{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:28:37Z","timestamp":1791584917144,"version":"4.3.4"},"reference-count":45,"publisher":"Impact Journals, LLC","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,5,30]]},"DOI":"10.18632\/oncotarget.16661","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T21:02:52Z","timestamp":1490821372000},"page":"36137-36148","source":"Crossref","is-referenced-by-count":171,"title":["Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21\/VEGF signal"],"prefix":"10.18632","volume":"8","author":[{"given":"Xu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotang","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Stroke Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji C.","family":"Bihl","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China"},{"name":"Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH 45435, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,3,29]]},"reference":[{"key":"1","first-page":"ii1","article-title":"CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010","volume":"15","author":"Barnholtz-Sloan","year":"2013","journal-title":"Neuro Oncol"},{"key":"2","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1021\/acs.molpharmaceut.5b00694","article-title":"Nanoparticle-Delivered Antisense MicroRNA-21 Enhances the Effects of Temozolomide on Glioblastoma Cells","volume":"12","author":"Massoud","year":"2015","journal-title":"Mol Pharm"},{"key":"3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"Bates","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s13238-010-0078-y","article-title":"Cancer stem cells in glioblastoma\u2014molecular signaling and therapeutic targeting","volume":"1","author":"Bao","year":"2010","journal-title":"Protein Cell"},{"key":"5","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1158\/0008-5472.CAN-04-1364","article-title":"Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma","volume":"64","author":"Vescovi","year":"2004","journal-title":"Cancer Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Rich","year":"2006","journal-title":"Nature"},{"key":"7","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/nou223","article-title":"CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011","volume":"16","author":"Barnholtz-Sloan","year":"2014","journal-title":"Neuro Oncol"},{"key":"8","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ccr.2012.03.003","article-title":"Cancer stem cells: impact, heterogeneity, and uncertainty","volume":"21","author":"Morrison","year":"2012","journal-title":"Cancer Cell"},{"key":"9","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/sj.cdd.4401872","article-title":"Chemotherapy resistance of glioblastoma stem cells","volume":"13","author":"De","year":"2006","journal-title":"Cell Death Differ"},{"key":"10","first-page":"100","article-title":"Dual inhibition of PDK1 and Aurora Kinase A: an effective strategy to induce differentiation and apoptosis of human glioblastoma multiforme stem cells","volume":"8","author":"Rapposelli","year":"2016","journal-title":"ACS Chem Neurosci"},{"key":"11","doi-asserted-by":"crossref","first-page":"7843","DOI":"10.1158\/0008-5472.CAN-06-1010","article-title":"Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor","volume":"66","author":"Rich","year":"2006","journal-title":"Cancer Res"},{"key":"12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1596\/neo.12432","article-title":"Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition","volume":"14","author":"Kuo","year":"2012","journal-title":"Neoplasia"},{"key":"13","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/stem.98","article-title":"Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens","volume":"27","author":"Weiss","year":"2009","journal-title":"Stem Cells"},{"key":"14","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1158\/0008-5472.CAN-04-4449","article-title":"A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions","volume":"65","author":"Toker","year":"2005","journal-title":"Cancer Res"},{"key":"15","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1158\/0008-5472.CAN-03-1860","article-title":"Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta","volume":"64","author":"Schafer","year":"2004","journal-title":"Cancer Res"},{"key":"16","first-page":"572729","article-title":"Effects of endothelial progenitor cell-derived microvesicles on hypoxia\/reoxygenation-induced endothelial dysfunction and apoptosis","volume":"2013","author":"Chen","year":"2013","journal-title":"Oxid Med Cell Longev"},{"key":"17","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.2337\/db15-1563","article-title":"Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice","volume":"65","author":"Fan","year":"2016","journal-title":"Diabetes"},{"key":"18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/22115528113020020001","article-title":"Exosomes Function in Pro- and Anti-Angiogenesis","volume":"2","author":"Fan","year":"2013","journal-title":"Curr Angiogenes"},{"key":"19","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood-2014-05-576116","article-title":"Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1","volume":"124","author":"Ohyashiki","year":"2014","journal-title":"Blood"},{"key":"20","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","article-title":"Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers","volume":"10","author":"Breakefield","year":"2008","journal-title":"Nat Cell Biol"},{"key":"21","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/359843a0","article-title":"Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis","volume":"359","author":"Keshet","year":"1992","journal-title":"Nature"},{"key":"22","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ijc.2910590415","article-title":"Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possibleregulatory mechanisms","volume":"59","author":"Risau","year":"1994","journal-title":"Int J Cancer"},{"key":"23","doi-asserted-by":"crossref","first-page":"e19139","DOI":"10.1371\/journal.pone.0019139","article-title":"MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1alpha expression","volume":"6","author":"Jiang","year":"2011","journal-title":"PLoS One"},{"key":"24","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s12031-012-9759-8","article-title":"MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide","volume":"47","author":"Shi","year":"2012","journal-title":"J Mol Neurosci"},{"key":"25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","article-title":"Identification of human brain tumour initiating cells","volume":"432","author":"Dirks","year":"2004","journal-title":"Nature"},{"key":"26","first-page":"5821","article-title":"Identification of a cancer stem cell in human brain tumors","volume":"63","author":"Dirks","year":"2003","journal-title":"Cancer Res"},{"key":"27","doi-asserted-by":"publisher","first-page":"60736","DOI":"10.18632\/oncotarget.11177","article-title":"The functions and clinical applications of tumor-derived exosomes","volume":"7","author":"Zheng","year":"2016","journal-title":"Oncotarget"},{"key":"28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2015.10.011","article-title":"STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells","volume":"370","author":"Liu","year":"2016","journal-title":"Cancer Lett"},{"key":"29","doi-asserted-by":"publisher","first-page":"50349","DOI":"10.18632\/oncotarget.10387","article-title":"TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells","volume":"7","author":"Lalloue","year":"2016","journal-title":"Oncotarget"},{"key":"30","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1161\/CIRCRESAHA.106.141986","article-title":"MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation","volume":"100","author":"Zhang","year":"2007","journal-title":"Circ Res"},{"key":"31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-4598-6-60","article-title":"OncomiRs: the discovery and progress of microRNAs in cancers","volume":"6","author":"Cho","year":"2007","journal-title":"Mol Cancer"},{"key":"32","first-page":"2","article-title":"The emerging role of extracellular vesicle-derived miRNAs: implication in cancer progression and stem cell related diseases","author":"Al-Hendy","year":"2016","journal-title":"J Clin Epigenet"},{"key":"33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/sonc.2002.37263","article-title":"Role of angiogenesis in tumor growth and metastasis","volume":"29","author":"Folkman","year":"2002","journal-title":"Semin Oncol"},{"key":"34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1750-3639.2005.tb00115.x","article-title":"Angiogenesis in gliomas: biology and molecular pathophysiology","volume":"15","author":"Zagzag","year":"2005","journal-title":"Brain Pathol"},{"key":"35","doi-asserted-by":"crossref","first-page":"12743","DOI":"10.1007\/s13277-016-5165-0","article-title":"From glioblastoma to endothelial cells through extracellular vesicles: messages for angiogenesis","volume":"37","author":"Dolo","year":"2016","journal-title":"Tumour Biol"},{"key":"36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000333256","article-title":"Signaling pathways governing tumor angiogenesis","volume":"81","author":"Kudo","year":"2011","journal-title":"Oncology"},{"key":"37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1593\/neo.05583","article-title":"Bioavailability of VEGF in tumor-shed vesicles depends on vesicle burst induced by acidic pH","volume":"8","author":"Dolo","year":"2006","journal-title":"Neoplasia"},{"key":"38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0008-6363(00)00268-6","article-title":"Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family","volume":"49","author":"Gliki","year":"2001","journal-title":"Cardiovasc Res"},{"key":"39","doi-asserted-by":"crossref","first-page":"32714","DOI":"10.1074\/jbc.M103130200","article-title":"Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor\/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively","volume":"276","author":"Mukhopadhyay","year":"2001","journal-title":"J Biol Chem"},{"key":"40","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1158\/0008-5472.CAN-06-4180","article-title":"CD133(+) and CD133(\u2212) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles","volume":"67","author":"Beier","year":"2007","journal-title":"Cancer Res"},{"key":"41","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3892\/ol.2012.896","article-title":"microRNA-21 overexpression contributes to cell proliferation by targeting PTEN in endometrioid endometrial cancer","volume":"4","author":"Fu","year":"2012","journal-title":"Oncol Lett"},{"key":"42","doi-asserted-by":"crossref","first-page":"2639728","DOI":"10.1155\/2016\/2639728","article-title":"The Novel Methods for Analysis of Exosomes Released from Endothelial Cells and Endothelial Progenitor Cells","volume":"2016","author":"Bihl","year":"2016","journal-title":"Stem Cells Int"},{"key":"43","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.22641","article-title":"Quantitative analysis of histological staining and fluorescence using ImageJ","volume":"296","author":"Jensen","year":"2013","journal-title":"Anat Rec. (Hoboken.)"},{"key":"44","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/HYPERTENSIONAHA.111.00202","article-title":"Angiotensin-converting enzyme 2 priming enhances the function of endothelial progenitor cells and their therapeutic efficacy","volume":"61","author":"Chen","year":"2013","journal-title":"Hypertension"},{"key":"45","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2184.2006.00375.x","article-title":"Effects of rapamycin on number activity and eNOS of endothelial progenitor cells from peripheral blood","volume":"39","author":"Wang","year":"2006","journal-title":"Cell Prolif"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T19:22:09Z","timestamp":1750188129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,29]]},"references-count":45,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2017,5,30]]}},"alternative-id":["16661","28410224"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.16661","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,29]]}}}