{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:59:34Z","timestamp":1771495174420,"version":"3.50.1"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,5,23]]},"DOI":"10.18632\/oncotarget.16655","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T19:57:53Z","timestamp":1490817473000},"page":"34565-34575","source":"Crossref","is-referenced-by-count":22,"title":["Reprogramming induced by isoliquiritigenin diminishes melanoma cachexia through mTORC2-AKT-GSK3\u03b2 signaling"],"prefix":"10.18632","volume":"8","author":[{"given":"Xiao-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Chun","family":"Han","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Xinjiang Endemic Phytomedicine Resources of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, 832002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Ping","family":"Dong","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Na","family":"Yu","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Hai","family":"Pan","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan-Jun","family":"Qu","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Guo","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu-Sheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Binzhou Medical University, Yantai, Shandong, 264003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.cell.2008.01.015","article-title":"Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming","volume":"132","author":"Young","year":"2008","journal-title":"Cell"},{"key":"2","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature05944","article-title":"reprogramming of fibroblasts into a pluripotent ES-cell-like state","volume":"448","author":"Jaenisch","year":"2007","journal-title":"Nature"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.237","article-title":"Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming","volume":"32","author":"Matushansky","year":"2013","journal-title":"Oncogene"},{"key":"4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/2030","article-title":"Differentiation and reversal of malignant changes in colon cancer through PPAR gamma","volume":"4","author":"Spiegelman","year":"1998","journal-title":"Nat Med"},{"key":"5","first-page":"1129","article-title":"Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor gamma innon-small cell lung cancer","volume":"60","author":"Szabo","year":"2000","journal-title":"Cancer Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1097-2765(00)80047-7","article-title":"Terminal differentiation of human breast cancer through PPAR gamma","volume":"1","author":"Spiegelman","year":"1998","journal-title":"Mol Cell"},{"key":"7","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.cell.2008.08.021","article-title":"Cancer cell metabolism: Warburg and beyond","volume":"134","author":"Sabatini","year":"2008","journal-title":"Cell"},{"key":"8","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Weinberg","year":"2011","journal-title":"Cell"},{"key":"9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2049-3002-2-18","article-title":"Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia","volume":"2","author":"Singh","year":"2014","journal-title":"Cancer Metab"},{"key":"10","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3892\/etm.2012.787","article-title":"Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus","volume":"5","author":"Li","year":"2013","journal-title":"Exp Ther Med"},{"key":"11","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ceb.2005.09.009","article-title":"Growing roles for the mTOR pathway","volume":"17","author":"Sabatini","year":"2005","journal-title":"Curr Opin Cell Biol"},{"key":"12","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1371\/journal.pbio.1000038","article-title":"Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2","volume":"7","author":"Shokat","year":"2009","journal-title":"PLoS Biol"},{"key":"13","article-title":"mTOR Signaling","volume":"4","author":"Sabatini","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"14","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.1182\/blood-2006-06-030833","article-title":"Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML","volume":"109","author":"Konopleva","year":"2007","journal-title":"Blood"},{"key":"15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.7497\/j.issn.2095-3941.2014.04.004","article-title":"Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance","volume":"11","author":"Mischel","year":"2014","journal-title":"Cancer Biol Med"},{"key":"16","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.immuni.2016.08.017","article-title":"mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation","volume":"45","author":"Locasale","year":"2016","journal-title":"Immunity"},{"key":"17","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.cmet.2013.03.017","article-title":"WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation","volume":"17","author":"Long","year":"2013","journal-title":"Cell Metab"},{"key":"18","doi-asserted-by":"publisher","first-page":"4691","DOI":"10.1128\/MCB.00764-09","article-title":"The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts","volume":"29","author":"Houghton","year":"2009","journal-title":"Mol Cell Biol"},{"key":"19","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.cmet.2013.09.013","article-title":"mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc","volume":"18","author":"Yang","year":"2013","journal-title":"Cell Metab"},{"key":"20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1476-4598-9-57","article-title":"Targeting mTORC2 inhibits colon cancer cell proliferationand tumor formation","volume":"9","author":"Dormond","year":"2010","journal-title":"Mol Cancer"},{"key":"21","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1002\/ijc.28023","article-title":"Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: new strategies for overcoming resistanceto VEGFR and mTORC1 inhibitors","volume":"133","author":"Brechbiel","year":"2013","journal-title":"Int J Cancer"},{"key":"22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1055\/s-2001-18361","article-title":"Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells","volume":"67","author":"Xu","year":"2001","journal-title":"Planta Med"},{"key":"23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1248\/bpb.25.247","article-title":"Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis","volume":"25","author":"Okuyama","year":"2002","journal-title":"Biol Pharm Bull"},{"key":"24","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1021\/jf010774e","article-title":"Novel polyphenol molecule isolated from licorice root (Glycrrhiza glabra) induces apoptosis, G2\/M cell cycle arrest, and Bcl-2 phosphorylation in tumor cell lines","volume":"50","author":"DiPaola","year":"2002","journal-title":"J Agric Food Chem"},{"key":"25","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.freeradbiomed.2008.11.011","article-title":"Isoliquiritigenin induces monocytic differentiation of HL-60 cells","volume":"46","author":"Li","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"26","doi-asserted-by":"publisher","first-page":"534934","DOI":"10.1155\/2012\/534934","article-title":"Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line","volume":"2012","author":"Zheng","year":"2012","journal-title":"Oxid Med Cell Longev"},{"key":"27","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.gene.2016.07.052","article-title":"Differentiation-inducing and anti-proliferative activities of isoliquiritigenin and all-trans-retinoic acid on B16F0 melanoma cells: Mechanisms profiling by RNA-seq","volume":"592","author":"Zheng","year":"2016","journal-title":"Gene"},{"key":"28","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2174\/1573406412666160307151904","article-title":"Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis inMouse Melanoma B16F10 Cells","volume":"11","author":"Zheng","year":"2016","journal-title":"Recent Pat Anticancer Drug Discov"},{"key":"29","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1073\/pnas.95.4.1511","article-title":"A unique glucose-dependent apoptotic pathway induced by c-Myc","volume":"95","author":"Dang","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"30","first-page":"929","article-title":"Treatment of acute promyelocytic leukemia with all-trans retinoic acid: an update of the New York experience","volume":"8","author":"Frankel","year":"1994","journal-title":"Leukemia"},{"key":"31","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.molonc.2011.01.006","article-title":"Tyrosinase related protein 1 (TYRP1\/gp75) in human cutaneous melanoma","volume":"5","author":"Fabrice","year":"2011","journal-title":"Mol Oncol"},{"key":"32","doi-asserted-by":"publisher","first-page":"e2734","DOI":"10.1371\/journal.pone.0002734","article-title":"Oncogenic BRAF regulates melanoma proliferation through the lineage specific factor MITF","volume":"3","author":"Marais","year":"2008","journal-title":"PLoS One"},{"key":"33","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.ccr.2012.02.014","article-title":"Metabolic reprogramming: a cancer hallmark even warburg did not anticipate","volume":"21","author":"Thompson","year":"2012","journal-title":"Cancer Cell"},{"key":"34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1159\/000335792","article-title":"Defining the molecular basis of tumor metabolism: a continuing challenge since Warburg's discovery","volume":"28","author":"Cavagis","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"35","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/ng.2762","article-title":"Emerging landscape of oncogenic signatures across human cancers","volume":"45","author":"Sander","year":"2013","journal-title":"Nat Genet"},{"key":"36","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.gde.2012.12.005","article-title":"mTOR in aging, metabolism, and cancer","volume":"23","author":"Hall","year":"2013","journal-title":"Curr Opin Genet Dev"},{"key":"37","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1042\/BST20130041","article-title":"A growing role for mTOR in promoting anabolic metabolism","volume":"41","author":"Manning","year":"2013","journal-title":"Biochem Soc Trans"},{"key":"38","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1158\/2159-8290.CD-11-0124","article-title":"Oncogenic EGFR signaling activates an mTORC2-NF-\u03baB pathway that promotes chemotherapy resistance","volume":"1","author":"Dibble","year":"2011","journal-title":"Cancer Discov"},{"key":"39","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.molcel.2013.08.019","article-title":"TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks","volume":"51","author":"Gasser","year":"2013","journal-title":"Mol Cell"},{"key":"40","doi-asserted-by":"publisher","first-page":"e1000374","DOI":"10.1371\/journal.pgen.1000374","article-title":"A drosophila model for EGFR- Ras and PI3K-dependent human glioma","volume":"5","author":"Thomas","year":"2009","journal-title":"PLoS Genet"},{"key":"41","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1073\/pnas.96.8.4240","article-title":"New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide3-kinase\/AKT pathway","volume":"96","author":"Neel","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"42","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.bbrc.2005.07.041","article-title":"Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation","volume":"334","author":"Minamoto","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"43","first-page":"581","article-title":"Mechanism of cellular 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction","volume":"69","author":"Schubert","year":"1997","journal-title":"J Neurochem"},{"key":"44","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.18632\/oncotarget.1202","article-title":"Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness","volume":"4","author":"Hermeking","year":"2013","journal-title":"Oncotarget"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T19:26:21Z","timestamp":1589138781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,29]]},"references-count":44,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2017,5,23]]}},"alternative-id":["16655","28410220"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.16655","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,29]]}}}