{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:27:01Z","timestamp":1787023621878,"version":"build-2736575974"},"reference-count":29,"publisher":"Impact Journals, LLC","issue":"52","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2016,12,27]]},"DOI":"10.18632\/oncotarget.13379","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T13:30:28Z","timestamp":1479303028000},"page":"86266-86279","source":"Crossref","is-referenced-by-count":28,"title":["Assessment of differentially expressed plasma microRNAs in nonsyndromic cleft palate and nonsyndromic cleft lip with cleft palate"],"prefix":"10.18632","volume":"7","author":[{"given":"Jingyun","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijun","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,11,16]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1597\/10-178","article-title":"Genetics of nonsyndromic orofacial clefts","volume":"49","author":"Murray","year":"2012","journal-title":"Cleft Palate Craniofac J"},{"key":"2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<126::AID-AJMG2>3.0.CO;2-R","article-title":"Classification and birth prevalence of orofacial clefts","volume":"75","author":"Cervenka","year":"1998","journal-title":"Am J Med Genet"},{"key":"3","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3389\/fphys.2016.00067","article-title":"Epidemiology, Etiology, and Treatment of Isolated Cleft Palate","volume":"7","author":"Figueiredo","year":"2016","journal-title":"Front Physiol"},{"key":"4","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1136\/bmj.39458.563611.AE","article-title":"Familial risk of oral clefts by morphological type and severity: population based cohort study of first degree relatives","volume":"336","author":"Lie","year":"2008","journal-title":"BMJ"},{"key":"5","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/ajmg.c.31381","article-title":"Genetics of cleft lip and cleft palate","volume":"163C","author":"Marazita","year":"2013","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"6","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12881-016-0322-2","article-title":"Nonsynonymous variants in MYH9 and ABCA4 are the most frequent risk loci associated with nonsyndromic orofacial cleft in Taiwanese population","volume":"17","author":"Cheng","year":"2016","journal-title":"BMC Med Genet"},{"key":"7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/ng985","article-title":"Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes","volume":"32","author":"Lammer","year":"2002","journal-title":"Nat Genet"},{"key":"8","doi-asserted-by":"publisher","first-page":"272","DOI":"10.4103\/0971-6866.107973","article-title":"Small players with a big role: MicroRNAs in pathophysiology of cleft lip and palate","volume":"18","author":"Radhakrishna","year":"2012","journal-title":"Indian J Hum Genet"},{"key":"9","doi-asserted-by":"publisher","first-page":"e1003785","DOI":"10.1371\/journal.pgen.1003785","article-title":"MicroRNA-17-92, a direct Ap-2alpha transcriptional target, modulates T-box factor activity in orofacial clefting","volume":"9","author":"Martin","year":"2013","journal-title":"PLoS Genet"},{"key":"10","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/dgd.12140","article-title":"MicroRNA expression profiling of the developing murine upper lip","volume":"56","author":"Greene","year":"2014","journal-title":"Dev Growth Differ"},{"key":"11","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.biopha.2016.05.033","article-title":"Expression profile of plasma microRNAs in nonsyndromic cleft lip and their clinical significance as biomarkers","volume":"82","author":"Guo","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"12","doi-asserted-by":"publisher","first-page":"19030","DOI":"10.3390\/molecules201019030","article-title":"miRNA Stability in Frozen Plasma Samples","volume":"20","author":"Deiana","year":"2015","journal-title":"Molecules"},{"key":"13","doi-asserted-by":"publisher","first-page":"S397","DOI":"10.1245\/s10434-012-2600-3","article-title":"miRNA-199a-3p in plasma as a potential diagnostic biomarker for gastric cancer","volume":"20","author":"Zhu","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"14","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/ijc.27840","article-title":"Diagnostic and prognostic significance of miRNA signatures in tissues and plasma of endometrioid endometrial carcinoma patients","volume":"132","author":"Maciejewski","year":"2013","journal-title":"Int J Cancer"},{"key":"15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3233\/DMA-2011-0882","article-title":"Association between the miRNA signatures in plasma and bronchoalveolar fluid in respiratory pathologies","volume":"32","author":"Paz-Ares","year":"2012","journal-title":"Dis Markers"},{"key":"16","doi-asserted-by":"publisher","first-page":"26682","DOI":"10.1038\/srep26682","article-title":"Complementary Characteristics of Correlation Patterns in Morphometric Correlation Networks of Cortical Thickness, Surface Area, and Gray Matter Volume","volume":"6","author":"Lee","year":"2016","journal-title":"Sci Rep"},{"key":"17","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1093\/bioinformatics\/bti169","article-title":"Generalized Venn diagrams: a new method of visualizing complex genetic set relations","volume":"21","author":"Buchholz","year":"2005","journal-title":"Bioinformatics"},{"key":"18","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.ydbio.2014.12.006","article-title":"Tak1, Smad4 and Trim33 redundantly mediate TGF-beta3 signaling during palate development","volume":"398","author":"Kaartinen","year":"2015","journal-title":"Dev Biol"},{"key":"19","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3389\/fphys.2016.00378","article-title":"MORN5 Expression during Craniofacial Development and Its Interaction with the BMP and TGFbeta Pathways","volume":"7","author":"Buchtova","year":"2016","journal-title":"Front Physiol"},{"key":"20","doi-asserted-by":"publisher","first-page":"e0136951","DOI":"10.1371\/journal.pone.0136951","article-title":"Altered FGF Signaling Pathways Impair Cell Proliferation and Elevation of Palate Shelves","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"key":"21","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/ejhg.2008.250","article-title":"Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations","volume":"17","author":"Jee","year":"2009","journal-title":"Eur J Hum Genet"},{"key":"22","doi-asserted-by":"publisher","first-page":"4340","DOI":"10.1093\/hmg\/ddv167","article-title":"DLX4 is associated with orofacial clefting and abnormal jaw development","volume":"24","author":"Zhuan","year":"2015","journal-title":"Hum Mol Genet"},{"key":"23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.ydbio.2013.03.008","article-title":"Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression","volume":"377","author":"Epstein","year":"2013","journal-title":"Dev Biol"},{"key":"24","doi-asserted-by":"publisher","first-page":"2524","DOI":"10.1093\/hmg\/dds071","article-title":"Tbx1 regulates oral epithelial adhesion and palatal development","volume":"21","author":"Yanagisawa","year":"2012","journal-title":"Hum Mol Genet"},{"key":"25","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/ng.242","article-title":"Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip","volume":"40","author":"Lie","year":"2008","journal-title":"Nat Genet"},{"key":"26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/bdra.20747","article-title":"Fetal genetic risk of isolated cleft lip only versus isolated cleft lip and palate: a subphenotype analysis using two population-based studies of orofacial clefts in Scandinavia","volume":"91","author":"Murray","year":"2011","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta","volume":"25","author":"Schmittgen","year":"2001","journal-title":"C(T)) Method. Methods"},{"key":"28","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2307\/2340521","article-title":"On the interpretation of x(2) from contingency tables, and the calculation of P","volume":"85","author":"Fisher","year":"1922","journal-title":"Journal of the Royal Statistical Society"},{"key":"29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1467-9868.2004.00439.x","article-title":"Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach","volume":"66","author":"Siegmund","year":"2004","journal-title":"Journal of the Royal Statistical Society"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.13379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T12:47:13Z","timestamp":1589287633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.13379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,16]]},"references-count":29,"journal-issue":{"issue":"52","published-print":{"date-parts":[[2016,12,27]]}},"alternative-id":["13379","27863433"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.13379","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,16]]}}}