{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:22:40Z","timestamp":1781835760716,"version":"3.54.5"},"reference-count":33,"publisher":"Impact Journals, LLC","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.18632\/oncotarget.16929","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T19:36:12Z","timestamp":1491593772000},"page":"50673-50679","source":"Crossref","is-referenced-by-count":20,"title":["Association of genetic polymorphisms in <i>IL-1R1<\/i> and <i>IL-1R2<\/i> genes with IgA nephropathy in the Han Chinese population"],"prefix":"10.18632","volume":"8","author":[{"given":"Maowei","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daofa","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenning","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keying","family":"Fu","sequence":"additional","affiliation":[{"name":"Central Laboratory, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiluan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hainan General Hospital, Haikou Hainan 570311, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,4,7]]},"reference":[{"key":"1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nrneph.2014.92","article-title":"Pathology of IgA nephropathy","volume":"10","author":"Roberts","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"2","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.humimm.2015.09.044","article-title":"Genetic polymorphisms in TNFSF13 and FDX1 are associated with IgA nephropathy in the Han Chinese population","volume":"76","author":"Li","year":"2015","journal-title":"Hum Immunol"},{"key":"3","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1172\/jci109998","article-title":"Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus","volume":"66","author":"Michael","year":"1980","journal-title":"J Clin Invest"},{"key":"4","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1111\/j.1523-1755.2004.05407.x","article-title":"Aberrant glycosylation in IgA nephropathy (IgAN)","volume":"65","author":"Amore","year":"2004","journal-title":"Kidney Int"},{"key":"5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.semnephrol.2004.01.001","article-title":"Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome","volume":"24","author":"D\u2019Amico","year":"2004","journal-title":"Semin Nephrol"},{"key":"6","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1046\/j.1523-1755.2000.00032.x","article-title":"Evidence for genetic factors in the development and progression of IgA nephropathy","volume":"57","author":"Owen","year":"2000","journal-title":"Kidney Int"},{"key":"7","first-page":"317","article-title":"Inherited forms of IgA nephropathy","volume":"16","author":"Scolari","year":"2003","journal-title":"J Nephrol"},{"key":"8","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/ncpneph0492","article-title":"The genetics of IgA nephropathy","volume":"3","author":"Gharavi","year":"2007","journal-title":"Nat Clin Pract Nephrol"},{"key":"9","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1096\/fasebj.3.12.2676681","article-title":"The interleukins","volume":"3","author":"Mizel","year":"1989","journal-title":"Faseb j"},{"key":"10","first-page":"S1","article-title":"The IL-1 family and inflammatory diseases","volume":"20","author":"Dinarello","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"11","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1161\/atvbaha.107.140384","article-title":"Haplotypes of IL1B, IL1RN, IL1R1, and IL1R2 and the risk of venous thrombosis","volume":"27","author":"Rosendaal","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"12","first-page":"789","article-title":"[IL1\/IL1 Ra, CTLA-4 and Apo1\/Fas genes polymorphisms and susceptibility to IgA nephropathy in Tunisian patients]","volume":"88","author":"Ayed","year":"2010","journal-title":"Tunis Med"},{"key":"13","first-page":"539","article-title":"Interleukin-1 receptors","volume":"5","author":"Dower","year":"1994","journal-title":"Eur Cytokine Netw"},{"key":"14","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1096\/fasebj.8.15.8001745","article-title":"The interleukin-1 family: 10 years of discovery","volume":"8","author":"Dinarello","year":"1994","journal-title":"Faseb j"},{"key":"15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1073\/pnas.95.2.588","article-title":"A family of human receptors structurally related to Drosophila Toll","volume":"95","author":"Bazan","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"16","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/ng.787","article-title":"Genome-wide association study identifies susceptibility loci for IgA nephropathy","volume":"43","author":"Wang","year":"2011","journal-title":"Nat Genet"},{"key":"17","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/ng.1047","article-title":"A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy","volume":"44","author":"Yin","year":"2011","journal-title":"Nat Genet"},{"key":"18","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3109\/08830189809043005","article-title":"Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist","volume":"16","author":"Dinarello","year":"1998","journal-title":"Int Rev Immunol"},{"key":"19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0952-7915(01)00306-5","article-title":"IL-1 and IL-18 receptors, and their extended family","volume":"14","author":"Sims","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"20","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/cmi.2014.43","article-title":"Relationship between interleukin-1 type 1 and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors","volume":"12","author":"Sennikov","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"21","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/0167-569990217-8","article-title":"The type II \u2018decoy\u2019 receptor: a novel regulatory pathway for interleukin 1","volume":"15","author":"Mantovani","year":"1994","journal-title":"Immunol Today"},{"key":"22","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1073\/pnas.90.13.6155","article-title":"Interleukin 1 signaling occurs exclusively via the type I receptor","volume":"90","author":"Shanebeck","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"23","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1002\/cncr.20142","article-title":"Interleukin-1 (IL-1alpha and IL-1beta) and its receptors (IL-1RI, IL-1RII, and IL-1Ra) in prostate carcinoma","volume":"100","author":"Royuela","year":"2004","journal-title":"Cancer"},{"key":"24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/1471-2350-11-50","article-title":"Allelic variants of IL1R1 gene associate with severe hand osteoarthritis","volume":"11","author":"Kujala","year":"2010","journal-title":"BMC Med Genet"},{"key":"25","doi-asserted-by":"publisher","first-page":"e62144","DOI":"10.1371\/journal.pone.0062144","article-title":"Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease","volume":"8","author":"D\u2019Inca","year":"2013","journal-title":"PLoS One"},{"key":"26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2012.11.006","article-title":"IL-1 receptor 2 (IL-1R2) and its role in immune regulation","volume":"32","author":"Freund","year":"2013","journal-title":"Brain Behav Immun"},{"key":"27","doi-asserted-by":"publisher","first-page":"908","DOI":"10.3109\/14397595.2015.1024302","article-title":"Association of IL-1R2 genetic polymorphisms with the susceptibility of ankylosing spondylitis in Northern Chinese Han population","volume":"25","author":"Zhao","year":"2015","journal-title":"Mod Rheumatol"},{"key":"28","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.4049\/jimmunol.1402155","article-title":"IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages","volume":"194","author":"Iwakura","year":"2015","journal-title":"J Immunol"},{"key":"29","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.bbalip.2011.05.014","article-title":"Type II interleukin-1 receptor expression is reduced in monocytes\/macrophages and atherosclerotic lesions","volume":"1811","author":"Alegret","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"30","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/s0002-944063990-9","article-title":"Decreased expression of the decoy interleukin-1 receptor type II in human endometriosis","volume":"158","author":"Aube","year":"2001","journal-title":"Am J Pathol"},{"key":"31","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1136\/bmj.320.7247.1468","article-title":"Statistics notes. The odds ratio","volume":"320","author":"Altman","year":"2000","journal-title":"Bmj"},{"key":"32","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Daly","year":"2005","journal-title":"Bioinformatics"},{"key":"33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/sj.cr.7290272","article-title":"SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci","volume":"15","author":"He","year":"2005","journal-title":"Cell Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16929","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T20:55:26Z","timestamp":1589144126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,7]]},"references-count":33,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2017,8,1]]}},"alternative-id":["16929","28881593"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.16929","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,7]]}}}