{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:29:31Z","timestamp":1790828971718,"version":"4.1.0"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"17","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,4,25]]},"DOI":"10.18632\/oncotarget.14083","type":"journal-article","created":{"date-parts":[[2016,12,22]],"date-time":"2016-12-22T16:29:38Z","timestamp":1482424178000},"page":"29370-29382","source":"Crossref","is-referenced-by-count":15,"title":["Changes of circulating Th22 cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection"],"prefix":"10.18632","volume":"8","author":[{"given":"Dawei","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Center of Community Health Service of Qingbo Street, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidong","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Hangzhou Children\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifen","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxia","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoliang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufa","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China"},{"name":"Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/1471-2458-6-180","article-title":"Sentinel surveillance for human enterovirus 71 in Sarawak, Malaysia: lessons from the first 7 years","volume":"6","author":"Arif","year":"2006","journal-title":"BMC public health"},{"issue":"12","key":"2","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/jmv.21006","article-title":"Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data","volume":"79","author":"Su","year":"2007","journal-title":"Journal of medical virology"},{"key":"3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/1471-2334-14-251","article-title":"Clinical and epidemiological characteristics of adult hand, foot, and mouth disease in northern Zhejiang, China, May 2008-November 2013","volume":"14","author":"Yu","year":"2014","journal-title":"BMC infectious diseases"},{"key":"4","first-page":"651872","article-title":"Increased frequency of circulating follicular helper T cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection","volume":"2014","author":"Yu","year":"2014","journal-title":"Journal of immunology research"},{"issue":"2","key":"5","doi-asserted-by":"crossref","first-page":"e1001958","DOI":"10.1371\/journal.pmed.1001958","article-title":"Hand, Foot, and Mouth Disease in China: Modeling Epidemic Dynamics of Enterovirus Serotypes and Implications for Vaccination","volume":"13","author":"Leung","year":"2016","journal-title":"PLoS medicine"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1086\/314032","article-title":"Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group","volume":"31","author":"Anderson","year":"2000","journal-title":"Clinical infectious diseases"},{"issue":"9","key":"7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1348-0421.2002.tb02743.x","article-title":"Outbreak of central nervous system disease associated with hand, foot, and mouth disease in Japan during the summer of 2000: detection and molecular epidemiology of enterovirus 71","volume":"46","author":"Nishio","year":"2002","journal-title":"Microbiology and immunology"},{"issue":"1","key":"8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3201\/eid1301.020112","article-title":"Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore","volume":"9","author":"Ling","year":"2003","journal-title":"Emerging infectious diseases"},{"issue":"4","key":"9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcv.2009.02.002","article-title":"An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China","volume":"44","author":"Wang","year":"2009","journal-title":"Journal of clinical virology"},{"issue":"7","key":"10","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1128\/JCM.02369-09","article-title":"Clinical and etiological characteristics of enterovirus 71-related diseases during a recent 2-year period in Korea","volume":"48","author":"Cheon","year":"2010","journal-title":"Journal of clinical microbiology"},{"issue":"13","key":"11","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group","volume":"341","author":"Shih","year":"1999","journal-title":"The New England journal of medicine"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1473-3099(13)70342-6","article-title":"Hand, foot, and mouth disease in China, 2008-12: an epidemiological study","volume":"14","author":"Farrar","year":"2014","journal-title":"The Lancet Infectious diseases"},{"issue":"4","key":"13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1086\/376998","article-title":"Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema","volume":"188","author":"Liu","year":"2003","journal-title":"The Journal of infectious diseases"},{"issue":"4","key":"14","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1203\/01.pdr.0000238247.86041.19","article-title":"Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71","volume":"60","author":"Huang","year":"2006","journal-title":"Pediatric research"},{"key":"15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.virusres.2013.11.021","article-title":"Peripheral T lymphocyte subset imbalances in children with enterovirus 71-induced hand, foot and mouth disease","volume":"180","author":"Chen","year":"2014","journal-title":"Virus research"},{"issue":"5","key":"16","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/jmv.23254","article-title":"Increased frequency of Th17 cells in the peripheral blood of children infected with enterovirus 71","volume":"84","author":"Xu","year":"2012","journal-title":"Journal of medical virology"},{"issue":"8","key":"17","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/ni.1770","article-title":"Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells","volume":"10","author":"Spits","year":"2009","journal-title":"Nature immunology"},{"issue":"8","key":"18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1767","article-title":"Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells","volume":"10","author":"Sallusto","year":"2009","journal-title":"Nature immunology"},{"issue":"3","key":"19","first-page":"246","article-title":"Th22 Cells Contribution in Immunopathogenesis of Rheumatic Diseases","volume":"14","author":"Mirshafiey","year":"2015","journal-title":"Iranian journal of allergy, asthma, and immunology"},{"issue":"11","key":"20","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/sj.cr.7310106","article-title":"Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes","volume":"16","author":"Dong","year":"2006","journal-title":"Cell research"},{"key":"21","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1146\/annurev-immunol-032414-112123","article-title":"Interleukin-22: immunobiology and pathology","volume":"33","author":"van den Brink","year":"2015","journal-title":"Annual review of immunology"},{"issue":"6","key":"22","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.jaci.2009.03.041","article-title":"IL-22-producing \u201cT22\u201d T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells","volume":"123","author":"Guttman-Yassky","year":"2009","journal-title":"The Journal of allergy and clinical immunology"},{"issue":"10","key":"23","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"Fouser","year":"2006","journal-title":"The Journal of experimental medicine"},{"issue":"1","key":"24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/imr.12027","article-title":"IL-22, not simply a Th17 cytokine","volume":"252","author":"Ouyang","year":"2013","journal-title":"Immunological reviews"},{"issue":"3","key":"25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/intimm\/dxr001","article-title":"Recent advances in IL-22 biology","volume":"23","author":"Flavell","year":"2011","journal-title":"International immunology"},{"key":"26","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1038\/srep08904","article-title":"Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013","volume":"5","author":"Klena","year":"2015","journal-title":"Scientific reports"},{"issue":"4","key":"27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1586\/14737159.7.4.419","article-title":"Basic rationale, current methods and future directions for molecular typing of human enterovirus","volume":"7","author":"Pozzetto","year":"2007","journal-title":"Expert review of molecular diagnostics"},{"issue":"2","key":"28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.7150\/ijbs.10178","article-title":"Changes in follicular helper T cells in idiopathic thrombocytopenic purpura patients","volume":"11","author":"Yuan","year":"2015","journal-title":"International journal of biological sciences"},{"issue":"27","key":"29","doi-asserted-by":"crossref","first-page":"e1137","DOI":"10.1097\/MD.0000000000001137","article-title":"Immunologic Characterization of Cytokine Responses to Enterovirus 71 and Coxsackievirus A16 Infection in Children","volume":"94","author":"Lu","year":"2015","journal-title":"Medicine"},{"issue":"6","key":"30","doi-asserted-by":"crossref","first-page":"e67430","DOI":"10.1371\/journal.pone.0067430","article-title":"Comparative study of the cytokine\/chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease","volume":"8","author":"Jin","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/mi.2012.72","article-title":"A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis","volume":"5","author":"Loutfy","year":"2012","journal-title":"Mucosal immunology"},{"issue":"4","key":"32","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s10875-011-9540-8","article-title":"Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis","volume":"31","author":"Wang","year":"2011","journal-title":"Journal of clinical immunology"},{"issue":"4","key":"33","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10875-013-9878-1","article-title":"Th22, but not Th17 might be a good index to predict the tissue involvement of systemic lupus erythematosus","volume":"33","author":"Wang","year":"2013","journal-title":"Journal of clinical immunology"},{"issue":"3","key":"34","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1007\/s12026-015-8765-7","article-title":"Th9 and Th22 immune response in young patients with type 1 diabetes","volume":"64","author":"Mysliwska","year":"2016","journal-title":"Immunologic research"},{"issue":"5","key":"35","doi-asserted-by":"crossref","first-page":"R136","DOI":"10.1186\/ar4317","article-title":"Th17 and Th22 cells in psoriatic arthritis and psoriasis","volume":"15","author":"Gaston","year":"2013","journal-title":"Arthritis research & therapy"},{"key":"36","doi-asserted-by":"crossref","unstructured":"Karner, Wawrzyniak, Tankov, Runnel, Aints, Kisand, Altraja, Kingo, Akdis, Akdis, Rebane. Increased microRNA-323-3p in IL-22\/IL-17-producing T cells and asthma: a role in the regulation of the TGF-beta pathway and IL-22 production. Allergy. 2016.","DOI":"10.1111\/all.12907"},{"issue":"6","key":"37","doi-asserted-by":"crossref","first-page":"e176","DOI":"10.1212\/NXI.0000000000000176","article-title":"Immunologic and MRI markers of the therapeutic effect of IFN-beta-1a in relapsing-remitting MS","volume":"2","author":"Markovic-Plese","year":"2015","journal-title":"Neurology(R) neuroimmunology & neuroinflammation"},{"issue":"2","key":"38","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.intimp.2015.11.005","article-title":"Down-regulation of the Th1, Th17, and Th22 pathways due to anti-TNF-alpha treatment in psoriasis","volume":"29","author":"Liu","year":"2015","journal-title":"International immunopharmacology"},{"issue":"6","key":"39","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.immuni.2012.08.024","article-title":"Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria","volume":"37","author":"Weaver","year":"2012","journal-title":"Immunity"},{"issue":"20","key":"40","doi-asserted-by":"publisher","first-page":"17958","DOI":"10.18632\/oncotarget.4641","article-title":"Elevated Th22 as well as Th17 cells associated with therapeutic outcome and clinical stage are potential targets in patients with multiple myeloma","volume":"6","author":"Ma","year":"2015","journal-title":"Oncotarget"},{"issue":"7","key":"41","first-page":"1261","article-title":"Clinical characteristics of hand, foot and mouth disease in Harbin and the prediction of severe cases","volume":"125","author":"Zhang","year":"2012","journal-title":"Chinese medical journal"},{"issue":"3","key":"42","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/jamaneurol.2015.4388","article-title":"Clinical Characteristics and Functional Motor Outcomes of Enterovirus 71 Neurological Disease in Children","volume":"73","author":"Farrar","year":"2016","journal-title":"JAMA neurology"},{"issue":"6","key":"43","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1086\/527326","article-title":"Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication","volume":"197","author":"Chen","year":"2008","journal-title":"The Journal of infectious diseases"},{"key":"44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2015.10.011","article-title":"Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses","volume":"124","author":"Lee","year":"2015","journal-title":"Antiviral research"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T18:27:27Z","timestamp":1589135247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":44,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2017,4,25]]}},"alternative-id":["14083","28030850"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.14083","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}