{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T11:30:44Z","timestamp":1782127844539,"version":"3.54.5"},"reference-count":51,"publisher":"Impact Journals, LLC","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,4,4]]},"DOI":"10.18632\/oncotarget.15579","type":"journal-article","created":{"date-parts":[[2017,2,22]],"date-time":"2017-02-22T16:33:37Z","timestamp":1487781217000},"page":"23360-23375","source":"Crossref","is-referenced-by-count":33,"title":["Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation"],"prefix":"10.18632","volume":"8","author":[{"given":"Ran","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Hong","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haorui","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibin","family":"Zang","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimin","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghui","family":"Xia","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nri3212","article-title":"Advances in graft-versus-host disease biology and therapy","volume":"12","author":"Abedi","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"2","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(09)60237-3","article-title":"Graft-versus-host disease","volume":"373","author":"Holler","year":"2009","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbmt.2012.09.018","article-title":"Endothelial vulnerability and endothelial damage are associated with risk of graft-versus-host disease and response to steroid treatment","volume":"19","author":"Luft","year":"2013","journal-title":"Biol Blood Marrow Transplant"},{"key":"4","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.bbmt.2014.05.002","article-title":"Endothelial dysfunction and altered mechanical and structural properties of resistance arteries in a murine model of graft-versus-host disease","volume":"20","author":"Endemann","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12185-013-1421-x","article-title":"Pathogenesis of graft-versus-host disease: innate immunity amplifying acute alloimmune responses","volume":"98","author":"Maeda","year":"2013","journal-title":"Int J Hematol"},{"key":"6","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1182\/blood.V99.2.520","article-title":"Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1","volume":"99","author":"Hecker","year":"2002","journal-title":"Blood"},{"key":"7","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1182\/blood-2015-01-622662","article-title":"Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects","volume":"126","author":"Comerford","year":"2015","journal-title":"Blood"},{"key":"8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.leukres.2011.08.005","article-title":"Elevated Fas\/FasL system and endothelial cell microparticles are involved in endothelial damage in acute graft-versus-host disease: a clinical analysis","volume":"36","author":"Xia","year":"2012","journal-title":"Leuk Res"},{"key":"9","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/01.tp.0000209218.24916.ba","article-title":"Endothelial cell-derived microparticles in allogeneic hematopoietic stem cell recipients","volume":"81","author":"Kolb","year":"2006","journal-title":"Transplantation"},{"key":"10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.bbmt.2008.04.005","article-title":"Evaluation of angiopoietins and cell-derived microparticles after stem cell transplantation","volume":"14","author":"Hayashi","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"11","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00432-015-2029-8","article-title":"Membrane microparticles: shedding new light into cancer cell communication","volume":"142","author":"Maia","year":"2016","journal-title":"J Cancer Res Clin Oncol"},{"key":"12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/cvr\/cvs007","article-title":"Microparticles: major transport vehicles for distinct microRNAs in circulation","volume":"93","author":"Peter","year":"2012","journal-title":"Cardiovasc Res"},{"key":"13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1476-4598-11-37","article-title":"Microparticle conferred microRNA profiles\u2014implications in the transfer and dominance of cancer traits","volume":"11","author":"Bebawy","year":"2012","journal-title":"Mol Cancer"},{"key":"14","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/1471-2164-13-357","article-title":"Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types","volume":"13","author":"Simpson","year":"2012","journal-title":"BMC Genomics"},{"key":"16","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1093\/nar\/gkq601","article-title":"Export of microRNAs and microRNA-protective protein by mammalian cells","volume":"38","author":"Galas","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"17","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1080\/08830180903093796","article-title":"miR-155: on the crosstalk between inflammation and cancer","volume":"28","author":"Michaille","year":"2009","journal-title":"Int Rev Immunol"},{"key":"18","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function","volume":"316","author":"Enright","year":"2007","journal-title":"Science"},{"key":"19","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.1182\/blood-2011-10-387522","article-title":"Regulation of acute graft-versus-host disease by microRNA-155","volume":"119","author":"Nuovo","year":"2012","journal-title":"Blood"},{"key":"20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.immuni.2008.11.010","article-title":"Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein","volume":"30","author":"Rudensky","year":"2009","journal-title":"Immunity"},{"key":"21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.atherosclerosis.2010.12.024","article-title":"Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration","volume":"215","author":"Qin","year":"2011","journal-title":"Atherosclersis"},{"key":"22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.vph.2016.05.016","article-title":"Endothelial microparticles: Pathogenic or passive players in endothelial dysfunction in autoimmune rheumatic diseases?","volume":"86","author":"Alexander","year":"2016","journal-title":"Vascul Pharmacol"},{"key":"23","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s12185-011-0803-1","article-title":"Implications of TNF-alpha in the pathogenesis and management of GVHD","volume":"93","author":"Levine","year":"2011","journal-title":"Int J Hematol"},{"key":"24","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"25","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1016\/j.ijcard.2013.08.050","article-title":"Endothelial microparticles exert differential effects on functions of Th1 in patients with acute coronary syndrome","volume":"168","author":"Fu","year":"2013","journal-title":"Int J Cardiol"},{"key":"26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11239-005-0343-8","article-title":"Losartan and simvastatin inhibit platelet activation in hypertensive patients","volume":"18","author":"Iwasaka","year":"2004","journal-title":"J Thromb Thrombolysis"},{"key":"27","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.bbmt.2010.02.008","article-title":"Endothelial dysfunction after hematopoietic stem cell transplantation: role of the conditioning regimen and the type of transplantation","volume":"16","author":"Carreras","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"28","first-page":"2670","article-title":"Endothelial injury, an intriguing effect of methotrexate and cyclophosphamide during hematopoietic stem cell transplantation in mice","volume":"40","author":"Wang","journal-title":"Transplant Proc"},{"key":"29","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1097\/TP.0000000000000385","article-title":"Changes in circulating endothelial cells count could become a valuable tool in the diagnostic definition of acute graft-versus-host disease","volume":"98","author":"Russo","year":"2014","journal-title":"Transplantation"},{"key":"30","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.4049\/jimmunol.1303431","article-title":"Endothelial microparticles interact with and support the proliferation of T cells","volume":"193","author":"Grau","year":"2014","journal-title":"J Immunol"},{"key":"31","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/CIRCRESAHA.110.226456","article-title":"Microparticles: protagonists of a novel communication network for intercellular information exchange","volume":"107","author":"Weber","year":"2010","journal-title":"Circ Res"},{"issue":"109","key":"32","first-page":"E2110","article-title":"MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response","volume":"2012","author":"Ozer","journal-title":"Proc Natl Acad Sci USA"},{"key":"33","first-page":"a81","article-title":"Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection","volume":"2","author":"Schober","year":"2009","journal-title":"Sci Signal"},{"key":"34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/nar\/gkp857","article-title":"Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs","volume":"38","author":"Lim","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/ctr.12314","article-title":"Serum microRNA155 is increased in patients with acute graft-versus-host disease","volume":"28","author":"Kong","year":"2014","journal-title":"Clin Transplant"},{"key":"36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cellimm.2013.04.001","article-title":"MicroRNA-155 regulates T cell proliferation through targeting GSK3beta in cardiac allograft rejection in a murine transplantation model","volume":"281","author":"Zheng","year":"2013","journal-title":"Cell Immunol"},{"key":"37","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2010.09.009","article-title":"MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development","volume":"33","author":"Baltimore","year":"2010","journal-title":"Immunity"},{"key":"38","doi-asserted-by":"crossref","first-page":"e46082","DOI":"10.1371\/journal.pone.0046082","article-title":"MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1","volume":"7","author":"Liao","year":"2012","journal-title":"PLoS One"},{"key":"39","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.1141229","article-title":"Regulation of the germinal center response by microRNA-155","volume":"316","author":"Yancopoulos","year":"2007","journal-title":"Science"},{"key":"40","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood-2008-06-162420","article-title":"In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations","volume":"113","author":"Serody","year":"2009","journal-title":"Blood"},{"key":"41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1084\/jem.20020399","article-title":"Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation","volume":"196","author":"Strober","year":"2002","journal-title":"J Exp Med"},{"key":"42","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"27","author":"Kuchroo","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"43","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1182\/blood-2011-03-340315","article-title":"Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORgammat in mice","volume":"118","author":"Yu","year":"2011","journal-title":"Blood"},{"key":"44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/path.1825","article-title":"BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas","volume":"207","author":"van den Berg","year":"2005","journal-title":"J Pathol"},{"key":"45","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1158\/0008-5472.CAN-09-4250","article-title":"MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene","volume":"70","author":"Wang","year":"2010","journal-title":"Cancer Res"},{"key":"46","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/00007890-197410000-00001","article-title":"Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors","volume":"18","author":"Thomas","year":"1974","journal-title":"Transplantation"},{"key":"47","unstructured":"Przepiorka, Weisdorf, Martin, Klingemann, Beatty, Hows, Thomas. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant. 1995; 15:pp. 825\u2013828."},{"key":"48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4049\/jimmunol.155.2.585","article-title":"Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease","volume":"155","author":"Ferrara","year":"1995","journal-title":"J Immunol"},{"key":"49","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1182\/blood.V88.8.3230.bloodjournal8883230","article-title":"An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin","volume":"88","author":"Ferrara","year":"1996","journal-title":"Blood"},{"key":"50","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.4049\/jimmunol.173.9.5467","article-title":"Target antigens determine graft-versus-host disease phenotype","volume":"173","author":"Shlomchik","year":"2004","journal-title":"J Immunol"},{"key":"51","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5551\/jat.12.138","article-title":"A simple method of isolating mouse aortic endothelial cells","volume":"12","author":"Kodama","year":"2005","journal-title":"J Atheroscler Thromb"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T16:33:59Z","timestamp":1719074039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.15579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":51,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,4,4]]}},"alternative-id":["15579","28423578"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.15579","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}