{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:40:13Z","timestamp":1792183213929,"version":"4.4.0"},"reference-count":35,"publisher":"Impact Journals, LLC","issue":"48","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,11,29]]},"DOI":"10.18632\/oncotarget.12819","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T11:30:26Z","timestamp":1477135826000},"page":"79515-79525","source":"Crossref","is-referenced-by-count":59,"title":["Deubiquitinase USP9X deubiquitinates \u03b2-catenin and promotes high grade glioma cell growth"],"prefix":"10.18632","volume":"7","author":[{"given":"Bo","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"},{"name":"Department of Oncology, Wuhan General Hospital of Guangzhou Command PLA, Wuchang District, Wuhan, 430070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"},{"name":"Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghua","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"},{"name":"Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuchang District, Wuhan, 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,10,22]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.cancergen.2012.10.009","article-title":"Genetics of adult glioma","volume":"205","author":"Jenkins","year":"2012","journal-title":"Cancer Genet"},{"key":"2","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Kleihues","year":"2007","journal-title":"Acta Neuropathol"},{"key":"3","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1111\/j.1349-7006.2011.02064.x","article-title":"Targeting glioma stem cells: a novel framework for brain tumors","volume":"102","author":"Germano","year":"2011","journal-title":"Cancer Sci"},{"key":"4","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1038\/onc.2011.398","article-title":"Standard of care therapy for malignant glioma and its effect on tumor and stromal cells","volume":"31","author":"Holland","year":"2012","journal-title":"Oncogene"},{"issue":"Suppl 2","key":"5","doi-asserted-by":"publisher","first-page":"ii1","DOI":"10.1093\/neuonc\/not151","article-title":"CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010","volume":"15","author":"Barnholtz-Sloan","year":"2013","journal-title":"Neuro Oncol"},{"key":"6","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00432-003-0431-0","article-title":"The Wnt signaling pathway and its role in tumor development","volume":"129","author":"Behrens","year":"2003","journal-title":"J Cancer Res Clin Oncol"},{"key":"7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"He","year":"2009","journal-title":"Dev Cell"},{"key":"8","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","article-title":"Wnt signaling and cancer","volume":"14","author":"Polakis","year":"2000","journal-title":"Genes Dev"},{"key":"9","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4161\/org.4.2.5851","article-title":"Wnt signal transduction pathways","volume":"4","author":"Habas","year":"2008","journal-title":"Organogenesis"},{"key":"10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1083\/jcb.200701083","article-title":"Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity","volume":"178","author":"Hall","year":"2007","journal-title":"J Cell Biol"},{"key":"11","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/S0002-9440(10)62550-3","article-title":"Role of beta-catenin\/T-cell factor-regulated genes in ovarian endometrioid adenocarcinomas","volume":"160","author":"Cho","year":"2002","journal-title":"Am J Pathol"},{"key":"12","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1007\/s12032-010-9476-5","article-title":"beta-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells","volume":"28","author":"Ling","year":"2011","journal-title":"Med Oncol"},{"key":"13","doi-asserted-by":"publisher","first-page":"753","DOI":"10.4161\/cbt.11.8.14894","article-title":"beta-catenin and Gli1 are prognostic markers in glioblastoma","volume":"11","author":"Bakker","year":"2011","journal-title":"Cancer Biol Ther"},{"key":"14","doi-asserted-by":"publisher","first-page":"3797","DOI":"10.1093\/emboj\/16.13.3797","article-title":"beta-catenin is a target for the ubiquitin-proteasome pathway","volume":"16","author":"Kemler","year":"1997","journal-title":"EMBO J"},{"key":"15","doi-asserted-by":"publisher","first-page":"24735","DOI":"10.1074\/jbc.272.40.24735","article-title":"Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin","volume":"272","author":"Byers","year":"1997","journal-title":"J Biol Chem"},{"key":"16","doi-asserted-by":"publisher","first-page":"18666","DOI":"10.1073\/pnas.1105725108","article-title":"alpha-Synuclein fate is determined by USP9X-regulated monoubiquitination","volume":"108","author":"Engelender","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"17","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1046\/j.1365-2443.1999.00297.x","article-title":"The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin","volume":"4","author":"Kaibuchi","year":"1999","journal-title":"Genes Cells"},{"key":"18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature08646","article-title":"Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival","volume":"463","author":"Huang","year":"2010","journal-title":"Nature"},{"key":"19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ccr.2006.03.019","article-title":"High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients","volume":"9","author":"Hanamura","year":"2006","journal-title":"Cancer Cell"},{"key":"20","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1056\/NEJMoa055351","article-title":"A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling","volume":"354","author":"Harder","year":"2006","journal-title":"N Engl J Med"},{"key":"21","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nature11114","article-title":"The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma","volume":"486","author":"Stemple","year":"2012","journal-title":"Nature"},{"key":"22","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1097\/00006123-199710000-00027","article-title":"Antiproliferative effect of c-myc antisense phosphorothioate oligodeoxynucleotides in malignant glioma cells","volume":"41","author":"Fillmore","year":"1997","journal-title":"Neurosurgery"},{"key":"23","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Yamanaka","year":"2006","journal-title":"Cell"},{"key":"24","doi-asserted-by":"publisher","first-page":"e3769","DOI":"10.1371\/journal.pone.0003769","article-title":"c-Myc is required for maintenance of glioma cancer stem cells","volume":"3","author":"Rich","year":"2008","journal-title":"PLoS One"},{"key":"25","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","article-title":"Identification of c-MYC as a target of the APC pathway","volume":"281","author":"Kinzler","year":"1998","journal-title":"Science"},{"key":"26","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/(SICI)1096-9896(199907)188:3<289::AID-PATH351>3.0.CO;2-X","article-title":"Cyclin D1 expression in astrocytomas is associated with cell proliferation activity and patient prognosis","volume":"188","author":"Haapasalo","year":"1999","journal-title":"J Pathol"},{"key":"27","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/18884","article-title":"Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells","volume":"398","author":"McCormick","year":"1999","journal-title":"Nature"},{"key":"28","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1007\/s12032-009-9320-y","article-title":"A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastoma","volume":"27","author":"Zhu","year":"2010","journal-title":"Med Oncol"},{"key":"29","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1182\/blood-2010-03-276477","article-title":"Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis","volume":"117","author":"Donato","year":"2011","journal-title":"Blood"},{"key":"30","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1593\/neo.12598","article-title":"Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1","volume":"14","author":"Rudner","year":"2012","journal-title":"Neoplasia"},{"key":"31","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1007\/s11064-008-9906-3","article-title":"Wnt\/beta-catenin\/Tcf signaling pathway activation in malignant progression of rat gliomas induced by transplacental N-ethyl-N-nitrosourea exposure","volume":"34","author":"Babu","year":"2009","journal-title":"Neurochem Res"},{"key":"32","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.neuint.2009.03.016","article-title":"Activation of Wnt\/beta-catenin\/Tcf signaling pathway in human astrocytomas","volume":"55","author":"Babu","year":"2009","journal-title":"Neurochem Int"},{"key":"33","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Weinberg","year":"2000","journal-title":"Cell"},{"key":"34","doi-asserted-by":"publisher","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","article-title":"Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis","volume":"273","author":"Porter","year":"1998","journal-title":"J Biol Chem"},{"key":"35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev.biochem.73.011303.073706","article-title":"Cytochrome C-mediated apoptosis","volume":"73","author":"Wang","year":"2004","journal-title":"Annu Rev Biochem"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T14:44:34Z","timestamp":1589294674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.12819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,22]]},"references-count":35,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2016,11,29]]}},"alternative-id":["12819","27783990"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.12819","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,22]]}}}