{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T07:12:06Z","timestamp":1778224326300,"version":"3.51.4"},"reference-count":40,"publisher":"Impact Journals, LLC","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,4,4]]},"DOI":"10.18632\/oncotarget.15333","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T19:17:50Z","timestamp":1487186270000},"page":"23575-23587","source":"Crossref","is-referenced-by-count":37,"title":["An anthocyanin rich strawberry extract induces apoptosis and ROS while decreases glycolysis and fibrosis in human uterine leiomyoma cells"],"prefix":"10.18632","volume":"8","author":[{"given":"Md Soriful","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"},{"name":"Biotechnology and Microbiology Laboratory, Department of Botany, University of Rajshahi, Rajshahi, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Giampieri","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milijana","family":"Janjusevic","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Gasparrini","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara Y.","family":"Forbes-Hernandez","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Greco","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano Raffaele","family":"Giannubilo","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ciavattini","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Mezzetti","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Capocasa","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Castellucci","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Battino","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquapina","family":"Ciarmela","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"},{"name":"Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1210\/jc.2012-3237","article-title":"Uterine leiomyoma: available medical treatments and new possible therapeutic options","volume":"98","author":"Ciarmela","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Schectman","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/ajcp\/94.4.435","article-title":"The frequency of uterine leiomyomas","volume":"94","author":"Patel","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"4","first-page":"211","article-title":"The estimated annual cost of uterine leiomyomata in the United States","volume":"206","author":"Segars","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"5","first-page":"65","article-title":"GnRH agonist and iron versus placebo and iron in the anemic patient before surgery for leiomyomas: A randomized controlled trial","volume":"86","author":"Scialli","year":"1995","journal-title":"The Leuprolide Study Group. Obstet Gynecol"},{"key":"6","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/0002-9378(91)91419-W","article-title":"A randomized trial evaluating leuprolide acetate before hysterectomy as treatment for leiomyomas","volume":"164","author":"Woodruff","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"7","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/mnfr.201400134","article-title":"Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: Promising options for prevention and treatment of uterine fibroids?","volume":"58","author":"Ciarmela","year":"2014","journal-title":"Mol Nutr Food Res"},{"key":"8","first-page":"289","article-title":"Green tea extract inhibits proliferation of uterine leiomyoma cells in vitro and in nude mice","volume":"202","author":"Al-Hendy","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.nutres.2007.11.009","article-title":"Chemoprevention of fibroid tumors by[\u2212]-epigallocatechin-3-gallate in quail","volume":"28","author":"Kucuk","year":"2008","journal-title":"Nutr Res"},{"key":"10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2147\/IJWH.S41021","article-title":"Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study","volume":"5","author":"Al-Hendy","year":"2013","journal-title":"Int J Womens Health"},{"key":"11","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.3945\/ajcn.111.016600","article-title":"Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata","volume":"94","author":"Rosenberg","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.nut.2011.08.009","article-title":"The strawberry: composition, nutritional quality, and impact on human health","volume":"28","author":"Battino","year":"2012","journal-title":"Nutrition"},{"key":"13","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.1021\/jf0478049","article-title":"Inhibitory effect on activator protein-1, nuclear factor-kappaB, and cell transformation by extracts of strawberries (Fragaria\u00d7 ananassa Duch.)","volume":"53","author":"Ding","year":"2005","journal-title":"J Agric Food Chem"},{"key":"14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/carcin\/22.2.351","article-title":"Inhibition of cellular transformation by berry extracts","volume":"22","author":"Klaunig","year":"2001","journal-title":"Carcinogenesis"},{"key":"15","doi-asserted-by":"crossref","first-page":"9329","DOI":"10.1021\/jf061750g","article-title":"Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro","volume":"54","author":"Heber","year":"2006","journal-title":"J Agric Food Chem"},{"key":"16","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1021\/jf071989c","article-title":"Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties","volume":"56","author":"Heber","year":"2008","journal-title":"J Agric Food Chem"},{"key":"17","doi-asserted-by":"crossref","first-page":"e46470","DOI":"10.1371\/journal.pone.0046470","article-title":"Increasing strawberry fruit sensorial and nutritional quality using wild and cultivated germplasm","volume":"7","author":"Mezzetti","year":"2012","journal-title":"PLoS One"},{"key":"18","doi-asserted-by":"crossref","first-page":"E775","DOI":"10.1210\/jc.2013-2623","article-title":"Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function","volume":"99","author":"Ciarmela","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/jcp.22783","article-title":"PAI-1 in tissue fibrosis","volume":"227","author":"Vaughan","year":"2012","journal-title":"J Cell Physiol"},{"key":"20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ndt\/gfh653","article-title":"Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis","volume":"20","author":"Peters","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"21","doi-asserted-by":"crossref","first-page":"13781","DOI":"10.1021\/bi9808262","article-title":"Random versus selective membrane phospholipid oxidation in apoptosis: role of phosphatidylserine","volume":"37","author":"Kagan","year":"1998","journal-title":"Biochemistry (Mosc)"},{"key":"22","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/35037747","article-title":"From bench to clinic with apoptosis-based therapeutic agents","volume":"407","author":"Nicholson","year":"2000","journal-title":"Nature"},{"key":"23","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.210504","article-title":"The biology of oxygen radicals","volume":"201","author":"Fridovich","year":"1978","journal-title":"Science"},{"key":"24","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Aw","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"25","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1038\/sj.onc.1209597","article-title":"Glycolysis inhibition for anticancer treatment","volume":"25","author":"Huang","year":"2006","journal-title":"Oncogene"},{"key":"26","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1158\/0008-5472.CAN-07-6339","article-title":"Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia","volume":"68","author":"Vaupel","year":"2008","journal-title":"Cancer Res"},{"key":"27","first-page":"900","article-title":"Relative overexpression of collagen type I, collagen type III messenger ribonucleic acids by uterine leiomyomas during the proliferative phase of the menstrual cycle","volume":"79","author":"Nowak","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"28","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0015-0282(00)00418-0","article-title":"Transforming growth factor-beta3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression, cell proliferation","volume":"73","author":"Sozen","year":"2000","journal-title":"Fertil Steril"},{"key":"29","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1177\/1933719109343310","article-title":"Transforming growth factor beta3 regulates the versican variants in the extracellular matrix-rich uterine leiomyomas","volume":"16","author":"Catherino","year":"2009","journal-title":"Reprod Sci"},{"key":"30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/01.RES.88.5.458","article-title":"Regulation of vascular cell Behavior by collagen form is function","volume":"88","author":"Pickering","year":"2001","journal-title":"Circ Res"},{"key":"31","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1242\/jcs.00059","article-title":"Fibronectin at a glance","volume":"115","author":"Yamada","year":"2002","journal-title":"J Cell Sci"},{"key":"32","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0955-0674(02)00375-7","article-title":"Versican: a versatile extracellular matrix proteoglycan in cell biology","volume":"14","author":"Wight","year":"2002","journal-title":"Curr Opin Cell Biol"},{"key":"33","first-page":"1","article-title":"Versican in inflammation and tissue remodelling: the impact on lung disorders","author":"Karlsson","year":"2014","journal-title":"Glycobiology"},{"key":"34","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.fertnstert.2009.01.081","article-title":"Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor beta-3","volume":"93","author":"Catherino","year":"2010","journal-title":"Fertil Steril"},{"key":"35","doi-asserted-by":"crossref","first-page":"E754","DOI":"10.1210\/jc.2010-2131","article-title":"1,25-Dihydroxyvitamin D reduces TGF-\u03b23-induced fibrosis-related gene expression in human uterine leiomyoma cells","volume":"96","author":"Al-Hendy","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"36","doi-asserted-by":"crossref","first-page":"e25878","DOI":"10.1371\/journal.pone.0025878","article-title":"Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase","volume":"6","author":"Battino","year":"2011","journal-title":"PLoS One"},{"key":"37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jnutbio.2013.11.002","article-title":"One-month strawberry-rich anthocyanin supplementation ameliorates cardiovascular risk, oxidative stress markers and platelet activation in humans","volume":"25","author":"Battino","year":"2014","journal-title":"J Nutr Biochem"},{"key":"38","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1039\/C4FO00048J","article-title":"An anthocyanin-rich strawberry extract protects against oxidative stress damage and improves mitochondrial functionality in human dermal fibroblasts exposed to an oxidizing agent","volume":"5","author":"Mezzetti","year":"2014","journal-title":"Food & function"},{"key":"39","volume-title":"Current protocols in toxicology","author":"Sipes","year":"1998"},{"key":"40","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3892\/ijo.2015.2885","article-title":"Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells","volume":"46","author":"Agarwal","year":"2015","journal-title":"Int J Oncol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T18:13:02Z","timestamp":1589134382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":40,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,4,4]]}},"alternative-id":["15333","28212568"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.15333","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,15]]}}}