{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:10:57Z","timestamp":1780380657202,"version":"3.54.1"},"reference-count":51,"publisher":"Impact Journals, LLC","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,6,28]]},"DOI":"10.18632\/oncotarget.10044","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T13:29:54Z","timestamp":1465997394000},"page":"39316-39331","source":"Crossref","is-referenced-by-count":46,"title":["Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during <i>Schistosoma J.<\/i> infection"],"prefix":"10.18632","volume":"7","author":[{"given":"Nan","family":"Meng","sequence":"first","affiliation":[{"name":"Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Qi","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna M.","family":"Boini","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Lan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Xian","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,6,14]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"e412","DOI":"10.1371\/journal.pntd.0000412","article-title":"Neglected tropical diseases in sub-saharan Africa: review of their prevalence, distribution, and disease burden","volume":"3","author":"Kamath","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13071-015-0983-2","article-title":"Can human schistosomiasis mansoni control be sustained in high-risk transmission foci in Egypt?","volume":"8","author":"Barakat","year":"2015","journal-title":"Parasit Vectors"},{"key":"3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"Utzinger","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.freeradbiomed.2014.03.015","article-title":"Upregulation of cannabinoid receptor-1 and fibrotic activation of mouse hepatic stellate cells during Schistosoma J. infection: role of NADPH oxidase","volume":"71","author":"Tang","year":"2014","journal-title":"Free Radic Biol Med"},{"key":"5","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/CMR.00044-09","article-title":"Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam","volume":"23","author":"Ross","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20071570","article-title":"Liver fibrosis","volume":"411","author":"Wright","year":"2008","journal-title":"Biochem J"},{"key":"7","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","article-title":"Human schistosomiasis","volume":"368","author":"Kestens","year":"2006","journal-title":"Lancet"},{"issue":"Supp 1","key":"8","first-page":"S3","article-title":"Praziquantel","volume":"90","author":"Pica-Mattoccia","year":"2003","journal-title":"Parasitol Res"},{"key":"9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1079\/JOH2005307","article-title":"Towards control of schistosomiasis in sub-Saharan Africa","volume":"79","author":"Hagan","year":"2005","journal-title":"J Helminthol"},{"key":"10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nature10759","article-title":"Inflammasomes in health and disease","volume":"481","author":"Flavell","year":"2012","journal-title":"Nature"},{"key":"11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ni.2228","article-title":"A role for the NLRP3 inflammasome in metabolic diseases\u2014did Warburg miss inflammation?","volume":"13","author":"O'Neill","year":"2012","journal-title":"Nat Immunol"},{"key":"12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.bbamcr.2014.01.033","article-title":"Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing","volume":"1843","author":"Li","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"13","first-page":"440","article-title":"An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology","volume":"4","author":"Stehlik","year":"2013","journal-title":"Front Immunol"},{"key":"14","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1111\/jcmm.12657","article-title":"Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1","volume":"19","author":"Zhang","year":"2015","journal-title":"J Cell Mol Med"},{"key":"15","doi-asserted-by":"crossref","first-page":"a016287","DOI":"10.1101\/cshperspect.a016287","article-title":"Inflammasomes","volume":"6","author":"Flavell","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"16","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Tschopp","year":"2010","journal-title":"Cell"},{"key":"17","first-page":"462","article-title":"Interactions between Nod-Like Receptors and Intestinal Bacteria","volume":"4","author":"Flavell","year":"2013","journal-title":"Front Immunol"},{"key":"18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Tschopp","year":"2002","journal-title":"Mol Cell"},{"key":"19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nri2690","article-title":"Intracellular DNA recognition","volume":"10","author":"Latz","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.cell.2004.05.004","article-title":"Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases","volume":"117","author":"Tschopp","year":"2004","journal-title":"Cell"},{"key":"21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ncprheum0681","article-title":"Primer: inflammasomes and interleukin 1beta in inflammatory disorders","volume":"4","author":"McDermott","year":"2008","journal-title":"Nat Clin Pract Rheumatol"},{"key":"22","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1159\/000430169","article-title":"Inflammasome Inhibition Suppresses Alveolar Cell Permeability Through Retention of Neuregulin-1 (NRG-1)","volume":"36","author":"Kolliputi","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"23","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/hum.2010.145","article-title":"Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice","volume":"22","author":"Fang","year":"2011","journal-title":"Hum Gene Ther"},{"key":"24","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1089\/ars.2014.6148","article-title":"Molecular activation of the NLRP3 Inflammasome in fibrosis: common threads linking divergent fibrogenic diseases","volume":"22","author":"Thacker","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"25","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1172\/JCI12568","article-title":"Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis","volume":"107","author":"Gauldie","year":"2001","journal-title":"J Clin Invest"},{"key":"26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/SHK.0b013e318234f7ff","article-title":"A protective role for inflammasome activation following injury","volume":"37","author":"Lederer","year":"2012","journal-title":"Shock"},{"key":"27","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.2353\/ajpath.2009.080765","article-title":"Disruption of interleukin-1 signaling improves the quality of wound healing","volume":"174","author":"Albina","year":"2009","journal-title":"Am J Pathol"},{"key":"28","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Li","year":"2015","journal-title":"Antioxid Redox Signal"},{"key":"29","doi-asserted-by":"crossref","first-page":"G1248","DOI":"10.1152\/ajpgi.90223.2008","article-title":"Inflammasome-mediated regulation of hepatic stellate cells","volume":"296","author":"Mehal","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/sj.icb.7100014","article-title":"Immunopathology of schistosomiasis","volume":"85","author":"Wynn","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"31","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3748\/wjg.v19.i8.1230","article-title":"Schistosoma japonicum egg antigen up-regulates fibrogenesis and inhibits proliferation in primary hepatic stellate cells in a concentration-dependent manner","volume":"19","author":"Tang","year":"2013","journal-title":"World J Gastroenterol"},{"key":"32","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbamcr.2014.11.012","article-title":"Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritis","volume":"1853","author":"Li","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Tschopp","year":"2011","journal-title":"Nature"},{"key":"34","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Dixit","year":"2006","journal-title":"Nature"},{"key":"35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nri2936","article-title":"Emerging inflammasome effector mechanisms","volume":"11","author":"Lamkanfi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"36","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1074\/jbc.M608083200","article-title":"ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages","volume":"282","author":"Ojcius","year":"2007","journal-title":"J Biol Chem"},{"key":"37","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Tschopp","year":"2008","journal-title":"Science"},{"key":"38","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Schroder","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"39","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Tschopp","year":"2010","journal-title":"Nat Immunol"},{"key":"40","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.ajpath.2014.01.032","article-title":"Endothelial NLRP3 inflammasome activation and enhanced neointima formation in mice by adipokine visfatin","volume":"184","author":"Li","year":"2014","journal-title":"Am J Pathol"},{"key":"41","doi-asserted-by":"crossref","first-page":"C182","DOI":"10.1152\/ajpcell.00086.2013","article-title":"NLRP3 deletion protects from hyperoxia-induced acute lung injury","volume":"305","author":"Kolliputi","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"42","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1038\/onc.2008.310","article-title":"Lysosomal membrane permeabilization in cell death","volume":"27","author":"Kroemer","year":"2008","journal-title":"Oncogene"},{"key":"43","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1038\/sj.onc.1207512","article-title":"Lysosomes in cell death","volume":"23","author":"Gores","year":"2004","journal-title":"Oncogene"},{"key":"44","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1164\/rccm.200808-1274OC","article-title":"Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis","volume":"179","author":"Couillin","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"45","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Fitzgerald","year":"2010","journal-title":"Nature"},{"key":"46","doi-asserted-by":"crossref","first-page":"e2469","DOI":"10.1371\/journal.pntd.0002469","article-title":"NLRP3 controls Trypanosoma cruzi infection through a caspase-1-dependent IL-1R-independent NO production","volume":"7","author":"Bortoluci","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"47","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/hep.1840070411","article-title":"The synthesis of proteoglycans in fat-storing cells of rat liver","volume":"7","author":"Gressner","year":"1987","journal-title":"Hepatology"},{"key":"48","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.3748\/wjg.v17.i46.5075","article-title":"Osteopontin expression is associated with hepatopathologic changes in Schistosoma japonicum infected mice","volume":"17","author":"Li","year":"2011","journal-title":"World J Gastroenterol"},{"key":"49","first-page":"468","article-title":"Comparison of collagen fiber staining between Van-Gieson staining and Masson trichrome staining of hepatic specimens in mice with Schistosoma japonicum infection [Article in Chinese]","volume":"24","author":"Shen","year":"2012","journal-title":"Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi"},{"key":"50","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.apjtm.2015.09.011","article-title":"Effect of Rheum palmatum L. on NF-kappaB signaling pathway of mice with acute liver failure","volume":"8","author":"Mao","year":"2015","journal-title":"Asian Pac J Trop Med"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8023","article-title":"Instigation of NLRP3 inflammasome activation and glomerular injury in mice on the high fat diet: role of acid sphingomyelinase gene","author":"Li","year":"2016","journal-title":"Oncotarget"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.10044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T21:43:48Z","timestamp":1589233428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.10044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,14]]},"references-count":51,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2016,6,28]]}},"alternative-id":["10044","27322427"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.10044","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,14]]}}}