{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T16:03:11Z","timestamp":1789833791278,"version":"4.0.1"},"reference-count":265,"publisher":"Impact Journals, LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aging"],"published-print":{"date-parts":[[2026,2,11]]},"DOI":"10.18632\/aging.206423","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:20:47Z","timestamp":1789831247000},"page":"1280-1315","source":"Crossref","is-referenced-by-count":0,"title":["mTOR signaling in aging: from causality to geroprotective interventions and hallmark-level outcomes"],"prefix":"10.18632","volume":"18","author":[{"given":"Natalia","family":"Bobok","sequence":"first","affiliation":[{"name":"Chief Scientific Officer, INSTYTUTUM AG, Zug 6300, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.tibs.2022.03.003","article-title":"Protein kinase C: release from quarantine by mTORC2.","volume":"4","author":"Baffi","year":"2022","journal-title":"Trends Biochem Sci"},{"key":"2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3892\/ijmm.2017.3036","article-title":"The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (Review).","volume":"4","author":"Ardito","year":"2017","journal-title":"Int J Mol Med"},{"key":"3","doi-asserted-by":"publisher","first-page":"17504","DOI":"10.3390\/ijms242417504","article-title":"An Update on Protein Kinases as Therapeutic Targets-Part II: Peptides as Allosteric Protein Kinase C Modulators Targeting Protein-Protein Interactions.","volume":"2","author":"Zerihun","year":"2023","journal-title":"Int J Mol Sci"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.113285","article-title":"An insight on protein kinases and their therapeutic perspective.","author":"Dhal","year":"2024","journal-title":"Metabolism\u2014Annual Volume 2024"},{"key":"5","doi-asserted-by":"publisher","first-page":"102247","DOI":"10.1016\/j.jbc.2022.102247","article-title":"Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors.","volume":"29","author":"Arter","year":"2022","journal-title":"J Biol Chem"},{"key":"6","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.2741\/4867","article-title":"Structural and strategic landscape of PIKK protein family and their inhibitors: an overview.","volume":"2","author":"Angira","year":"2020","journal-title":"Front Biosci (Landmark Ed)"},{"key":"7","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/jcp.30573","article-title":"Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k\/Akt signaling and PIKKs crosstalk.","volume":"23","author":"Alemi","year":"2022","journal-title":"J Cell Physiol"},{"key":"8","doi-asserted-by":"publisher","first-page":"102651","DOI":"10.1016\/j.sbi.2023.102651","article-title":"Structure and function of the apical PIKKs in double-strand break repair.","volume":"8","author":"Xu","year":"2023","journal-title":"Curr Opin Struct Biol"},{"key":"9","doi-asserted-by":"publisher","first-page":"707372","DOI":"10.3389\/fragi.2021.707372","article-title":"The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Physiology and Aging.","volume":"2","author":"Fernandes","year":"2021","journal-title":"Front Aging"},{"key":"10","doi-asserted-by":"publisher","first-page":"a012716","DOI":"10.1101\/cshperspect.a012716","article-title":"DNA damage sensing by the ATM and ATR kinases.","volume":"5","author":"Mar\u00e9chal","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"11","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1523\/JNEUROSCI.4213-15.2016","article-title":"DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.","volume":"3","author":"Enriquez-Rios","year":"2017","journal-title":"J Neurosci"},{"key":"12","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3390\/biomedicines13020397","article-title":"The mTOR Signaling Pathway: Key Regulator and Therapeutic Target for Heart Disease.","volume":"1","author":"Wang","year":"2025","journal-title":"Biomedicines"},{"key":"13","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.3390\/molecules27165295","article-title":"Overview of Research into mTOR Inhibitors.","volume":"2","author":"Mao","year":"2022","journal-title":"Molecules"},{"key":"14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1101\/gad.352084.124","article-title":"mTORC1, the maestro of cell metabolism and growth.","volume":"3","author":"He","year":"2025","journal-title":"Genes Dev"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17196.1","article-title":"mTOR as a central regulator of lifespan and aging.","volume":"8","author":"Papadopoli","year":"2019","journal-title":"F1000Res"},{"key":"16","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/s41392-025-02493-4","article-title":"mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics.","volume":"1","author":"Zhang","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"17","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR Signaling in Growth, Metabolism, and Disease.","volume":"16","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"18","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41392-023-01608-z","article-title":"Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease.","volume":"8","author":"Panwar","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"19","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.molcel.2010.05.017","article-title":"Structure of the human mTOR complex I and its implications for rapamycin inhibition.","volume":"3","author":"Yip","year":"2010","journal-title":"Mol Cell"},{"key":"20","doi-asserted-by":"publisher","first-page":"6141","DOI":"10.3390\/ijms25116141","article-title":"mTOR: Its Critical Role in Metabolic Diseases, Cancer, and the Aging Process.","volume":"2","author":"Marafie","year":"2024","journal-title":"Int J Mol Sci"},{"key":"21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/cr.2016.10","article-title":"Structural insights of mTOR complex 1.","volume":"2","author":"Yuan","year":"2016","journal-title":"Cell Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1083\/jcb.201306041","article-title":"Where is mTOR and what is it doing there?","volume":"20","author":"Betz","year":"2013","journal-title":"J Cell Biol"},{"key":"23","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1038\/s41556-024-01523-7","article-title":"Spatial and functional separation of mTORC1 signalling in response to different amino acid sources.","volume":"2","author":"Fernandes","year":"2024","journal-title":"Nat Cell Biol"},{"key":"24","doi-asserted-by":"publisher","first-page":"4385","DOI":"10.1016\/j.molcel.2024.10.008","article-title":"mTORC1 activity licenses its own release from the lysosomal surface.","volume":"8","author":"Acharya","year":"2024","journal-title":"Mol Cell"},{"key":"25","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1152\/physrev.00026.2020","article-title":"Regulation and metabolic functions of mTORC1 and mTORC2.","volume":"10","author":"Szwed","year":"2021","journal-title":"Physiol Rev"},{"key":"26","doi-asserted-by":"publisher","first-page":"e19960","DOI":"10.7554\/eLife.19960","article-title":"Dynamics of mTORC1 activation in response to amino acids.","volume":"5","author":"Manifava","year":"2016","journal-title":"Elife"},{"key":"27","doi-asserted-by":"publisher","first-page":"971","DOI":"10.2741\/4762","article-title":"Recent advances in understanding of amino acid signaling to mTORC1 activation.","volume":"2","author":"Zhuang","year":"2019","journal-title":"Front Biosci (Landmark Ed)"},{"key":"28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s12929-020-00679-2","article-title":"Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes.","volume":"2","author":"Takahara","year":"2020","journal-title":"J Biomed Sci"},{"key":"29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1042\/EBC20240007","article-title":"New developments in AMPK and mTORC1 cross-talk.","volume":"6","author":"Smiles","year":"2024","journal-title":"Essays Biochem"},{"key":"30","doi-asserted-by":"publisher","first-page":"1015500","DOI":"10.3389\/fphys.2022.1015500","article-title":"Role of AMPK in autophagy.","volume":"1","author":"Wang","year":"2022","journal-title":"Front Physiol"},{"key":"31","doi-asserted-by":"publisher","first-page":"17803","DOI":"10.1038\/s41598-020-75030-8","article-title":"Fine-tuning of AMPK-ULK1-mTORC1 regulatory triangle is crucial for autophagy oscillation.","volume":"1","author":"Holczer","year":"2020","journal-title":"Sci Rep"},{"key":"32","doi-asserted-by":"publisher","first-page":"975","DOI":"10.3390\/ijms17060975","article-title":"Role of mTOR Inhibitors in Kidney Disease.","volume":"1","author":"Kajiwara","year":"2016","journal-title":"Int J Mol Sci"},{"key":"33","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.3390\/ijms21041199","article-title":"Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.","volume":"2","author":"Sridharan","year":"2020","journal-title":"Int J Mol Sci"},{"key":"34","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1038\/s41419-022-05081-4","article-title":"Beyond controlling cell size: functional analyses of S6K in tumorigenesis.","volume":"1","author":"Wu","year":"2022","journal-title":"Cell Death Dis"},{"key":"35","doi-asserted-by":"publisher","first-page":"13062","DOI":"10.1093\/nar\/gkab1157","article-title":"Phosphorylation of ribosomal protein S6 differentially affects mRNA translation based on ORF length.","volume":"4","author":"Bohlen","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20110892","article-title":"Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.","volume":"44","author":"Magnuson","year":"2012","journal-title":"Biochem J"},{"key":"37","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1101\/gad.912401","article-title":"Hierarchical phosphorylation of the translation inhibitor 4E-BP1.","volume":"1","author":"Gingras","year":"2001","journal-title":"Genes Dev"},{"key":"38","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1080\/15384101.2016.1151581","article-title":"4E-BP1, a multifactor regulated multifunctional protein.","volume":"1","author":"Qin","year":"2016","journal-title":"Cell Cycle"},{"key":"39","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1016\/j.molcel.2021.03.031","article-title":"The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1.","volume":"8","author":"B\u00f6hm","year":"2021","journal-title":"Mol Cell"},{"key":"40","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.2174\/0929867329666220224112042","article-title":"The mTOR\/4E-BP1\/eIF4E Signalling Pathway as a Source of Cancer Drug Targets.","volume":"2","author":"Maracci","year":"2022","journal-title":"Curr Med Chem"},{"key":"41","doi-asserted-by":"publisher","first-page":"RP101531","DOI":"10.7554\/eLife.101531","article-title":"The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy.","volume":"1","author":"Hama","year":"2025","journal-title":"Elife"},{"key":"42","doi-asserted-by":"publisher","first-page":"100519","DOI":"10.1016\/j.coisb.2024.100519","article-title":"ODE-based models of signaling networks in autophagy.","volume":"3","author":"Galhuber","year":"2024","journal-title":"Curr Opin Syst Biol"},{"key":"43","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1042\/EBC20170021","article-title":"The mammalian ULK1 complex and autophagy initiation.","volume":"6","author":"Zachari","year":"2017","journal-title":"Essays Biochem"},{"key":"44","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/biom7030052","article-title":"Regulation of Autophagy through TORC1 and mTORC1.","volume":"7","author":"Noda","year":"2017","journal-title":"Biomolecules"},{"key":"45","doi-asserted-by":"publisher","first-page":"e201911047","DOI":"10.1083\/jcb.201911047","article-title":"ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.","volume":"21","author":"Shi","year":"2020","journal-title":"J Cell Biol"},{"key":"46","doi-asserted-by":"publisher","first-page":"168631","DOI":"10.1016\/j.jmb.2024.168631","article-title":"FIP200 Phosphorylation Regulates Late Steps in Mitophagy.","volume":"43","author":"Eickhorst","year":"2024","journal-title":"J Mol Biol"},{"key":"47","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.3390\/genes11091045","article-title":"Regulation of mTORC2 Signaling.","volume":"1","author":"Fu","year":"2020","journal-title":"Genes (Basel)"},{"key":"48","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1042\/BCJ20220325","article-title":"The mTORC2 signaling network: targets and cross-talks.","volume":"48","author":"Ragupathi","year":"2024","journal-title":"Biochem J"},{"key":"49","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/s41422-018-0029-3","article-title":"Cryo-EM structure of human mTOR complex 2.","volume":"2","author":"Chen","year":"2018","journal-title":"Cell Res"},{"key":"50","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3389\/fimmu.2018.00215","article-title":"Loss of Rictor in Monocyte\/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice.","volume":"9","author":"Babaev","year":"2018","journal-title":"Front Immunol"},{"key":"51","doi-asserted-by":"publisher","first-page":"102288","DOI":"10.1016\/j.jbc.2022.102288","article-title":"Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.","volume":"29","author":"Yu","year":"2022","journal-title":"J Biol Chem"},{"key":"52","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1093\/nsr\/nwz171","article-title":"Sin1-mediated mTOR signaling in cell growth, metabolism and immune response.","volume":"6","author":"Ruan","year":"2019","journal-title":"Natl Sci Rev"},{"key":"53","doi-asserted-by":"publisher","first-page":"e1464","DOI":"10.1002\/ctm2.1464","article-title":"Unmasking the tumourigenic role of SIN1\/MAPKAP1 in the mTOR complex 2.","volume":"1","author":"Ezine","year":"2023","journal-title":"Clin Transl Med"},{"key":"54","doi-asserted-by":"publisher","first-page":"e19594","DOI":"10.7554\/eLife.19594","article-title":"Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.","volume":"6","author":"Tatebe","year":"2017","journal-title":"Elife"},{"key":"55","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1083\/jcb.201610060","article-title":"Localization of mTORC2 activity inside cells.","volume":"21","author":"Ebner","year":"2017","journal-title":"J Cell Biol"},{"key":"56","doi-asserted-by":"publisher","first-page":"4793","DOI":"10.1074\/jbc.RA118.006524","article-title":"T cells transduce T-cell receptor signal strength by generating different phosphatidylinositols.","volume":"29","author":"Hawse","year":"2019","journal-title":"J Biol Chem"},{"key":"57","doi-asserted-by":"publisher","first-page":"105097","DOI":"10.1016\/j.jbc.2023.105097","article-title":"Alkaline intracellular pH (pHi) increases PI3K activity to promote mTORC1 and mTORC2 signaling and function during growth factor limitation.","volume":"29","author":"Kazyken","year":"2023","journal-title":"J Biol Chem"},{"key":"58","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.tem.2019.09.005","article-title":"Growth Factor-Dependent and -Independent Activation of mTORC2.","volume":"3","author":"Knudsen","year":"2020","journal-title":"Trends Endocrinol Metab"},{"key":"59","doi-asserted-by":"publisher","first-page":"713806","DOI":"10.3389\/fcell.2021.713806","article-title":"Expanding TOR Complex 2 Signaling: Emerging Regulators and New Connections.","volume":"9","author":"An","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"60","doi-asserted-by":"publisher","first-page":"eaav3249","DOI":"10.1126\/scisignal.aav3249","article-title":"AMPK directly activates mTORC2 to promote cell survival during acute energetic stress.","volume":"1","author":"Kazyken","year":"2019","journal-title":"Sci Signal"},{"key":"61","doi-asserted-by":"publisher","first-page":"108427","DOI":"10.1016\/j.celrep.2020.108427","article-title":"Hetero-oligomerization of Rho and Ras GTPases Connects GPCR Activation to mTORC2-AKT Signaling.","volume":"3","author":"Senoo","year":"2020","journal-title":"Cell Rep"},{"key":"62","doi-asserted-by":"publisher","first-page":"jcs234930","DOI":"10.1242\/jcs.234930","article-title":"Ras, PI3K and mTORC2 - three's a crowd?","volume":"13","author":"Smith","year":"2020","journal-title":"J Cell Sci"},{"key":"63","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1080\/15548627.2020.1713640","article-title":"Autophagy drives fibroblast senescence through MTORC2 regulation.","volume":"1","author":"Bernard","year":"2020","journal-title":"Autophagy"},{"key":"64","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/bab.2104","article-title":"The interplay of ROS and the PI3K\/Akt pathway in autophagy regulation.","volume":"6","author":"Kma","year":"2022","journal-title":"Biotechnol Appl Biochem"},{"key":"65","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.3892\/ijo.2018.4597","article-title":"The Akt pathway in oncology therapy and beyond (Review).","volume":"5","author":"Nitulescu","year":"2018","journal-title":"Int J Oncol"},{"key":"66","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/s41598-018-19689-0","article-title":"Defining the Akt1 interactome and its role in regulating the cell cycle.","volume":"8","author":"Duggal","year":"2018","journal-title":"Sci Rep"},{"key":"67","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1242\/bio.024505","article-title":"Akt3 is responsible for the survival and proliferation of embryonic stem cells.","volume":"6","author":"Wang","year":"2017","journal-title":"Biol Open"},{"key":"68","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.3390\/cells13171500","article-title":"PI3K\/AKT\/mTOR Signaling Network in Human Health and Diseases.","volume":"1","author":"Omolekan","year":"2024","journal-title":"Cells"},{"key":"69","doi-asserted-by":"publisher","first-page":"21064","DOI":"10.18632\/oncotarget.8383","article-title":"PI3K\/Akt promotes feedforward mTORC2 activation through IKK\u03b1.","volume":"7","author":"Dan","year":"2016","journal-title":"Oncotarget"},{"key":"70","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1016\/j.bbamcr.2011.03.010","article-title":"Akt, FoxO and regulation of apoptosis.","volume":"181","author":"Zhang","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"71","doi-asserted-by":"publisher","first-page":"995","DOI":"10.15252\/embj.201695534","article-title":"AKT-phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1-MAPK interaction.","volume":"3","author":"Pan","year":"2017","journal-title":"EMBO J"},{"key":"72","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3390\/jcdd12070266","article-title":"MAPK, PI3K\/Akt Pathways, and GSK-3\u03b2 Activity in Severe Acute Heart Failure in Intensive Care Patients: An Updated Review.","volume":"1","author":"Meco","year":"2025","journal-title":"J Cardiovasc Dev Dis"},{"key":"73","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.3390\/cells9061388","article-title":"Glycogen Synthase Kinase 3\u03b2 in Cancer Biology and Treatment.","volume":"9","author":"Domoto","year":"2020","journal-title":"Cells"},{"key":"74","doi-asserted-by":"publisher","first-page":"10210","DOI":"10.1038\/s41467-024-53886-y","article-title":"GSK3 inhibition improves skeletal muscle function and whole-body metabolism in male mouse models of Duchenne muscular dystrophy.","volume":"1","author":"Marcella","year":"2024","journal-title":"Nat Commun"},{"key":"75","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3390\/cells9051120","article-title":"Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3\u03b2) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity.","volume":"9","author":"Gupte","year":"2020","journal-title":"Cells"},{"key":"76","doi-asserted-by":"publisher","first-page":"104159","DOI":"10.1016\/j.isci.2022.104159","article-title":"Premise and peril of Wnt signaling activation through GSK-3\u03b2 inhibition.","volume":"2","author":"Law","year":"2022","journal-title":"iScience"},{"key":"77","doi-asserted-by":"publisher","first-page":"1320964","DOI":"10.3389\/fphys.2023.1320964","article-title":"Revving the engine: PKB\/AKT as a key regulator of cellular glucose metabolism.","volume":"1","author":"Li","year":"2024","journal-title":"Front Physiol"},{"key":"78","doi-asserted-by":"publisher","first-page":"e23532","DOI":"10.1096\/fj.202301833RR","article-title":"mTORC2-AKT signaling to PFKFB2 activates glycolysis that enhances stemness and tumorigenicity of intestinal epithelial cells.","volume":"3","author":"Li","year":"2024","journal-title":"FASEB J"},{"key":"79","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.7150\/ijbs.27173","article-title":"The PI3K\/AKT pathway in obesity and type 2 diabetes.","volume":"1","author":"Huang","year":"2018","journal-title":"Int J Biol Sci"},{"key":"80","doi-asserted-by":"publisher","first-page":"eabe4509","DOI":"10.1126\/scisignal.abe4509","article-title":"mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.","volume":"1","author":"Baffi","year":"2021","journal-title":"Sci Signal"},{"key":"81","doi-asserted-by":"publisher","first-page":"818688","DOI":"10.3389\/fphys.2022.818688","article-title":"Protein Kinase C Life Cycle: Explained Through Systems Biology Approach.","volume":"1","author":"Aslam","year":"2022","journal-title":"Front Physiol"},{"key":"82","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3390\/biom13060915","article-title":"Activation Mechanisms and Diverse Functions of Mammalian Phospholipase C.","volume":"1","author":"Kanemaru","year":"2023","journal-title":"Biomolecules"},{"key":"83","doi-asserted-by":"publisher","first-page":"e70474","DOI":"10.1002\/mco2.70474","article-title":"Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions.","volume":"6","author":"Li","year":"2025","journal-title":"MedComm (2020)"},{"key":"84","doi-asserted-by":"publisher","first-page":"110966","DOI":"10.1016\/j.cellsig.2023.110966","article-title":"The role of PKC and PKD in CXCL12 and CXCL13 directed malignant melanoma and acute monocytic leukemic cancer cell migration.","volume":"11","author":"Hamshaw","year":"2024","journal-title":"Cell Signal"},{"key":"85","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1189\/jlb.0812371","article-title":"The emerging role of protein kinase C\u03b8 in cytoskeletal signaling.","volume":"9","author":"Michalczyk","year":"2013","journal-title":"J Leukoc Biol"},{"key":"86","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12929-018-0445-1","article-title":"MARCKS and MARCKS-like proteins in development and regeneration.","volume":"2","author":"El Amri","year":"2018","journal-title":"J Biomed Sci"},{"key":"87","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.3390\/ijms21041502","article-title":"ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.","volume":"2","author":"Garc\u00eda-Ortiz","year":"2020","journal-title":"Int J Mol Sci"},{"key":"88","doi-asserted-by":"publisher","first-page":"102035","DOI":"10.1016\/j.jbc.2022.102035","article-title":"PKC regulation of ion channels: The involvement of PIP","volume":"29","author":"Gada","year":"2022","journal-title":"J Biol Chem"},{"key":"89","doi-asserted-by":"publisher","first-page":"11482","DOI":"10.3390\/ijms262311482","article-title":"Impact of C-Terminal PKC Phosphorylation on TRPC6 Current Kinetics.","volume":"2","author":"Keck","year":"2025","journal-title":"Int J Mol Sci"},{"key":"90","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/jnc.15710","article-title":"Membrane retrieval after Immediately Releasable Pool (IRP) exocytosis is produced by dynamin-dependent and dynamin-independent\/protein kinase C-dependent mechanisms.","volume":"16","author":"Bayon\u00e9s","year":"2022","journal-title":"J Neurochem"},{"key":"91","doi-asserted-by":"publisher","first-page":"14488","DOI":"10.3389\/abp.2025.14488","article-title":"PKC in the perspective of dopamine receptor signaling.","volume":"7","author":"Ma","year":"2025","journal-title":"Acta Biochim Pol"},{"key":"92","doi-asserted-by":"publisher","first-page":"105692","DOI":"10.1016\/j.jbc.2024.105692","article-title":"Protein kinase C signaling \u201cin\u201d and \u201cto\u201d the nucleus: Master kinases in transcriptional regulation.","volume":"30","author":"Kazanietz","year":"2024","journal-title":"J Biol Chem"},{"key":"93","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1038\/s41401-018-0087-6","article-title":"Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds.","volume":"3","author":"Gong","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"94","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.apsb.2018.07.001","article-title":"Serum and glucocorticoid inducible protein kinases (SGKs): a potential target for cancer intervention.","volume":"8","author":"Basnet","year":"2018","journal-title":"Acta Pharm Sin B"},{"key":"95","doi-asserted-by":"publisher","first-page":"1036844","DOI":"10.3389\/fphar.2022.1036844","article-title":"Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors.","volume":"1","author":"Jang","year":"2022","journal-title":"Front Pharmacol"},{"key":"96","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.3390\/cancers14102385","article-title":"SGK1 in Cancer: Biomarker and Drug Target.","volume":"1","author":"Cicenas","year":"2022","journal-title":"Cancers (Basel)"},{"key":"97","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.ibneur.2024.12.003","article-title":"The role of SGK1 in neurologic diseases: A friend or foe?","volume":"1","author":"Chen","year":"2024","journal-title":"IBRO Neurosci Rep"},{"key":"98","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/bjc.2017.293","article-title":"SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway.","volume":"11","author":"Liu","year":"2017","journal-title":"Br J Cancer"},{"key":"99","doi-asserted-by":"publisher","first-page":"110778","DOI":"10.1016\/j.cellsig.2023.110778","article-title":"SGK1 is necessary to FoxO3a negative regulation, oxidative stress and cardiac fibroblast activation induced by TGF-\u03b21.","volume":"10","author":"Gonz\u00e1lez-Herrera","year":"2023","journal-title":"Cell Signal"},{"key":"100","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.3390\/ijms17081307","article-title":"Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis.","volume":"1","author":"Lou","year":"2016","journal-title":"Int J Mol Sci"},{"key":"101","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.hroo.2025.02.015","article-title":"Exploring serum and glucocorticoid-regulated kinase 1: A promising target for COVID-19 and atrial fibrillation treatment.","volume":"6","author":"E-Fatima","year":"2025","journal-title":"Heart Rhythm O2"},{"key":"102","doi-asserted-by":"publisher","first-page":"108821","DOI":"10.1016\/j.celrep.2021.108821","article-title":"SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells.","volume":"3","author":"Mason","year":"2021","journal-title":"Cell Rep"},{"key":"103","doi-asserted-by":"publisher","first-page":"R187","DOI":"10.1530\/EC-20-0225","article-title":"The functional duality of SGK1 in the regulation of hyperglycemia.","volume":"9","author":"Yang","year":"2020","journal-title":"Endocr Connect"},{"key":"104","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.isci.2019.06.014","article-title":"Chemogenetic Activation of Prefrontal Cortex in Shank3-Deficient Mice Ameliorates Social Deficits, NMDAR Hypofunction, and Sgk2 Downregulation.","volume":"1","author":"Qin","year":"2019","journal-title":"iScience"},{"key":"105","doi-asserted-by":"publisher","first-page":"F1496","DOI":"10.1152\/ajprenal.00075.2010","article-title":"Expression and role of serum and glucocorticoid-regulated kinase 2 in the regulation of Na+\/H+ exchanger 3 in the mammalian kidney.","volume":"29","author":"Pao","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"106","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bcp.2015.11.024","article-title":"Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.","volume":"10","author":"Wang","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"107","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1124\/jpet.113.209379","article-title":"Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells.","volume":"34","author":"Gotoh","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"108","doi-asserted-by":"publisher","first-page":"780312","DOI":"10.3389\/fphys.2021.780312","article-title":"Protein Kinase SGK2 Is Induced by the \u03b2Adrenergic Receptor-cAMP-PKA-PGC-1\u03b1\/NT-PGC-1\u03b1 Axis but Dispensable for Brown\/Beige Adipose Tissue Thermogenesis.","volume":"1","author":"Park","year":"2021","journal-title":"Front Physiol"},{"key":"109","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.1038\/s41388-020-01433-6","article-title":"Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cells.","volume":"3","author":"Ranzuglia","year":"2020","journal-title":"Oncogene"},{"key":"110","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41419-023-05614-5","article-title":"SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.","volume":"1","author":"Cheng","year":"2023","journal-title":"Cell Death Dis"},{"key":"111","doi-asserted-by":"publisher","first-page":"1007924","DOI":"10.3389\/fcell.2022.1007924","article-title":"Contributions of SGK3 to transporter-related diseases.","volume":"1","author":"Liao","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"112","doi-asserted-by":"publisher","first-page":"e186534","DOI":"10.1172\/JCI186534","article-title":"Serum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis.","volume":"13","author":"Chen","year":"2025","journal-title":"J Clin Invest"},{"key":"113","doi-asserted-by":"publisher","first-page":"810473","DOI":"10.3389\/fphys.2021.810473","article-title":"Serum and Glucocorticoid-Inducible Kinase 3\/Nedd4-2 Signaling Pathway Participates in Podocyte Injury by Regulating the Stability of Nephrin.","volume":"1","author":"Dong","year":"2022","journal-title":"Front Physiol"},{"key":"114","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1096\/fj.201700393RR","article-title":"Lack of serum- and glucocorticoid-inducible kinase 3 leads to podocyte dysfunction.","volume":"3","author":"Peng","year":"2018","journal-title":"FASEB J"},{"key":"115","doi-asserted-by":"publisher","first-page":"e022802","DOI":"10.1161\/JAHA.121.022802","article-title":"Serine\/Threonine-Protein Kinase 3 Facilitates Myocardial Repair After Cardiac Injury Possibly Through the Glycogen Synthase Kinase-3\u03b2\/\u03b2-Catenin Pathway.","volume":"1","author":"Li","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"116","doi-asserted-by":"publisher","first-page":"138438","DOI":"10.1016\/j.jhazmat.2025.138438","article-title":"Methotrexate-induced disruption of the serum-glucocorticoid inducible protein kinase 3 signaling pathway and its effects on brain development.","volume":"49","author":"Ham","year":"2025","journal-title":"J Hazard Mater"},{"key":"117","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bbrc.2016.07.094","article-title":"Serum- and glucocorticoid-inducible kinases in microglia.","volume":"47","author":"Inoue","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"118","doi-asserted-by":"publisher","first-page":"102931","DOI":"10.1016\/j.redox.2023.102931","article-title":"The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance.","volume":"6","author":"Wang","year":"2023","journal-title":"Redox Biol"},{"key":"119","doi-asserted-by":"publisher","first-page":"992","DOI":"10.17179\/excli2025-8384","article-title":"Exploring the role of mTOR pathway in aging and age-related disorders.","volume":"2","author":"Raghuvanshi","year":"2025","journal-title":"EXCLI J"},{"key":"120","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.18632\/aging.206300","article-title":"What is the clinical evidence to support off-label rapamycin therapy in healthy adults?","volume":"1","author":"Hands","year":"2025","journal-title":"Aging (Albany NY)"},{"key":"121","doi-asserted-by":"publisher","first-page":"4955","DOI":"10.1007\/s11357-025-01640-7","article-title":"German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway.","volume":"4","author":"Kolbe","year":"2025","journal-title":"Geroscience"},{"key":"122","doi-asserted-by":"publisher","first-page":"e13457","DOI":"10.1111\/acel.13457","article-title":"Genetic reduction of mTOR extends lifespan in a mouse model of Hutchinson-Gilford Progeria syndrome.","volume":"2","author":"Cabral","year":"2021","journal-title":"Aging Cell"},{"key":"123","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.cmet.2016.05.009","article-title":"The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.","volume":"2","author":"Kennedy","year":"2016","journal-title":"Cell Metab"},{"key":"124","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3390\/biom11050681","article-title":"mTOR Signaling in Metabolic Stress Adaptation.","volume":"1","author":"Wu","year":"2021","journal-title":"Biomolecules"},{"key":"125","doi-asserted-by":"publisher","first-page":"11088","DOI":"10.3390\/ijms222011088","article-title":"Role of PI3K-AKT-mTOR Pathway as a Pro-Survival Signaling and Resistance-Mediating Mechanism to Therapy of Prostate Cancer.","volume":"2","author":"Pungsrinont","year":"2021","journal-title":"Int J Mol Sci"},{"key":"126","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1007\/s00018-025-05836-0","article-title":"The role of the SIRT1 and mTOR pathways in exercise-induced \u03b2-cell senescence reduction in type 2 diabetes mellitus.","volume":"8","author":"Hoseini","year":"2025","journal-title":"Cell Mol Life Sci"},{"key":"127","doi-asserted-by":"publisher","first-page":"268ra179","DOI":"10.1126\/scitranslmed.3009892","article-title":"mTOR inhibition improves immune function in the elderly.","volume":"6","author":"Mannick","year":"2014","journal-title":"Sci Transl Med"},{"key":"128","doi-asserted-by":"publisher","first-page":"231","DOI":"10.18632\/aging.100872","article-title":"Reversal of phenotypes of cellular senescence by pan-mTOR inhibition.","volume":"8","author":"Walters","year":"2016","journal-title":"Aging (Albany NY)"},{"key":"129","doi-asserted-by":"publisher","first-page":"e14040","DOI":"10.1111\/acel.14040","article-title":"Endothelial cell-specific reduction in mTOR ameliorates age-related arterial and metabolic dysfunction.","volume":"2","author":"Islam","year":"2024","journal-title":"Aging Cell"},{"key":"130","doi-asserted-by":"publisher","first-page":"ra75","DOI":"10.1126\/scisignal.2000559","article-title":"mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.","volume":"2","author":"Chen","year":"2009","journal-title":"Sci Signal"},{"key":"131","doi-asserted-by":"publisher","first-page":"263","DOI":"10.14336\/AD.2014.0500263","article-title":"mTOR Signaling from Cellular Senescence to Organismal Aging.","volume":"5","author":"Xu","year":"2013","journal-title":"Aging Dis"},{"key":"132","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.3390\/genes11091043","article-title":"The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation.","volume":"1","author":"Bjedov","year":"2020","journal-title":"Genes (Basel)"},{"key":"133","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3390\/biom7040077","article-title":"Evolutionary Conservation of the Components in the TOR Signaling Pathways.","volume":"7","author":"Tatebe","year":"2017","journal-title":"Biomolecules"},{"key":"134","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/acel.12015","article-title":"Gene expression analysis of mTOR pathway: association with human longevity.","volume":"1","author":"Passtoors","year":"2013","journal-title":"Aging Cell"},{"key":"135","doi-asserted-by":"publisher","first-page":"719713","DOI":"10.3389\/fgene.2021.719713","article-title":"Cross-Species and Human Inter-Tissue Network Analysis of Genes Implicated in Longevity and Aging Reveal Strong Support for Nutrient Sensing.","volume":"1","author":"Podder","year":"2021","journal-title":"Front Genet"},{"key":"136","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1186\/s12864-023-09554-4","article-title":"Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals.","volume":"2","author":"Yang","year":"2023","journal-title":"BMC Genomics"},{"key":"137","doi-asserted-by":"publisher","first-page":"8747","DOI":"10.3390\/ijms23158747","article-title":"mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity.","volume":"2","author":"Mota-Martorell","year":"2022","journal-title":"Int J Mol Sci"},{"key":"138","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1007\/s11357-020-00210-3","article-title":"Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity.","volume":"4","author":"Mota-Martorell","year":"2020","journal-title":"Geroscience"},{"key":"139","doi-asserted-by":"publisher","first-page":"20071","DOI":"10.1038\/s41598-019-56237-w","article-title":"mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells.","volume":"9","author":"Schaub","year":"2019","journal-title":"Sci Rep"},{"key":"140","doi-asserted-by":"publisher","first-page":"5414","DOI":"10.3390\/molecules27175414","article-title":"mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity.","volume":"2","author":"Jimenez","year":"2022","journal-title":"Molecules"},{"key":"141","doi-asserted-by":"publisher","first-page":"e13014","DOI":"10.1111\/acel.13014","article-title":"Hypothalamic mTORC2 is essential for metabolic health and longevity.","volume":"1","author":"Chellappa","year":"2019","journal-title":"Aging Cell"},{"key":"142","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41580-018-0033-y","article-title":"Autophagy as a promoter of longevity: insights from model organisms.","volume":"1","author":"Hansen","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"143","doi-asserted-by":"publisher","first-page":"101020","DOI":"10.1016\/j.mam.2021.101020","article-title":"Macroautophagy and aging: The impact of cellular recycling on health and longevity.","volume":"8","author":"Nieto-Torres","year":"2021","journal-title":"Mol Aspects Med"},{"key":"144","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1111\/acel.12514","article-title":"mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts.","volume":"1","author":"Romero","year":"2016","journal-title":"Aging Cell"},{"key":"145","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3389\/fcell.2019.00183","article-title":"Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy.","volume":"7","author":"Bareja","year":"2019","journal-title":"Front Cell Dev Biol"},{"key":"146","doi-asserted-by":"publisher","first-page":"e13431","DOI":"10.1111\/acel.13431","article-title":"mTORC2: The other mTOR in autophagy regulation.","volume":"2","author":"Ballesteros-\u00c1lvarez","year":"2021","journal-title":"Aging Cell"},{"key":"147","doi-asserted-by":"publisher","first-page":"e70018","DOI":"10.1111\/acel.70018","article-title":"Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice.","volume":"2","author":"Chowdhury","year":"2025","journal-title":"Aging Cell"},{"key":"148","doi-asserted-by":"publisher","first-page":"101038","DOI":"10.1016\/j.arr.2020.101038","article-title":"Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment.","volume":"6","author":"Dorling","year":"2020","journal-title":"Ageing Res Rev"},{"key":"149","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.18632\/aging.101498","article-title":"Caloric restriction effects on liver mTOR signaling are time-of-day dependent.","volume":"1","author":"Tulsian","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"150","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1038\/s41467-022-29714-6","article-title":"Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.","volume":"1","author":"Ham","year":"2022","journal-title":"Nat Commun"},{"key":"151","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12929-025-01188-w","article-title":"The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans.","volume":"3","author":"Ching","year":"2025","journal-title":"J Biomed Sci"},{"key":"152","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/s42003-024-06679-4","article-title":"Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles.","volume":"7","author":"Ataman","year":"2024","journal-title":"Commun Biol"},{"key":"153","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.18632\/aging.101269","article-title":"The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome.","volume":"9","author":"Derous","year":"2017","journal-title":"Aging (Albany NY)"},{"key":"154","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.ebiom.2019.04.005","article-title":"The impact of dietary protein intake on longevity and metabolic health.","volume":"4","author":"Kitada","year":"2019","journal-title":"EBioMedicine"},{"key":"155","doi-asserted-by":"publisher","first-page":"e13626","DOI":"10.1111\/acel.13626","article-title":"Protein restriction and branched-chain amino acid restriction promote geroprotective shifts in metabolism.","volume":"2","author":"Trautman","year":"2022","journal-title":"Aging Cell"},{"key":"156","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.3390\/nu16111725","article-title":"Mediterranean Dietary Pattern for Healthy and Active Aging: A Narrative Review of an Integrative and Sustainable Approach.","volume":"1","author":"Dobroslavska","year":"2024","journal-title":"Nutrients"},{"key":"157","doi-asserted-by":"publisher","first-page":"100015","DOI":"10.1016\/j.jnphys.2026.100015","article-title":"The Mediterranean diet as a metabolic strategy for healthy aging and non-communicable disease prevention.","volume":"5","author":"Srambikkal Vinesh","year":"2026","journal-title":"The Journal of Nutritional Physiology"},{"key":"158","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.3390\/nu16172878","article-title":"Molecular Mechanisms of Healthy Aging: The Role of Caloric Restriction, Intermittent Fasting, Mediterranean Diet, and Ketogenic Diet-A Scoping Review.","volume":"1","author":"Surugiu","year":"2024","journal-title":"Nutrients"},{"key":"159","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.arr.2016.07.004","article-title":"Targeting mTOR signaling by polyphenols: A new therapeutic target for ageing.","volume":"3","author":"Pazoki-Toroudi","year":"2016","journal-title":"Ageing Res Rev"},{"key":"160","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/gerona\/glx227","article-title":"Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms.","volume":"7","author":"Tosti","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"161","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1186\/s12916-025-04176-x","article-title":"Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study.","volume":"2","author":"Xu","year":"2025","journal-title":"BMC Med"},{"key":"162","doi-asserted-by":"publisher","first-page":"5934","DOI":"10.1038\/s41598-026-36742-5","article-title":"Association between lifelong physical activity, physical fitness, and quality of life in older adults in Poland.","volume":"1","author":"Kaczorowska","year":"2026","journal-title":"Sci Rep"},{"key":"163","doi-asserted-by":"publisher","first-page":"100970","DOI":"10.1016\/j.jshs.2024.100970","article-title":"Interplay between physical activity volume and intensity with modeled life expectancy in women and men: A prospective cohort analysis.","volume":"1","author":"Zaccardi","year":"2025","journal-title":"J Sport Health Sci"},{"key":"164","doi-asserted-by":"publisher","first-page":"12096","DOI":"10.3390\/ijms262412096","article-title":"Exercise-Induced Molecular Adaptations in Chronic Non-Communicable Diseases-Narrative Review.","volume":"2","author":"Fuentes-Barr\u00eda","year":"2025","journal-title":"Int J Mol Sci"},{"key":"165","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.3390\/ijms27041817","article-title":"Metabolic Overdrive in Elite Sport: A Systems Model of AMPK-mTOR Oscillation, NADEconomy, and Epigenetic Drift.","volume":"2","author":"M\u0103nescu","year":"2026","journal-title":"Int J Mol Sci"},{"key":"166","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.","volume":"6","author":"Garcia","year":"2017","journal-title":"Mol Cell"},{"key":"167","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1096\/fj.201700442R","article-title":"AMPK in skeletal muscle function and metabolism.","volume":"3","author":"Kj\u00f8bsted","year":"2018","journal-title":"FASEB J"},{"key":"168","doi-asserted-by":"publisher","first-page":"4286","DOI":"10.1021\/acs.jproteome.4c00242","article-title":"Mechanical Loading Modulates AMPK and mTOR Signaling in Muscle Cells.","volume":"2","author":"Zhou","year":"2024","journal-title":"J Proteome Res"},{"key":"169","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.3390\/ph18081222","article-title":"Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging.","volume":"1","author":"Tero-Vescan","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"key":"170","doi-asserted-by":"publisher","first-page":"e70277","DOI":"10.1096\/fj.202402064R","article-title":"mTOR Ser1261 is an AMPK-dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity.","volume":"3","author":"Li","year":"2025","journal-title":"FASEB J"},{"key":"171","doi-asserted-by":"publisher","first-page":"E63","DOI":"10.1152\/ajpendo.00389.2021","article-title":"Exercise increases phosphorylation of the putative mTORC2 activity readout NDRG1 in human skeletal muscle.","volume":"32","author":"Knudsen","year":"2022","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"172","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41514-024-00138-4","article-title":"Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment.","volume":"1","author":"Lelarge","year":"2024","journal-title":"NPJ Aging"},{"key":"173","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3390\/biom15060860","article-title":"Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions.","volume":"1","author":"Saliev","year":"2025","journal-title":"Biomolecules"},{"key":"174","doi-asserted-by":"publisher","first-page":"8489","DOI":"10.2147\/DDDT.S543211","article-title":"Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics.","volume":"1","author":"Alum","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"175","doi-asserted-by":"publisher","first-page":"8149","DOI":"10.3390\/ijms22158149","article-title":"mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership.","volume":"2","author":"Cayo","year":"2021","journal-title":"Int J Mol Sci"},{"key":"176","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1016\/j.molcel.2021.03.018","article-title":"Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.","volume":"8","author":"van Vliet","year":"2021","journal-title":"Mol Cell"},{"key":"177","doi-asserted-by":"publisher","first-page":"112359","DOI":"10.1016\/j.exger.2024.112359","article-title":"Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence.","volume":"18","author":"Fan","year":"2024","journal-title":"Exp Gerontol"},{"key":"178","doi-asserted-by":"publisher","first-page":"995","DOI":"10.2174\/18715206113139990129","article-title":"Inhibition of Akt\/mTOR signaling by the dietary flavonoid fisetin.","volume":"1","author":"Syed","year":"2013","journal-title":"Anticancer Agents Med Chem"},{"key":"179","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.3390\/ijms20133177","article-title":"The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism.","volume":"2","author":"Reyes-Farias","year":"2019","journal-title":"Int J Mol Sci"},{"key":"180","doi-asserted-by":"publisher","first-page":"100206","DOI":"10.1016\/j.prenap.2025.100206","article-title":"Quercetin promises anticancer activity through PI3K-AKT-mTOR pathway: a literature review.","volume":"7","author":"Hasan","year":"2025","journal-title":"Pharmacol Res Nat Prod"},{"key":"181","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1007\/s12015-023-10526-0","article-title":"The Regulation of the AMPK\/mTOR Axis Mitigates Tendon Stem\/Progenitor Cell Senescence and Delays Tendon Aging.","volume":"1","author":"Dai","year":"2023","journal-title":"Stem Cell Rev Rep"},{"key":"182","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10522-018-9773-5","article-title":"Metformin as a geroprotector: experimental and clinical evidence.","volume":"2","author":"Piskovatska","year":"2019","journal-title":"Biogerontology"},{"key":"183","doi-asserted-by":"publisher","first-page":"118046","DOI":"10.1016\/j.ejmech.2025.118046","article-title":"Recent advances of the mechanistic target of rapamycin (mTOR) inhibitors for drug discovery.","volume":"29","author":"Ni","year":"2025","journal-title":"Eur J Med Chem"},{"key":"184","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1016\/S2666-7568(23)00258-1","article-title":"Targeting ageing with rapamycin and its derivatives in humans: a systematic review.","volume":"5","author":"Lee","year":"2024","journal-title":"Lancet Healthy Longev"},{"key":"185","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nature08221","article-title":"Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.","volume":"46","author":"Harrison","year":"2009","journal-title":"Nature"},{"key":"186","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/acel.12587","article-title":"Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.","volume":"1","author":"Wang","year":"2017","journal-title":"Aging Cell"},{"key":"187","doi-asserted-by":"publisher","first-page":"e70364","DOI":"10.1111\/acel.70364","article-title":"Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage.","volume":"2","author":"Kell","year":"2026","journal-title":"Aging Cell"},{"key":"188","doi-asserted-by":"publisher","first-page":"908","DOI":"10.18632\/aging.206235","article-title":"Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.","volume":"1","author":"Moel","year":"2025","journal-title":"Aging (Albany NY)"},{"key":"189","doi-asserted-by":"publisher","first-page":"9250722","DOI":"10.26599\/FSHW.2025.9250722","article-title":"Arresting idiopathic pulmonary fibrosis progression: EZY-1 targets mTORC2 to inhibit senescence-associated secretory phenotype.","volume":"1","author":"Tu","year":"2026","journal-title":"Food Sci Hum Wellness"},{"key":"190","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jbior.2016.12.001","article-title":"Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects.","volume":"6","author":"Jhanwar-Uniyal","year":"2017","journal-title":"Adv Biol Regul"},{"key":"191","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1038\/s43587-023-00416-y","article-title":"Targeting the biology of aging with mTOR inhibitors.","volume":"3","author":"Mannick","year":"2023","journal-title":"Nat Aging"},{"key":"192","doi-asserted-by":"publisher","first-page":"eaaq1564","DOI":"10.1126\/scitranslmed.aaq1564","article-title":"TORC1 inhibition enhances immune function and reduces infections in the elderly.","volume":"1","author":"Mannick","year":"2018","journal-title":"Sci Transl Med"},{"key":"193","doi-asserted-by":"publisher","first-page":"24","DOI":"10.20517\/jca.2023.10","article-title":"The mTOR signaling pathway in cardiac aging.","volume":"3","author":"Dai","year":"2023","journal-title":"J Cardiovasc Aging"},{"key":"194","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41580-019-0199-y","article-title":"mTOR at the nexus of nutrition, growth, ageing and disease.","volume":"2","author":"Liu","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"195","doi-asserted-by":"publisher","first-page":"2640342","DOI":"10.1155\/2018\/2640342","article-title":"mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?","volume":"201","author":"Kezic","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"196","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1007\/s11357-023-00818-1","article-title":"Evaluation of off-label rapamycin use to promote healthspan in 333 adults.","volume":"4","author":"Kaeberlein","year":"2023","journal-title":"Geroscience"},{"key":"197","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.exger.2017.12.026","article-title":"A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.","volume":"10","author":"Kraig","year":"2018","journal-title":"Exp Gerontol"},{"key":"198","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: An expanding universe.","volume":"18","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"199","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1080\/14756366.2021.1955873","article-title":"The role of mTOR in age-related diseases.","volume":"3","author":"Chrienova","year":"2021","journal-title":"J Enzyme Inhib Med Chem"},{"key":"200","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances.","volume":"1","author":"Xu","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"201","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s10522-025-10273-4","article-title":"Mitochondrial dysfunction and aging: multidimensional mechanisms and therapeutic strategies.","volume":"2","author":"Wei","year":"2025","journal-title":"Biogerontology"},{"key":"202","doi-asserted-by":"publisher","first-page":"eads1842","DOI":"10.1126\/sciadv.ads1842","article-title":"Metabolic rewiring caused by mitochondrial dysfunction promotes mTORC1-dependent skeletal aging.","volume":"1","author":"Bubb","year":"2025","journal-title":"Sci Adv"},{"key":"203","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/j.cellsig.2016.05.007","article-title":"Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic \u03b2 cells.","volume":"2","author":"Wang","year":"2016","journal-title":"Cell Signal"},{"key":"204","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3390\/antiox14050512","article-title":"Nitazoxanide Modulates Mitochondrial Function and Inflammatory Metabolism in Chondrocytes from Patients with Osteoarthritis via AMPK\/mTORC1 Signaling.","volume":"1","author":"Kim","year":"2025","journal-title":"Antioxidants (Basel)"},{"key":"205","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00018-022-04595-6","article-title":"Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK\/mTOR\/ERK signaling.","volume":"7","author":"Ashraf","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"206","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.cmet.2021.12.017","article-title":"Mosaic dysfunction of mitophagy in mitochondrial muscle disease.","volume":"3","author":"Mito","year":"2022","journal-title":"Cell Metab"},{"key":"207","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.14336\/AD.2024.0362","article-title":"Aging and Autophagy: Roles in Musculoskeletal System Injury.","volume":"1","author":"Zhang","year":"2024","journal-title":"Aging Dis"},{"key":"208","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12964-025-02240-w","article-title":"mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage.","volume":"2","author":"Verdejo","year":"2025","journal-title":"Cell Commun Signal"},{"key":"209","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.cmet.2017.07.019","article-title":"Regulation of Stem Cell Aging by Metabolism and Epigenetics.","volume":"2","author":"Ren","year":"2017","journal-title":"Cell Metab"},{"key":"210","doi-asserted-by":"publisher","first-page":"1433702","DOI":"10.3389\/fragi.2024.1433702","article-title":"Editorial: Stem cell exhaustion in aging.","volume":"5","author":"Rezazadeh","year":"2024","journal-title":"Front Aging"},{"key":"211","doi-asserted-by":"publisher","first-page":"12073","DOI":"10.18632\/aging.206078","article-title":"Targeting multiple hallmarks of mammalian aging with combinations of interventions.","volume":"1","author":"Panchin","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"212","doi-asserted-by":"publisher","first-page":"e13499","DOI":"10.1111\/cpr.13499","article-title":"mTOR signalling pathway in stem cell bioactivities and angiogenesis potential.","volume":"5","author":"Lotfimehr","year":"2023","journal-title":"Cell Prolif"},{"key":"213","doi-asserted-by":"publisher","first-page":"112160","DOI":"10.1016\/j.mad.2026.112160","article-title":"Mechanistic insights into stem cell aging: Pathways and processes.","volume":"23","author":"Fauzi","year":"2026","journal-title":"Mech Ageing Dev"},{"key":"214","doi-asserted-by":"publisher","first-page":"29937","DOI":"10.18632\/oncotarget.8729","article-title":"Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice.","volume":"7","author":"Selman","year":"2016","journal-title":"Oncotarget"},{"key":"215","doi-asserted-by":"publisher","first-page":"e53081","DOI":"10.15252\/embr.202153081","article-title":"The mTORC1-eIF4F axis controls paused pluripotency.","volume":"2","author":"Xu","year":"2022","journal-title":"EMBO Rep"},{"key":"216","doi-asserted-by":"publisher","first-page":"e55439","DOI":"10.15252\/embr.202255439","article-title":"Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures.","volume":"2","author":"Nanba","year":"2023","journal-title":"EMBO Rep"},{"key":"217","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.3390\/ijms20092158","article-title":"Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.","volume":"2","author":"Mohammad","year":"2019","journal-title":"Int J Mol Sci"},{"key":"218","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1093\/neuonc\/now237","article-title":"Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells.","volume":"1","author":"Han","year":"2017","journal-title":"Neuro Oncol"},{"key":"219","doi-asserted-by":"publisher","first-page":"eadi2671","DOI":"10.1126\/sciadv.adi2671","article-title":"Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation.","volume":"1","author":"Mattila","year":"2024","journal-title":"Sci Adv"},{"key":"220","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1016\/j.stem.2017.11.008","article-title":"mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.","volume":"2","author":"Haller","year":"2017","journal-title":"Cell Stem Cell"},{"key":"221","doi-asserted-by":"publisher","first-page":"7598","DOI":"10.3390\/ijms26157598","article-title":"mTOR Signaling in Macrophages: All Depends on the Context.","volume":"2","author":"Fedor","year":"2025","journal-title":"Int J Mol Sci"},{"key":"222","doi-asserted-by":"publisher","first-page":"1186850","DOI":"10.3389\/fcell.2023.1186850","article-title":"Regulation of hematopoietic stem cells differentiation, self-renewal, and quiescence through the mTOR signaling pathway.","volume":"1","author":"Ling","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"223","doi-asserted-by":"publisher","first-page":"14279","DOI":"10.3390\/ijms241814279","article-title":"Genomic Instability and Epigenetic Changes during Aging.","volume":"2","author":"L\u00f3pez-Gil","year":"2023","journal-title":"Int J Mol Sci"},{"key":"224","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00335-020-09836-2","article-title":"Epigenetics and genome stability.","volume":"3","author":"Feng","year":"2020","journal-title":"Mamm Genome"},{"key":"225","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.bbamcr.2018.06.011","article-title":"mTORC1 pathway in DNA damage response.","volume":"186","author":"Ma","year":"2018","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"226","doi-asserted-by":"publisher","first-page":"e172370","DOI":"10.1172\/jci.insight.172370","article-title":"Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage.","volume":"1","author":"Braun","year":"2025","journal-title":"JCI Insight"},{"key":"227","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1080\/15384101.2021.1897271","article-title":"Regulation of DNA duplication by the mTOR signaling pathway.","volume":"2","author":"He","year":"2021","journal-title":"Cell Cycle"},{"key":"228","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/s41556-017-0033-8","article-title":"The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168.","volume":"2","author":"Xie","year":"2018","journal-title":"Nat Cell Biol"},{"key":"229","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.21037\/atm-21-4544","article-title":"Narrative review of emerging roles for AKT-mTOR signaling in cancer radioimmunotherapy.","volume":"9","author":"Shen","year":"2021","journal-title":"Ann Transl Med"},{"key":"230","doi-asserted-by":"publisher","first-page":"e00577","DOI":"10.1128\/MCB.00577-16","article-title":"mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells.","volume":"3","author":"Silvera","year":"2017","journal-title":"Mol Cell Biol"},{"key":"231","doi-asserted-by":"publisher","first-page":"34","DOI":"10.46439\/cancerbiology.6.072","article-title":"Nuclear mTORC2 and its emerging role in gene regulation.","volume":"6","author":"Moinuddin","year":"2025","journal-title":"J Cancer Biol"},{"key":"232","doi-asserted-by":"publisher","first-page":"101035","DOI":"10.1016\/j.mcpro.2025.101035","article-title":"mTORC2 Regulates Non-homologous End Joining Through Modulating the Temporal Dynamics of 53BP1.","volume":"2","author":"Wang","year":"2025","journal-title":"Mol Cell Proteomics"},{"key":"233","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.neo.2021.05.007","article-title":"mTORC2 regulates ribonucleotide reductase to promote DNA replication and gemcitabine resistance in non-small cell lung cancer.","volume":"2","author":"Tian","year":"2021","journal-title":"Neoplasia"},{"key":"234","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1021\/acs.jproteome.2c00240","article-title":"Phosphoproteomic Analysis Defines BABAM1 as mTORC2 Downstream Effector Promoting DNA Damage Response in Glioblastoma Cells.","volume":"2","author":"Kalpongnukul","year":"2022","journal-title":"J Proteome Res"},{"key":"235","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1158\/1535-7163.MCT-15-0720","article-title":"The Enigma of Rapamycin Dosage.","volume":"1","author":"Mukhopadhyay","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"236","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/s43587-025-00876-4","article-title":"The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan.","volume":"5","author":"Gkioni","year":"2025","journal-title":"Nat Aging"},{"key":"237","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.joca.2019.01.009","article-title":"Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.","volume":"2","author":"Kakiuchi","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"238","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.3390\/ijms20112774","article-title":"mTOR and Aging: An Old Fashioned Dress.","volume":"2","author":"Stallone","year":"2019","journal-title":"Int J Mol Sci"},{"key":"239","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/s41392-026-02630-7","article-title":"Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets.","volume":"1","author":"Zheng","year":"2026","journal-title":"Signal Transduct Target Ther"},{"key":"240","doi-asserted-by":"publisher","first-page":"168","DOI":"10.3390\/biom11020168","article-title":"TOR Signaling Pathway in Cardiac Aging and Heart Failure.","volume":"1","author":"Daneshgar","year":"2021","journal-title":"Biomolecules"},{"key":"241","doi-asserted-by":"publisher","first-page":"1620669","DOI":"10.3389\/fcvm.2025.1620669","article-title":"Post-translational modifications orchestrate mTOR-driven cell death in cardiovascular disease.","volume":"1","author":"Guo","year":"2025","journal-title":"Front Cardiovasc Med"},{"key":"242","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1080\/15548627.2025.2474603","article-title":"Leucine accelerates atherosclerosis through dose-dependent MTOR activation in macrophages.","volume":"2","author":"Zhang","year":"2025","journal-title":"Autophagy"},{"key":"243","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1172\/JCI131048","article-title":"Chronic mTOR activation induces a degradative smooth muscle cell phenotype.","volume":"13","author":"Li","year":"2020","journal-title":"J Clin Invest"},{"key":"244","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1161\/CIRCRESAHA.122.321542","article-title":"Loss of Macrophage mTORC2 Drives Atherosclerosis via FoxO1 and IL-1\u03b2 Signaling.","volume":"13","author":"Zhang","year":"2023","journal-title":"Circ Res"},{"key":"245","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.celrep.2015.03.010","article-title":"mTORC2 regulates cardiac response to stress by inhibiting MST1.","volume":"1","author":"Sciarretta","year":"2015","journal-title":"Cell Rep"},{"key":"246","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1038\/s41401-018-0079-6","article-title":"mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt\/GSK-3\u03b2\/C\/EBP\u03b1 signaling pathway.","volume":"3","author":"Yang","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"247","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.biochi.2018.06.001","article-title":"Inflammation-induced mTORC2-Akt-mTORC1 signaling promotes macrophage foam cell formation.","volume":"15","author":"Banerjee","year":"2018","journal-title":"Biochimie"},{"key":"248","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuron.2024.09.015","article-title":"Autophagy, aging, and age-related neurodegeneration.","volume":"11","author":"Palmer","year":"2025","journal-title":"Neuron"},{"key":"249","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3390\/antiox10050794","article-title":"Mitophagy and Oxidative Stress: The Role of Aging.","volume":"1","author":"De Gaetano","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"250","doi-asserted-by":"publisher","first-page":"e14463","DOI":"10.1111\/cns.14463","article-title":"mTOR signaling and Alzheimer's disease: What we know and where we are?","volume":"3","author":"Davoody","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"251","doi-asserted-by":"publisher","first-page":"136","DOI":"10.33594\/000000858","article-title":"mTOR Signalling in Neurodegenerative Disorders: Unveiling Key Factors, Mechanistic Insights, and Possible Therapeutic Interventions.","volume":"6","author":"Jha","year":"2026","journal-title":"Cell Physiol Biochem"},{"key":"252","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1515\/jtim-2025-0059","article-title":"Metabolic reprogramming in neurodegenerative diseases: New insights into mTOR-mediated microglial polarization.","volume":"1","author":"Song","year":"2025","journal-title":"J Transl Int Med"},{"key":"253","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.4103\/NRR.NRR-D-25-00544","article-title":"Rictor\/mTORC2 signaling pathway protects endogenous neural stem cells to promote recovery after spinal cord injury.","volume":"2","author":"Tong","year":"2026","journal-title":"Neural Regen Res"},{"key":"254","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.tem.2023.01.001","article-title":"mTORC1 syndrome (TorS): unified paradigm for diabetes\/metabolic syndrome.","volume":"3","author":"Bar-Tana","year":"2023","journal-title":"Trends Endocrinol Metab"},{"key":"255","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s13098-024-01450-5","article-title":"The relation of mTOR with diabetic complications and insulin resistance in patients with type 2 diabetes mellitus.","volume":"1","author":"Amin","year":"2024","journal-title":"Diabetol Metab Syndr"},{"key":"256","doi-asserted-by":"publisher","first-page":"621","DOI":"10.3389\/fendo.2018.00621","article-title":"mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus.","volume":"9","author":"Guill\u00e9n","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"257","doi-asserted-by":"publisher","first-page":"E589","DOI":"10.1152\/ajpendo.00338.2022","article-title":"Hepatic mTORC2 compensates for loss of adipose mTORC2 in mediating energy storage and glucose homeostasis.","volume":"32","author":"Frei","year":"2023","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"258","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.jmb.2018.02.013","article-title":"mTORC2 Signaling: A Path for Pancreatic \u03b2 Cell's Growth and Function.","volume":"43","author":"Yuan","year":"2018","journal-title":"J Mol Biol"},{"key":"259","doi-asserted-by":"publisher","first-page":"ra25","DOI":"10.1126\/scisignal.2002469","article-title":"A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.","volume":"5","author":"Dalle Pezze","year":"2012","journal-title":"Sci Signal"},{"key":"260","doi-asserted-by":"publisher","first-page":"e00141","DOI":"10.1128\/MCB.00141-19","article-title":"Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia.","volume":"3","author":"Joseph","year":"2019","journal-title":"Mol Cell Biol"},{"key":"261","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1152\/japplphysiol.00987.2024","article-title":"Constitutively active mTORC1 signaling modifies the skeletal muscle metabolome and lipidome response to exercise.","volume":"13","author":"Kalenta","year":"2025","journal-title":"J Appl Physiol (1985)"},{"key":"262","doi-asserted-by":"publisher","first-page":"e12943","DOI":"10.1111\/acel.12943","article-title":"mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism.","volume":"1","author":"Tang","year":"2019","journal-title":"Aging Cell"},{"key":"263","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/jcsm.13121","article-title":"Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.","volume":"1","author":"Crombie","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"264","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13395-019-0217-y","article-title":"mTORC2 affects the maintenance of the muscle stem cell pool.","volume":"9","author":"Rion","year":"2019","journal-title":"Skelet Muscle"},{"key":"265","doi-asserted-by":"publisher","first-page":"e0312859","DOI":"10.1371\/journal.pone.0312859","article-title":"Rapamycin administration causes a decrease in muscle contractile function and systemic glucose intolerance concomitant with reduced skeletal muscle Rictor, the mTORC2 component, expression independent of energy intake in young rats.","volume":"1","author":"Ato","year":"2024","journal-title":"PLoS One"}],"container-title":["Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:20:51Z","timestamp":1789831251000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.aging-us.com\/lookup\/doi\/10.18632\/aging.206423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":265,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2,11]]}},"alternative-id":["206423"],"URL":"https:\/\/doi.org\/10.18632\/aging.206423","relation":{},"ISSN":["1945-4589"],"issn-type":[{"value":"1945-4589","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]}}}