{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:41:40Z","timestamp":1789195300680,"version":"build-2803163510"},"reference-count":27,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,1,24]]},"DOI":"10.18632\/oncotarget.14322","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T01:27:19Z","timestamp":1482974839000},"page":"6929-6939","source":"Crossref","is-referenced-by-count":41,"title":["A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition"],"prefix":"10.18632","volume":"8","author":[{"given":"Jian\u2019an","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Hospital Affiliated with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Hospital Affiliated with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Linyi People's Hospital, Dezhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Linyi People's Hospital, Dezhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/MPA.0b013e3181ec124e","article-title":"The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems","volume":"39","author":"Suster","year":"2010","journal-title":"Pancreas"},{"key":"2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3322\/caac.20097","article-title":"Recent progress in the understanding, diagnosis, and treatment of gastroenteropancreatic neuroendocrine tumors","volume":"61","author":"Kvols","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"3","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \"carcinoid\": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"Evans","year":"2008","journal-title":"Journal of clinical oncology"},{"key":"4","first-page":"337","article-title":"Gastroenteropancreatic neuroendocrine neoplasms: a 10-year experience of a single center","volume":"125","author":"Hubalewska-Dydejczyk","year":"2015","journal-title":"Polskie Archiwum Medycyny Wewnetrznej"},{"key":"5","first-page":"758","article-title":"An update on gastroenteropancreatic neuroendocrine tumors","volume":"28","author":"Strosberg","year":"2014","journal-title":"Oncology"},{"key":"6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1161","article-title":"Mutations in PCSK9 cause autosomal dominant hypercholesterolemia","volume":"34","author":"Chambaz","year":"2003","journal-title":"Nature genetics"},{"key":"7","article-title":"PCSK9 (Proprotein convertase subtilisin\/kexin type 9) inhibitors: past, present, and the future","author":"Cannon","year":"2015","journal-title":"European heart journal"},{"key":"8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"Tuschl","year":"2001","journal-title":"Science"},{"key":"9","article-title":"The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis","author":"Hsiao","year":"2015","journal-title":"Gut"},{"key":"10","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s13277-014-2805-0","article-title":"MicroRNA-224 and its target CAMKK2 synergistically influence tumor progression and patient prognosis in prostate cancer","volume":"36","author":"Zhong","year":"2015","journal-title":"Tumour biology"},{"key":"11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/hep.26659","article-title":"Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224","volume":"59","author":"Liu","year":"2014","journal-title":"Hepatology"},{"key":"12","first-page":"7","article-title":"Cell Death Signaling","author":"Llambi","year":"2015","journal-title":"Cold Spring Harbor perspectives in biology"},{"key":"13","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1200\/JCO.2014.60.2532","article-title":"Carcinoid and neuroendocrine tumors: building on success","volume":"33","author":"Kunz","year":"2015","journal-title":"Journal of clinical oncology"},{"key":"14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000098011","article-title":"Rare functioning pancreatic endocrine tumors","volume":"84","author":"European Neuroendocrine Tumor","year":"2006","journal-title":"Neuroendocrinology"},{"key":"15","doi-asserted-by":"crossref","unstructured":"Garcia-Carbonero, Sorbye, Baudin, Raymond, Wiedenmann, Niederle, Sedlackova, Toumpanakis, Anlauf, Cwikla, Caplin, O'Toole, Perren. A and all other Vienna Consensus Conference p. Consensus Guidelines for High Grade Gastro-Entero-Pancreatic (GEP) Neuroendocrine Tumours and Neuroendocrine Carcinomas (NEC). Neuroendocrinology. 2016.","DOI":"10.1159\/000443172"},{"key":"16","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000242109","article-title":"and representatives of 21 German NETC. The German NET-registry: an audit on the diagnosis and therapy of neuroendocrine tumors","volume":"90","author":"Lohmann","year":"2009","journal-title":"Neuroendocrinology"},{"key":"17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1530\/JOE-14-0456","article-title":"Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK","volume":"223","author":"Matthews","year":"2014","journal-title":"The Journal of endocrinology"},{"key":"18","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3342\/ceo.2014.7.2.112","article-title":"Dexamethasone Induces Apoptosis of Nasal Polyp-Derived Tissue Cultures Through JNK and p38 MAPK Activation","volume":"7","author":"Park","year":"2014","journal-title":"Clinical and experimental otorhinolaryngology"},{"key":"19","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1210\/en.2015-1092","article-title":"Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess","volume":"156","author":"Grefhorst","year":"2015","journal-title":"Endocrinology"},{"key":"20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1530\/JOE-15-0023","article-title":"Adrenocortical LDL receptor function negatively influences glucocorticoid output","volume":"226","author":"Hoekstra","year":"2015","journal-title":"The Journal of endocrinology"},{"key":"21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1001\/jamainternmed.2015.7248","article-title":"Proprotein Convertase Subtilisin\/Kexin Type 9 (PCSK9) Inhibitors for Treatment of High Cholesterol Levels: Effectiveness and Value","volume":"176","author":"Pearson","year":"2016","journal-title":"JAMA internal medicine"},{"key":"22","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.atherosclerosis.2015.08.023","article-title":"MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis","volume":"242","author":"Done","year":"2015","journal-title":"Atherosclerosis"},{"key":"23","doi-asserted-by":"crossref","first-page":"10154","DOI":"10.1038\/ncomms10154","article-title":"Abasic pivot substitution harnesses target specificity of RNA interference","volume":"6","author":"Chi","year":"2015","journal-title":"Nature communications"},{"key":"24","doi-asserted-by":"publisher","first-page":"21802","DOI":"10.18632\/oncotarget.5224","article-title":"MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7","volume":"6","author":"Croce","year":"2015","journal-title":"Oncotarget"},{"key":"25","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.3390\/jcm4091713","article-title":"MicroRNA-224 Induces G1\/S Checkpoint Release in Liver Cancer","volume":"4","author":"Selaru","year":"2015","journal-title":"Journal of clinical medicine"},{"key":"26","doi-asserted-by":"crossref","first-page":"E4288","DOI":"10.1073\/pnas.1502068112","article-title":"MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer","volume":"112","author":"Jin","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"27","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1158\/1078-0432.CCR-13-3396","article-title":"Functional genetic approach identifies MET, HER3, IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer","volume":"20","author":"Li","year":"2014","journal-title":"Clinical cancer research"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T14:51:52Z","timestamp":1596725512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1,24]]}},"alternative-id":["14322","28036293"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.14322","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,28]]}}}