{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:49:10Z","timestamp":1792000150190,"version":"4.4.0"},"reference-count":16,"publisher":"Impact Journals, LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,1,24]]},"DOI":"10.18632\/oncotarget.14346","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T01:27:19Z","timestamp":1482974839000},"page":"6984-6993","source":"Crossref","is-referenced-by-count":164,"title":["Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth"],"prefix":"10.18632","volume":"8","author":[{"given":"Ye","family":"Xiangyun","sequence":"first","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niu","family":"Xiaomin","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"linping","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yunhua","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ziming","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yongfeng","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhiwei","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Shun","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"1","first-page":"3267","article-title":"Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors","volume":"18","author":"Vaupel","year":"1998","journal-title":"Anticancer Res"},{"key":"2","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review","volume":"49","author":"Okunieff","year":"1989","journal-title":"Cancer Res"},{"key":"3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"4","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.semcancer.2005.04.009","article-title":"Pyruvate kinase type M2 and its role in tumor growth and spreading","volume":"15","author":"Eigenbrodt","year":"2005","journal-title":"Semin Cancer Biol"},{"key":"5","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/1097-0142(19910515)67:10<2552::AID-CNCR2820671027>3.0.CO;2-K","article-title":"Pyruvate kinase activity and isozyme composition in normal fibrous tissue and fibroblastic proliferations","volume":"67","author":"Staal","year":"1991","journal-title":"Cancer"},{"key":"6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/carcin\/19.1.99","article-title":"Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient\/DL-ethionine-supplemented diet","volume":"19","author":"Bannasch","year":"1998","journal-title":"Carcinogenesis"},{"key":"7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/nature06734","article-title":"The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth","volume":"452","author":"Cantley","year":"2008","journal-title":"Nature"},{"key":"8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nature06667","article-title":"Pyruvate kinase M2 is a phosphotyrosine-binding protein","volume":"452","author":"Cantley","year":"2008","journal-title":"Nature"},{"key":"9","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.molcel.2011.04.025","article-title":"Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth","volume":"42","author":"Xiong","year":"2011","journal-title":"Mol Cell"},{"key":"10","doi-asserted-by":"publisher","first-page":"ra73","DOI":"10.1126\/scisignal.2000431","article-title":"Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth","volume":"2","author":"Polakiewicz","year":"2009","journal-title":"Sci Signal"},{"key":"11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.molcel.2013.09.004","article-title":"Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization","volume":"52","author":"Xiong","year":"2013","journal-title":"Mol Cell"},{"key":"12","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1126\/science.1211485","article-title":"Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses","volume":"334","author":"Cantley","year":"2011","journal-title":"Science"},{"key":"13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18632\/aging.100009","volume-title":"Aging","volume":"1","author":"Sinclair","year":"2009"},{"key":"14","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1101\/sqb.2007.72.024","article-title":"Sirtuins in aging and disease","volume":"72","author":"Guarente","year":"2007","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"15","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.1091\/mbc.E05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"Horikawa","year":"2005","journal-title":"Mol Biol Cell"},{"key":"16","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.molcel.2013.06.001","article-title":"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways","volume":"50","author":"Zhao","year":"2013","journal-title":"Mol Cell"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T14:54:02Z","timestamp":1596725642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,1,24]]}},"alternative-id":["14346","28036303"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.14346","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,28]]}}}