{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:38:03Z","timestamp":1788233883664,"version":"build-2803163510"},"reference-count":32,"publisher":"Impact Journals, LLC","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,5,9]]},"DOI":"10.18632\/oncotarget.15565","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T16:33:37Z","timestamp":1487781217000},"page":"31355-31367","source":"Crossref","is-referenced-by-count":12,"title":["Expression of BRCA1 and ERCC1 as predictive clinical outcome after radiochemotherapy in patients with locoregionally moderate-advanced nasopharyngeal carcinoma"],"prefix":"10.18632","volume":"8","author":[{"given":"Shan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LiJun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozhi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingbo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.7314\/APJCP.2013.14.12.7395","article-title":"Long-term efficacy of microwave hyperthermia combined with chemoradiotherapy in treatment of nasopharyngeal carcinoma with cervical lymph node metastases","volume":"14","author":"Wang","year":"2013","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"2","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1158\/1055-9965.EPI-06-0353","article-title":"The enigmatic epidemiology of nasopharyngeal carcinoma","volume":"15","author":"Adami","year":"2006","journal-title":"Cancer Epidemiology Biomarkers & Prevention"},{"key":"3","first-page":"1223","article-title":"Chemotherapy in advanced nasopharyngeal cancer","volume":"14","author":"Al-Sarraf","year":"2000","journal-title":"Oncology"},{"key":"4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0360-3016(92)90740-9","article-title":"Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure","volume":"23","author":"Ho","year":"1992","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"5","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1002\/cncr.25754","article-title":"Local control, survival, and late toxicities of locally advanced nasopharyngeal carcinoma treated by simultaneous modulated accelerated radiotherapy combined with cisplatin concurrent chemotherapy: long-term results of a phase 2 study","volume":"117","author":"Zhao","year":"2011","journal-title":"Cancer"},{"key":"6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.anorl.2010.10.003","article-title":"Treatment for metastatic nasopharyngeal carcinoma","volume":"128","author":"Errihani","year":"2011","journal-title":"European Annals of Otorhinolaryngology Head & Neck Diseases"},{"key":"7","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.oraloncology.2012.05.021","article-title":"Salvage gemcitabine-vinorelbine chemotherapy in patients with metastatic nasopharyngeal carcinoma pretreated with platinum-based chemotherapy","volume":"48","author":"Li","year":"2012","journal-title":"Oral Oncology"},{"key":"8","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1158\/1078-0432.CCR-07-2238","article-title":"Platinum resistance: the role of DNA repair pathways","volume":"14","author":"Schilder","year":"2008","journal-title":"Clinical Cancer Research"},{"key":"9","first-page":"1","article-title":"ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and\/or docetaxel","volume":"8","author":"Liu","year":"2008","journal-title":"BMC Cancer"},{"key":"10","first-page":"1120","article-title":"BRCA1 Up-Regulation Is Associated with Repair-mediated Resistance to cis-Diamminedichloroplatinum(II)","volume":"58","author":"Spriggs","year":"1998","journal-title":"Cancer Research"},{"key":"11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1056\/NEJMp068308","article-title":"DNA repair and survival in lung cancer--the two faces of Janus","volume":"356","author":"Gazdar","year":"2007","journal-title":"New England Journal of Medicine"},{"key":"12","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5732\/cjc.013.10118","article-title":"Nasopharyngeal carcinoma incidence and mortality in China in 2009","volume":"32","author":"Chen","year":"2013","journal-title":"Chin J Cancer"},{"key":"13","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ijrobp.2009.12.072","article-title":"Can the Analysis of ERCC1 Expression Contribute to Individualized Therapy in Nasopharyngeal Carcinoma?","volume":"79","author":"Lee","year":"2011","journal-title":"International Journal of Radiation Oncology Biology Physics"},{"key":"14","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1200\/JCO.2005.12.081","article-title":"Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: a pooled data analysis of two phase III trials","volume":"23","author":"Hua-Qing","year":"2005","journal-title":"Journal of Clinical"},{"key":"15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.radonc.2008.02.003","article-title":"Potential improvement of tumor control probability by induction chemotherapy for advanced nasopharyngeal carcinoma","volume":"87","author":"Yau","year":"2008","journal-title":"Radiotherapy and Oncology"},{"key":"16","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/hed.20421","article-title":"Induction chemotherapy with cisplatin and gemcitabine followed by accelerated radiotherapy and concurrent cisplatin in patients with stage IV(A-B) nasopharyngeal carcinoma","volume":"28","author":"Soong","year":"2006","journal-title":"Head & Neck"},{"key":"17","first-page":"1","article-title":"Concurrent image-guided intensity modulated radiotherapy and chemotherapy following neoadjuvant chemotherapy for locally advanced nasopharyngeal carcinoma","volume":"6","author":"Hsieh","year":"2011","journal-title":"Radiation Oncology"},{"key":"18","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1245\/s10434-008-9815-3","article-title":"The genomic heritage of lymph node metastases: Implications for clinical management of patients with breast cancer","volume":"15","author":"Ellsworth","year":"2008","journal-title":"Annals of Surgical Oncology"},{"key":"19","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1365-2559.2011.04012.x","article-title":"Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma","volume":"59","author":"Kim","year":"2011","journal-title":"Histopathology"},{"key":"20","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1200\/JCO.2004.00.117","article-title":"Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies","volume":"22","author":"Cascinu","year":"2004","journal-title":"Journal of Clinical Oncology"},{"key":"21","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/annonc\/mdi282","article-title":"Epidermal growth factor receptor (EGFR) status in primary colorectal tumors correlates with EGFR expression in related metastatic sites: biological and clinical implications","volume":"16","author":"Michiels","year":"2005","journal-title":"Annals of Oncology"},{"key":"22","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.oraloncology.2009.12.007","article-title":"High expression of excision repair cross-complementation group1 protein predicts poor outcome in patients with nasopharyngeal cancer","volume":"46","author":"Kim","year":"2010","journal-title":"Oral Oncology"},{"key":"23","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.oraloncology.2012.04.003","article-title":"Expression of ERCC1 predicts clinical outcome in locoregionally advanced nasopharyngeal carcinoma treated with cisplatin-based induction chemotherapy","volume":"48","author":"Zhang","year":"2012","journal-title":"Oral Oncology"},{"key":"24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ijrobp.2010.02.061","article-title":"Expression of Excision Repair Cross-Complementation Group 1 as Predictive Marker for Nasopharyngeal Cancer Treated With Concurrent Chemoradiotherapy","volume":"80","author":"Baek","year":"2011","journal-title":"International Journal of Radiation Oncology Biology Physics"},{"key":"25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.oraloncology.2012.04.003","article-title":"Expression of ERCC1 predicts clinical outcome in locoregionally advanced nasopharyngeal carcinoma treated with cisplatin-based induction chemotherapy","volume":"48","author":"Li","year":"2012","journal-title":"Oral Oncology"},{"key":"26","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1158\/1078-0432.CCR-07-0252","article-title":"Excision repair cross complementation group 1 immunohistochemical expression predicts objective response and cancer-specific survival in patients treated by Cisplatin-based induction chemotherapy for locally advanced head and neck squamous cell carcinoma","volume":"13","author":"Fouret","year":"2007","journal-title":"Clinical Cancer Research"},{"key":"27","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1002\/cncr.29413","article-title":"Clinical utility of plasma Epstein-Barr virus DNA and ERCC1 single nucleotide polymorphism in nasopharyngeal carcinoma","volume":"121","author":"Cheng","year":"2015","journal-title":"Cancer"},{"key":"28","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/annonc\/mdp002","article-title":"Class III beta-tubulin, but not ERCC1, is a strong predictive and prognostic marker in locally advanced head and neck squamous cell carcinoma","volume":"20","author":"Sung","year":"2009","journal-title":"Annals of Oncology"},{"key":"29","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/j.1349-7006.2010.01514.x","article-title":"BRCA1 and XRCC1 polymorphisms associated with survival in advanced gastric cancer treated with taxane and cisplatin","volume":"101","author":"Lee","year":"2010","journal-title":"Cancer Science"},{"key":"30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/annonc\/mdq333","article-title":"BRCA1 mRNA expression and outcome to neoadjuvant cisplatin-based chemotherapy in bladder cancer","volume":"22","author":"Rodr\u00edguez","year":"2011","journal-title":"Annals of Oncology"},{"key":"31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/annonc\/mdg077","article-title":"AJCC Cancer Staging Manual, 6th edition","volume":"14","author":"Fleming","year":"2003","journal-title":"Annals of Oncology"},{"key":"32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.lungcan.2011.08.016","article-title":"RT-PCR versus immunohistochemistry for correlation and quantification of ERCC1, BRCA1, TUBB3 and RRM1 in NSCLC","volume":"75","author":"Sorensen","year":"2012","journal-title":"Lung Cancer"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T18:45:25Z","timestamp":1589136325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":32,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2017,5,9]]}},"alternative-id":["15565","28404895"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.15565","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}