{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:20:22Z","timestamp":1786987222692,"version":"build-2736575974"},"reference-count":51,"publisher":"Impact Journals, LLC","issue":"19","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,5,9]]},"DOI":"10.18632\/oncotarget.16075","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T17:32:04Z","timestamp":1489167124000},"page":"31065-31078","source":"Crossref","is-referenced-by-count":25,"title":["Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head"],"prefix":"10.18632","volume":"8","author":[{"given":"Yi-Xuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Cong","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hui","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Microsurgery on Extremities, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Shui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Qing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China"},{"name":"Institute of Microsurgery on Extremities, Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1097\/01.alc.0000192039.21305.55","article-title":"Alcohol-induced bone loss and deficient bone repair","volume":"29","author":"Chakkalakal","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"issue":"B","key":"2","first-page":"320","article-title":"The effect of alcohol intake and the use of oral corticosteroids on the risk of idiopathic osteonecrosis of the femoral head: a case-control study in Japan","volume":"95","author":"Hirota","year":"2013","journal-title":"Bone Joint J"},{"key":"3","first-page":"365","article-title":"[Research progress of alcohol-induced osteonecrosis of femoral head]. [Article in Chinese]","volume":"27","author":"Zhang","year":"2013","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"4","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.arth.2009.05.022","article-title":"Prevalence of osteonecrosis of the femoral head: a nationwide epidemiologic analysis in Korea","volume":"24","author":"Rhyu","year":"2009","journal-title":"J Arthroplasty"},{"key":"5","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1007\/s11999-010-1292-x","article-title":"Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head","volume":"468","author":"Hirota","year":"2010","journal-title":"Clin Orth Relat Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/0366-6999.172567","article-title":"Etiologies and outcome of osteonecrosis of the femoral head: Etiology and outcome study in a Taiwan population","volume":"79","author":"Chen","year":"2016","journal-title":"J Chin Med Assoc"},{"key":"7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10354-013-0258-5","article-title":"Alcohol and bone","volume":"164","author":"Mikosch","year":"2014","journal-title":"Wien Med Wochenschr"},{"key":"8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF03346365","article-title":"Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol","volume":"31","author":"Minisola","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1359\/jbmr.2001.16.2.270","article-title":"The dose-response effects of ethanol on the human fetal osteoblastic cell line","volume":"16","author":"Turner","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1359\/jbmr.071023","article-title":"Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats","volume":"23","author":"Ronis","year":"2008","journal-title":"J Bone Miner Res"},{"key":"11","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/jbmr.7","article-title":"A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt\/beta-catenin signaling","volume":"25","author":"Ronis","year":"2010","journal-title":"J Bone Miner Res"},{"key":"12","first-page":"165","article-title":"Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITFand","volume":"30","author":"Tsukamoto","year":"2012","journal-title":"Int J Mol Med"},{"key":"13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/ten.2005.11.41","article-title":"Modulation of proliferation and differentiation of human bone marrow stromal cells by fibroblast growth factor 2: potential implications for tissue engineering of tendons and ligaments","volume":"11","author":"Van Griensven","year":"2005","journal-title":"Tissue Eng"},{"key":"14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bone.2011.09.036","article-title":"N-cadherin adherens junctions mediate osteogenesis through PI3K signaling","volume":"50","author":"Naski","year":"2012","journal-title":"Bone"},{"key":"15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0959-437X(98)80062-2","article-title":"Mechanism of activation and function of protein kinase B","volume":"8","author":"Cohen","year":"1998","journal-title":"Curr Opin Genet Dev"},{"key":"16","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0960-9822(02)00972-7","article-title":"High-resolution structure of the pleckstrin homology domain of protein kinase b\/akt bound to phosphatidylinositol (3, 4, 5)-trisphosphate","volume":"12","author":"van Aalten","year":"2002","journal-title":"Curr Biol"},{"key":"17","doi-asserted-by":"crossref","first-page":"31515","DOI":"10.1074\/jbc.272.50.31515","article-title":"Role of translocation in the activation and function of protein kinase B","volume":"272","author":"Hemmings","year":"1997","journal-title":"J Biol Chem"},{"key":"18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.onc.1201947","article-title":"Akt activation by growth factors is a multiple-step process: the role of the PH domain","volume":"17","author":"Tsichlis","year":"1998","journal-title":"Oncogene"},{"key":"19","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","article-title":"Mechanism of activation of protein kinase B by insulin and IGF-1","volume":"15","author":"Hemmings","year":"1996","journal-title":"EMBO J"},{"key":"20","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1042\/bj20031229","article-title":"Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change","volume":"375","author":"Van Aalten","year":"2003","journal-title":"Biochem J"},{"key":"21","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1371\/journal.pbio.0050095","article-title":"Intramolecular and intermolecular interactions of protein kinase B define its activation","volume":"5","author":"Larijani","year":"2007","journal-title":"PLoS Biol"},{"key":"22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20150041","article-title":"Akt\/PKB: one kinase, many modifications","volume":"468","author":"Srebrow","year":"2015","journal-title":"Biochem J"},{"key":"23","doi-asserted-by":"crossref","first-page":"23771","DOI":"10.1074\/jbc.M111.251116","article-title":"An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts","volume":"286","author":"Mason","year":"2011","journal-title":"J Biol Chem"},{"key":"24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/jor.22884","article-title":"microRNA-21 promotes osteogenic differentiation of mesenchymal stem cells by the PI3K\/beta-catenin pathway","volume":"33","author":"Yang","year":"2015","journal-title":"J Orthop Res"},{"key":"25","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1359\/jbmr.081011","article-title":"Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts","volume":"24","author":"Ronis","year":"2009","journal-title":"J Bone Miner Res"},{"key":"26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxlet.2013.11.029","article-title":"Fluoride promotes osteoblastic differentiation through canonical Wnt\/beta-catenin signaling pathway","volume":"225","author":"Sun","year":"2014","journal-title":"Toxicol Lett"},{"key":"27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1530-0277.1982.tb05017.x","article-title":"The feeding of alcohol in liquid diets: two decades of applications and 1982 update","volume":"6","author":"DeCarli","year":"1982","journal-title":"Alcohol Clin Exp Res"},{"key":"28","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/iep.12035","article-title":"Experimental rat model for alcohol-induced osteonecrosis of the femoral head","volume":"94","author":"Matsumoto","year":"2013","journal-title":"Int J Exp Pathol"},{"key":"29","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1002\/art.30365","article-title":"Osteonecrosis development in a novel rat model characterized by a single application of oxidative stress","volume":"63","author":"Matsumoto","year":"2011","journal-title":"Arthritis Rheum"},{"key":"30","first-page":"227","article-title":"Femoral head osteonecrosis can be caused by disruption of the systemic immune response via the toll-like receptor 4 signalling pathway","volume":"48","author":"Matsumoto","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.scr.2013.09.009","article-title":"Novel markers of osteogenic and adipogenic differentiation of human bone marrow stromal cells identified using a quantitative proteomics approach","volume":"12","author":"Karlsson","year":"2014","journal-title":"Stem Cell Res"},{"key":"32","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1002\/hep.25543","article-title":"Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice","volume":"55","author":"Nieto","year":"2012","journal-title":"Hepatology"},{"key":"33","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/hep.24708","article-title":"Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase\/sterol regulatory element-binding protein 1 signaling in mice","volume":"55","author":"You","year":"2012","journal-title":"Hepatology"},{"key":"34","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/hep.24599","article-title":"An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice","volume":"54","author":"Catalano","year":"2011","journal-title":"Hepatology"},{"key":"35","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/hep.26200","article-title":"Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury","volume":"57","author":"Nagy","year":"2013","journal-title":"Hepatology"},{"key":"36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2009.02.007","article-title":"Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action","volume":"114","author":"Harvey","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"key":"37","doi-asserted-by":"crossref","first-page":"8616143","DOI":"10.1155\/2016\/8616143","article-title":"The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs","volume":"2016","author":"Tong","year":"2016","journal-title":"Stem Cell Int"},{"key":"38","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3892\/ijmm.2015.2340","article-title":"Lithium chloride attenuates the abnormal osteogenic\/adipogenic differentiation of bone marrow-derived mesenchymal stem cells obtained from rats with steroid-related osteonecrosis by activating the beta-catenin pathway","volume":"36","author":"Wang","year":"2015","journal-title":"Int J Mol Med"},{"key":"39","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Kneissel","year":"2013","journal-title":"Nat Med"},{"key":"40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/cb2003237","article-title":"Effects of ethanol on conformational changes of Akt studied by chemical cross-linking, mass spectrometry, and (18)O labeling","volume":"7","author":"Kim","year":"2012","journal-title":"ACS Chem Biol"},{"key":"41","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1073\/pnas.1202810109","article-title":"Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death","volume":"109","author":"Rigby","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"42","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/onc.2013.2","article-title":"Site-specific activation of AKT protects cells from death induced by glucose deprivation","volume":"33","author":"Ding","year":"2014","journal-title":"Oncogene"},{"key":"43","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1073\/pnas.1424641112","article-title":"ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis","volume":"112","author":"Montminy","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"44","doi-asserted-by":"crossref","first-page":"e17894","DOI":"10.1371\/journal.pone.0017894","article-title":"Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner","volume":"6","author":"Burton","year":"2011","journal-title":"PloS One"},{"key":"45","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.toxlet.2013.10.032","article-title":"Exposure to ethanol and nicotine induces stress responses in human placental BeWo cells","volume":"224","author":"Loikkanen","year":"2014","journal-title":"Toxicol Lett"},{"key":"46","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.3390\/biom5042538","article-title":"Endoplasmic Reticulum Stress and Ethanol Neurotoxicity","volume":"5","author":"Luo","year":"2015","journal-title":"Biomolecules"},{"key":"47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/acer.12311","article-title":"The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity","volume":"38","author":"Ke","year":"2014","journal-title":"Alcohol Clin Exp Res"},{"key":"48","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/stem.2392","article-title":"Chronic High Dose Alcohol Induces Osteopenia via Activation of mTOR Signaling in Bone Marrow Mesenchymal Stem Cells","volume":"34","author":"Liu","year":"2016","journal-title":"Stem Cells"},{"key":"49","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.4161\/auto.21376","article-title":"Autophagy is a protective response to ethanol neurotoxicity","volume":"8","author":"Luo","year":"2012","journal-title":"Autophagy"},{"key":"50","first-page":"6","article-title":"ROS, MAPK\/ERK and PKC play distinct roles in EGF-stimulated human corneal cell proliferation and migration","volume":"61","author":"Zheng","year":"2015","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"51","doi-asserted-by":"crossref","first-page":"26835","DOI":"10.1038\/srep26835","article-title":"Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T17:19:30Z","timestamp":1750094370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,10]]},"references-count":51,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2017,5,9]]}},"alternative-id":["16075","28415692"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.16075","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,10]]}}}