{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:37:10Z","timestamp":1790645830337,"version":"4.1.0"},"reference-count":33,"publisher":"Impact Journals, LLC","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,3,28]]},"DOI":"10.18632\/oncotarget.15504","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T16:33:37Z","timestamp":1487781217000},"page":"21167-21176","source":"Crossref","is-referenced-by-count":11,"title":["CDKN2B gene rs1063192 polymorphism decreases the risk of glaucoma"],"prefix":"10.18632","volume":"8","author":[{"given":"Zhenxian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenliang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Tongde Hospital of Zhejiang Province, Hangzhou 310012, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,2,18]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Broman","year":"2006","journal-title":"The British journal of ophthalmology"},{"key":"2","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Khaw","year":"2004","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1071\/PY10042","article-title":"Risk factors for glaucoma: what do they really mean?","volume":"17","author":"Grimmer-Somers","year":"2011","journal-title":"Aust J Prim Health"},{"key":"4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.exer.2011.08.007","article-title":"Molecular genetics in glaucoma","volume":"93","author":"Allingham","year":"2011","journal-title":"Experimental eye research"},{"key":"5","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1172\/JCI43085","article-title":"Glaucoma: genes, phenotypes, and new directions for therapy","volume":"120","author":"Wiggs","year":"2010","journal-title":"J Clin Invest"},{"key":"6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Kalenak","year":"1997","journal-title":"Science"},{"key":"7","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Sarfarazi","year":"2002","journal-title":"Science"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Monemi, Spaeth, DaSilva, Popinchalk, Ilitchev, Liebmann, Ritch, Heon, Crick, Child, Sarfarazi. Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1. Human molecular genetics. 2005; 14:725\u2013733.","DOI":"10.1093\/hmg\/ddi068"},{"key":"9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/ng.824","article-title":"Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1","volume":"43","author":"Wood","year":"2011","journal-title":"Nature genetics"},{"key":"10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","article-title":"p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest","volume":"371","author":"Beach","year":"1994","journal-title":"Nature"},{"key":"11","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/hmg\/ddt522","article-title":"Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age","volume":"23","author":"Klaver","year":"2014","journal-title":"Human molecular genetics"},{"key":"12","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1093\/hmg\/dds103","article-title":"A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma","volume":"21","author":"Nakamura","year":"2012","journal-title":"Human molecular genetics"},{"key":"13","doi-asserted-by":"crossref","first-page":"e39278","DOI":"10.1371\/journal.pone.0039278","article-title":"CDKN2B polymorphism is associated with primary open-angle glaucoma (POAG) in the Afro-Caribbean population of Barbados, West Indies","volume":"7","author":"Hejtmancik","year":"2012","journal-title":"PloS one"},{"key":"14","doi-asserted-by":"crossref","first-page":"e40107","DOI":"10.1371\/journal.pone.0040107","article-title":"Common variants on chromosome 9p21 are associated with normal tension glaucoma","volume":"7","author":"Kawashima","year":"2012","journal-title":"PloS one"},{"key":"15","doi-asserted-by":"crossref","first-page":"e0119703","DOI":"10.1371\/journal.pone.0119703","article-title":"Genetic association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1\/SIX6 with the endophenotypes of primary open angle glaucoma in Indian population","volume":"10","author":"Sarangapani","year":"2015","journal-title":"PloS one"},{"key":"16","doi-asserted-by":"crossref","first-page":"3416","DOI":"10.1167\/iovs.16-19401","article-title":"Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma","volume":"57","author":"Mackey","year":"2016","journal-title":"Investigative ophthalmology & visual science"},{"key":"17","first-page":"1471","article-title":"Association of known common genetic variants with primary open angle, primary angle closure, and pseudoexfoliation glaucoma in Pakistani cohorts","volume":"20","author":"den Hollander","year":"2014","journal-title":"Molecular vision"},{"key":"18","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.ophtha.2012.02.044","article-title":"Association between genetic variants associated with vertical cup-to-disc ratio and phenotypic features of primary open-angle glaucoma","volume":"119","author":"Tsukahara","year":"2012","journal-title":"Ophthalmology"},{"key":"19","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1167\/iovs.13-12779","article-title":"Investigation of known genetic risk factors for primary open angle glaucoma in two populations of African ancestry","volume":"54","author":"Pasquale","year":"2013","journal-title":"Investigative ophthalmology & visual science"},{"key":"20","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1167\/iovs.10-6339","article-title":"Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population","volume":"52","author":"Wiggs","year":"2011","journal-title":"Investigative ophthalmology & visual science"},{"key":"21","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.ajo.2012.04.023","article-title":"Genetic investigation into the endophenotypic status of central corneal thickness and optic disc parameters in relation to open-angle glaucoma","volume":"154","author":"Craig","year":"2012","journal-title":"American journal of ophthalmology"},{"key":"22","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1167\/iovs.14-16269","article-title":"Genetic Variants Associated With Different Risks for High Tension Glaucoma and Normal Tension Glaucoma in a Chinese Population","volume":"56","author":"Sun","year":"2015","journal-title":"Investigative ophthalmology & visual science"},{"key":"23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ajo.2014.09.020","article-title":"Association of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study","volume":"159","author":"Craig","year":"2015","journal-title":"American journal of ophthalmology"},{"key":"24","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1089\/gtmb.2016.0140","article-title":"Analysis of Cyclin-Dependent Kinase Inhibitor-2B rs1063192 Polymorphism in Saudi Patients with Primary Open-Angle Glaucoma","volume":"20","author":"Al-Obeidan","year":"2016","journal-title":"Genetic testing and molecular biomarkers"},{"key":"25","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1038\/srep08378","article-title":"The genetics of POAG in black South Africans: a candidate gene association study","volume":"5","author":"Ramsay","year":"2015","journal-title":"Scientific reports"},{"key":"26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ajo.2014.11.023","article-title":"Involvement of genetic variants associated with primary open-angle glaucoma in pathogenic mechanisms and family history of glaucoma","volume":"159","author":"Tsukahara","year":"2015","journal-title":"American journal of ophthalmology"},{"key":"27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.preteyeres.2013.09.001","article-title":"The vast complexity of primary open angle glaucoma: disease genes, risks, molecular mechanisms and pathobiology","volume":"37","author":"Bergen","year":"2013","journal-title":"Progress in retinal and eye research"},{"key":"28","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1093\/hmg\/ddv128","article-title":"A common variant near TGFBR3 is associated with primary open angle glaucoma","volume":"24","author":"Abu-Amero","year":"2015","journal-title":"Human molecular genetics"},{"key":"29","doi-asserted-by":"crossref","first-page":"e1002654","DOI":"10.1371\/journal.pgen.1002654","article-title":"Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma","volume":"8","author":"Crenshaw","year":"2012","journal-title":"PLoS genetics"},{"key":"30","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"key":"31","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Thompson","year":"2002","journal-title":"Stat Med"},{"key":"32","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1001\/jama.295.6.676","article-title":"Comparison of two methods to detect publication bias in meta-analysis","volume":"295","author":"Rushton","year":"2006","journal-title":"Jama"},{"key":"33","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1037\/1082-989X.6.3.203","article-title":"The power of statistical tests in meta-analysis","volume":"6","author":"Pigott","year":"2001","journal-title":"Psychol Methods"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T17:39:46Z","timestamp":1589132386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,18]]},"references-count":33,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2017,3,28]]}},"alternative-id":["15504","28416752"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.15504","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,18]]}}}