{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:56:36Z","timestamp":1787806596786,"version":"build-2784847793"},"reference-count":65,"publisher":"Impact Journals, LLC","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,8,23]]},"DOI":"10.18632\/oncotarget.11026","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T03:12:58Z","timestamp":1470193978000},"page":"54274-54289","source":"Crossref","is-referenced-by-count":17,"title":["Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency"],"prefix":"10.18632","volume":"7","author":[{"given":"Tsung-Hsien","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ru","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chin","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-Wen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"},{"name":"Institute of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Han","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gan-Guang","family":"Liou","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ying","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chia Nan University of Pharmacy and Science, Tainan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Chung","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pao-Hsien","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Wang","family":"Liao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt Ming-Chao","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Zhunan, Miaoli, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1106180","article-title":"Proteotoxicity and cardiac dysfunction\u2014Alzheimer's disease of the heart?","volume":"368","author":"Patterson","year":"2013","journal-title":"The New England Journal of Medicine"},{"key":"2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.4161\/auto.6502","article-title":"Protein misfolding and cardiac disease: establishing cause and effect","volume":"4","author":"Robbins","year":"2008","journal-title":"Autophagy"},{"key":"3","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1161\/CIRCRESAHA.116.305372","article-title":"Proteotoxicity and Cardiac Dysfunction","volume":"116","author":"Robbins","year":"2015","journal-title":"Circulation Research"},{"key":"4","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1056\/NEJMc1302511","article-title":"Proteotoxicity and cardiac dysfunction","volume":"368","author":"Wahlster","year":"2013","journal-title":"The New England Journal of Medicine"},{"key":"5","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1056\/NEJMc1302511","article-title":"Proteotoxicity and cardiac dysfunction","volume":"368","author":"Galli","year":"2013","journal-title":"The New England Journal of Medicine"},{"key":"6","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1161\/01.RES.0000252342.61447.a2","article-title":"Heart failure and protein quality control","volume":"99","author":"Robbins","year":"2006","journal-title":"Circulation Research"},{"key":"7","first-page":"a004374","article-title":"Cellular strategies of protein quality control","volume":"3","author":"Frydman","year":"2011","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"key":"8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cmet.2015.01.016","article-title":"Protein quality control and metabolism: bidirectional control in the heart","volume":"21","author":"Hill","year":"2015","journal-title":"Cell Metabolism"},{"key":"9","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.tcm.2010.02.005","article-title":"Mechanisms of cardiac fibrosis in inflammatory heart disease","volume":"19","author":"Eriksson","year":"2009","journal-title":"Trends in Cardiovascular Medicine"},{"key":"10","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nri2852","article-title":"The impact of the extracellular matrix on inflammation","volume":"10","author":"Sorokin","year":"2010","journal-title":"Nature Reviews Immunology"},{"key":"11","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/01.CIR.97.17.1708","article-title":"Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy","volume":"97","author":"Spinale","year":"1998","journal-title":"Circulation"},{"key":"12","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1161\/01.RES.0000013290.12884.A3","article-title":"Matrix metalloproteinases: regulation and dysregulation in the failing heart","volume":"90","author":"Spinale","year":"2002","journal-title":"Circulation Research"},{"key":"13","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/01.CIR.102.16.1944","article-title":"A matrix metalloproteinase induction\/activation system exists in the human left ventricular myocardium and is upregulated in heart failure","volume":"102","author":"Crumbley","year":"2000","journal-title":"Circulation"},{"key":"14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.febslet.2011.02.013","article-title":"Cytotoxicity of red fluorescent protein DsRed is associated with the suppression of Bcl-xL translation","volume":"585","author":"Xia","year":"2011","journal-title":"FEBS Letters"},{"key":"15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1472-6750-2-11","article-title":"Embryonic stem cells and mice expressing different GFP variants for multiple non-invasive reporter usage within a single animal","volume":"2","author":"Nagy","year":"2002","journal-title":"BMC Biotechnology"},{"key":"16","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/CIRCRESAHA.116.303787","article-title":"Untangling autophagy measurements: all fluxed up","volume":"116","author":"Taylor","year":"2015","journal-title":"Circulation Research"},{"key":"17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4161\/auto.5603","article-title":"A method to measure cardiac autophagic flux","volume":"4","author":"Gottlieb","year":"2008","journal-title":"Autophagy"},{"key":"18","first-page":"273","article-title":"Animal models of cardiac fibrosis","volume":"117","author":"Weber","year":"2005","journal-title":"Methods in Molecular Medicine"},{"key":"19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1365-2613.2009.00647.x","article-title":"Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy","volume":"90","author":"Hoefler","year":"2009","journal-title":"International Journal of Experimental Pathology"},{"key":"20","doi-asserted-by":"crossref","first-page":"e55427","DOI":"10.1371\/journal.pone.0055427","article-title":"Losartan prevents heart fibrosis induced by long-term intensive exercise in an animal model","volume":"8","author":"Serrano-Mollar","year":"2013","journal-title":"PLoS One"},{"key":"21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/cncr.25394","article-title":"Elevated plasma tissue inhibitor of metalloproteinase-1 levels predict decreased survival in castration-resistant prostate cancer patients","volume":"117","author":"Lipton","year":"2011","journal-title":"Cancer"},{"key":"22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/ERC-11-0076","article-title":"BRAFV600E mutation, TIMP-1 upregulation, and NF-kappaB activation: closing the loop on the papillary thyroid cancer trilogy","volume":"18","author":"Galluzzo","year":"2011","journal-title":"Endocrine-Related Cancer"},{"key":"23","doi-asserted-by":"crossref","first-page":"34955","DOI":"10.1074\/jbc.M604616200","article-title":"A novel mechanism of tissue inhibitor of metalloproteinases-1 activation by interleukin-1 in primary human astrocytes","volume":"281","author":"Kordula","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/74914","article-title":"Transgenic expression of green fluorescence protein can cause dilated cardiomyopathy","volume":"6","author":"Izumo","year":"2000","journal-title":"Nature Medicine"},{"key":"25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth0506-331","article-title":"GFP expression in muscle cells impairs actin-myosin interactions: implications for cell therapy","volume":"3","author":"Menasche","year":"2006","journal-title":"Nature Methods"},{"key":"26","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1006\/bbrc.1999.0954","article-title":"Is green fluorescent protein toxic to the living cells?","volume":"260","author":"Ke","year":"1999","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"27","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1371\/journal.pone.0000054","article-title":"The dark side of EGFP: defective polyubiquitination","volume":"1","author":"Marynen","year":"2006","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-313X.2012.04917.x","article-title":"High-resolution imaging of Ca2+, redox status, ROS and pH using GFP biosensors","volume":"70","author":"Gilroy","year":"2012","journal-title":"The Plant Journal"},{"key":"29","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1182\/blood-2003-01-0049","article-title":"Green fluorescent protein selectively induces HSP70-mediated up-regulation of COX-2 expression in endothelial cells","volume":"102","author":"Rafii","year":"2003","journal-title":"Blood"},{"key":"30","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1101\/gad.1188204","article-title":"Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling","volume":"18","author":"Sharp","year":"2004","journal-title":"Genes & Development"},{"key":"31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1634\/stemcells.2006-0553","article-title":"Enhanced green fluorescent protein is a nearly ideal long-term expression tracer for hematopoietic stem cells, whereas DsRed-express fluorescent protein is not","volume":"25","author":"Broxmeyer","year":"2007","journal-title":"Stem Cells"},{"key":"32","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/gene.20095","article-title":"Mouse in red: red fluorescent protein expression in mouse ES cells, embryos, and adult animals","volume":"40","author":"Nagy","year":"2004","journal-title":"Genesis"},{"key":"33","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1472-6750-5-20","article-title":"Genetic and spectrally distinctimaging: embryonic stem cells and mice with widespread expression of a monomeric red fluorescent protein","volume":"5","author":"Hadjantonakis","year":"2005","journal-title":"BMC Biotechnology"},{"key":"34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4077\/CJP.2015.BAC264","article-title":"Establishment of a DsRed-monomer-harboring ICR transgenic mouse model and effects of the transgene on tissue development","volume":"58","author":"Wu","year":"2015","journal-title":"The Chinese Journal of Physiology"},{"key":"35","doi-asserted-by":"crossref","first-page":"H1220","DOI":"10.1152\/ajpheart.00601.2011","article-title":"Desmin-related cardiomyopathy: an unfolding story","volume":"301","author":"Robbins","year":"2011","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"key":"36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCRESAHA.111.244707","article-title":"Autophagy and p62 in cardiac proteinopathy","volume":"109","author":"Wang","year":"2011","journal-title":"Circulation Research"},{"key":"37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1476-5381.2008.00025.x","article-title":"Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors","volume":"156","author":"Souza","year":"2009","journal-title":"British Journal of Pharmacology"},{"key":"38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/cvr\/cvp287","article-title":"The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective","volume":"85","author":"Wang","year":"2010","journal-title":"Cardiovascular Research"},{"key":"39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2013.12.016","article-title":"Ubiquitin-proteasome system and hereditary cardiomyopathies","volume":"71","author":"Carrier","year":"2014","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"40","first-page":"1","article-title":"Relationship between the proteasomal system and autophagy","volume":"4","author":"Lilienbaum","year":"2013","journal-title":"International Journal of Biochemistry and Molecular Biology"},{"key":"41","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tcm.2012.05.015","article-title":"p62 Stages an interplay between the ubiquitin-proteasome system and autophagy in the heart of defense against proteotoxic stress","volume":"21","author":"Wang","year":"2011","journal-title":"Trends in Cardiovascular Medicine"},{"key":"42","doi-asserted-by":"crossref","first-page":"e100715","DOI":"10.1371\/journal.pone.0100715","article-title":"Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"43","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.molcel.2013.08.003","article-title":"Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy","volume":"51","author":"Takagi","year":"2013","journal-title":"Molecular Cell"},{"key":"44","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1152\/ajpendo.00204.2014","article-title":"Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx\/atrogin-1","volume":"307","author":"Baehr","year":"2014","journal-title":"American Journal of Physiology Endocrinology and Metabolism"},{"key":"45","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1113\/jphysiol.2011.212845","article-title":"Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids","volume":"589","author":"Bodine","year":"2011","journal-title":"The Journal of Physiology"},{"key":"46","first-page":"R110","article-title":"Oxidative stress-mediated regulation of proteasome complexes","volume":"10","author":"Huang","year":"2011","journal-title":"Molecular & Cellular Proteomics"},{"key":"47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1677\/joe.0.1600043","article-title":"Local renin-angiotensin system contributes to hyperthyroidism-induced cardiac hypertrophy","volume":"160","author":"Saruta","year":"1999","journal-title":"The Journal of Endocrinology"},{"key":"48","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system","volume":"83","author":"Brilla","year":"1991","journal-title":"Circulation"},{"key":"49","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.CIR.104.3.346","article-title":"Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension","volume":"104","author":"Inagami","year":"2001","journal-title":"Circulation"},{"key":"50","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/01.STR.7.1.54","article-title":"Cerebral infarction following bilateral carotid artery ligation in normotensive and spontaneously hypertensive rats: a pathological study","volume":"7","author":"Omae","year":"1976","journal-title":"Stroke"},{"key":"51","doi-asserted-by":"publisher","first-page":"914","DOI":"10.18632\/aging.100252","article-title":"Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy","volume":"2","author":"Sinclair","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"52","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/01.HYP.0000024573.17293.23","article-title":"TIMP-1: a marker of left ventricular diastolic dysfunction and fibrosis in hypertension","volume":"40","author":"Dunn","year":"2002","journal-title":"Hypertension"},{"key":"53","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cardiores.2005.12.009","article-title":"Myocardial proteases and matrix remodeling in inflammatory heart disease","volume":"69","author":"Pauschinger","year":"2006","journal-title":"Cardiovascular Research"},{"key":"54","doi-asserted-by":"crossref","first-page":"H149","DOI":"10.1152\/ajpheart.00370.2004","article-title":"Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition","volume":"288","author":"Spinale","year":"2005","journal-title":"American Journal of Physiology Heart and Circulatory Physiology"},{"key":"55","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1472-8206.2012.01053.x","article-title":"Prognostic value of serum PIIINP, MMP1 and TIMP1 levels in hypertensive patients: a community-based prospective cohort study","volume":"27","author":"Zannad","year":"2013","journal-title":"Fundamental & Clinical Pharmacology"},{"key":"56","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S1053-2498(02)00557-0","article-title":"Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure","volume":"22","author":"Yacoub","year":"2003","journal-title":"The Journal of Heart and Lung Transplantation"},{"key":"57","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijcard.2010.04.053","article-title":"Fibrosis in endstage human heart failure: severe changes in collagen metabolism and MMP\/TIMP profiles","volume":"151","author":"Kostin","year":"2011","journal-title":"International Journal of Cardiology"},{"key":"58","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/CIRCRESAHA.110.227819","article-title":"Endoplasmic reticulum stress as a therapeutic target in cardiovascular disease","volume":"107","author":"Kitakaze","year":"2010","journal-title":"Circulation Research"},{"key":"59","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/CIRCRESAHA.111.243212","article-title":"Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1\/CCR2 pathway","volume":"110","author":"Niu","year":"2012","journal-title":"Circulation Research"},{"key":"60","doi-asserted-by":"publisher","first-page":"6936","DOI":"10.18632\/oncotarget.2206","article-title":"Tuberin-deficiency downregulates N-cadherin and upregulates vimentin in kidney tumor of TSC patients","volume":"5","author":"Habib","year":"2014","journal-title":"Oncotarget"},{"key":"61","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ajpath.2012.03.017","article-title":"Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug","volume":"181","author":"Pestell","year":"2012","journal-title":"The American Journal of Pathology"},{"key":"62","doi-asserted-by":"publisher","first-page":"15722","DOI":"10.18632\/oncotarget.4652","article-title":"Unleashing rapamycin in fibrosis","volume":"6","author":"Gelbard","year":"2015","journal-title":"Oncotarget"},{"key":"63","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1038\/cddis.2009.17","article-title":"Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR","volume":"1","author":"Blagosklonny","year":"2010","journal-title":"Cell Death & Disease"},{"key":"64","doi-asserted-by":"crossref","first-page":"e15842","DOI":"10.1371\/journal.pone.0015842","article-title":"Notch signaling regulates late-stage epidermal differentiation and maintains postnatal hair cycle homeostasis","volume":"6","author":"Yang","year":"2011","journal-title":"PLoS One"},{"key":"65","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/dvg.20666","article-title":"RU486-inducible recombination in the salivary glands of lactoferrin promoter-driven green fluorescent Cre transgenic mice","volume":"48","author":"Lin","year":"2010","journal-title":"Genesis"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.11026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T20:18:32Z","timestamp":1656965912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.11026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,2]]},"references-count":65,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2016,8,23]]}},"alternative-id":["11026","27494843"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.11026","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,2]]}}}