{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:07:22Z","timestamp":1784354842705,"version":"3.55.0"},"reference-count":73,"publisher":"Impact Journals, LLC","issue":"37","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,9,13]]},"DOI":"10.18632\/oncotarget.11049","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T13:51:43Z","timestamp":1470318703000},"page":"60053-60073","source":"Crossref","is-referenced-by-count":38,"title":["Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis"],"prefix":"10.18632","volume":"7","author":[{"given":"Jinping","family":"Gu","sequence":"first","affiliation":[{"name":"High-field NMR Research Center, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Hu","sequence":"additional","affiliation":[{"name":"High-field NMR Research Center, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shao","sequence":"additional","affiliation":[{"name":"High-field NMR Research Center, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R. China"},{"name":"Department of Pathology, The Affiliated Chenggong Hospital, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhai","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Chenggong Hospital, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Affiliated Chenggong Hospital, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Zhuo","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Affiliated Zhongshan Hospital, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeyu","family":"Jin","sequence":"additional","affiliation":[{"name":"High-field NMR Research Center, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Chen","sequence":"additional","affiliation":[{"name":"High-field NMR Research Center, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Xiamen University of Technology, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Lin","sequence":"additional","affiliation":[{"name":"High-field NMR Research Center, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,8,4]]},"reference":[{"key":"1","first-page":"106","article-title":"Cancer Statistics 2006","volume":"56","author":"Thun","year":"2006","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10120-003-0265-0","article-title":"The future of gastric cancer prevention","volume":"7","author":"Camargo","year":"2004","journal-title":"Gastric Cancer"},{"key":"3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1440-1746.2008.05314.x","article-title":"Asia-Pacific consensus guidelines on gastric cancer prevention","volume":"23","author":"Kim","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"4","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1172\/JCI31537","article-title":"A cytokine-mediated link between innate immunity inflammation and cancer","volume":"117","author":"Karin","year":"2007","journal-title":"J Clin Invest"},{"key":"5","doi-asserted-by":"crossref","first-page":"e24143","DOI":"10.1371\/journal.pone.0024143","article-title":"Plasma Free Amino Acid Profiling of Five Types of Cancer Patients and Its Application for Early Detection","volume":"6","author":"Chiba","year":"2011","journal-title":"PLoS ONE"},{"key":"6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/bmc.1671","article-title":"Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer","volume":"26","author":"Yoshida","year":"2012","journal-title":"Biomed Chromatogr"},{"key":"7","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/j.1440-1746.2011.06724.x","article-title":"Metabolomic phenotype of gastric cancer and precancerous stages based on gas chromatography time-of-flight mass spectrometry","volume":"26","author":"Shi","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"8","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.copbio.2010.07.002","article-title":"Metabolic reconstruction constraint-based analysis and game theory to probe genome-scale metabolic networks","volume":"21","author":"Schuster","year":"2010","journal-title":"Current Opinion in Biotechnology"},{"key":"9","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.1021\/pr1002615","article-title":"Two-Dimensional Statistical Recoupling for the Identification of Perturbed Metabolic Networks from NMR Spectroscopy","volume":"9","author":"Toulhoat","year":"2010","journal-title":"Journal of Proteome Research"},{"key":"10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nprot.2009.203","article-title":"A protocol for generating a high-quality genome-scale metabolic reconstruction","volume":"5","author":"Palsson","year":"2010","journal-title":"Nature protocols"},{"key":"11","doi-asserted-by":"crossref","first-page":"21797","DOI":"10.1074\/jbc.C000023200","article-title":"Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc","volume":"275","author":"Dang","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"12","doi-asserted-by":"crossref","first-page":"e1000729","DOI":"10.1371\/journal.pcbi.1000729","article-title":"Metabolic Network Topology Reveals Transcriptional Regulatory Signatures of Type 2 Diabetes","volume":"6","author":"Patil","year":"2010","journal-title":"PLoS Computational Biology"},{"key":"13","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/ac048630x","article-title":"Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from MetabolicH NMR Data Sets","volume":"77","author":"Nicholson","year":"2005","journal-title":"Analytical Chemistry"},{"key":"14","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1021\/ac9007754","article-title":"Statistical Recoupling Prior to Significance Testing in Nuclear Magnetic Resonance Based Metabonomics","volume":"81","author":"Toulhoat","year":"2009","journal-title":"Analytical Chemistry"},{"key":"15","doi-asserted-by":"crossref","first-page":"4342","DOI":"10.1021\/pr200489n","article-title":"Orthogonal Filtered Recoupled-STOCSY to Extract Metabolic Networks Associated with Minor Perturbations from NMR Spectroscopy","volume":"10","author":"Toulhoat","year":"2011","journal-title":"Journal of Proteome Research"},{"key":"16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cem.695","article-title":"Orthogonal projections to latent structures (O-PLS)","volume":"16","author":"Wold","year":"2002","journal-title":"Journal of Chemometrics"},{"key":"17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/321992.321993","article-title":"Efficient Algorithms for Shortest Paths in Sparse Networks","volume":"24","author":"Johnson","year":"1977","journal-title":"J ACM"},{"key":"18","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.0501179102","article-title":"Subnets of scale-free networks are not scale-free: Sampling properties of networks","volume":"102","author":"May","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"19","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/sj.bjc.6690117","article-title":"Attenuation by all-trans-retinoic acid of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N[prime]-nitro-N-nitrosoguanidine in Wistar rats","volume":"79","author":"Nakaizumi","year":"1999","journal-title":"Br J Cancer"},{"key":"20","first-page":"5254","article-title":"Promotion by Bombesin of Gastric Carcinogenesis Induced by N-Methyl-N\u2032-nitro-N-nitrosoguanidine in Wistar Rats","volume":"49","author":"Taniguchi","year":"1989","journal-title":"Cancer Research"},{"key":"21","first-page":"6332","article-title":"Enhancement by Prolonged Administration of Caerulein of Experimental Carcinogenesis Induced by N-Methyl-N\u2032-nitro-N-nitrosoguanidine in Rat Stomach","volume":"48","author":"Taniguchi","year":"1988","journal-title":"Cancer Research"},{"key":"22","first-page":"1161","article-title":"the Participants in the International Workshop on the Histopathology of Gastritis Houston 1994 Classification and Grading of Gastritis: The Updated Sydney System","volume":"20","author":"Correa","year":"1996","journal-title":"The American Journal of Surgical Pathology"},{"key":"23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00000478-200002000-00001","article-title":"Gastric Dysplasia: The Padova International Classification","volume":"24","author":"Watanabe","year":"2000","journal-title":"The American Journal of Surgical Pathology"},{"key":"24","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1021\/ac00101a004","article-title":"750 MHzH andH-C NMR Spectroscopy of Human Blood Plasma","volume":"67","author":"Lindon","year":"1995","journal-title":"Analytical Chemistry"},{"key":"25","doi-asserted-by":"crossref","first-page":"e16957","DOI":"10.1371\/journal.pone.0016957","article-title":"The Human Serum Metabolome","volume":"6","author":"Knox","year":"2011","journal-title":"PLOS ONE"},{"key":"26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0303-7207(01)00650-5","article-title":"The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor","volume":"188","author":"B\u00f8g-Hansen","year":"2002","journal-title":"Molecular and Cellular Endocrinology"},{"key":"27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1590\/S0100-879X2011007500158","article-title":"Serum metabolic profiling of human gastric cancer based on gas chromatography\/mass spectrometry","volume":"45","author":"Lu","year":"2012","journal-title":"Brazilian J Med Biol Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.3748\/wjg.v16.i46.5874","article-title":"Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry","volume":"16","author":"Gu","year":"2010","journal-title":"World J Gastroenterol"},{"key":"29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/gut.42.3.351","article-title":"Oxidative DNA damage accumulation in gastric carcinogenesis","volume":"42","author":"Naccarato","year":"1998","journal-title":"Gut"},{"key":"30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0304-3835(97)00520-X","article-title":"Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma","volume":"125","author":"Kim","year":"1998","journal-title":"Cancer Letters"},{"key":"31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3835(00)00686-8","article-title":"Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population","volume":"163","author":"Nakano","year":"2001","journal-title":"Cancer Letters"},{"key":"32","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.freeradbiomed.2012.05.006","article-title":"The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate","volume":"53","author":"Ghigo","year":"2012","journal-title":"Free Radical Biology and Medicine"},{"key":"33","doi-asserted-by":"crossref","first-page":"12874","DOI":"10.3748\/wjg.v20.i36.12874","article-title":"Potential role of metabolomics in diagnosis and surveillance of gastric cancer","volume":"20","author":"Sawyer","year":"2014","journal-title":"WJG"},{"key":"34","doi-asserted-by":"crossref","first-page":"30409","DOI":"10.1074\/jbc.R200006200","article-title":"The Key Role of Anaplerosis and Cataplerosis for Citric Acid Cycle Function","volume":"277","author":"Hanson","year":"2002","journal-title":"Journal of Biological Chemistry"},{"key":"35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40170-015-0128-2","article-title":"Mitochondria as biosynthetic factories for cancer proliferation","volume":"3","author":"Metallo","year":"2015","journal-title":"Cancer & Metabolism"},{"key":"36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation","volume":"7","author":"Thompson","year":"2008","journal-title":"Cell Metabolism"},{"key":"37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.nutr.012809.104638","article-title":"Proline Metabolism and Microenvironmental Stress","volume":"30","author":"Zabirnyk","year":"2010","journal-title":"Annual Review of Nutrition"},{"key":"38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1476-4598-5-55","article-title":"Pathway-specific differences between tumor cell lines and normal and tumor tissue cells","volume":"5","author":"Tozeren","year":"2006","journal-title":"Molecular Cancer"},{"key":"39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0304-4165(86)90220-5","article-title":"Demonstration of a NADPH-linked \u03941-pyrroline-5-carboxylate-proline shuttle in a cell-free rat liver system","volume":"884","author":"Hagedorn","year":"1986","journal-title":"Biochimica et Biophysica Acta (BBA) - General Subjects"},{"key":"40","doi-asserted-by":"crossref","first-page":"6414","DOI":"10.1158\/0008-5472.CAN-09-1223","article-title":"Proline oxidase functions as a mitochondrial tumor suppressor in human cancers","volume":"69","author":"Phang","year":"2009","journal-title":"Cancer Research"},{"key":"41","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/srep00342","article-title":"Detecting early-warning signals for sudden deterioration of complex diseases by dynamical network biomarkers","volume":"2","author":"Aihara","year":"2012","journal-title":"Scientific Reports"},{"key":"42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/med.21293","article-title":"Early Diagnosis of Complex Diseases by Molecular Biomarkers Network Biomarkers and Dynamical Network Biomarkers","volume":"34","author":"Chen","year":"2014","journal-title":"Medicinal Research Reviews"},{"key":"43","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1074\/mcp.M110.000661","article-title":"A Combined Proteomics and Metabolomics Profiling of Gastric Cardia Cancer Reveals Characteristic Dysregulations in Glucose Metabolism","volume":"9","author":"Xie","year":"2010","journal-title":"Mol Cell Proteomics"},{"key":"44","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.1218595","article-title":"Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation","volume":"336","author":"Mootha","year":"2012","journal-title":"Science"},{"key":"45","doi-asserted-by":"crossref","first-page":"19786","DOI":"10.1074\/jbc.R112.357194","article-title":"Resurgence of Serine: An Often Neglected but Indispensable Amino Acid","volume":"287","author":"Hanson","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"46","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tibs.2014.02.004","article-title":"Serine and glycine metabolism in cancer","volume":"39","author":"Melino","year":"2014","journal-title":"Trends in Biochemical Sciences"},{"key":"47","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1158\/0008-5472.CAN-05-1146","article-title":"Alterations of Choline Phospholipid Metabolism in Ovarian Tumor Progression","volume":"65","author":"Podo","year":"2005","journal-title":"Cancer Research"},{"key":"48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jcb.10659","article-title":"Choline phospholipid metabolism: A target in cancer cells?","volume":"90","author":"Bhujwalla","year":"2003","journal-title":"Journal of Cellular Biochemistry"},{"key":"49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/10409238.2012.735643","article-title":"The role of phosphatidylcholine and choline metabolites to cell proliferation and survival","volume":"48","author":"Ridgway","year":"2013","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"key":"50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2013.05.017","article-title":"Cellular Fatty Acid Metabolism and Cancer","volume":"18","author":"Farese Jr Robert","year":"2013","journal-title":"Cell Metabolism"},{"key":"51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0167-4838(00)00153-9","article-title":"Alpha-1-acid glycoprotein","volume":"1482","author":"Porquet","year":"2000","journal-title":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology"},{"key":"52","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1084\/jem.178.5.1629","article-title":"Antiinflammatory properties of hepatic acute phase proteins: preferential induction of interleukin 1 (IL-1) receptor antagonist over IL-1 beta synthesis by human peripheral blood mononuclear cells","volume":"178","author":"Mier","year":"1993","journal-title":"The Journal of Experimental Medicine"},{"key":"53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00916390","article-title":"\u03b11-Acid glycoprotein expression in human leukocytes: possible correlation between 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis","volume":"17","author":"Matsuda","year":"1993","journal-title":"Inflammation"},{"key":"54","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1073\/pnas.1522586113","article-title":"Part mutual information for quantifying direct associations in networks","volume":"113","author":"Chen","year":"2016","journal-title":"PNAS"},{"key":"55","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1093\/nar\/gku1315","article-title":"Conditional mutual inclusive information enables accurate quantification of associations in gene regulatory networks","volume":"43","author":"Chen","year":"2015","journal-title":"Nucleic Acids Research"},{"key":"56","first-page":"726","article-title":"Network deconvolution as a general method to distinguish direct dependencies in networks","volume":"32","author":"Kellis","year":"2015","journal-title":"Nat Biotechnol"},{"key":"57","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/(SICI)1097-0215(19990827)82:5<665::AID-IJC8>3.0.CO;2-E","article-title":"Attenuation by d-limonene of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N\u2032-nitro-N-nitrosoguanidine in Wistar rats","volume":"82","author":"Uedo","year":"1999","journal-title":"Int J Cancer"},{"key":"58","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1038\/nprot.2007.376","article-title":"Metabolic profiling metabolomic and metabonomic procedures for NMR spectroscopy of urine plasma serum and tissue extracts","volume":"2","author":"Nicholson","year":"2007","journal-title":"Nat Protocols"},{"key":"59","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1021\/tx000231j","article-title":"Metabonomic Investigations into Hydrazine Toxicity in the Rat","volume":"14","author":"Nicholson","year":"2001","journal-title":"Chemical Research in Toxicology"},{"key":"60","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jmr.2009.11.012","article-title":"icoshift: A versatile tool for the rapid alignment of 1D NMR spectra","volume":"202","author":"Engelsen","year":"2010","journal-title":"Journal of Magnetic Resonance"},{"key":"61","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1021\/ac0519312","article-title":"Scaling and Normalization Effects in NMR Spectroscopic Metabonomic Data Sets","volume":"78","author":"Lindon","year":"2006","journal-title":"Analytical Chemistry"},{"key":"62","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2164-7-142","article-title":"Centering scaling and transformations: improving the biological information content of metabolomics data","volume":"7","author":"van der Werf","year":"2006","journal-title":"Bmc Genomics"},{"key":"63","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/bioinformatics\/btt136","article-title":"SRV: an open-source toolbox to accelerate the recovery of metabolic biomarkers and correlations from metabolic phenotyping datasets","volume":"29","author":"Blaise","year":"2013","journal-title":"Bioinformatics"},{"key":"64","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bioinformatics\/18.1.39","article-title":"Tumor classification by partial least squares using microarray gene expression data","volume":"18","author":"Rocke","year":"2002","journal-title":"Bioinformatics"},{"key":"65","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/pr060594q","article-title":"Chemometrics in metabonomics","volume":"6","author":"Lundstedt","year":"2007","journal-title":"Journal of Proteome Research"},{"key":"66","first-page":"581","article-title":"Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach","volume":"112","author":"Tenenhaus","year":"2003","journal-title":"Hum Genet"},{"key":"67","volume-title":"Multi- and Megavariate Data Analysis","author":"Wold","year":"2006","edition":"Second"},{"key":"68","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/biomet\/36.3-4.317","article-title":"A General Distribution Theory for a Class of Likelihood Criteria","volume":"36","author":"Box","year":"1949","journal-title":"Biometrika"},{"key":"69","first-page":"517","article-title":"Evaluation of the Orthogonal Projection on Latent Structure Model Limitations Caused by Chemical Shift Variability and Improved Visualization of Biomarker Changes inH NMR Spectroscopic Metabonomic Studies","volume":"77","author":"Holmes","year":"2004","journal-title":"Analytical Chemistry"},{"key":"70","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"71","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/bioinformatics\/btl611","article-title":"Dynamic exploration and editing of KEGG pathway diagrams","volume":"23","author":"Schreiber","year":"2007","journal-title":"Bioinformatics"},{"key":"72","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1093\/bioinformatics\/btq418","article-title":"MetPA: a web-based metabolomics tool for pathway analysis and visualization","volume":"26","author":"Wishart","year":"2010","journal-title":"Bioinformatics"},{"key":"73","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3 0\u2014making metabolomics more meaningful","volume":"43","author":"Wishart","year":"2015","journal-title":"Nucleic Acids Research"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.11049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T12:21:14Z","timestamp":1596716474000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.11049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,4]]},"references-count":73,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2016,9,13]]}},"alternative-id":["11049","27527852"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.11049","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,4]]}}}