{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T05:11:18Z","timestamp":1791436278065,"version":"4.3.3"},"reference-count":39,"publisher":"Impact Journals, LLC","issue":"50","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,12,13]]},"DOI":"10.18632\/oncotarget.13090","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T15:42:25Z","timestamp":1478274145000},"page":"83330-83341","source":"Crossref","is-referenced-by-count":27,"title":["Altered expression of miRNAs and methylation of their promoters are correlated in neuroblastoma"],"prefix":"10.18632","volume":"7","author":[{"given":"Marco","family":"Maugeri","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Biotecnologiche, Sezione di Biologia e Genetica G Sichel, Unit\u00e0 di BioMedicina Molecolare, Genomica e dei Sistemi Complessi, Universit\u00e0 di Catania, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Barbagallo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Biotecnologiche, Sezione di Biologia e Genetica G Sichel, Unit\u00e0 di BioMedicina Molecolare, Genomica e dei Sistemi Complessi, Universit\u00e0 di Catania, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Barbagallo","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Biotecnologiche, Sezione di Biologia e Genetica G Sichel, Unit\u00e0 di BioMedicina Molecolare, Genomica e dei Sistemi Complessi, Universit\u00e0 di Catania, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Banelli","sequence":"additional","affiliation":[{"name":"UOS Epigenetica dei Tumori, IRCCS A.O.U. San Martino-IST, Genova, Italy, EU"},{"name":"Department of HealthSciences, University of Genova, Genova, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Dipartimento di Biomedicina Clinica e Molecolare, Universit\u00e0 di Catania, Ospedale Garibaldi, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Purrello","sequence":"additional","affiliation":[{"name":"Dipartimento di Biomedicina Clinica e Molecolare, Universit\u00e0 di Catania, Ospedale Garibaldi, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Magro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Chirurgiche e Tecnologie Avanzate G.F. Ingrassia, Universit\u00e0 di Catania, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ragusa","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Biotecnologiche, Sezione di Biologia e Genetica G Sichel, Unit\u00e0 di BioMedicina Molecolare, Genomica e dei Sistemi Complessi, Universit\u00e0 di Catania, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Biotecnologiche, Sezione di Biologia e Genetica G Sichel, Unit\u00e0 di BioMedicina Molecolare, Genomica e dei Sistemi Complessi, Universit\u00e0 di Catania, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Romani","sequence":"additional","affiliation":[{"name":"UOS Epigenetica dei Tumori, IRCCS A.O.U. San Martino-IST, Genova, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Purrello","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche e Biotecnologiche, Sezione di Biologia e Genetica G Sichel, Unit\u00e0 di BioMedicina Molecolare, Genomica e dei Sistemi Complessi, Universit\u00e0 di Catania, Catania, Italy, EU"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"1","first-page":"659","article-title":"A developmental model of neuroblastoma: differentiating stroma-poor tumors' progress along an extra-adrenal chromaffin lineage","volume":"75","author":"P\u00e5hlman","year":"1996","journal-title":"Lab Invest"},{"key":"2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1200\/JCO.2008.16.6785","article-title":"The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report","volume":"27","author":"Garaventa","year":"2009","journal-title":"J Clin Oncol"},{"key":"3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrc1014","article-title":"Neuroblastoma: biological insights into a clinical enigma","volume":"3","author":"Brodeur","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"4","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/sj.onc.1201673","article-title":"Genomics and transcription analysis of human TFIID","volume":"16","author":"Roeder","year":"1998","journal-title":"Oncogene"},{"key":"5","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2174\/138161209787315837","article-title":"MicroRNA involvement in the pathogenesis of neuroblastoma: potential for microRNA mediated therapeutics","volume":"15","author":"Stallings","year":"2009","journal-title":"Curr Pharm Des"},{"key":"6","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1007\/s00109-010-0643-0","article-title":"MIR152, MIR200B, and MIR338, human positional and functional neuroblastoma candidates, are involved in neuroblast differentiation and apoptosis","volume":"88","author":"Purrello","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-med-011514-023121","article-title":"Neuroblastoma: molecular pathogenesis and therapy","volume":"66","author":"Shohet","year":"2015","journal-title":"Annu Rev Med"},{"key":"8","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/nrg2634","article-title":"Causes and consequences of miRNA dysregulation in cancer","volume":"10","author":"Croce","year":"2009","journal-title":"Nat Rev Genet"},{"key":"9","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1152\/physrev.00006.2010","article-title":"MiRNAs in development and disease","volume":"91","author":"Abdellatif","year":"2011","journal-title":"Physiol Rev"},{"key":"10","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.18632\/oncotarget.1877","article-title":"Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another \u201cdouble hit\u201d lymphoma with very poor outcome?","volume":"5","author":"Gr\u00f8nb\u00e6k","year":"2014","journal-title":"Oncotarget"},{"key":"11","doi-asserted-by":"publisher","first-page":"35183","DOI":"10.18632\/oncotarget.5930","article-title":"Epigenetic silencing of miR-145-5p contributes to brain metastasis","volume":"6","author":"Segatto","year":"2015","journal-title":"Oncotarget"},{"key":"12","doi-asserted-by":"publisher","first-page":"7610","DOI":"10.18632\/oncotarget.2282","article-title":"Silencing of miRNA-148a by hypermethylation activates the integrin-mediated signaling pathway in nasopharyngeal carcinoma","volume":"5","author":"Chang","journal-title":"Oncotarget"},{"key":"13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4103\/1477-3163.115720","article-title":"Restoration of the methylation status of hypermethylated gene promoters by miRNA-29b in human breast cancer: A novel epigenetic therapeutic approach","volume":"12","author":"Lyn-Cook","year":"2013","journal-title":"J Carcinog"},{"key":"14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1523-5378.2010.00782.x","article-title":"Genetic and epigenetic alteration in gastric carcinogenesis","volume":"15","author":"Machado","year":"2010","journal-title":"Helicobacter"},{"key":"15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00383-012-3239-7","article-title":"The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis","volume":"29","author":"Bray","year":"2013","journal-title":"Pediatr Surg Int"},{"key":"16","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1517\/14656566.2013.794222","article-title":"5-Azacytidine for the treatment of myelodysplastic syndromes","volume":"14","author":"Giles","year":"2013","journal-title":"Expert Opin Pharmacother"},{"key":"17","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1038\/onc.2012.311","article-title":"Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs","volume":"32","author":"van Sluis","year":"2013","journal-title":"Oncogene"},{"key":"18","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/ijc.26254","article-title":"Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer","volume":"130","author":"Ohishi","year":"2012","journal-title":"Int J Cancer"},{"key":"19","doi-asserted-by":"publisher","first-page":"5204","DOI":"10.18632\/oncotarget.2477","article-title":"MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation","volume":"6","author":"Speleman","year":"2015","journal-title":"Oncotarget"},{"key":"20","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1158\/0008-5472.CAN-08-4517","article-title":"MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: potential implications for immune based therapy of human solid tumors","volume":"69","author":"Cheung","year":"2009","journal-title":"Cancer Res"},{"key":"21","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/gcc.22189","article-title":"Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis","volume":"53","author":"Cheung","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"key":"22","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.cell.2009.04.040","article-title":"SnapShot: MicroRNAs in Cancer","volume":"137","author":"Calin","year":"2009","journal-title":"Cell"},{"key":"23","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1479-5876-12-52","article-title":"Epigenetic inactivation of mir-34b\/c in addition to mir-34a and DAPK1 in chronic lymphocytic leukemia","volume":"12","author":"Chim","year":"2014","journal-title":"J Transl Med"},{"key":"24","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1158\/1541-7786.MCR-07-2102","article-title":"A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene","volume":"6","author":"Maris","year":"2008","journal-title":"Mol Cancer Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1038\/sj.onc.1210293","article-title":"MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells","volume":"26","author":"Stallings","year":"2007","journal-title":"Oncogene"},{"key":"26","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1093\/nar\/gkq342","article-title":"Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma","volume":"38","author":"Schramm","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1093\/abbs\/gmt124","article-title":"MiR-181c-5p modulates the proliferation, migration, and invasion of neuroblastoma cells by targeting Smad7","volume":"46","author":"Yue","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"28","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/carcin\/bgq013","article-title":"Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis","volume":"31","author":"Yuasa","year":"2010","journal-title":"Carcinogenesis"},{"key":"29","first-page":"1661","article-title":"Restoration of miR-517a-3p expression induces cell apoptosis in bladder cancer cell lines","volume":"25","author":"Nakagawa","year":"2011","journal-title":"Oncol Rep"},{"key":"30","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.3892\/ol.2016.4269","article-title":"miR-517a is an independent prognostic marker and contributes to cell migration and invasion in human colorectal cancer","volume":"11","author":"Zhou","year":"2016","journal-title":"Oncol Lett"},{"key":"31","first-page":"1661","article-title":"Restoration of miR-517a expression induces cell apoptosis in bladder cancer cell lines","volume":"25","author":"Nakagawa","year":"2011","journal-title":"Oncol Rep"},{"key":"32","doi-asserted-by":"publisher","first-page":"132","DOI":"10.18632\/oncoscience.19","article-title":"Highly skewed distribution of miRNAs and proteins between colorectal cancer cells and their exosomes following Cetuximab treatment: biomolecular, genetic and translational implications","volume":"1","author":"Di Pietro","year":"2014","journal-title":"Oncoscience"},{"key":"33","first-page":"RESEARCH0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Speleman","year":"2002","journal-title":"Genome Biol"},{"key":"34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) Method","volume":"25","author":"Schmittgen","year":"2001","journal-title":"Methods"},{"key":"35","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ccell.2016.08.016","article-title":"Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome","volume":"30","author":"Jalink","year":"2016","journal-title":"Cancer Cell"},{"key":"36","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/ijc.24768","article-title":"Outcome prediction and risk assessment by quantitative pyrosequencing methylation analysis of the SFN gene in advanced stage, high-risk, neuroblastic tumor patients","volume":"126","author":"Romani","year":"2010","journal-title":"Int J Cancer"},{"key":"37","doi-asserted-by":"publisher","first-page":"4746","DOI":"10.18632\/oncotarget.6621","article-title":"Dysregulated miR-671-5p \/ CDR1-AS \/ CDR1 \/ VSNL1 axis is involved in glioblastoma multiforme","volume":"7","author":"Vasquez","year":"2016","journal-title":"Oncotarget"},{"key":"38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/bioinformatics\/btn501","article-title":"Integrating and Annotating the Interactome using the MiMI plugin for Cytoscape","volume":"25","author":"States","year":"2009","journal-title":"Bioinformatics"},{"key":"39","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Ideker","year":"2003","journal-title":"Genome Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.13090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T14:06:47Z","timestamp":1596722807000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.13090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,4]]},"references-count":39,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2016,12,13]]}},"alternative-id":["13090","27829219"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.13090","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,4]]}}}