{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:45:10Z","timestamp":1782938710071,"version":"3.54.5"},"reference-count":62,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2026,2,11]]},"DOI":"10.18632\/aging.206390","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:11:23Z","timestamp":1782936683000},"page":"768-786","source":"Crossref","is-referenced-by-count":0,"title":["Senescent cells accumulate lipid droplets"],"prefix":"10.18632","volume":"18","author":[{"given":"Noa","family":"Rachmian-Cooper","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riva","family":"Shmulevich","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagay","family":"Akiva","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarka","family":"Pokorna","sequence":"additional","affiliation":[{"name":"J. Heyrovsky Institute of Physical Chemistry of the Czech Academy of Sciences, 18223 Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bareket","family":"Dassa","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulysse","family":"Cherqui","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Malitsky","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Itkin","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyamin Amichai","family":"Kliger","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Goliand","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer Meir","family":"Salame","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Core Facilities, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery","family":"Krizhanovsky","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology, Weizmann Institute of Science, 7610001, Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular Senescence: Defining a Path Forward.","volume":"17","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"2","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence.","volume":"12","author":"Herranz","year":"2018","journal-title":"J Clin Invest"},{"key":"3","doi-asserted-by":"publisher","first-page":"4150","DOI":"10.1016\/j.cell.2024.05.059","article-title":"Guidelines for minimal information on cellular senescence experimentation","volume":"18","author":"Ogrodnik","year":"2024","journal-title":"Cell"},{"key":"4","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/s0092-8674(00)81902-9","article-title":"Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.","volume":"8","author":"Serrano","year":"1997","journal-title":"Cell"},{"key":"5","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cell.2008.06.049","article-title":"Senescence of activated stellate cells limits liver fibrosis.","volume":"13","author":"Krizhanovsky","year":"2008","journal-title":"Cell"},{"key":"6","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.","volume":"3","author":"Demaria","year":"2014","journal-title":"Dev Cell"},{"key":"7","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ncb2070","article-title":"The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.","volume":"1","author":"Jun","year":"2010","journal-title":"Nat Cell Biol"},{"key":"8","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/4601085a","article-title":"Stem cells: The promises and perils of p53.","volume":"46","author":"Krizhanovsky","year":"2009","journal-title":"Nature"},{"key":"9","doi-asserted-by":"publisher","first-page":"e100849","DOI":"10.15252\/embj.2018100849","article-title":"Molecular pathways of senescence regulate placental structure and function.","volume":"3","author":"Gal","year":"2019","journal-title":"EMBO J"},{"key":"10","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.cell.2013.10.041","article-title":"Senescence is a developmental mechanism that contributes to embryonic growth and patterning.","volume":"15","author":"Storer","year":"2013","journal-title":"Cell"},{"key":"11","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.cell.2013.10.019","article-title":"Programmed cell senescence during mammalian embryonic development.","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2013","journal-title":"Cell"},{"key":"12","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLoS Biol"},{"key":"13","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1016\/j.celrep.2018.03.009","article-title":"p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence.","volume":"2","author":"Sagiv","year":"2018","journal-title":"Cell Rep"},{"key":"14","doi-asserted-by":"publisher","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease.","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat Commun"},{"key":"15","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis.","volume":"35","author":"Childs","year":"2016","journal-title":"Science"},{"key":"16","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.","volume":"56","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"17","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/s41593-024-01620-8","article-title":"Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain.","volume":"2","author":"Rachmian","year":"2024","journal-title":"Nat Neurosci"},{"key":"18","doi-asserted-by":"publisher","first-page":"109228","DOI":"10.1016\/j.celrep.2021.109228","article-title":"Replicative senescence dictates the emergence of disease-associated microglia and contributes to A\u03b2 pathology.","volume":"3","author":"Hu","year":"2021","journal-title":"Cell Rep"},{"key":"19","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1021\/pr501221g","article-title":"Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease.","volume":"1","author":"James","year":"2015","journal-title":"J Proteome Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"e158447","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging.","volume":"13","author":"Miwa","year":"2022","journal-title":"J Clin Invest"},{"key":"21","doi-asserted-by":"publisher","first-page":"6001","DOI":"10.1038\/ncomms7001","article-title":"Fumarate induces redox-dependent senescence by modifying glutathione metabolism.","volume":"6","author":"Zheng","year":"2015","journal-title":"Nat Commun"},{"key":"22","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/acel.12351","article-title":"Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells.","volume":"1","author":"Takebayashi","year":"2015","journal-title":"Aging Cell"},{"key":"23","doi-asserted-by":"publisher","first-page":"4495","DOI":"10.1128\/MCB.01868-08","article-title":"Mitochondrial dysfunction contributes to oncogene-induced senescence.","volume":"2","author":"Moiseeva","year":"2009","journal-title":"Mol Cell Biol"},{"key":"24","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature12437","article-title":"Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.","volume":"50","author":"D\u00f6rr","year":"2013","journal-title":"Nature"},{"key":"25","doi-asserted-by":"publisher","first-page":"17075","DOI":"10.1038\/cddiscovery.2017.75","article-title":"A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence.","volume":"3","author":"Flor","year":"2017","journal-title":"Cell Death Discov"},{"key":"26","doi-asserted-by":"publisher","first-page":"102294","DOI":"10.1016\/j.arr.2024.102294","article-title":"Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases.","volume":"9","author":"Zeng","year":"2024","journal-title":"Ageing Res Rev"},{"key":"27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets.","volume":"2","author":"Olzmann","year":"2019","journal-title":"Nat Rev Mol Cell Biol"},{"key":"28","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease.","volume":"1","author":"Zadoorian","year":"2023","journal-title":"Nat Rev Endocrinol"},{"key":"29","doi-asserted-by":"publisher","first-page":"5053","DOI":"10.3390\/molecules25215053","article-title":"Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease.","volume":"2","author":"Geltinger","year":"2020","journal-title":"Molecules"},{"key":"30","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41419-020-2297-3","article-title":"Lipid droplets: platforms with multiple functions in cancer hallmarks.","volume":"1","author":"Cruz","year":"2020","journal-title":"Cell Death Dis"},{"key":"31","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41420-025-02314-1","article-title":"Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition.","volume":"1","author":"Zhang","year":"2025","journal-title":"Cell Death Discov"},{"key":"32","doi-asserted-by":"publisher","first-page":"101861","DOI":"10.1016\/j.arr.2023.101861","article-title":"Deciphering the role of lipoproteins and lipid metabolic alterations in ageing and ageing-associated renal fibrosis.","volume":"8","author":"Liu","year":"2023","journal-title":"Ageing Res Rev"},{"key":"33","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/s41467-023-36432-0","article-title":"Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats.","volume":"1","author":"Talari","year":"2023","journal-title":"Nat Commun"},{"key":"34","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/febs.16649","article-title":"Senescent cells in the brain and where to find them.","volume":"29","author":"Rachmian","year":"2023","journal-title":"FEBS J"},{"key":"35","doi-asserted-by":"publisher","first-page":"e13296","DOI":"10.1111\/acel.13296","article-title":"Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.","volume":"2","author":"Ogrodnik","year":"2021","journal-title":"Aging Cell"},{"key":"36","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.","volume":"2","author":"Marschallinger","year":"2020","journal-title":"Nat Neurosci"},{"key":"37","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.","volume":"62","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"38","doi-asserted-by":"publisher","first-page":"e17175","DOI":"10.15252\/emmm.202217175","article-title":"Aged lipid-laden microglia display impaired responses to stroke.","volume":"1","author":"Arbaizar-Rovirosa","year":"2023","journal-title":"EMBO Mol Med"},{"key":"39","doi-asserted-by":"publisher","first-page":"742","DOI":"10.3389\/fnins.2020.00742","article-title":"Lipid Droplets in Neurodegenerative Disorders.","volume":"1","author":"Farmer","year":"2020","journal-title":"Front Neurosci"},{"key":"40","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.immuni.2025.04.029","article-title":"Amyloid-\u03b2 induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease.","volume":"5","author":"Prakash","year":"2025","journal-title":"Immunity"},{"key":"41","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer's 1907 paper, \u201cUber eine eigenartige Erkankung der Hirnrinde\u201d.","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin Anat"},{"key":"42","first-page":"146","article-title":"Uber Eine Eigenartige Erkrankung Der Hirnrinde.","volume":"6","author":"Alzheimer","year":"1907","journal-title":"All Z Psychiatr"},{"key":"43","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.15252\/embj.201695553","article-title":"p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling.","volume":"3","author":"Yosef","year":"2017","journal-title":"EMBO J"},{"key":"44","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/emboj.2010.330","article-title":"ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair.","volume":"3","author":"Cosentino","year":"2011","journal-title":"EMBO J"},{"key":"45","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.neuint.2010.12.004","article-title":"Effects of fatty acid unsaturation numbers on membrane fluidity and \u03b1-secretase-dependent amyloid precursor protein processing.","volume":"5","author":"Yang","year":"2011","journal-title":"Neurochem Int"},{"key":"46","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1007\/s00018-014-1691-3","article-title":"Physiological and pathological consequences of cellular senescence.","volume":"7","author":"Burton","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"47","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev-nutr-071812-161148","article-title":"AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.","volume":"3","author":"Hardie","year":"2014","journal-title":"Annu Rev Nutr"},{"key":"48","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.cmet.2024.03.014","article-title":"Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.","volume":"3","author":"Li","year":"2024","journal-title":"Cell Metab"},{"key":"49","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41591-019-0695-9","article-title":"Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease.","volume":"2","author":"Zhou","year":"2020","journal-title":"Nat Med"},{"key":"50","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.3892\/ol.2020.11769","article-title":"Implications of lipid droplets in lung cancer: Associations with drug resistance.","volume":"2","author":"Jin","year":"2020","journal-title":"Oncol Lett"},{"key":"51","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/978-3-031-63657-8_4","article-title":"Lipid Storage, Lipolysis, and Lipotoxicity in Obesity.","volume":"146","author":"Engin","year":"2024","journal-title":"Adv Exp Med Biol"},{"key":"52","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1159\/000535131","article-title":"Brain Lipids and Lipid Droplet Dysregulation in Alzheimer's Disease and Neuropsychiatric Disorders.","volume":"9","author":"Zhao","year":"2023","journal-title":"Complex Psychiatry"},{"key":"53","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41586-023-06120-6","article-title":"Myelin dysfunction drives amyloid-\u03b2 deposition in models of Alzheimer's disease.","volume":"61","author":"Depp","year":"2023","journal-title":"Nature"},{"key":"54","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neurobiolaging.2003.03.001","article-title":"Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease.","volume":"2","author":"Bartzokis","year":"2004","journal-title":"Neurobiol Aging"},{"key":"55","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00018-022-04547-0","article-title":"Perilipin-2 limits remyelination by preventing lipid droplet degradation.","volume":"7","author":"Loix","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"56","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41586-022-05534-y","article-title":"Microglia regulate central nervous system myelin growth and integrity.","volume":"61","author":"McNamara","year":"2023","journal-title":"Nature"},{"key":"57","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/nph.13852","article-title":"Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol.","volume":"21","author":"Malitsky","year":"2016","journal-title":"New Phytol"},{"key":"58","doi-asserted-by":"publisher","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation.","volume":"5","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"59","doi-asserted-by":"publisher","first-page":"e70009","DOI":"10.1002\/cpz1.70009","article-title":"LipidOne 2.0: A Web Tool for Discovering Biological Meanings Hidden in Lipidomic Data.","volume":"4","author":"Alabed","year":"2024","journal-title":"Curr Protoc"},{"key":"60","doi-asserted-by":"publisher","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.","volume":"2","author":"Oakley","year":"2006","journal-title":"J Neurosci"},{"key":"61","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1038\/s41596-018-0016-7","article-title":"Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry.","volume":"1","author":"Han","year":"2018","journal-title":"Nat Protoc"},{"key":"62","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.","volume":"1","author":"Saul","year":"2022","journal-title":"Nat Commun"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:11:24Z","timestamp":1782936684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2,11]]}},"alternative-id":["206390"],"URL":"https:\/\/doi.org\/10.18632\/aging.206390","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]}}}