{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:20:19Z","timestamp":1768641619457,"version":"3.49.0"},"reference-count":47,"publisher":"Impact Journals, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,2,14]]},"DOI":"10.18632\/oncotarget.12565","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T02:27:03Z","timestamp":1476239223000},"page":"12364-12373","source":"Crossref","is-referenced-by-count":13,"title":["Aging, obesity, and post-therapy cognitive recovery in breast cancer survivors"],"prefix":"10.18632","volume":"8","author":[{"given":"Zhezhou","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Elderly Health, Division of Noncommunicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cancer Control and Prevention, Division of Noncommunicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Noncommunicable Disease Surveillance, Division of Noncommunicable Disease and Injury, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ou","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Mandilaras, Wan-Chow-Wah, Monette, Gaba, Monette, Alfonso. The impact of cancer therapy on cognition in the elderly. Front Pharmacol. 2013 [cited 2015 May 5]; 4. doi: 10.3389\/fphar.2013.00048.","DOI":"10.3389\/fphar.2013.00048"},{"key":"2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1007\/s11912-013-0307-7","article-title":"Clearing the air: a review of our current understanding of \u201cchemo fog.\u201d","volume":"15","author":"Collins","year":"2013","journal-title":"Curr Oncol Rep"},{"key":"3","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fonc.2015.00059","article-title":"A meta-analysis of cognitive impairment and decline associated with adjuvant chemotherapy in women with breast cancer","volume":"5","author":"Shum","year":"2015","journal-title":"Neuro-Oncol"},{"key":"4","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10549-014-3044-1","article-title":"Long-term cognitive function change among breast cancer survivors","volume":"146","author":"Dai","year":"2014","journal-title":"Breast Cancer Res Treat"},{"key":"5","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.critrevonc.2013.04.002","article-title":"Late effects of adjuvant chemotherapy for adult onset non-CNS cancer; cognitive impairment, brain structure and risk of dementia","volume":"88","author":"Schagen","year":"2013","journal-title":"Crit Rev Oncol Hematol"},{"key":"6","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.cger.2013.07.002","article-title":"Normal Cognitive Aging","volume":"29","author":"Triebel","year":"2013","journal-title":"Clin Geriatr Med"},{"key":"7","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.orcp.2014.05.001","article-title":"Examining the relationship between obesity and cognitive function: A systematic literature review","volume":"9","author":"Stolwyk","year":"2015","journal-title":"Obes Res Clin Pract"},{"key":"8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1365-2796.2010.02281.x","article-title":"Physical activity and risk of cognitive decline: a meta-analysis of prospective studies","volume":"269","author":"Macchi","year":"2011","journal-title":"J Intern Med"},{"key":"9","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1017\/S0007114514002207","article-title":"The association between obesity and fluid intelligence impairment is mediated by chronic low-grade inflammation","volume":"112","author":"Margioris","year":"2014","journal-title":"Br J Nutr"},{"key":"10","first-page":"3645","article-title":"Association of cognitive performance with the physical activity and body mass index in middle-aged and older rural inhabitants","volume":"18","author":"Suwalska","year":"2014","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1196\/annals.1440.009","article-title":"Cognitive neuroscience of aging","volume":"1124","author":"Grady","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"12","doi-asserted-by":"crossref","DOI":"10.1201\/9781420005523","volume-title":"Brain Aging: Models, Methods, and Mechanisms","author":"Riddle","year":"2007"},{"key":"13","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature08983","article-title":"Neural mechanisms of ageing and cognitive decline","volume":"464","author":"Yankner","year":"2010","journal-title":"Nature"},{"key":"14","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11065-014-9268-3","article-title":"Structural imaging measures of brain aging","volume":"24","author":"DeCarli","year":"2014","journal-title":"Neuropsychol Rev"},{"key":"15","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1016\/j.neuropsychologia.2007.11.030","article-title":"Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies","volume":"46","author":"Sperling","year":"2008","journal-title":"Neuropsychologia"},{"key":"16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/ana.20163","article-title":"Medial temporal lobe function and structure in mild cognitive impairment","volume":"56","author":"Sperling","year":"2004","journal-title":"Ann Neurol"},{"key":"17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jgo.2016.04.008","article-title":"Chemotherapy-related cognitive impairment in older patients with cancer","volume":"7","author":"Ahles","year":"2016","journal-title":"J Geriatr Oncol"},{"key":"18","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1200\/JCO.2012.43.0116","article-title":"Cancer- and Cancer Treatment-Associated Cognitive Change: An Update on the State of the Science","volume":"30","author":"Ryan","year":"2012","journal-title":"J Clin Oncol"},{"key":"19","unstructured":"Dahl. Body mass index, cognitive ability, and dementia: prospective associations and methodological issues in late life. J\u00f6nk\u00f6ping: Intellecta infolog. 2009. [cited 2015 Feb 10]. Available from http:\/\/hj.diva-portal.org\/smash\/get\/diva2:233987\/FULLTEXT01.pdf."},{"key":"20","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/WAD.0b013e3181a6bf3f","article-title":"Body nass index and cognitive decline in mild cognitive impairment","volume":"24","author":"Burns","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"21","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.bbr.2014.10.010","article-title":"Brain structure and cognitive correlates of body mass index in healthy older adults","volume":"278C","author":"Paul","year":"2014","journal-title":"Behav Brain Res"},{"key":"22","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s11682-013-9230-7","article-title":"Impact of body mass index on neuronal fiber bundle lengths among healthy older adults","volume":"7","author":"Paul","year":"2013","journal-title":"Brain Imaging Behav"},{"issue":"Suppl 1","key":"23","doi-asserted-by":"publisher","first-page":"S194","DOI":"10.1016\/j.neurobiolaging.2014.05.036","article-title":"Physical activity, body mass index, and brain atrophy in Alzheimer's disease","volume":"36","author":"Thompson","year":"2015","journal-title":"Neurobiol Aging"},{"key":"24","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1002\/oby.20815","article-title":"White matter integrity in older females is altered by increased body fat","volume":"22","author":"Walther","year":"2014","journal-title":"Obes Silver Spring Md"},{"key":"25","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1001\/archneur.62.10.1545","article-title":"Central obesity and the aging brain","volume":"62","author":"Haan","year":"2005","journal-title":"Arch Neurol"},{"key":"26","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1532-5415.2010.03219.x","article-title":"Women's Health Initiative Memory Study. Interaction between body mass index and central adiposity and risk of incident cognitive impairment and dementia: results from the Women's Health Initiative Memory Study","volume":"59","author":"Espeland","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3349\/ymj.2015.56.1.89","article-title":"Insulin Resistance Is an Important Risk Factor for Cognitive Impairment in Elderly Patients with Primary Hypertension","volume":"56","author":"Li","year":"2015","journal-title":"Yonsei Med J"},{"key":"28","doi-asserted-by":"publisher","first-page":"R125","DOI":"10.1530\/ERC-14-0580","article-title":"Body fatness as a cause of cancer: epidemiologic clues to biologic mechanisms","volume":"22","author":"Sedjo","year":"2015","journal-title":"Endocr Relat Cancer"},{"key":"29","doi-asserted-by":"publisher","first-page":"5023","DOI":"10.18632\/oncotarget.6517","article-title":"Association of cancer mortality with postdiagnosis overweight and obesity using body mass index","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"30","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11912-016-0539-4","article-title":"The Obesity Paradox in Cancer: a Review","volume":"18","author":"Renehan","year":"2016","journal-title":"Curr Oncol Rep"},{"key":"31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ejca.2014.12.017","article-title":"Systematic review of pharmacologic and non-pharmacologic interventions to manage cognitive alterations after chemotherapy for breast cancer","volume":"51","author":"Chan","year":"1990","journal-title":"Eur J Cancer Oxf Engl"},{"key":"32","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s12529-010-9079-8","article-title":"Effects of a Weight Loss Intervention on Body Mass, Fitness, and Inflammatory Biomarkers in Overweight or Obese Breast Cancer Survivors","volume":"18","author":"Mills","year":"2011","journal-title":"Int J Behav Med"},{"key":"33","article-title":"Objectively measured physical activity and cognitive functioning in breast cancer survivors","author":"Hartman","year":"2014","journal-title":"J Cancer Surviv Res Pract"},{"key":"34","doi-asserted-by":"crossref","unstructured":"Potential factors associated with perceived cognitive impairment in breast cancer survivors - Springer. [cited 2015 May 11]; . doi: 10.1007\/s00520-015-2708-7.","DOI":"10.1007\/s00520-015-2708-7"},{"key":"35","doi-asserted-by":"publisher","first-page":"E31","DOI":"10.1188\/12.ONF.E31-E40","article-title":"Chemotherapy-related cognitive impairment: the breast cancer experience","volume":"39","author":"Myers","year":"2012","journal-title":"Oncol Nurs Forum"},{"key":"36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2147\/CIA.S39506","article-title":"Physical exercise and cognitive performance in the elderly: current perspectives","volume":"9","author":"McGough","year":"2013","journal-title":"Clin Interv Aging"},{"key":"37","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1001\/jama.2009.1783","article-title":"Soy Food Intake and Breast Cancer Survival","volume":"302","author":"Lu","year":"2009","journal-title":"JAMA J Am Med Assoc"},{"key":"38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/13854049508401598","article-title":"Neuropsychological assessment of chinese elderly in the Shanghai dementia survey","volume":"9","author":"Yu","year":"1995","journal-title":"Clin Neuropsychol"},{"key":"39","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1017\/S135561779956606X","article-title":"Performance of 7- to 95-year-old individuals in a Chinese version of the category fluency test","volume":"5","author":"Poon","year":"1999","journal-title":"J Int Neuropsychol Soc JINS"},{"key":"40","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1076\/1380-3395(200008)22:4;1-0;FT465","article-title":"Stroop interference in Chinese and English","volume":"22","author":"Chan","year":"2000","journal-title":"J Clin Exp Neuropsychol"},{"issue":"Suppl","key":"41","first-page":"1","article-title":"Department of Disease Control Ministry of Health, PR China. The guidelines for prevention and control of overweight and obesity in Chinese adults","volume":"17","author":"Lu","year":"2004","journal-title":"Biomed Environ Sci BES"},{"key":"42","unstructured":"World Health Organization. Waist circumference and waist-hip ratio. Geneva. 2011. [cited 2015 May 13]. Available from http:\/\/www.who.int\/nutrition\/publications\/obesity\/WHO_report_waistcircumference_and_waisthip_ratio\/en\/."},{"key":"43","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1249\/00005768-199301000-00011","article-title":"Compendium of physical activities: classification of energy costs of human physical activities","volume":"25","author":"Paffenbarger","year":"1993","journal-title":"Med Sci Sports Exerc"},{"key":"44","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1249\/MSS.0b013e31821ece12","article-title":"Compendium of Physical Activities: a second update of codes and MET values","volume":"43","author":"Leon","year":"2011","journal-title":"Med Sci Sports Exerc"},{"key":"45","unstructured":"World Health Organization. Global Recommendations on Physical Activity for Health. 2010. [cited 2015 May 13]; p. 58. p. Available from http:\/\/www.who.int\/dietphysicalactivity\/publications\/9789241599979\/en\/."},{"key":"46","volume-title":"Statistical Power Analysis for the Behavioral Sciences (2nd Edition)","author":"Cohen","year":"1988"},{"key":"47","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/1477-7525-4-70","article-title":"Responsiveness and minimal important differences for patient reported outcomes","volume":"4","author":"Aaronson","year":"2006","journal-title":"Health Qual Life Outcomes"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T16:06:31Z","timestamp":1589126791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,11]]},"references-count":47,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,2,14]]}},"alternative-id":["12565","27738306"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.12565","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,11]]}}}