{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T04:18:46Z","timestamp":1789359526298,"version":"build-2803163510"},"reference-count":60,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,1,24]]},"DOI":"10.18632\/oncotarget.14255","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T01:36:04Z","timestamp":1482888964000},"page":"6663-6680","source":"Crossref","is-referenced-by-count":31,"title":["Interleukin-17A promotes tongue squamous cell carcinoma metastasis through activating miR-23b\/versican pathway"],"prefix":"10.18632","volume":"8","author":[{"given":"Tai","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, School of Life Science, University of Science and Technology of China, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking University Third Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai-Nan","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, and Beijing Key Laboratory of Digital Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"1","article-title":"Tumor microenvironment and therapeutic response","author":"Dai","year":"2016","journal-title":"Cancer Lett"},{"key":"2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/cmi.2010.21","article-title":"Interleukin-17 and its expanding biological functions","volume":"7","author":"Cao","year":"2010","journal-title":"Cell Mol Immunol"},{"key":"3","doi-asserted-by":"crossref","first-page":"11874","DOI":"10.1038\/srep11874","article-title":"IL-17A and its homologs IL-25\/IL-17E recruit the c-RAF\/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells","volume":"5","author":"Giustiniani","year":"2015","journal-title":"Sci Rep"},{"key":"4","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1007\/s00262-008-0502-9","article-title":"Virulizin induces production of IL-17E to enhance antitumor activity by recruitment of eosinophils into tumors","volume":"57","author":"Young","year":"2008","journal-title":"Cancer Immunol Immunother"},{"key":"5","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1002\/pros.23058","article-title":"Expression of IL-17A, E, and F and their receptors in human prostatic cancer: Comparison with benign prostatic hyperplasia","volume":"75","author":"Sun","year":"2015","journal-title":"Prostate"},{"key":"6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s12026-015-8722-5","article-title":"Identification and characterization of distinct IL-17F expression patterns and signaling pathways in chronic lymphocytic leukemia and normal B lymphocytes","volume":"63","author":"Chiorazzi","year":"2015","journal-title":"Immunol Res"},{"key":"7","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nm.2110","article-title":"T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis","volume":"16","author":"Kolkowitz","year":"2010","journal-title":"Nat Med"},{"key":"8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/jcb.22326","article-title":"IL-17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti-TNF-alpha antibody: a novel mechanism of osteoclastogenesis by IL-17","volume":"108","author":"Kotake","year":"2009","journal-title":"J Cell Biochem"},{"key":"9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1006\/bbrc.2001.4618","article-title":"Expression of IL-17 mRNA in ovarian cancer","volume":"282","author":"Aono","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.canlet.2006.05.019","article-title":"Thymosinalpha1 stimulates cell proliferation by activating ERK1\/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells","volume":"248","author":"Yao","year":"2007","journal-title":"Cancer Lett"},{"key":"11","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1476-4598-10-150","article-title":"IL-17 induces AKT-dependent IL-6\/JAK2\/STAT3 activation and tumor progression in hepatocellular carcinoma","volume":"10","author":"Zhou","year":"2011","journal-title":"Mol Cancer"},{"key":"12","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nm.3291","article-title":"An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy","volume":"19","author":"Ferrara","year":"2013","journal-title":"Nat Med"},{"key":"13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00441-013-1567-0","article-title":"High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer","volume":"352","author":"Liu","year":"2013","journal-title":"Cell Tissue Res"},{"key":"14","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1182\/blood.V99.6.2114","article-title":"Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism","volume":"99","author":"Tartour","year":"2002","journal-title":"Blood"},{"key":"15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1445-2197.2008.04791.x","article-title":"Prognostic factors in the surgical treatment of patients with oral carcinoma","volume":"79","author":"O'Brien","year":"2009","journal-title":"ANZ J Surg"},{"key":"16","first-page":"242","article-title":"Clinicopathological analysis of local spread of carcinoma of the tongue","volume":"175","author":"Lam","year":"1998","journal-title":"Am J Surg"},{"key":"17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1200\/JCO.2005.09.128","article-title":"Oral cancer prevention and the evolution of molecular-targeted drug development","volume":"23","author":"Hong","year":"2005","journal-title":"J Clin Oncol"},{"key":"18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F","article-title":"Oral leukoplakia and malignant transformation. A follow-up study of 257 patients","volume":"53","author":"Lozada","year":"1984","journal-title":"Cancer"},{"key":"19","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1349-7006.2008.00863.x","article-title":"Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis","volume":"99","author":"Cheng","year":"2008","journal-title":"Cancer Sci"},{"key":"20","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/nm.3337","article-title":"CSF-1R inhibition alters macrophage polarization and blocks glioma progression","volume":"19","author":"Oei","year":"2013","journal-title":"Nat Med"},{"key":"21","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1056\/NEJMoa067208","article-title":"Aspirin and the risk of colorectal cancer in relation to the expression of COX-2","volume":"356","author":"Fuchs","year":"2007","journal-title":"N Engl J Med"},{"key":"22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"23","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1002\/ijc.28667","article-title":"Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma","volume":"135","author":"Yu","year":"2014","journal-title":"Int J Cancer"},{"key":"24","doi-asserted-by":"crossref","first-page":"e108435","DOI":"10.1371\/journal.pone.0108435","article-title":"miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14","volume":"9","author":"Yu","year":"2014","journal-title":"PLoS One"},{"key":"25","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.canlet.2014.04.012","article-title":"Regulation of miR-23b expression and its dual role on ROS production and tumour development","volume":"349","author":"Palmieri","year":"2014","journal-title":"Cancer Lett"},{"key":"26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3892\/ijo.2014.2752","article-title":"Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b\/27b cluster in bladder cancer","volume":"46","author":"Enokida","year":"2015","journal-title":"Int J Oncol"},{"key":"27","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.juro.2014.07.001","article-title":"Expression of the tumor suppressive miRNA-23b\/27b cluster is a good prognostic marker in clear cell renal cell carcinoma","volume":"192","author":"Enokida","year":"2014","journal-title":"J Urol"},{"key":"28","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha","volume":"18","author":"Qian","year":"2012","journal-title":"Nat Med"},{"key":"29","volume-title":"AJCC cancer staging manual","author":"Trotti","year":"2010","edition":"7th ed"},{"key":"30","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1016\/j.bmcl.2005.06.021","article-title":"Novel peptide derivatives of bleomycin A5: synthesis, antitumor activity and interaction with DNA","volume":"15","author":"Yang","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"31","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1097\/IGC.0b013e31822d2abd","article-title":"Interleukin 17 induces up-regulation of chemokine and cytokine expression via activation of the nuclear factor kappaB and extracellular signal-regulated kinase 1\/2 pathways in gynecologic cancer cell lines","volume":"21","author":"Xi","year":"2011","journal-title":"Int J Gynecol Cancer"},{"key":"32","doi-asserted-by":"crossref","first-page":"e21816","DOI":"10.1371\/journal.pone.0021816","article-title":"Interleukin 17A promotes hepatocellular carcinoma metastasis via NF-kB induced matrix metalloproteinases 2 and 9 expression","volume":"6","author":"Guan","year":"2011","journal-title":"PLoS One"},{"key":"33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jcp.24444","article-title":"Interleukin-17A stimulates migration of periodontal ligament fibroblasts via p38 MAPK\/NF-kappaB -dependent MMP-1 expression","volume":"229","author":"Peng","year":"2014","journal-title":"J Cell Physiol"},{"key":"34","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","article-title":"NF-kappaB functions as a tumour promoter in inflammation-associated cancer","volume":"431","author":"Ben-Neriah","year":"2004","journal-title":"Nature"},{"key":"35","doi-asserted-by":"crossref","first-page":"32999","DOI":"10.1016\/S0021-9258(20)30090-9","article-title":"Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter","volume":"269","author":"Iozzo","year":"1994","journal-title":"J Biol Chem"},{"key":"36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10555-009-9182-y","article-title":"The biological role and regulation of versican levels in cancer","volume":"28","author":"Horsfall","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"37","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ygyno.2010.05.029","article-title":"Up-regulation of stromal versican expression in advanced stage serous ovarian cancer","volume":"119","author":"Mok","year":"2010","journal-title":"Gynecol Oncol"},{"key":"38","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/art.21749","article-title":"Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort)","volume":"54","author":"Portek","year":"2006","journal-title":"Arthritis Rheum"},{"key":"39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12935-014-0104-x","article-title":"Interleukin-23A is associated with tumor growth in Helicobacter-pylori-related human gastric cancer","volume":"14","author":"Zhu","year":"2014","journal-title":"Cancer Cell Int"},{"key":"40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2217\/fon.12.180","article-title":"Elevated IL-17A levels in early stages of bladder cancer regardless of smoking status","volume":"9","author":"Ghaderi","year":"2013","journal-title":"Future Oncol"},{"key":"41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tripleo.2010.11.032","article-title":"Increased prevalence of T(H)17 cells in the peripheral blood of patients with head and neck squamous cell carcinoma","volume":"112","author":"Zhang","year":"2011","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000055357","article-title":"Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumor-specific immunity in mice","volume":"61","author":"Tamura","year":"2001","journal-title":"Oncology"},{"key":"43","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1038\/srep03456","article-title":"IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1\/2","volume":"3","author":"Bastid","year":"2013","journal-title":"Sci Rep"},{"key":"44","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1182\/blood-2002-05-1461","article-title":"Interleukin-17 promotes angiogenesis and tumor growth","volume":"101","author":"Lotze","year":"2003","journal-title":"Blood"},{"key":"45","doi-asserted-by":"publisher","first-page":"7748","DOI":"10.18632\/oncotarget.2294","article-title":"The microRNA-23b\/27b\/24-1 cluster is a disease progression marker and tumor suppressor in prostate cancer","volume":"5","author":"Seki","year":"2014","journal-title":"Oncotarget"},{"key":"46","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/mt.2009.207","article-title":"Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes","volume":"18","author":"Ochiya","year":"2010","journal-title":"Mol Ther"},{"key":"47","doi-asserted-by":"crossref","first-page":"21342","DOI":"10.1074\/jbc.273.33.21342","article-title":"The G3 domain of versican enhances cell proliferation via epidermial growth factor-like motifs","volume":"273","author":"Yang","year":"1998","journal-title":"J Biol Chem"},{"key":"48","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/00005072-199906000-00004","article-title":"Versican enhances locomotion of astrocytoma cells and reduces cell adhesion through its G1 domain","volume":"58","author":"Yang","year":"1999","journal-title":"J Neuropathol Exp Neurol"},{"key":"49","doi-asserted-by":"crossref","first-page":"19358","DOI":"10.1074\/jbc.M512980200","article-title":"Versican G3 domain regulates neurite growth and synaptic transmission of hippocampal neurons by activation of epidermal growth factor receptor","volume":"281","author":"Lu","year":"2006","journal-title":"J Biol Chem"},{"key":"50","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/annonc\/mdl370","article-title":"Prognostic significance of stromal versican expression in human endometrial cancer","volume":"18","author":"Hiramatsu","year":"2007","journal-title":"Ann Oncol"},{"key":"51","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.humpath.2004.10.010","article-title":"Versican in nonsmall cell lung cancer: relation to hyaluronan, clinicopathologic factors, and prognosis","volume":"36","author":"Kosma","year":"2005","journal-title":"Hum Pathol"},{"key":"52","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1091\/mbc.e04-04-0295","article-title":"The roles of versican V1 and V2 isoforms in cell proliferation and apoptosis","volume":"16","author":"Yang","year":"2005","journal-title":"Mol Biol Cell"},{"key":"53","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1158\/0008-5472.CAN-06-3610","article-title":"The ability of versican to simultaneously cause apoptotic resistance and sensitivity","volume":"67","author":"Yang","year":"2007","journal-title":"Cancer Res"},{"key":"54","first-page":"701","article-title":"Roles of versican in cancer biology--tumorigenesis, progression and metastasis","volume":"28","author":"Yee","year":"2013","journal-title":"Histol Histopathol"},{"key":"55","doi-asserted-by":"crossref","first-page":"10814","DOI":"10.1074\/jbc.M606991200","article-title":"Formation of hyaluronan- and versican-rich pericellular matrix by prostate cancer cells promotes cell motility","volume":"282","author":"Horsfall","year":"2007","journal-title":"J Biol Chem"},{"key":"56","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1096\/fj.03-0660fje","article-title":"The globular domains of PG-M\/versican modulate the proliferation-apoptosis equilibrium and invasive capabilities of tumor cells","volume":"18","author":"Perris","year":"2004","journal-title":"FASEB J"},{"key":"57","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbagen.2007.10.005","article-title":"Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines","volume":"1780","author":"Tzanakakis","year":"2008","journal-title":"Biochimica Biophys Acta"},{"key":"58","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/(SICI)1097-4652(199803)174:3<353::AID-JCP9>3.0.CO;2-N","article-title":"Growth factor modulation of mitogenic responses and proteoglycan synthesis by human periodontal fibroblasts","volume":"174","author":"Bartold","year":"1998","journal-title":"J Cell Physiol"},{"key":"59","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/(SICI)1097-4644(20000501)77:2<298::AID-JCB12>3.0.CO;2-D","article-title":"Alteration of proteoglycan synthesis in human lung fibroblasts induced by interleukin-1beta and tumor necrosis factor-alpha","volume":"77","author":"Westergren-Thorsson","year":"2000","journal-title":"J Cell Biochem"},{"key":"60","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.oraloncology.2008.05.021","article-title":"Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma","volume":"45","author":"Lourenco","year":"2009","journal-title":"Oral Oncol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T02:36:33Z","timestamp":1658284593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,27]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1,24]]}},"alternative-id":["14255","28035060"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.14255","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,27]]}}}