{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:18:18Z","timestamp":1789435098091,"version":"build-2803163510"},"reference-count":49,"publisher":"Impact Journals, LLC","issue":"47","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,11,22]]},"DOI":"10.18632\/oncotarget.12717","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T17:06:07Z","timestamp":1476810367000},"page":"77516-77531","source":"Crossref","is-referenced-by-count":13,"title":["Protein phosphatase Mg2+\/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals"],"prefix":"10.18632","volume":"7","author":[{"given":"Shih-Hsin","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Breast Medical Center, Taipei Medical University Hospital, Taipei, Taiwan"},{"name":"Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"School of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan"},{"name":"Breast Center, Cathay General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Sheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan"},{"name":"Department of Medicine, Mackay Medical College, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Wen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hsi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsiung","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Surgery, En Chu Kong Hospital, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ching","family":"Chen","sequence":"additional","affiliation":[{"name":"Breast Medical Center, Taipei Medical University Hospital, Taipei, Taiwan"},{"name":"Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Soon","family":"Ho","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei, Taiwan"},{"name":"Comprehensive Cancer Center of Taipei Medical University, Taipei, Taiwan"},{"name":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,10,18]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10549-010-1248-6","article-title":"Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features","volume":"129","author":"Huebner","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s10549-007-9621-9","article-title":"Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years","volume":"109","author":"Breast Cancer Family R, Kathleen Cuningham Consortium for Research into Familial Breast C, Ontario Cancer Genetics N","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/carcin\/bgq017","article-title":"Mutagen sensitivity, tobacco smoking and breast cancer risk: a case-control study","volume":"31","author":"Zheng","year":"2010","journal-title":"Carcinogenesis"},{"key":"4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1023\/A:1014422101452","article-title":"Normal breast epithelial cells induce p53-dependent apoptosis and p53-independent cell cycle arrest of breast cancer cells","volume":"71","author":"Le Bourhis","year":"2002","journal-title":"Breast Cancer Res Treat"},{"key":"5","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/carcin\/bgi330","article-title":"Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study","volume":"27","author":"Keku","year":"2006","journal-title":"Carcinogenesis"},{"key":"6","first-page":"953","article-title":"Cigarette smoking and the risk of breast cancer in women: a review of the literature","volume":"11","author":"Rohan","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"7","first-page":"1987","article-title":"Prevalence and spectrum of p53 mutations associated with smoking in breast cancer","volume":"62","author":"Newman","year":"2002","journal-title":"Cancer Res"},{"key":"8","first-page":"255","article-title":"Cigarette smoking and other risk factors in relation to p53 expression in breast cancer among young women","volume":"8","author":"Thompson","year":"1999","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1196\/annals.1397.006","article-title":"Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells","volume":"1095","author":"Ranftler","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"10","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1349-7006.2002.tb01331.x","article-title":"Estradiol stabilizes p53 protein in breast cancer cell line, MCF-7","volume":"93","author":"Nakashima","year":"2002","journal-title":"Jpn J Cancer Res"},{"key":"11","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1093\/emboj\/16.13.4117","article-title":"Participation of the human p53 3\u2032UTR in translational repression and activation following gamma-irradiation","volume":"16","author":"Benchimol","year":"1997","journal-title":"EMBO J"},{"key":"12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/387299a0","article-title":"Regulation of p53 stability by Mdm2","volume":"387","author":"Vousden","year":"1997","journal-title":"Nature"},{"key":"13","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1021\/mp300543t","article-title":"Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2","volume":"10","author":"Lim","year":"2013","journal-title":"Mol Pharm"},{"key":"14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1158\/1535-7163.MCT-15-0651","article-title":"Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1\/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner","volume":"15","author":"Lunec","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"15","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1038\/onc.2009.71","article-title":"Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2","volume":"28","author":"Fersht","year":"2009","journal-title":"Oncogene"},{"key":"16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1042\/bj3420133","article-title":"Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers","volume":"342","author":"Hupp","year":"1999","journal-title":"Biochem J"},{"key":"17","doi-asserted-by":"crossref","first-page":"13777","DOI":"10.1073\/pnas.96.24.13777","article-title":"Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage","volume":"96","author":"Halazonetis","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"18","doi-asserted-by":"crossref","first-page":"9391","DOI":"10.1128\/MCB.20.24.9391-9398.2000","article-title":"Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination","volume":"20","author":"Mukhopadhyay","year":"2000","journal-title":"Mol Cell Biol"},{"key":"19","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/jn\/134.10.2705","article-title":"Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteins","volume":"134","author":"Wang","year":"2004","journal-title":"J Nutr"},{"key":"20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/jn\/136.1.106","article-title":"Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets","volume":"136","author":"Wang","year":"2006","journal-title":"J Nutr"},{"key":"21","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/jnci\/djq300","article-title":"Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells","volume":"102","author":"Ho","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"22","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/jnci\/djq314","article-title":"From nicotine to breast cancer, implications of cholinergic receptor pathway","volume":"102","author":"Linnoila","year":"2010","journal-title":"J Natl Cancer Inst"},{"key":"23","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.4161\/cc.29421","article-title":"POPX2 phosphatase regulates cell polarity and centrosome placement","volume":"13","author":"Koh","year":"2014","journal-title":"Cell Cycle"},{"key":"24","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1021\/pr301113c","article-title":"Integrative transcriptome and proteome study to identify the signaling network regulated by POPX2 phosphatase","volume":"12","author":"Koh","year":"2013","journal-title":"J Proteome Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"e109508","DOI":"10.1371\/journal.pone.0109508","article-title":"Overexpression of microRNA-200c predicts poor outcome in patients with PR-negative breast cancer","volume":"9","author":"Mannermaa","year":"2014","journal-title":"PLoS One"},{"key":"26","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1128\/MCB.06212-11","article-title":"MicroRNA-200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPM1F","volume":"32","author":"Sahin","year":"2012","journal-title":"Mol Cell Biol"},{"key":"27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4161\/cc.9.1.10406","article-title":"The POPX2 phosphatase regulates cancer cell motility and invasiveness","volume":"9","author":"Koh","year":"2010","journal-title":"Cell Cycle"},{"key":"28","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1002\/pmic.201100044","article-title":"Investigation of POPX2 phosphatase functions by comparative phosphoproteomic analysis","volume":"11","author":"Koh","year":"2011","journal-title":"Proteomics"},{"key":"29","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10549-010-1209-0","article-title":"Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells","volume":"129","author":"Ho","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"30","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1245\/s10434-011-1598-2","article-title":"Nicotine promotes cell migration through alpha7 nicotinic acetylcholine receptor in gastric cancer cells","volume":"18","author":"Chang","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"31","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1245\/s10434-010-1504-3","article-title":"Nicotine enhances colon cancer cell migration by induction of fibronectin","volume":"18","author":"Chang","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/toxsci\/kfn086","article-title":"Rapid activation of Stat3 and ERK1\/2 by nicotine modulates cell proliferation in human bladder cancer cells","volume":"104","author":"Wang","year":"2008","journal-title":"Toxicol Sci"},{"key":"33","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1158\/1078-0432.CCR-10-2434","article-title":"Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy","volume":"17","author":"Ho","year":"2011","journal-title":"Clin Cancer Res"},{"key":"34","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1021\/acs.jafc.6b00624","article-title":"Pu-erh Tea Extract Attenuates Nicotine-Induced Foam Cell Formation in Primary Cultured Monocytes: AnMechanistic Study","volume":"64","author":"Ho","year":"2016","journal-title":"J Agric Food Chem"},{"key":"35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/mnfr.201000254","article-title":"Tea polyphenol (\u2212)-epigallocatechin-3-gallate inhibits nicotine- and estrogen-induced alpha9-nicotinic acetylcholine receptor upregulation in human breast cancer cells","volume":"55","author":"Ho","year":"2011","journal-title":"Mol Nutr Food Res"},{"key":"36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10549-010-0821-3","article-title":"Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins","volume":"125","author":"Ho","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1021\/jf9031684","article-title":"Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors","volume":"58","author":"Ho","year":"2010","journal-title":"J Agric Food Chem"},{"key":"38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/mc.20365","article-title":"Polymorphisms in drug metabolism genes, smoking, and p53 mutations in breast cancer","volume":"47","author":"Sawyer","year":"2008","journal-title":"Mol Carcinog"},{"key":"39","first-page":"435","article-title":"p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment","volume":"104","author":"Harris","year":"1996","journal-title":"Environ Health Perspect"},{"key":"40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-4274(95)03643-1","article-title":"Deichmann Lecture--p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment","author":"Harris","year":"1995","journal-title":"Toxicol Lett"},{"key":"41","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ijc.2910570410","article-title":"Association among p53 gene mutation, nuclear accumulation of the p53 protein and aggressive phenotypes in breast cancer","volume":"57","author":"Hirohashi","year":"1994","journal-title":"Int J Cancer"},{"key":"42","first-page":"967","article-title":"Isolation of two human tumor epithelial cell lines from solid breast carcinomas","volume":"61","author":"Redfield","year":"1978","journal-title":"J Natl Cancer Inst"},{"key":"43","first-page":"5251","article-title":"Neu differentiation factor (heregulin) induces expression of intercellular adhesion molecule 1: implications for mammary tumors","volume":"53","author":"Lupu","year":"1993","journal-title":"Cancer Res"},{"key":"44","doi-asserted-by":"crossref","unstructured":"Cailleau, Olive, Cruciger. Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. In Vitro. 1978; 14:911\u2013915.","DOI":"10.1007\/BF02616120"},{"key":"45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/jnci\/56.2.279","article-title":"Reexpression of the original tumor pattern by a human breast carcinoma cell line (MCF-7) in sponge culture","volume":"56","author":"Rich","year":"1976","journal-title":"J Natl Cancer Inst"},{"key":"46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jnci\/53.3.661","article-title":"Breast tumor cell lines from pleural effusions","volume":"53","author":"Reeves","year":"1974","journal-title":"J Natl Cancer Inst"},{"key":"47","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.fct.2007.01.012","article-title":"Tubulozole-induced G2\/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1\/2 and Chk1 kinase activation","volume":"45","author":"Wu","year":"2007","journal-title":"Food Chem Toxicol"},{"key":"48","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s10549-012-1986-8","article-title":"Human breast cancer cell metastasis is attenuated by lysyl oxidase inhibitors through down-regulation of focal adhesion kinase and the paxillin-signaling pathway","volume":"134","author":"Ho","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"49","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/S0006-3495(01)75886-9","article-title":"Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes","volume":"81","author":"Liu","year":"2001","journal-title":"Biophys J"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T12:27:25Z","timestamp":1596716845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,18]]},"references-count":49,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2016,11,22]]}},"alternative-id":["12717","27769050"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.12717","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,18]]}}}