{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:48:59Z","timestamp":1778176139385,"version":"3.51.4"},"reference-count":41,"publisher":"Impact Journals, LLC","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,8,30]]},"DOI":"10.18632\/oncotarget.10031","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T20:29:07Z","timestamp":1465936147000},"page":"57277-57289","source":"Crossref","is-referenced-by-count":44,"title":["Optical imaging of gastric cancer with near-infrared heptamethine carbocyanine fluorescence dyes"],"prefix":"10.18632","volume":"7","author":[{"given":"Ningning","family":"Zhao","sequence":"first","affiliation":[{"name":"Laboratory Animal Center, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Bai","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaze","family":"An","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Boyang","family":"Wu","sequence":"additional","affiliation":[{"name":"Uro-Oncology Research Program, Samuel Oschin Comprehensive Cancer Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Shi","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center, the Fourth Military Medical University, Xi'an, Shaanxi 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1016\/j.biomaterials.2011.11.081","article-title":"A NIR heptamethine dye with intrinsic cancer targeting imaging and photosensitizing properties","volume":"33","author":"Shi","year":"2012","journal-title":"Biomaterials"},{"key":"2","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1016\/j.biomaterials.2013.04.020","article-title":"Tumor targeting and MR imaging with lipophilic cyanine-mediated near-infrared responsive porous Gd silicate nanoparticles","volume":"34","author":"Ho","year":"2013","journal-title":"Biomaterials"},{"key":"3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.juro.2012.09.056","article-title":"Optical imaging of kidney cancer with novel near infrared heptamethine carbocyanine fluorescent dyes","volume":"189","author":"Chung","year":"2013","journal-title":"The Journal of urology"},{"key":"4","first-page":"254","article-title":"Near-infrared fluoresence and nuclear imaging and targeting of prostate cancer","volume":"2","author":"Chung","year":"2013","journal-title":"Transl Androl Urol"},{"key":"5","doi-asserted-by":"crossref","first-page":"6612","DOI":"10.1016\/j.biomaterials.2010.05.007","article-title":"A near-infrared heptaethine indocyanine dye with preferential tumor accumulation for in vivo imaging","volume":"31","author":"Shi","year":"2010","journal-title":"Biomaterials"},{"key":"6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bcp.2014.06.008","article-title":"Advances in patient-derived tumor xenografts: from target identification to predicting clinical response rates in oncology","volume":"91","author":"Gerber","year":"2014","journal-title":"Biochemical pharmacology"},{"key":"7","doi-asserted-by":"publisher","first-page":"10114","DOI":"10.18632\/oncotarget.2464","article-title":"Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1alpha\/OATPs signaling axis","volume":"5","author":"Chung","year":"2014","journal-title":"Oncotarget"},{"key":"8","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1158\/1078-0432.CCR-10-0059","article-title":"Near IR heptamethine cyanine dye-mediated cancer imaging","volume":"16","author":"Chung","year":"2010","journal-title":"Clinical cancer research"},{"key":"9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.12659\/MSM.892437","article-title":"IR-780 dye for near-infrared fluorescence imaging in prostate cancer","volume":"21","author":"Yuan","year":"2015","journal-title":"Medical science monitor"},{"key":"10","doi-asserted-by":"crossref","first-page":"e88967","DOI":"10.1371\/journal.pone.0088967","article-title":"Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer","volume":"9","author":"Posadas","year":"2014","journal-title":"PloS one"},{"key":"11","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1021\/ja512613j","article-title":"Monoamine oxidase a inhibitor-near-infrared dye conjugate reduces prostate tumor growth","volume":"137","author":"Shih","year":"2015","journal-title":"Journal of the American Chemical Society"},{"key":"12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2015.07.028","article-title":"Near-infrared fluorescence heptamethine carbocyanine dyes mediate imaging and targeted drug delivery for human brain tumor","volume":"67","author":"Chung","year":"2015","journal-title":"Biomaterials"},{"key":"13","doi-asserted-by":"crossref","first-page":"8175","DOI":"10.1016\/j.biomaterials.2014.05.073","article-title":"Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1alpha\/OATPs signaling axis","volume":"35","author":"Chung","year":"2014","journal-title":"Biomaterials"},{"key":"14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5487\/TR.2014.30.1.001","article-title":"Human tumor xenograft models for preclinical assessment of anticancer drug development","volume":"30","author":"Jung","year":"2014","journal-title":"Toxicological research"},{"key":"15","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1158\/0008-5472.CAN-13-1069","article-title":"Patient-derived tumor xenografts: transforming clinical samples into mouse models","volume":"73","author":"Hannon","year":"2013","journal-title":"Cancer research"},{"key":"16","doi-asserted-by":"crossref","first-page":"e85308","DOI":"10.1371\/journal.pone.0085308","article-title":"Establishment and characterization of 7 novel hepatocellular carcinoma cell lines from patient-derived tumor xenografts","volume":"9","author":"Qin","year":"2014","journal-title":"PloS one"},{"key":"17","first-page":"4417","article-title":"Evaluation of the antitumor activity of gemcitabine (2\u2032 2\u2032-difluoro-2\u2032-deoxycytidine)","volume":"50","author":"Grindey","year":"1990","journal-title":"Cancer research"},{"key":"18","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1158\/1078-0432.CCR-10-1360","article-title":"Hypoxia and hypoxia-inducible factors: master regulators of metastasis","volume":"16","author":"Kang","year":"2010","journal-title":"Clinical cancer research"},{"key":"19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-pharmtox-010510-100556","article-title":"The expression and function of organic anion transporting polypeptides in normal tissues and in cancer","volume":"52","author":"Hagenbuch","year":"2012","journal-title":"Annual review of pharmacology and toxicology"},{"key":"20","first-page":"863539","article-title":"Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy","volume":"2013","author":"Thalhammer","year":"2013","journal-title":"Journal of drug delivery"},{"key":"21","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/j.1476-5381.2011.01724.x","article-title":"OATPs OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies","volume":"165","author":"Hagenbuch","year":"2012","journal-title":"British journal of pharmacology"},{"key":"22","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1172\/JCI70982","article-title":"Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis","volume":"124","author":"Chung","year":"2014","journal-title":"J Clin Invest"},{"key":"23","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5009\/gnl14118","article-title":"Diagnosis and management of high risk group for gastric cancer","volume":"9","author":"Kim","year":"2015","journal-title":"Gut and liver"},{"key":"24","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.1440-1746.2008.05469.x","article-title":"Current application of confocal endomicroscopy in gastrointestinal disorders","volume":"23","author":"Leong","year":"2008","journal-title":"Journal of gastroenterology and hepatology"},{"key":"25","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1158\/1078-0432.CCR-12-2408","article-title":"The promise of patient-derived xenografts: the best laid plans of mice and men","volume":"18","author":"Powis","year":"2012","journal-title":"Clinical cancer research"},{"key":"26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bcp.2013.06.020","article-title":"Animal models of disease: pre-clinical animal models of cancer and their applications and utility in drug discovery","volume":"87","author":"Miknyoczki","year":"2014","journal-title":"Biochemical pharmacology"},{"key":"27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nbt1085","article-title":"In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe","volume":"23","author":"Gremlich","year":"2005","journal-title":"Nature biotechnology"},{"key":"28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nbt764","article-title":"Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots","volume":"21","author":"Bruchez","year":"2003","journal-title":"Nature biotechnology"},{"key":"29","first-page":"448","article-title":"High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen","volume":"4","author":"Frangioni","year":"2005","journal-title":"Molecular imaging"},{"key":"30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/bjc.1985.24","article-title":"Heterogeneous expression of cell-surface antigens in normal epithelia and their tumours revealed by monoclonal antibodies","volume":"51","author":"Edwards","year":"1985","journal-title":"British journal of cancer"},{"key":"31","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrclinonc.2012.61","article-title":"Patient-derived tumour xenografts as models for oncology drug development","volume":"9","author":"Eckhardt","year":"2012","journal-title":"Nature reviews Clinical oncology"},{"key":"32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s12094-010-0540-6","article-title":"Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review","volume":"12","author":"Li","year":"2010","journal-title":"Clinical & translational oncology"},{"key":"33","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ygyno.2004.09.025","article-title":"Establishment of subrenal capsule xenografts of primary human ovarian tumors in SCID mice: potential models","volume":"96","author":"Wang","year":"2005","journal-title":"Gynecologic oncology"},{"key":"34","first-page":"1057","article-title":"Statins and gastric cancer risk","volume":"58","author":"Shimoyama","year":"2011","journal-title":"Hepato-gastroenterology"},{"key":"35","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3748\/wjg.v18.i2.136","article-title":"Characterization of gastric cancer models from different cell lines orthotopically constructed using improved implantation techniques","volume":"18","author":"Wu","year":"2012","journal-title":"World journal of gastroenterology"},{"key":"36","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.2042-7158.1998.tb04012.x","article-title":"Delayed healing of chronic gastric ulcer after Helicobacter pylori infection in mice","volume":"50","author":"Tabata","year":"1998","journal-title":"The Journal of pharmacy and pharmacology"},{"key":"37","doi-asserted-by":"crossref","first-page":"e28670","DOI":"10.1371\/journal.pone.0028670","article-title":"Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer","volume":"6","author":"Zhau","year":"2011","journal-title":"PloS one"},{"key":"38","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/nar\/gkq960","article-title":"An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer","volume":"39","author":"Amster","year":"2011","journal-title":"Nucleic acids research"},{"key":"39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ejca.2008.10.032","article-title":"Genome-wide expression profile of sporadic gastric cancers with microsatellite instability","volume":"45","author":"Dogliotti","year":"2009","journal-title":"European journal of cancer"},{"key":"40","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1158\/1078-0432.CCR-10-2180","article-title":"Gene expression signature-based prognostic risk score in gastric cancer","volume":"17","author":"Lee","year":"2011","journal-title":"Clinical cancer research"},{"key":"41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12032-010-9766-y","article-title":"Upregulated INHBA expression is associated with poor survival in gastric cancer","volume":"29","author":"Peng","year":"2012","journal-title":"Medical oncology"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.10031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T10:03:57Z","timestamp":1589277837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.10031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,14]]},"references-count":41,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2016,8,30]]}},"alternative-id":["10031","27329598"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.10031","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,14]]}}}