{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:22:08Z","timestamp":1789780928980,"version":"4.0.1"},"reference-count":14,"publisher":"Impact Journals, LLC","issue":"9-10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Cancer"],"published-print":{"date-parts":[[2014,9,8]]},"DOI":"10.18632\/genesandcancer.32","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T15:26:38Z","timestamp":1450365998000},"page":"348-352","source":"Crossref","is-referenced-by-count":13,"title":["Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-\u03b2 signaling disruption"],"prefix":"10.18632","volume":"5","author":[{"given":"Nina M.","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior H.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hyun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jin","family":"Gi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin Kumar","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Gagea","sequence":"additional","affiliation":[{"name":"Veterinary Medicine & Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Rashid","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lopa","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Gao B and Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011; 141(5):1572-1585. [PubMed] https:\/\/doi.org\/10.1053\/j.gastro.2011.09.002.","DOI":"10.1053\/j.gastro.2011.09.002"},{"key":"2","doi-asserted-by":"crossref","unstructured":"Rao R. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology. 2009; 50(2):638-644. [PubMed] https:\/\/doi.org\/10.1002\/hep.23009.","DOI":"10.1002\/hep.23009"},{"key":"3","doi-asserted-by":"crossref","unstructured":"Uesugi T, Froh M, Arteel GE, Bradford BU and Thurman RG. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology. 2001; 34(1):101-108. [PubMed]","DOI":"10.1053\/jhep.2001.25350"},{"key":"4","doi-asserted-by":"crossref","unstructured":"Massague J. TGFbeta in Cancer. Cell. 2008; 134(2):215-230. [PubMed] https:\/\/doi.org\/10.1016\/j.cell.2008.07.001.","DOI":"10.1016\/j.cell.2008.07.001"},{"key":"5","doi-asserted-by":"crossref","unstructured":"Tang Y, Katuri V, Dillner A, Mishra B, Deng CX and Mishra L. Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice. Science. 2003; 299(5606):574-577. [PubMed]","DOI":"10.1126\/science.1075994"},{"key":"6","doi-asserted-by":"crossref","unstructured":"Kitisin K, Ganesan N, Tang Y, Jogunoori W, Volpe EA, Kim SS, Katuri V, Kallakury B, Pishvaian M, Albanese C, Mendelson J, Zasloff M, Rashid A, et al. Disruption of transforming growth factor-beta signaling through betaspectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene. 2007; 26(50):7103-7110. [PubMed] https:\/\/doi.org\/10.1038\/sj.onc.1210513.","DOI":"10.1038\/sj.onc.1210513"},{"key":"7","doi-asserted-by":"crossref","unstructured":"Yang Y-A, Zhang G-M, Feigenbaum L and Zhang YE. Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl- 2. Cancer Cell. 2006; 9(6):445-457. [PubMed] https:\/\/doi.org\/10.1016\/j.ccr.2006.04.025.","DOI":"10.1016\/j.ccr.2006.04.025"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Day CP and James OF. Steatohepatitis: a tale of two \u201chits\u201d? Gastroenterology. 1998; 114(4):842-845.. 2006; 9(6):445-457. [PubMed]","DOI":"10.1016\/S0016-5085(98)70599-2"},{"key":"9","doi-asserted-by":"crossref","unstructured":"Dong M and Blobe GC. Role of transforming growth factor-beta in hematologic malignancies. Blood. 2006; 107(12):4589-4596.","DOI":"10.1182\/blood-2005-10-4169"},{"key":"10","doi-asserted-by":"crossref","unstructured":"Kadin ME, Cavaille-Coll MW, Gertz R, Massague J, Cheifetz S and George D. Loss of receptors for transforming growth factor beta in human T-cell malignancies. Proc Natl Acad Sci U S A. 1994; 91(13):6002-6006. [PubMed] https:\/\/doi.org\/10.1073\/pnas.91.13.6002.","DOI":"10.1073\/pnas.91.13.6002"},{"key":"11","doi-asserted-by":"crossref","unstructured":"Wolfraim LA, Fernandez TM, Mamura M, Fuller WL, Kumar R, Cole DE, Byfield S, Felici A, Flanders KC, Walz TM, Roberts AB, Aplan PD, Balis FM, et al. Loss of Smad3 in acute T-cell lymphoblastic leukemia. N Engl J Med. 2004; 351(6):552-559. [PubMed]","DOI":"10.1056\/NEJMoa031197"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Felsher DW and Bishop JM. Reversible Tumorigenesis by MYC in Hematopoietic Lineages. Molecular Cell. 1999; 4(2):199-207. [PubMed]","DOI":"10.1016\/S1097-2765(00)80367-6"},{"key":"13","doi-asserted-by":"crossref","unstructured":"Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK, Multani A, Chang S and Lozano G. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet. 2004; 36(1):63-68. [PubMed]","DOI":"10.1038\/ng1282"},{"key":"14","doi-asserted-by":"crossref","unstructured":"Canela A, Martin-Caballero J, Flores JM and Blasco MA. Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck- Tert mice. Mol Cell Biol. 2004; 24(10):4275-4293. [PubMed] https:\/\/doi.org\/10.1128\/MCB.24.10.4275-4293.2004.","DOI":"10.1128\/MCB.24.10.4275-4293.2004"}],"container-title":["Genes & Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.genesandcancer.com\/lookup\/doi\/10.18632\/genesandcancer.32","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T12:44:11Z","timestamp":1598791451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.genesandcancer.com\/lookup\/doi\/10.18632\/genesandcancer.32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,8]]},"references-count":14,"journal-issue":{"issue":"9-10","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["32","25352951"],"URL":"https:\/\/doi.org\/10.18632\/genesandcancer.32","relation":{},"ISSN":["1947-6027"],"issn-type":[{"value":"1947-6027","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,8]]}}}