{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:49:13Z","timestamp":1789951753832,"version":"4.0.1"},"reference-count":17,"publisher":"Impact Journals, LLC","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,2,14]]},"DOI":"10.18632\/oncotarget.14641","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T09:52:56Z","timestamp":1484733176000},"page":"10945-10953","source":"Crossref","is-referenced-by-count":26,"title":["Modeling the phenotype of spinal muscular atrophy by the direct conversion of human fibroblasts to motor neurons"],"prefix":"10.18632","volume":"8","author":[{"given":"Qi-Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Qian","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Lin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"},{"name":"Fujian Key Laboratory of Molecular Neurology, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology and Institute of Neurology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China"},{"name":"Fujian Key Laboratory of Molecular Neurology, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,1,13]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1001\/archneurol.2011.74","article-title":"Spinal muscular atrophy: a timely review","volume":"68","author":"Kissel","year":"2011","journal-title":"Arch Neurol"},{"key":"2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Yamanaka","year":"2006","journal-title":"Cell"},{"key":"3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Svendsen","year":"2009","journal-title":"Nature"},{"key":"4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/scrt476","article-title":"Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives","volume":"5","author":"Corti","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mcn.2014.12.005","article-title":"Pluripotent stem cell-based models of spinal muscular atrophy","volume":"64","author":"Corti","year":"2015","journal-title":"Mol Cell Neurosci"},{"key":"6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/nature08797","article-title":"Direct conversion of fibroblasts to functional neurons by defined factors","volume":"463","author":"Wernig","year":"2010","journal-title":"Nature"},{"key":"7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature10202","article-title":"Induction of human neuronal cells by defined transcription factors","volume":"476","author":"Wernig","year":"2011","journal-title":"Nature"},{"key":"8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.stem.2012.03.003","article-title":"Direct conversion of fibroblasts into stably expandable neural stem cells","volume":"10","author":"Edenhofer","year":"2012","journal-title":"Cell Stem Cell"},{"key":"9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.stem.2012.02.021","article-title":"Direct reprogramming of fibroblasts into neural stem cells by defined factors","volume":"10","author":"Lee","year":"2012","journal-title":"Cell Stem Cell"},{"key":"10","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1073\/pnas.1121003109","article-title":"Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells","volume":"109","author":"Wernig","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.stem.2011.07.014","article-title":"Conversion of mouse and human fibroblasts into functional spinal motor neurons","volume":"9","author":"Eggan","year":"2011","journal-title":"Cell stem cell"},{"key":"12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.stem.2015.06.003","article-title":"Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons","volume":"17","author":"Wang","year":"2015","journal-title":"Cell Stem Cell"},{"key":"13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.stem.2015.07.006","article-title":"Direct conversion of normal and Alzheimer\u2019s disease human fibroblasts into neuronal cells by small molecules","volume":"17","author":"Tang","year":"2015","journal-title":"Cell Stem Cell"},{"key":"14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.celrep.2015.12.018","article-title":"Direct lineage reprogramming reveals disease-specific phonotypes of motor neurons from human ALS patients","volume":"14","author":"Zhang","year":"2016","journal-title":"Cell Rep"},{"key":"15","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/stem.749","article-title":"Brief report: phenotypic rescue of induced pluripotent stem cell-derived motoneurons of a spinal muscular atrophy patient","volume":"29","author":"Yee","year":"2011","journal-title":"Stem Cells"},{"key":"16","first-page":"165ra162","article-title":"Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy","volume":"4","author":"Rizzo","year":"2012","journal-title":"Sci Transl Med"},{"key":"17","doi-asserted-by":"crossref","first-page":"e39113","DOI":"10.1371\/journal.pone.0039113","article-title":"Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy","volume":"7","author":"Svendsen","year":"2012","journal-title":"PLoS One"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T12:38:05Z","timestamp":1589114285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.14641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,13]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,2,14]]}},"alternative-id":["14641","28099929"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.14641","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,13]]}}}