{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:02:10Z","timestamp":1767826930013,"version":"3.49.0"},"reference-count":47,"publisher":"Impact Journals, LLC","issue":"45","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,11,8]]},"DOI":"10.18632\/oncotarget.12248","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T18:20:52Z","timestamp":1474914052000},"page":"73160-73170","source":"Crossref","is-referenced-by-count":9,"title":["Cyr61-positive cancer stem-like cells enhances distal metastases of pancreatic cancer"],"prefix":"10.18632","volume":"7","author":[{"given":"Weidong","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China"},{"name":"Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China"},{"name":"Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"1","first-page":"e421","article-title":"SnapShot: pancreatic cancer","volume":"23","author":"Von Hoff","year":"2013","journal-title":"Cancer Cell"},{"key":"2","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1053\/j.gastro.2013.01.071","article-title":"Roles for KRAS in pancreatic tumor development and progression","volume":"144","author":"Logsdon","year":"2013","journal-title":"Gastroenterology"},{"key":"3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/bjc.2014.215","article-title":"Oncogenic KRAS signalling in pancreatic cancer","volume":"111","author":"Saur","year":"2014","journal-title":"Br J Cancer"},{"key":"4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","article-title":"Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice","volume":"7","author":"Tuveson","year":"2005","journal-title":"Cancer Cell"},{"key":"5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1535-6108(03)00309-X","article-title":"Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse","volume":"4","author":"Liotta","year":"2003","journal-title":"Cancer Cell"},{"key":"6","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1093\/annonc\/mdn386","article-title":"The effects of surgery on tumor growth: a century of investigations","volume":"19","author":"Gukas","year":"2008","journal-title":"Ann Oncol"},{"key":"7","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1245\/s10434-010-1442-0","article-title":"Local and systemic recurrence is the Achilles heel of cancer surgery","volume":"18","author":"Singhal","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF02316807","article-title":"Local recurrence in breast cancer: implications for systemic disease","volume":"4","author":"Wagman","year":"1997","journal-title":"Ann Surg Oncol"},{"key":"9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S1091-255X(02)00002-1","article-title":"Local, intrahepatic, and systemic recurrence patterns after radiofrequency ablation of hepatic malignancies","volume":"6","author":"Sielaff","year":"2002","journal-title":"J Gastrointest Surg"},{"key":"10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1177\/014107689008300119","article-title":"Chondrosarcoma\u2014local recurrence and systemic embolization","volume":"83","author":"Staunton","year":"1990","journal-title":"Journal of the Royal Society of Medicine"},{"key":"11","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.2174\/0929867311209065984","article-title":"Stem cell dynamics and heterogeneity: implications for epidermal regeneration and skin cancer","volume":"19","author":"Niemann","year":"2012","journal-title":"Curr Med Chem"},{"key":"12","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrc1095","article-title":"Stem-cell hierarchy in skin cancer","volume":"3","author":"Balmain","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"13","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.2174\/0929867311209065965","article-title":"Stem cell niche in tissue homeostasis, aging and cancer","volume":"19","author":"Singh","year":"2012","journal-title":"Curr Med Chem"},{"key":"14","first-page":"5821","article-title":"Identification of a cancer stem cell in human brain tumors","volume":"63","author":"Dirks","year":"2003","journal-title":"Cancer Res"},{"key":"15","first-page":"495","article-title":"Expression of cancer stem cell markers CD133 and CD44 in locoregional recurrence of rectal cancer","volume":"31","author":"Fujiwara","year":"2011","journal-title":"Anticancer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1038\/sj.bjc.6605610","article-title":"Expansion of CD133(+) colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery","volume":"102","author":"Moore","year":"2010","journal-title":"Br J Cancer"},{"key":"17","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.4161\/cbt.10.11.13664","article-title":"CD44+ CD133+ population exhibits cancer stem cell-like characteristics in human gallbladder carcinoma","volume":"10","author":"Qin","year":"2010","journal-title":"Cancer Biol Ther"},{"key":"18","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4161\/cc.9.22.13823","article-title":"Finding markers for cancer stem cells in renal cell carcinoma: looking beyond CD133","volume":"9","author":"Ottaiano","year":"2010","journal-title":"Cell Cycle"},{"key":"19","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1158\/1541-7786.MCR-08-0035","article-title":"Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations","volume":"6","author":"Guan","year":"2008","journal-title":"Mol Cancer Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"11002","DOI":"10.18632\/oncotarget.6760","article-title":"Cancer stem cells and signaling pathways in radioresistance","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget"},{"key":"21","doi-asserted-by":"publisher","first-page":"40496","DOI":"10.18632\/oncotarget.5800","article-title":"Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?","volume":"6","author":"Tricot","year":"2015","journal-title":"Oncotarget"},{"key":"22","doi-asserted-by":"publisher","first-page":"39550","DOI":"10.18632\/oncotarget.6098","article-title":"Differentiation and transdifferentiation potentials of cancer stem cells","volume":"6","author":"Ouyang","year":"2015","journal-title":"Oncotarget"},{"key":"23","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1007\/s00018-011-0778-3","article-title":"CCN1\/CYR61: the very model of a modern matricellular protein","volume":"68","author":"Lau","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"24","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jcb.21194","article-title":"Functional properties and intracellular signaling of CCN1\/Cyr61","volume":"100","author":"Du","year":"2007","journal-title":"J Cell Biochem"},{"key":"25","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1111\/j.1742-4658.2006.05360.x","article-title":"Mechanical regulation of the Cyr61\/CCN1 and CTGF\/CCN2 proteins","volume":"273","author":"Goppelt-Struebe","year":"2006","journal-title":"FEBS J"},{"key":"26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/aja.2011.149","article-title":"Cyr61 is a potential prognostic marker for prostate cancer","volume":"14","author":"Getzenberg","year":"2012","journal-title":"Asian J Androl"},{"key":"27","first-page":"141","article-title":"The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives","volume":"10","author":"Lupu","year":"2003","journal-title":"Endocr Relat Cancer"},{"key":"28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.canlet.2011.10.016","article-title":"CYR61 controls p53 and NF-kappaB expression through PI3K\/Akt\/mTOR pathways in carboplatin-induced ovarian cancer cells","volume":"315","author":"Rho","year":"2012","journal-title":"Cancer Lett"},{"key":"29","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/jcp.2010.082768","article-title":"Expression of CTGF and Cyr61 in colorectal cancer","volume":"64","author":"West","year":"2011","journal-title":"J Clin Pathol"},{"key":"30","doi-asserted-by":"crossref","first-page":"14187","DOI":"10.1074\/jbc.M009755200","article-title":"Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease","volume":"276","author":"Koeffler","year":"2001","journal-title":"J Biol Chem"},{"key":"31","doi-asserted-by":"crossref","first-page":"24015","DOI":"10.1074\/jbc.M402305200","article-title":"Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation","volume":"279","author":"Kuo","year":"2004","journal-title":"J Biol Chem"},{"key":"32","doi-asserted-by":"publisher","first-page":"13520","DOI":"10.18632\/oncotarget.3760","article-title":"Cyr61 as mediator of Src signaling in triple negative breast cancer cells","volume":"6","author":"Martin-Perez","year":"2015","journal-title":"Oncotarget"},{"key":"33","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/onc.2013.122","article-title":"ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer","volume":"33","author":"She","year":"2014","journal-title":"Oncogene"},{"key":"34","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.3748\/wjg.v20.i7.1694","article-title":"Cyr61\/CTGF\/Nov family proteins in gastric carcinogenesis","volume":"20","author":"Lin","year":"2014","journal-title":"World J Gastroenterol"},{"key":"35","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1038\/sj.onc.1207628","article-title":"Cyr61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway","volume":"23","author":"Koeffler","year":"2004","journal-title":"Oncogene"},{"key":"36","doi-asserted-by":"crossref","first-page":"47709","DOI":"10.1074\/jbc.M107878200","article-title":"Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer","volume":"276","author":"Koeffler","year":"2001","journal-title":"J Biol Chem"},{"key":"37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/1534735411400315","article-title":"Qingyihuaji formula inhibits progress of liver metastases from advanced pancreatic cancer xenograft by targeting to decrease expression of Cyr61 and VEGF","volume":"11","author":"Liu","year":"2012","journal-title":"Integrative cancer therapies"},{"key":"38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11010-010-0619-y","article-title":"Proteome analysis of human pancreatic cancer cell lines with highly liver metastatic potential by antibody microarray","volume":"347","author":"Liu","year":"2011","journal-title":"Mol Cell Biochem"},{"key":"39","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.canlet.2009.03.030","article-title":"Identification of liver metastasis-related genes in a novel human pancreatic carcinoma cell model by microarray analysis","volume":"283","author":"Liu","year":"2009","journal-title":"Cancer Lett"},{"key":"40","doi-asserted-by":"crossref","first-page":"11147","DOI":"10.1007\/s13277-014-2423-x","article-title":"Cyr61 promotes growth of pancreatic carcinoma via nuclear exclusion of p27","volume":"35","author":"Meng","year":"2014","journal-title":"Tumour Biol"},{"key":"41","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/nprot.2014.183","article-title":"Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and\/or cell-tagging dyes","volume":"9","author":"Gittes","year":"2014","journal-title":"Nat Protoc"},{"key":"42","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000369686","article-title":"Modulation of FoxO1 Expression by miR-21 to Promote Growth of Pancreatic Ductal Adenocarcinoma","volume":"35","author":"Wang","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"43","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1007\/s13277-015-3466-3","article-title":"Transforming growth factor beta receptor signaling restrains growth of pancreatic carcinoma cells","volume":"36","author":"Li","year":"2015","journal-title":"Tumour Biol"},{"key":"44","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1159\/000430146","article-title":"Pax4 Expression does not Transduce Pancreatic Alpha Cells to Beta Cells","volume":"36","author":"Cai","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"45","doi-asserted-by":"publisher","first-page":"32039","DOI":"10.18632\/oncotarget.5055","article-title":"PI3K\/AKT\/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth","volume":"6","author":"Srivastava","year":"2015","journal-title":"Oncotarget"},{"key":"46","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1007\/s13277-015-3123-x","article-title":"Interplay of miR-21 and FoxO1 modulates growth of pancreatic ductal adenocarcinoma","volume":"36","author":"Li","year":"2015","journal-title":"Tumour Biol"},{"key":"47","doi-asserted-by":"crossref","first-page":"10081","DOI":"10.1038\/srep10081","article-title":"FoxO1-negative cells are cancer stem-like cells in pancreatic ductal adenocarcinoma","volume":"5","author":"Wang","year":"2015","journal-title":"Scientific reports"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T14:37:25Z","timestamp":1589294245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":47,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2016,11,8]]}},"alternative-id":["12248","27705906"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.12248","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]}}}