{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:32:50Z","timestamp":1792632770559,"version":"4.5.0"},"reference-count":75,"publisher":"Impact Journals, LLC","issue":"40","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,10,4]]},"DOI":"10.18632\/oncotarget.11872","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T03:22:53Z","timestamp":1473218573000},"page":"64605-64614","source":"Crossref","is-referenced-by-count":33,"title":["Interferon-gamma deficiency protects against aging-related goblet cell loss"],"prefix":"10.18632","volume":"7","author":[{"given":"Eugene A.","family":"Volpe","sequence":"first","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Tukler","family":"Henriksson","sequence":"additional","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"},{"name":"Eye Center, Second Affiliated Hospital of Zhejiang University, School of Medicine Zhejiang Provincial Key Laboratory of Ophthalmology, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia L.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahira","family":"Zaheer","sequence":"additional","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"},{"name":"Eye Institute of Xiamen University, Xiamen, Fujian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Pflugfelder","sequence":"additional","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia S.","family":"de Paiva","sequence":"additional","affiliation":[{"name":"Ocular Surface Center, Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/archophthalmol.2009.103","article-title":"Prevalence of dry eye disease among US men: estimates from the Physicians' Health Studies","volume":"127","author":"Sullivan","year":"2009","journal-title":"Arch Ophthalmol"},{"key":"2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0002-9394(03)00218-6","article-title":"Prevalence of dry eye syndrome among US women","volume":"136","author":"Dana","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"3","first-page":"e922","article-title":"Japan Ministry of Health study on prevalence of dry eye disease among Japanese high school students","volume":"146","author":"Tsubota","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"4","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1167\/iovs.10-5782","article-title":"Entrapment of conjunctival goblet cells by desiccation-induced cornification","volume":"52","author":"Pflugfelder","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00004397-197301310-00013","article-title":"The mucin-deficient dry eye","volume":"13","author":"Lemp","year":"1973","journal-title":"Int Ophthalmol Clin"},{"key":"6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1177\/112067210301300302","article-title":"Biopsy of the conjunctiva in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity","volume":"13","author":"Rivas","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/112067210301300201","article-title":"Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity","volume":"13","author":"Rivas","year":"2003","journal-title":"Eur J Ophthalmol"},{"key":"8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0161-6420(90)32478-8","article-title":"Conjunctival cytological features of primary Sjogren syndrome","volume":"97","author":"Tseng","year":"1990","journal-title":"Ophthalmology"},{"key":"9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/mi.2009.5","article-title":"IL-17 disrupts corneal barrier following desiccating stress","volume":"2","author":"Pflugfelder","year":"2009","journal-title":"Mucosal Immunol"},{"key":"10","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ajpath.2013.11.019","article-title":"Ocular Surface Disease and Dacryoadenitis in Aging C57BL\/6 Mice","volume":"184","author":"de Paiva","year":"2014","journal-title":"Am J Pathol"},{"key":"11","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","article-title":"Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression","volume":"182","author":"Dana","year":"2009","journal-title":"JImmunol"},{"key":"12","doi-asserted-by":"crossref","first-page":"7545","DOI":"10.1167\/iovs.15-17627","article-title":"Aqueous Tear Deficiency Increases Conjunctival Interferon-gamma (IFN-gamma) Expression and Goblet Cell Loss","volume":"56","author":"Corrales","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1749-6632.2000.tb06648.x","article-title":"Inherited variability of the mitochondrial genome and successful aging in humans","volume":"908","author":"Franceschi","year":"2000","journal-title":"AnnNYAcadSci"},{"key":"14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/ar974","article-title":"Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation","volume":"5","author":"Weyand","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/rheumatology\/34.3.226","article-title":"Interferon-gamma and epithelial cell activation in Sjogren's syndrome","volume":"34","author":"Maini","year":"1995","journal-title":"Br J Rheumatol"},{"key":"16","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1084\/jem.20061082","article-title":"IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis","volume":"203","author":"Sher","year":"2006","journal-title":"J Exp Med"},{"key":"17","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1371\/journal.pmed.0050041","article-title":"An antibiotic-responsive mouse model of fulminant ulcerative colitis","volume":"5","author":"Allen","year":"2008","journal-title":"PLoS Med"},{"key":"18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nri1132","article-title":"The immunological and genetic basis of inflammatory bowel disease","volume":"3","author":"Strober","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1006\/clim.2000.4894","article-title":"The increase of IFN-g production through aging correlates with the expanded CD8(+high)CD28(\u2212)CD57(+) subpopulation","volume":"96","author":"Sanchez-Ibarrola","year":"2000","journal-title":"Clin Immunol"},{"key":"20","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1007\/s11357-011-9316-3","article-title":"The dominant human conjunctival epithelial CD8alphabeta+ T cell population is maintained with age but the number of CD4+ T cells increases","volume":"34","author":"Curnow","year":"2012","journal-title":"Age (Dordr)"},{"key":"21","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","article-title":"Dry Eye-Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-{gamma}","volume":"48","author":"Pflugfelder","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"22","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/j.ajpath.2011.06.030","article-title":"Desiccating Stress Induces CD4(+) T-Cell-Mediated Sjogren's Syndrome-Like Corneal Epithelial Apoptosis via Activation of the Extrinsic Apoptotic Pathway by Interferon-gamma","volume":"179","author":"Pflugfelder","year":"2011","journal-title":"Am J Pathol"},{"key":"23","doi-asserted-by":"crossref","first-page":"6279","DOI":"10.1167\/iovs.10-7081","article-title":"Interferon-gamma exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways","volume":"52","author":"Pflugfelder","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.exer.2013.11.011","article-title":"Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye","volume":"118","author":"Pflugfelder","year":"2014","journal-title":"Exp Eye Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.4049\/jimmunol.1400016","article-title":"Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D\/RAE-1 and release of IFN-gamma in experimental dry eye","volume":"193","author":"de Paiva","year":"2014","journal-title":"J Immunol"},{"key":"26","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1189\/jlb.1110611","article-title":"Interferon-{gamma}-secreting NK cells promote induction of dry eye disease","volume":"89","author":"Dana","year":"2011","journal-title":"J Leukoc Biol"},{"key":"27","first-page":"30005","article-title":"Interferon-gamma-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjogren Syndrome","author":"Pflugfelder","year":"2016","journal-title":"Am J Pathol"},{"key":"28","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ajo.2008.08.032","article-title":"Tear Cytokine Profiles in Dysfunctional Tear Syndrome","volume":"147","author":"Pflugfelder","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"29","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/sj.jid.5701213","article-title":"Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells","volume":"128","author":"Krueger","year":"2008","journal-title":"J Invest Dermatol"},{"key":"30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clim.2003.09.013","article-title":"Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice","volume":"110","author":"Fujiyama","year":"2004","journal-title":"Clin Immunol"},{"key":"31","doi-asserted-by":"crossref","first-page":"e105351","DOI":"10.1371\/journal.pone.0105351","article-title":"Differential modulation by IL-17A of Cholangitis versus Colitis in IL-2Ralpha deleted mice","volume":"9","author":"Lian","year":"2014","journal-title":"PLoS One"},{"key":"32","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/art.23214","article-title":"Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjogren's syndrome: findings in humans and mice","volume":"58","author":"Peck","year":"2008","journal-title":"Arthritis Rheum"},{"key":"33","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/rheumatology\/kep357","article-title":"Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice","volume":"49","author":"Pflugfelder","year":"2010","journal-title":"Rheumatology"},{"key":"34","article-title":"Th17 cells play a critical role in the development of experimental Sjogren's syndrome","author":"Lu","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2559.1988.tb02024.x","article-title":"Conjunctival biopsy in Sjogren's syndrome: correlations between histological and immunohistochemical features","volume":"13","author":"Chomette","year":"1988","journal-title":"Histopathology"},{"key":"36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0161-6420(97)30330-3","article-title":"Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation","volume":"104","author":"Reis","year":"1997","journal-title":"Ophthalmology"},{"key":"37","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1167\/iovs.09-3910","article-title":"Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration","volume":"51","author":"Lashkari","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"38","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/jid.2009.65","article-title":"Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis","volume":"129","author":"Blauvelt","year":"2009","journal-title":"J Invest Dermatol"},{"key":"39","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"Sallusto","year":"2009","journal-title":"Nature Immunol"},{"key":"40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/mi.2010.82","article-title":"Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13","volume":"4","author":"Pflugfelder","year":"2011","journal-title":"Mucosal Immunol"},{"key":"41","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1167\/iovs.14-15496","article-title":"IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells","volume":"56","author":"Pflugfelder","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0002-9440(10)62232-8","article-title":"Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye","volume":"166","author":"Fini","year":"2005","journal-title":"Am J Pathol"},{"key":"43","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1167\/iovs.04-1426","article-title":"Decreased corneal sensitivity in patients with dry eye","volume":"46","author":"Belmonte","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.exger.2012.03.020","article-title":"Aging and dry eye disease","volume":"47","author":"Sullivan","year":"2012","journal-title":"Exp Gerontol"},{"key":"45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/03009740701678712","article-title":"Estimation of the prevalence of primary Sjogren's syndrome in two age-different community-based populations using two sets of classification criteria: the Hordaland Health Study","volume":"37","author":"Haga","year":"2008","journal-title":"Scand J Rheumatol"},{"issue":"Suppl 4","key":"46","first-page":"S61","article-title":"Prevalence of dry eye syndrome and Sjogren's syndrome in patients with rheumatoid arthritis","volume":"95","author":"Nilganuwong","year":"2012","journal-title":"J Med Assoc Thai"},{"key":"47","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archopht.122.3.369","article-title":"Incidence of dry eye in an older population","volume":"122","author":"Klein","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"48","first-page":"730","article-title":"The morphology of human conjunctival mucus","volume":"97","author":"Adams","year":"1979","journal-title":"ArchOphthalmol"},{"key":"49","first-page":"299","article-title":"Conjunctival goblet cell density in normal subjects and in dry eye syndromes","volume":"14","author":"Ralph","year":"1975","journal-title":"Invest Ophthalmol"},{"key":"50","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2332\/allergolint.55.329","article-title":"Elimination of IL-13 reverses established goblet cell metaplasia into ciliated epithelia in airway epithelial cell culture","volume":"55","author":"Nagai","year":"2006","journal-title":"Allergol Int"},{"key":"51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2172-9-11","article-title":"IL-4\/IL-13 independent goblet cell hyperplasia in experimental helminth infections","volume":"9","author":"Brombacher","year":"2008","journal-title":"BMC Immunol"},{"key":"52","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1165\/rcmb.4682","article-title":"Interleukin-13 induces goblet cell differentiation in primary cell culture from Guinea pig tracheal epithelium","volume":"27","author":"Nagai","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"53","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1172\/JCI200113557","article-title":"IL-13 alters mucociliary differentiation and ciliary beating of human respiratory epithelial cells","volume":"108","author":"Tournier","year":"2001","journal-title":"J Clin Invest"},{"key":"54","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1096\/fj.07-103721","article-title":"Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines","volume":"22","author":"Goetzl","year":"2008","journal-title":"FASEB J"},{"key":"55","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.exger.2013.09.003","article-title":"The Th17\/Treg balance is disturbed during aging","volume":"48","author":"Uciechowski","year":"2013","journal-title":"Exp Gerontol"},{"key":"56","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.cellimm.2010.10.007","article-title":"Potentiation of Th17 cytokines in aging process contributes to the development of colitis","volume":"266","author":"Xiong","year":"2011","journal-title":"Cell Immunol"},{"key":"57","first-page":"1393","article-title":"Effect of aging on airway remodeling and muscarinic receptors in a murine acute asthma model","volume":"8","author":"Kim","year":"2013","journal-title":"Clin Interv Aging"},{"key":"58","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cellsig.2003.09.008","article-title":"Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3, \u221213 and aggrecanase-1 genes in articular chondrocytes","volume":"16","author":"Zafarullah","year":"2004","journal-title":"Cell Signal"},{"key":"59","doi-asserted-by":"crossref","first-page":"H3356","DOI":"10.1152\/ajpheart.00928.2007","article-title":"IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38","volume":"293","author":"Chandrasekar","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"60","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Weaver","year":"2005","journal-title":"Nat Immunol"},{"key":"61","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni1261","article-title":"A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17","volume":"6","author":"Dong","year":"2005","journal-title":"Nat Immunol"},{"key":"62","doi-asserted-by":"crossref","first-page":"R234","DOI":"10.1186\/ar4077","article-title":"Deletion of interferon-gamma delays onset and severity of dacryoadenitis in CD25KO mice","volume":"14","author":"de Paiva","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"63","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.0300-9475.2004.01508.x","article-title":"A dual role for interferon-gamma in the pathogenesis of Sjogren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse","volume":"60","author":"Peck","year":"2004","journal-title":"Scand J Immunol"},{"key":"64","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/ar2787","article-title":"Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon- and counteraction by interferon-","volume":"11","author":"Matthys","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"65","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1084\/jem.20071258","article-title":"Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category","volume":"205","author":"Caspi","year":"2008","journal-title":"J Exp Med"},{"key":"66","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.4049\/jimmunol.140.5.1506","article-title":"Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma","volume":"140","author":"Carton","year":"1988","journal-title":"JImmunol"},{"key":"67","doi-asserted-by":"crossref","first-page":"890","DOI":"10.4049\/jimmunol.152.2.890","article-title":"Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice","volume":"152","author":"Heremans","year":"1994","journal-title":"JImmunol"},{"key":"68","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.22453","article-title":"Interferon-g regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17","volume":"56","author":"Elkon","year":"2007","journal-title":"Arthritis Rheum"},{"key":"69","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.4049\/jimmunol.1500610","article-title":"Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease","volume":"195","author":"Gronert","year":"2015","journal-title":"J Immunol"},{"key":"70","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/ICO.0000000000000721","article-title":"Differential Profiling of T-Cell Cytokines as Measured by Protein Microarray Across Dry Eye Subgroups","volume":"35","author":"Nichols","year":"2016","journal-title":"Cornea"},{"key":"71","first-page":"862","article-title":"Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease","volume":"16","author":"Calonge","year":"2010","journal-title":"MolVis"},{"key":"72","first-page":"R220","article-title":"Pathogenic effect of interleukin-17A in induction of Sjogren's syndrome-like disease using adenovirus-mediated gene transfer","volume":"12","author":"Peck","year":"2010","journal-title":"Arthritis ResTher"},{"key":"73","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0161-6420(98)96016-X","article-title":"The epidemiology of dry eye in Melbourne, Australia","volume":"105","author":"Taylor","year":"1998","journal-title":"Ophthalmology"},{"key":"74","first-page":"S102","article-title":"Prevalence, burden, and pharmacoeconomics of dry eye disease","volume":"14","author":"Pflugfelder","year":"2008","journal-title":"AmJManagCare"},{"key":"75","first-page":"723","article-title":"Prevalence of dry eye among the elderly","volume":"124","author":"West","year":"1997","journal-title":"AmJOphthalmol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.11872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:01:20Z","timestamp":1718780480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.11872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,6]]},"references-count":75,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2016,10,4]]}},"alternative-id":["11872","27623073"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.11872","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,6]]}}}