{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:17:24Z","timestamp":1779164244322,"version":"3.51.4"},"reference-count":63,"publisher":"Impact Journals, LLC","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,4,11]]},"DOI":"10.18632\/oncotarget.16108","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T22:56:20Z","timestamp":1489186580000},"page":"25599-25611","source":"Crossref","is-referenced-by-count":32,"title":["Global miRNA expression profiling of domestic cat livers following acute<i>Toxoplasma gondii<\/i>infection"],"prefix":"10.18632","volume":"8","author":[{"given":"Wei","family":"Cong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China"},{"name":"College of Marine Science, Shandong University at Weihai, Weihai, Shandong Province 264209, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Jun","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa-Cai","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hany M.","family":"Elsheikha","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Quan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"1","first-page":"313","volume-title":"Toxoplasmosis of animals and humans","author":"Dubey","year":"2010","edition":"Second edition"},{"key":"2","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Liesenfeld","year":"2004","journal-title":"Lancet"},{"key":"3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.puhe.2007.08.009","article-title":"Congenital toxoplasmosis: priorities for further health promotion action","volume":"122","author":"Elsheikha","year":"2008","journal-title":"Public Health"},{"key":"4","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.2460\/javma.1990.197.12.1616","article-title":"Acute primary toxoplasmic hepatitis in an adult cat shedding Toxoplasma gondii oocysts","volume":"197","author":"Osofsky Tobias","year":"1990","journal-title":"J Am Vet Med Assoc"},{"key":"5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-3164.2005.00434.x","article-title":"Feline cutaneous toxoplasmosis: a case report","volume":"16","author":"Abramo","year":"2005","journal-title":"Vet Dermatol"},{"key":"6","first-page":"E1","article-title":"Fatal disseminated toxoplasmosis in an immunocompetent cat","volume":"84","author":"Schoeman","year":"2013","journal-title":"J S Afr Vet Assoc"},{"key":"7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/01652176.2014.978510","article-title":"Hyperplastic cholangitis in a naturally Toxoplasma gondii-infected cat","volume":"34","author":"Bettini","year":"2014","journal-title":"Vet Q"},{"key":"8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1046\/j.1469-0691.2002.00485.x","article-title":"Toxoplasma gondii: transmission, diagnosis and prevention","volume":"8","author":"Dubey","year":"2002","journal-title":"Clin Microbiol Infect"},{"key":"9","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/104063871102300117","article-title":"Isolation and genotyping of Toxoplasma gondii causing fatal systemic toxoplasmosis in an immunocompetent 10-year-old cat","volume":"23","author":"Frey","year":"2011","journal-title":"J Vet Diagn Invest"},{"key":"10","first-page":"159","article-title":"Reactivated toxoplasmosis in a FIV-positive cat","volume":"28","author":"Martin","year":"1998","journal-title":"Aus Vet Pract"},{"key":"11","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1645\/GE-3257.1","article-title":"Ante-mortem diagnosis, diarrhea, oocyst shedding, treatment, isolation, and genetic typing of Toxoplasma gondii associated with clinical toxoplasmosis in a naturally infected cat","volume":"99","author":"Prowell","year":"2013","journal-title":"J Parasitol"},{"key":"12","first-page":"216","article-title":"A rare case of feline congenital Toxoplasma gondii infection: fatal outcome of systemic toxoplasmosis for the mother and its kitten","volume":"126","author":"Kul","year":"2013","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"13","doi-asserted-by":"crossref","first-page":"e0152022","DOI":"10.1371\/journal.pone.0152022","article-title":"Proteomic profiling of mouse liver following acute Toxoplasma gondii infection","volume":"11","author":"Zhu","year":"2016","journal-title":"PLoS One"},{"key":"14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13071-016-1716-x","article-title":"Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection","volume":"9","author":"Zhu","year":"2016","journal-title":"Parasit Vectors"},{"key":"15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"16","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1085242","article-title":"Role of microRNAs in plant and animal development","volume":"301","author":"Ambros","year":"2003","journal-title":"Science"},{"key":"17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Kim","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"18","first-page":"597","article-title":"The widespread regulation of microRNA biogenesis, functions and decay","volume":"33","author":"Filipowicz","year":"2010","journal-title":"Nat Rev Genet"},{"key":"19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1053\/jhep.2001.26517","article-title":"MultivirC Group. Factors affecting liver fibrosis in human immunodeficiency virus-and hepatitis C virus-coinfected patients: impact of protease inhibitor therapy","volume":"34","author":"Poynard","year":"2001","journal-title":"Hepatology"},{"key":"20","first-page":"5","article-title":"MicroRNAs in the host-apicomplexan parasites interactions: a review of immunopathological aspects","volume":"6","author":"Costa","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.meegid.2015.11.005","article-title":"Analysis of miRNA expression profiling in mouse spleen affected by acute Toxoplasma gondii infection","volume":"37","author":"Zhu","year":"2016","journal-title":"Infect Genet Evol"},{"key":"22","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1086\/338000","article-title":"Suppression of NF-kappaB activation by infection with Toxoplasma gondii","volume":"185","author":"Hunter","year":"2002","journal-title":"J Infect Dis"},{"key":"23","doi-asserted-by":"crossref","first-page":"e8742","DOI":"10.1371\/journal.pone.0008742","article-title":"Toxoplasma gondii infection specifically increases the levels of key host microRNAs","volume":"5","author":"Boothroyd","year":"2010","journal-title":"PLoS One"},{"key":"24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2008.12.027","article-title":"MicroRNA control in the immune system: basic principles","volume":"136","author":"Rajewsky","year":"2009","journal-title":"Cell"},{"key":"25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12920-014-0068-7","article-title":"Overexpression of miR-21-5p as a predictive marker for complete tumor regression to neoadjuvant chemoradiotherapy in rectal cancer patients","volume":"7","author":"Parmigiani","year":"2014","journal-title":"BMC Med Genomics"},{"key":"26","first-page":"1428271","article-title":"Differentially expressed miRNAs in tumor, adjacent, and normal tissues of lung adenocarcinoma","volume":"2016","author":"Ge","year":"2016","journal-title":"Biomed Res Int"},{"key":"27","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/jgh.13300","article-title":"MiR 21-5p as a predictor of recurrence in young gastric cancer patients","volume":"31","author":"Jung","year":"2016","journal-title":"J Gastroenterol Hepatol"},{"key":"28","doi-asserted-by":"crossref","first-page":"e8742","DOI":"10.1371\/journal.pone.0008742","article-title":"Toxoplasma gondii infection specifically increases the levels of key host microRNAs","volume":"5","author":"Boothroyd","year":"2010","journal-title":"PLoS One"},{"key":"29","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1038\/onc.2010.83","article-title":"De-repression of CTGF via the miR-17-92 cluster upon differentiation of human glioblastoma spheroid cultures","volume":"29","author":"Radlwimmer","year":"2010","journal-title":"Oncogene"},{"key":"30","doi-asserted-by":"crossref","first-page":"e1000920","DOI":"10.1371\/journal.ppat.1000920","article-title":"A complex small RNA repertoire is generated by a plant\/fungal-like machinery and effected by a metazoan-like argonaute in the single-cell human parasite Toxoplasma gondii","volume":"6","author":"Hakimi","year":"2010","journal-title":"PLoS Pathog"},{"key":"31","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.virol.2011.01.002","article-title":"Virus-encoded microRNAs","volume":"411","author":"Sullivan","year":"2011","journal-title":"Virology"},{"key":"32","doi-asserted-by":"crossref","first-page":"e1000681","DOI":"10.1371\/journal.ppat.1000681","article-title":"NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses","volume":"5","author":"Chen","year":"2009","journal-title":"PLoS Pathog"},{"key":"33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nature06607","article-title":"Regulation of progenitor cell proliferation and granulocyte function by microRNA-223","volume":"451","author":"Camargo","year":"2008","journal-title":"Nature"},{"key":"34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cell.2008.12.027","article-title":"MicroRNA control in the immune system: basic principles","volume":"136","author":"Rajewsky","year":"2009","journal-title":"Cell"},{"key":"35","doi-asserted-by":"crossref","first-page":"8191","DOI":"10.1128\/MCB.00242-06","article-title":"Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA","volume":"26","author":"Saunders","year":"2006","journal-title":"Mol Cell Biol"},{"key":"36","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nature03552","article-title":"A microRNA polycistron as a potential human oncogene","volume":"435","author":"Hammond","year":"2005","journal-title":"Nature"},{"key":"37","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1182\/blood.V126.23.3390.3390","article-title":"Franco-Penteado CF. miRNA-146a, miRNA-203a, and miRNA-223 modulate inflammatory response in LPS- acute lung injury in Sickle Cell transgenic mice","volume":"126","author":"Costa","year":"2015","journal-title":"Blood"},{"key":"38","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nature06607","article-title":"Regulation of progenitor cell proliferation and granulocyte function by microRNA-223","volume":"451","author":"Camargo","year":"2008","journal-title":"Nature"},{"key":"39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.biopha.2013.03.013","article-title":"MiR-223\/Ect2\/p21 signaling regulates osteosarcoma cell cycle progression and proliferation","volume":"67","author":"Xu","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"40","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbadis.2009.02.013","article-title":"miR-155 gene: a typical multifunctional microRNA","volume":"1792","author":"Bonmassar","year":"2009","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/imr.12057","article-title":"miR-155: an ancient regulator of the immune system","volume":"253","author":"Leyland","year":"2013","journal-title":"Immunol Rev"},{"key":"42","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Baltimore","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"43","first-page":"578","article-title":"MicroRNA-146a: a dominant, negative regulator of the innate immune response","volume":"5","author":"Booth","year":"2014","journal-title":"Front Immunol"},{"issue":"11","key":"44","first-page":"215","article-title":"miR-126, a new modulator of innate immunity","volume":"2014","author":"La Cava","journal-title":"Cell Mol Immunol"},{"key":"45","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/cr.2012.174","article-title":"miR-486 sustains NF-\u03baB activity by disrupting multiple NF-\u03baB-negative feedback loops","volume":"23","author":"Li","year":"2013","journal-title":"Cell Res"},{"key":"46","doi-asserted-by":"crossref","first-page":"28929","DOI":"10.1074\/jbc.M702633200","article-title":"A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection","volume":"282","author":"LaRusso","year":"2007","journal-title":"J Biol Chem"},{"key":"47","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.celrep.2014.02.002","article-title":"MiR-146a and miR-155 delineate a microRNA fingerprint associated with Toxoplasma persistence in the host brain","volume":"6","author":"Hakimi","year":"2014","journal-title":"Cell Rep"},{"key":"48","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/1756-3305-7-433","article-title":"Plasma microRNAs are promising novel biomarkers for the early detection of Toxoplasma gondii infection","volume":"7","author":"Chen","year":"2014","journal-title":"Parasit Vectors"},{"key":"49","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1128\/CVI.05578-11","article-title":"Vaccination with a DNA vaccine coding for perforin-like protein 1 and MIC6 induces significant protective immunity against Toxoplasma gondii","volume":"19","author":"Zhu","year":"2012","journal-title":"Clin Vaccine Immunol"},{"key":"50","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpara.2009.08.001","article-title":"Atypical Toxoplasma gondii genotypes identified in oocysts shed by cats in Germany","volume":"40","author":"Schares","year":"2010","journal-title":"Int J Parasitol"},{"key":"51","doi-asserted-by":"crossref","first-page":"e80213","DOI":"10.1371\/journal.pone.0080213","article-title":"Serotyping of Toxoplasma gondii in cats (Felis domesticus) reveals predominance of Type II infections in Germany","volume":"8","author":"Schares","year":"2013","journal-title":"PLoS One"},{"key":"52","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.vetpar.2016.06.008","article-title":"Comparison of genotypes of Toxoplasma gondii in domestic cats from Australia with latent infection or clinical toxoplasmosis","volume":"228","author":"Barrs","year":"2016","journal-title":"Vet Parasitol"},{"key":"53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.meegid.2016.01.005","article-title":"Molecular detection and genetic characterization of Toxoplasma gondii infection in sika deer (Cervus nippon) in China","volume":"39","author":"Zhu","year":"2016","journal-title":"Infect Genet Evol"},{"key":"54","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.canlet.2015.01.036","article-title":"Toxoplasma gondii infection in cancer patients: Prevalence, risk factors, genotypes and association with clinical diagnosis","volume":"359","author":"Zhu","year":"2015","journal-title":"Cancer Lett"},{"key":"55","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Salzberg","year":"2009","journal-title":"Genome Biol"},{"key":"56","first-page":"37","article-title":"miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades","volume":"40","author":"Rajewsky","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"57","first-page":"140","article-title":"miREvo: An integrative microRNA evolutionary analysis platform for next-generation sequencing experiments","volume":"13","author":"Tang","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"58","doi-asserted-by":"crossref","first-page":"e15224","DOI":"10.1371\/journal.pone.0015224","article-title":"Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma","volume":"5","author":"Shen","year":"2010","journal-title":"PLoS One"},{"key":"59","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1186\/gb-2003-5-1-r1","article-title":"MicroRNA targets in Drosophila","volume":"5","author":"Marks","year":"2003","journal-title":"Genome Biol"},{"key":"60","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.ymeth.2014.01.019","article-title":"Gene Ontology based housekeeping gene selection for RNA-seq normalization","volume":"67","author":"Pai","year":"2014","journal-title":"Methods"},{"key":"61","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1093\/bioinformatics\/bti430","article-title":"Automated genome annotation and pathway identification using the KEGG orthology (KO) as a controlled vocabulary","volume":"21","author":"Wei","year":"2005","journal-title":"Bioinformatics"},{"key":"62","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1093\/nar\/gni178","article-title":"Real-time quantification of microRNAs by stem-loop RT-PCR","volume":"33","author":"Andersen","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"63","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using realtime quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Schmittgen","year":"2001","journal-title":"Methods"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T22:51:28Z","timestamp":1719096688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,10]]},"references-count":63,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2017,4,11]]}},"alternative-id":["16108","28424428"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.16108","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,10]]}}}