{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:01:51Z","timestamp":1789682511416,"version":"4.0.1"},"reference-count":35,"publisher":"Impact Journals, LLC","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2013,8,31]]},"DOI":"10.18632\/oncotarget.1126","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T21:46:10Z","timestamp":1442439970000},"page":"1172-1184","source":"Crossref","is-referenced-by-count":27,"title":["Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target"],"prefix":"10.18632","volume":"4","author":[{"given":"Jun","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soji","family":"Kakiuchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung","family":"The Van","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatsugu","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Hanibuchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2013,7,8]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1056\/NEJMra050152","article-title":"Advances in malignant mesothelioma","volume":"353","author":"Lake","year":"2005","journal-title":"N Engl J Med"},{"key":"2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1378\/chest.08-2665","article-title":"Malignant pleural mesothelioma: an update on biomarkers and treatment","volume":"136","author":"Kindler","year":"2009","journal-title":"Chest"},{"key":"3","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.1158\/1078-0432.CCR-07-0501","article-title":"The therapeutic efficacy of anti-vascular endothelial growth factor antibody, bevacizumab, and pemetrexed against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice","volume":"13","author":"Sone","year":"2007","journal-title":"Clin Cancer Res"},{"key":"4","doi-asserted-by":"crossref","first-page":"7229","DOI":"10.1158\/1078-0432.CCR-09-1980","article-title":"E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangiogenic cytokine production profiles","volume":"15","author":"Sone","year":"2009","journal-title":"Clin Cancer Res"},{"key":"5","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1440-1843.2012.02193.x","article-title":"SU6668, a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model","volume":"17","author":"Sone","year":"2012","journal-title":"Respirology"},{"key":"6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00280-011-1655-3","article-title":"Review on clinical trials of targeted treatments in malignant mesothelioma","volume":"68","author":"S\u00f8rensen","year":"2011","journal-title":"Cancer Chemother Pharmacol"},{"key":"7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ccm.2006.01.004","article-title":"Management of malignant pleural mesothelioma","volume":"27","author":"Lee","year":"2006","journal-title":"Clin Chest Med"},{"key":"8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tips.2013.03.001","article-title":"Targeting tumor cell motility as a strategy against invasion and metastasis","volume":"34","author":"Lauffenburger","year":"2013","journal-title":"Trends Pharmacol Sci"},{"key":"9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(74)90553-5","article-title":"Characterization of four human pregnancy-associated plasma proteins","volume":"118","author":"Gall","year":"1974","journal-title":"Am J Obstet Gynecol"},{"key":"10","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1073\/pnas.96.6.3149","article-title":"The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy associated plasma protein-A","volume":"96","author":"Conover","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ghir.2006.11.003","article-title":"Pregnancy-associated plasma protein-A (PAPP-A): A local regulator of IGF bioavailability through cleavage of IGFBPs","volume":"17","author":"Conover","year":"2007","journal-title":"Growth Horm IGF Res"},{"key":"12","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1021\/bi062229i","article-title":"Quantitative analysis of insulin-like growth factor-modulated proteolysis of insulin-like growth factor binding protein-4 and -5 by pregnancy associated plasma protein-A","volume":"46","author":"Oxvig","year":"2007","journal-title":"Biochemistry"},{"key":"13","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrc2536","article-title":"Insulin and insulin-like growth factor signalling in neoplasia","volume":"8","author":"Pollak","year":"2008","journal-title":"Nature Rev Cancer"},{"key":"14","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1378\/chest.125.5.1843","article-title":"Gene expression profiling identifies matriptase overexpression in malignant mesothelioma","volume":"125","author":"Kratzke","year":"2004","journal-title":"Chest"},{"key":"15","doi-asserted-by":"crossref","first-page":"7479","DOI":"10.1158\/0008-5472.CAN-04-1898","article-title":"Selective activation of insulin receptor substrate-1 and -2 in pleural mesothelioma cells: association with distinct malignant phenotypes","volume":"64","author":"Kratzke","year":"2004","journal-title":"Cancer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.bjc.6605184","article-title":"Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma","volume":"101","author":"Kratzke","year":"2009","journal-title":"Br J Cancer"},{"key":"17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/157489212798357930","article-title":"Insulin-like growth factor: current concepts and new developments in cancer therapy","volume":"7","author":"Wong","year":"2012","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1474-9726.2007.00328.x","article-title":"Loss of pregnancy-associated plasma protein A extends lifespan in mice","volume":"6","author":"Bale","year":"2007","journal-title":"Aging Cell"},{"key":"19","first-page":"590","article-title":"Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A","volume":"65","author":"Marler","year":"2010","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/sj.bjc.6605141","article-title":"Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer","volume":"101","author":"Harmey","year":"2009","journal-title":"Br J Cancer"},{"key":"21","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1210\/en.2010-1095","article-title":"Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo","volume":"152","author":"Conover","year":"2011","journal-title":"Endocrinology"},{"key":"22","doi-asserted-by":"crossref","first-page":"e48799","DOI":"10.1371\/journal.pone.0048799","article-title":"Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"key":"23","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/ijc.27471","article-title":"Efficacy of anti-insulin-like growth factor I receptor monoclonal antibody cixutumumab in mesothelioma is highly correlated with insulin growth factor-I receptor sites\/cell","volume":"131","author":"Hassan","year":"2012","journal-title":"Int J Cancer"},{"key":"24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0955-2235(96)00007-5","article-title":"Serum proteolysis of IGFBP-3","volume":"6","author":"Bang","year":"1995","journal-title":"Prog Growth Factor Res"},{"key":"25","first-page":"1625","article-title":"Chemotaxis and chemokinesis of malignant mesothelioma cells to multiple growth factors","volume":"24","author":"Klominek","year":"2004","journal-title":"Anticancer Res"},{"key":"26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00280-010-1503-x","article-title":"The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice","volume":"68","author":"Sone","year":"2011","journal-title":"Cancer Chemother. Pharmacol"},{"key":"27","first-page":"2858","article-title":"Normal human mesothelial cells and mesothelioma cell lines express insulin-like growth factor I associated molecules","volume":"53","author":"Rom","year":"1993","journal-title":"Cancer Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/S0002-9440(10)62492-3","article-title":"Identification of novel candidate oncogenes and tumor suppressors in malignant pleural mesothelioma using large-scale transcriptional profiling","volume":"166","author":"Bueno","year":"2005","journal-title":"Am J Pathol"},{"key":"29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ghir.2007.09.005","article-title":"Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: Results of the Study of Health in Pomerania (SHIP)","volume":"18","author":"Wallaschofski","year":"2008","journal-title":"Growth Horm IGF Res"},{"key":"30","doi-asserted-by":"crossref","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes","volume":"101","author":"Hogenesch","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"31","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1074\/jbc.M111.267732","article-title":"Insulin-like growth factor binding protein-4 (IGFBP-4) differentially inhibits growth factor-induced angiogenesis","volume":"287","author":"Brooks","year":"2012","journal-title":"J Biol Chem"},{"key":"32","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1210\/en.2004-1351","article-title":"Pregnancy-associated plasma protein-A is involved in matrix mineralization of human adult mesenchymal stem cells and angiogenesis in the chick chorioallontoic membrane","volume":"146","author":"Campbell","year":"2005","journal-title":"Endocrinology"},{"key":"33","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/carcin\/bgp097","article-title":"EGFR suppresses proliferation of malignant mesothelioma cells","volume":"30","author":"Combined inhibition of","year":"2009","journal-title":"Carcinogenesis"},{"key":"34","doi-asserted-by":"crossref","first-page":"6239","DOI":"10.4049\/jimmunol.1300448","article-title":"A Novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody","volume":"190","author":"Yano","year":"2013","journal-title":"J Immmunol"},{"key":"35","doi-asserted-by":"crossref","first-page":"11572","DOI":"10.1158\/0008-5472.CAN-05-1196","article-title":"Novel role for PDEF in epithelial cell migration and invasion","volume":"65","author":"Brugge","year":"2005","journal-title":"Cancer Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T08:54:30Z","timestamp":1589446470000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,8]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8,31]]}},"alternative-id":["1126","23896451"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.1126","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,8]]}}}