15","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00018-019-03420-x","article-title":"Senescence in the pathogenesis of age-related macular degeneration.","volume":"7","author":"Blasiak","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"16","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1007\/s11357-021-00457-4","article-title":"Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration.","volume":"4","author":"Chae","year":"2021","journal-title":"Geroscience"},{"key":"17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3349\/ymj.2022.63.4.357","article-title":"Chemokine Receptor Profiles of T Cells in Patients with Age-Related Macular Degeneration.","volume":"6","author":"Choi","year":"2022","journal-title":"Yonsei Med J"},{"key":"18","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer.","volume":"7","author":"Campisi","year":"2013","journal-title":"Annu Rev Physiol"},{"key":"19","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.3390\/jcm13102978","article-title":"Androgen Deprivation Therapy and Newly Developed Neovascular Age-Related Macular Degeneration Risk in Patients with Prostate Cancer.","volume":"1","author":"Ha","year":"2024","journal-title":"J Clin Med"},{"key":"20","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis.","volume":"47","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"key":"21","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1200\/JCO.2005.06.081","article-title":"Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.","volume":"2","author":"Hicklin","year":"2005","journal-title":"J Clin Oncol"},{"key":"22","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","article-title":"Tumor angiogenesis: causes, consequences, challenges and opportunities.","volume":"7","author":"Lugano","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"23","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.addr.2015.11.004","article-title":"Studying the influence of angiogenesis incancer model systems.","volume":"9","author":"Roudsari","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"24","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.3390\/cancers12051172","article-title":"Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches.","volume":"1","author":"Saman","year":"2020","journal-title":"Cancers (Basel)"},{"key":"25","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3390\/cancers11030381","article-title":"Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies.","volume":"1","author":"Annese","year":"2019","journal-title":"Cancers (Basel)"},{"key":"26","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s11912-023-01421-5","article-title":"An Overview of Angiogenesis in Bladder Cancer.","volume":"2","author":"Elayat","year":"2023","journal-title":"Curr Oncol Rep"},{"key":"27","doi-asserted-by":"publisher","first-page":"6167","DOI":"10.3390\/cancers14246167","article-title":"Renal Carcinoma and Angiogenesis: Therapeutic Target and Biomarkers of Response in Current Therapies.","volume":"1","author":"Guillaume","year":"2022","journal-title":"Cancers (Basel)"},{"key":"28","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.3390\/ijms20112676","article-title":"Targeting Angiogenesis in Prostate Cancer.","volume":"2","author":"Melegh","year":"2019","journal-title":"Int J Mol Sci"},{"key":"29","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.3390\/cancers15184648","article-title":"Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors.","volume":"1","author":"Ngaha","year":"2023","journal-title":"Cancers (Basel)"},{"key":"30","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1507\/endocrj.EJ18-0537","article-title":"The roles and role-players in thyroid cancer angiogenesis.","volume":"6","author":"Rajabi","year":"2019","journal-title":"Endocr J"},{"key":"31","doi-asserted-by":"publisher","first-page":"258","DOI":"10.5173\/ceju.2016.830","article-title":"Role of angiogenesis in urothelial bladder carcinoma.","volume":"6","author":"Fus","year":"2016","journal-title":"Cent European J Urol"},{"key":"32","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1177\/1758834016667179","article-title":"Incorporating VEGF-targeted therapy in advanced urothelial cancer.","volume":"9","author":"Narayanan","year":"2017","journal-title":"Ther Adv Med Oncol"},{"key":"33","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.1442-2042.2005.01010.x","article-title":"Vascular endothelial growth factor-C (VEGF-C) expression predicts lymph node metastasis of transitional cell carcinoma of the bladder.","volume":"1","author":"Suzuki","year":"2005","journal-title":"Int J Urol"},{"key":"34","doi-asserted-by":"publisher","first-page":"645","DOI":"10.7314\/apjcp.2013.14.2.645","article-title":"Prognostic value of tissue vascular endothelial growth factor expression in bladder cancer: a meta-analysis.","volume":"1","author":"Huang","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"35","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/s0090-4295(99)00167-3","article-title":"Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer.","volume":"5","author":"Duque","year":"1999","journal-title":"Urology"},{"key":"36","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1097\/00005392-200102000-00095","article-title":"Vascular endothelial growth factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate carcinoma: evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts.","volume":"16","author":"Stewart","year":"2001","journal-title":"J Urol"},{"key":"37","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/1097-0045(20001101)45:3<216::aid-pros3>3.0.co;2-c","article-title":"Vascular endothelial growth factor and its correlation with angiogenesis and p53 expression in prostate cancer.","volume":"4","author":"Strohmeyer","year":"2000","journal-title":"Prostate"},{"key":"38","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.7150\/ijbs.70958","article-title":"VEGF\/VEGFR-Targeted Therapy and Immunotherapy in Non-small Cell Lung Cancer: Targeting the Tumor Microenvironment.","volume":"1","author":"Zhao","year":"2022","journal-title":"Int J Biol Sci"},{"key":"39","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1136\/jcp.2003.014498","article-title":"Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma.","volume":"5","author":"Esposito","year":"2004","journal-title":"J Clin Pathol"},{"key":"40","doi-asserted-by":"publisher","first-page":"G709","DOI":"10.1152\/ajpgi.90356.2008","article-title":"Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer.","volume":"29","author":"Masamune","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"41","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1158\/1078-0432.CCR-14-1051","article-title":"Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer.","volume":"2","author":"Whatcott","year":"2015","journal-title":"Clin Cancer Res"},{"key":"42","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.canlet.2004.05.020","article-title":"The significance of placenta growth factor in angiogenesis and clinical outcome of human gastric cancer.","volume":"21","author":"Chen","year":"2004","journal-title":"Cancer Lett"},{"key":"43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5230\/jgc.2017.17.e1","article-title":"Gastric Cancer and Angiogenesis: Is VEGF a Useful Biomarker to Assess Progression and Remission?","volume":"1","author":"Macedo","year":"2017","journal-title":"J Gastric Cancer"},{"key":"44","doi-asserted-by":"publisher","first-page":"1571731","DOI":"10.3389\/fimmu.2025.1571731","article-title":"Comprehensive review of the resistance mechanisms of colorectal cancer classified by therapy type.","volume":"1","author":"Oh","year":"2025","journal-title":"Front Immunol"},{"key":"45","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.prp.2015.04.003","article-title":"Expression and prognostic significance of VEGFR-2 in breast cancer.","volume":"21","author":"Yan","year":"2015","journal-title":"Pathol Res Pract"},{"key":"46","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3389\/fendo.2015.00159","article-title":"The Emerging Regulation of VEGFR-2 in Triple-Negative Breast Cancer.","volume":"6","author":"Zhu","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"47","doi-asserted-by":"publisher","first-page":"41067","DOI":"10.18632\/oncotarget.9392","article-title":"The novel VEGF receptor 2 inhibitor YLL545 inhibits angiogenesis and growth in breast cancer.","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"48","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1136\/mp.55.6.348","article-title":"Angiogenesis in epithelian ovarian cancer.","volume":"5","author":"Bamberger","year":"2002","journal-title":"Mol Pathol"},{"key":"49","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ebiom.2019.02.051","article-title":"OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling.","volume":"4","author":"Song","year":"2019","journal-title":"EBioMedicine"},{"key":"50","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41392-024-02075-w","article-title":"Hepatocellular carcinoma: signaling pathways and therapeutic advances.","volume":"1","author":"Zheng","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"51","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12575-025-00281-6","article-title":"Mechanisms of drug resistance in hepatocellular carcinoma.","volume":"2","author":"Zou","year":"2025","journal-title":"Biol Proced Online"},{"key":"52","doi-asserted-by":"publisher","first-page":"100211","DOI":"10.1016\/j.xops.2022.100211","article-title":"Relationships between Lipid-Related Metabolites and Age-Related Macular Degeneration Vary with Complement Genotype.","volume":"2","author":"Sim","year":"2022","journal-title":"Ophthalmol Sci"},{"key":"53","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1167\/iovs.65.12.20","article-title":"Aberrant Lipid Metabolism and Complement Activation in Age-Related Macular Degeneration.","volume":"6","author":"Tang","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"54","doi-asserted-by":"publisher","first-page":"3353","DOI":"10.1038\/s41467-020-16483-3","article-title":"Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.","volume":"1","author":"Zhang","year":"2020","journal-title":"Nat Commun"},{"key":"55","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1001\/jama.2014.5985","article-title":"Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.","volume":"31","author":"Rebbeck","year":"2015","journal-title":"JAMA"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T20:55:53Z","timestamp":1779483353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2,12]]}},"alternative-id":["206383"],"URL":"https:\/\/doi.org\/10.18632\/aging.206383","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}