{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:57:30Z","timestamp":1788814650584,"version":"build-2803163510"},"reference-count":38,"publisher":"Impact Journals, LLC","issue":"29","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,7,18]]},"DOI":"10.18632\/oncotarget.16789","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T10:43:47Z","timestamp":1491216227000},"page":"47052-47063","source":"Crossref","is-referenced-by-count":76,"title":["TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K\/AKT pathway and inducing EMT"],"prefix":"10.18632","volume":"8","author":[{"given":"Xinxing","family":"Li","sequence":"first","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houshan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolu","family":"Wang","sequence":"additional","affiliation":[{"name":"Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Liang","sequence":"additional","affiliation":[{"name":"Therapeutics Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital, Woolloongabba QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.amjsurg.2007.11.011","article-title":"Gallbladder cancer","volume":"196","author":"Salemis","year":"2008","journal-title":"Am J Surg"},{"key":"2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s13304-015-0328-x","article-title":"Surgical treatment of gallbladder carcinoma: a critical review","volume":"67","author":"Mafi","year":"2015","journal-title":"Updates Surg"},{"key":"3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1470-2045(03)01021-0","article-title":"Carcinoma of the gallbladder","volume":"4","author":"Sharma","year":"2003","journal-title":"Lancet Oncol"},{"key":"4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/dvdy.24242","article-title":"Trop2: from development to disease","volume":"244","author":"Wallace","year":"2015","journal-title":"Dev Dyn"},{"key":"5","doi-asserted-by":"publisher","first-page":"84","DOI":"10.18632\/genesandcancer.40","article-title":"Trop2 and its overexpression in cancers: regulation and clinical\/therapeutic implications","volume":"6","author":"Bonavida","year":"2015","journal-title":"Genes Cancer"},{"key":"6","first-page":"309","article-title":"Trop2: a possible therapeutic target for late stage epithelial carcinomas","volume":"1796","author":"Yao","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"7","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1073\/pnas.78.8.5147","article-title":"Human trophoblast cell-surface antigens defined by monoclonal antibodies","volume":"78","author":"Herzenberg","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"8","doi-asserted-by":"publisher","first-page":"6136","DOI":"10.18632\/oncotarget.6733","article-title":"Trop2 is overexpressed in gastric cancer and predicts poor prognosis","volume":"7","author":"Zhu","year":"2016","journal-title":"Oncotarget"},{"key":"9","doi-asserted-by":"crossref","first-page":"e75864","DOI":"10.1371\/journal.pone.0075864","article-title":"Overexpression of TROP2 predicts poor prognosis of patients with cervical cancer and promotes the proliferation and invasion of cervical cancer cells by regulating ERK signaling pathway","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/sj.bjc.6604677","article-title":"High expression of TROP2 correlates with poor prognosis in pancreatic cancer","volume":"99","author":"Spizzo","year":"2008","journal-title":"Br J Cancer"},{"key":"11","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1158\/1078-0432.CCR-05-1961","article-title":"Clinical significance of TROP2 expression in colorectal cancer","volume":"12","author":"Mori","year":"2006","journal-title":"Clin Cancer Res"},{"key":"12","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/emmm.201200222","article-title":"TROP2 is epigenetically inactivated and modulates IGF-1R signalling in lung adenocarcinoma","volume":"4","author":"Yang","year":"2012","journal-title":"EMBO Mol Med"},{"key":"13","doi-asserted-by":"publisher","first-page":"44492","DOI":"10.18632\/oncotarget.9876","article-title":"High expression of TROP2 characterizes different cell subpopulations in androgen-sensitive and androgen-independent prostate cancer cells","volume":"7","author":"Australian Prostate Cancer","year":"2016","journal-title":"Oncotarget"},{"key":"14","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/(SICI)1097-0215(19980529)76:5<671::AID-IJC10>3.0.CO;2-7","article-title":"Human Trop-2 is a tumor-associated calcium signal transducer","volume":"76","author":"Alberti","year":"1998","journal-title":"Int J Cancer"},{"key":"15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1476-4598-9-253","article-title":"Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway","volume":"9","author":"Yao","year":"2010","journal-title":"Mol Cancer"},{"key":"16","doi-asserted-by":"crossref","first-page":"11565","DOI":"10.1007\/s13277-014-2469-9","article-title":"Prognostic value of TROP2 expression in patients with gallbladder cancer","volume":"35","author":"Lei","year":"2014","journal-title":"Tumour Biol"},{"key":"17","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.bbrc.2012.02.090","article-title":"Characterization of cancer stem-like cells derived from a side population of a human gallbladder carcinoma cell line, SGC-996","volume":"419","author":"Yi","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"18","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1089\/scd.2011.0709","article-title":"Emodin as an effective agent in targeting cancer stem-like side population cells of gallbladder carcinoma","volume":"22","author":"Wang","year":"2013","journal-title":"Stem Cells Dev"},{"key":"19","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3892\/or.2012.2156","article-title":"Mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: glutathione reduction and MRP1 downregulation","volume":"29","author":"Wang","year":"2013","journal-title":"Oncol Rep"},{"key":"20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/07853890.2014.912836","article-title":"PI3K\/AKT signaling pathway and cancer: an updated review","volume":"46","author":"Hirsch","year":"2014","journal-title":"Ann Med"},{"key":"21","first-page":"252","article-title":"The PTEN\/PI3K\/AKT Pathway in vivo, Cancer Mouse Models","volume":"4","author":"Paramio","year":"2014","journal-title":"Front Oncol"},{"key":"22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00432-014-1803-3","article-title":"Current clinical regulation of PI3K\/PTEN\/Akt\/mTOR signalling in treatment of human cancer","volume":"141","author":"Yang","year":"2015","journal-title":"J Cancer Res Clin Oncol"},{"key":"23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/156800908784293659","article-title":"The PTEN\/PI3K\/AKT signalling pathway in cancer, therapeutic implications","volume":"8","author":"Leal","year":"2008","journal-title":"Curr Cancer Drug Targets"},{"key":"24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s10555-016-9607-3","article-title":"Molecular pathology in real time","volume":"35","author":"Ry\u0161ka","year":"2016","journal-title":"Cancer Metastasis Rev"},{"key":"25","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/PPO.0000000000000135","article-title":"Targeted Therapy for Cancer in the Genomic Era","volume":"21","author":"Sledge","year":"2015","journal-title":"Cancer J"},{"key":"26","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1101\/gad.196451.112","article-title":"Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via \u03b2-catenin signaling","volume":"26","author":"Witte","year":"2012","journal-title":"Genes Dev"},{"key":"27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3109\/00365529309098253","article-title":"Gallstone size and the risk of gallbladder cancer","volume":"28","author":"Schrover","year":"1993","journal-title":"Scand J Gastroenterol"},{"key":"28","first-page":"181","article-title":"Arsenic oxide targets stem cell marker CD133\/prominin-1 in gallbladder carcinoma","volume":"310","author":"Liu","year":"2011","journal-title":"Cancer Lett"},{"key":"29","first-page":"14","article-title":"SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K\/AKT pathway","volume":"27","author":"Jiang","year":"2015","journal-title":"Mol Cancer"},{"key":"30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13000-015-0381-2","article-title":"Inactivation of tumor suppressor gene pten in early and advanced gallbladder cancer","volume":"10","author":"Javle","year":"2015","journal-title":"Diagn Pathol"},{"key":"31","doi-asserted-by":"publisher","first-page":"894","DOI":"10.18632\/oncotarget.1808","article-title":"Role of aberrant PI3K pathway activation in gallbladder tumorigenesis","volume":"5","author":"Pandolfi","year":"2014","journal-title":"Oncotarget"},{"key":"32","doi-asserted-by":"crossref","first-page":"20882","DOI":"10.1073\/pnas.0811411106","article-title":"Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics","volume":"105","author":"Witte","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10555-008-9169-0","article-title":"the cytoskeleton, and cancer cell invasion","volume":"28","author":"Christofori","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"34","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.bbrc.2014.09.069","article-title":"Breast cancer stem cells, EMT and therapeutic targets","volume":"453","author":"Bhattacharya","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.canlet.2014.09.021","article-title":"EMT in cervical cancer: its role in tumour progression and response to therapy","volume":"356","author":"Rizvi","year":"2015","journal-title":"Cancer Lett"},{"key":"36","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1615\/CritRevOncog.2014011802","article-title":"The EMT universe: space between cancer cell dissemination and metastasis initiation","volume":"19","author":"Malanchi","year":"2014","journal-title":"Crit Rev Oncog"},{"key":"37","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1186\/s12885-016-2640-3","article-title":"Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation","volume":"16","author":"Liang","year":"2016","journal-title":"BMC Cancer"},{"key":"38","doi-asserted-by":"publisher","first-page":"9281","DOI":"10.18632\/oncotarget.2423","article-title":"Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC","volume":"5","author":"Michel","year":"2014","journal-title":"Oncotarget"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T16:26:07Z","timestamp":1589127967000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,3]]},"references-count":38,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2017,7,18]]}},"alternative-id":["16789","28423362"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.16789","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,3]]}}}