{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:16:37Z","timestamp":1772802997951,"version":"3.50.1"},"reference-count":59,"publisher":"Impact Journals, LLC","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,6,20]]},"DOI":"10.18632\/oncotarget.16981","type":"journal-article","created":{"date-parts":[[2017,4,9]],"date-time":"2017-04-09T18:20:33Z","timestamp":1491762033000},"page":"40132-40139","source":"Crossref","is-referenced-by-count":8,"title":["Telomere erosion in NF1 tumorigenesis"],"prefix":"10.18632","volume":"8","author":[{"given":"Rhiannon E.","family":"Jones","sequence":"first","affiliation":[{"name":"Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia W.","family":"Grimstead","sequence":"additional","affiliation":[{"name":"Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashni","family":"Sedani","sequence":"additional","affiliation":[{"name":"Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan","family":"Baird","sequence":"additional","affiliation":[{"name":"Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meena","family":"Upadhyaya","sequence":"additional","affiliation":[{"name":"Division of Cancer and Genetics, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,4,9]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S1470-2045(09)70033-6","article-title":"Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1","volume":"10","author":"Legius","year":"2009","journal-title":"Lancet Oncol"},{"key":"2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant Peripheral Nerve Sheath Tumours in Neurofibromatosis Type 1","volume":"39","author":"Moran","year":"2002","journal-title":"Journal of Medical Genetics"},{"key":"3","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00432-010-0846-3","article-title":"Molecular evolution of a neurofibroma to a malignant peripheral nerve sheath tumour (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings","volume":"136","author":"Upadhyaya","year":"2010","journal-title":"J Cancer Res Clin Oncol"},{"key":"4","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/gcc.20921","article-title":"Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors","volume":"50","author":"Kluwe","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"5","article-title":"Neurofibromatosis type 1; molecular and cellular biology","author":"Cooper","year":"2012","journal-title":"Upadhyaya and Cooper, Springer"},{"key":"6","first-page":"205","article-title":"Association between benign and malignant peripheral nerve sheath tumors in NF1","volume":"5","author":"Friedman","year":"2005","journal-title":"Neurology"},{"key":"7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jmg.2009.075937","article-title":"Clinical characterisation of 29 neurofibromatosis type-1 patients with molecularly ascertained 1.4 Mb type-1 NF1 deletions","volume":"47","author":"Kehrer-Sawatzki","year":"2010","journal-title":"J Med Genet"},{"key":"8","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/jmg.2004.021683","article-title":"Neurofibromatous neuropathy in neurofibromatosis 1 (NF1)","volume":"41","author":"Johnson","year":"2004","journal-title":"J Med Genet"},{"key":"9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2045-3329-2-17","article-title":"Malignant peripheral nerve sheath tumours in inherited disease","volume":"2","author":"Birch","year":"2012","journal-title":"Clin Sarcoma Res"},{"key":"10","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1158\/0008-5472.CAN-05-3330","article-title":"Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues","volume":"66","author":"Muir","year":"2006","journal-title":"Cancer Res"},{"key":"11","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1078-0432.CCR-07-1305","article-title":"High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization","volume":"14","author":"Upadhyaya","year":"2008","journal-title":"Clin Cancer Res"},{"key":"12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/gcc.20695","article-title":"Genome-wide highresolution analysis of DNA copy number alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array","volume":"48","author":"Upadhyaya","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/emmm.200900027","article-title":"Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene","volume":"1","author":"Lopez","year":"2009","journal-title":"EMBO Mol Med"},{"key":"14","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1158\/1078-0432.CCR-10-0613","article-title":"Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin","volume":"16","author":"Ratner","year":"2010","journal-title":"Clin Cancer Res"},{"key":"15","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/humu.22044","article-title":"Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for RhoGTPase pathway genes in NF1 tumorigenesis","volume":"33","author":"Yan","year":"2012","journal-title":"Hum Mutat"},{"key":"16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/pbc.24212","article-title":"18-fluorodeoxyglucose-positron emission tomography (FDG-PET) evaluation of nodular lesions in patients with Neurofibromatosis type 1 and plexiform neurofibromas (PN) or malignant peripheral nerve sheath tumors (MPNST)","volume":"60","author":"Widemann","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"17","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.cell.2013.01.053","article-title":"CXCR4\/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors","volume":"152","author":"McKay","year":"2013","journal-title":"Cell"},{"key":"18","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/ng.2641","article-title":"Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis","volume":"45","author":"Serra","year":"2013","journal-title":"Nat Genet"},{"key":"19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature13561","article-title":"PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies","volume":"514","author":"Vidaud","year":"2014","journal-title":"Nature"},{"key":"20","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/ng.3095","article-title":"PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors","volume":"46","author":"Huberman","year":"2014","journal-title":"Nat Genet"},{"key":"21","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/ng.3116","article-title":"Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors","volume":"46","author":"Wolinksy","year":"2014","journal-title":"Nat Genet"},{"key":"22","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1101\/gad.1346005","article-title":"The protein complex that shapes and safeguards human telomeres","volume":"19","author":"Shelterin","year":"2005","journal-title":"Genes Dev"},{"key":"23","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/j.1460-2075.1992.tb05245.x","article-title":"Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity","volume":"11","author":"Bacchetti","year":"1992","journal-title":"EMBO J"},{"key":"24","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.celrep.2014.07.007","article-title":"Escape from telomere-driven crisis is DNA ligase III dependent","volume":"8","author":"Baird","year":"2014","journal-title":"Cell Rep"},{"key":"25","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/35020592","article-title":"Telomere dysfunction promotes nonreciprocal translocations and epithelial cancers in mice","volume":"406","author":"DePinho","year":"2000","journal-title":"Nature"},{"key":"26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/bjh.13023","article-title":"Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease","volume":"167","author":"Fegan","year":"2014","journal-title":"Br J Haematol"},{"key":"27","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1038\/leu.2015.217","article-title":"Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial","volume":"29","author":"Steele","year":"2015","journal-title":"Leukemia"},{"key":"28","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.molonc.2015.02.003","article-title":"Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients","volume":"9","author":"Baird","year":"2015","journal-title":"Mol Oncol"},{"key":"29","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/gcc.20525","article-title":"Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals","volume":"47","author":"Upadhyaya","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"30","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1182\/blood-2010-02-272104","article-title":"Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis","volume":"116","author":"Baird","year":"2010","journal-title":"Blood"},{"key":"31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s10689-007-9149-5","article-title":"Somatic alterations of the NF1 gene in an NF1 individual with multiple benign tumours (internal and external) and malignant tumour types","volume":"6","author":"Upadhyaya","year":"2007","journal-title":"Fam Cancer"},{"key":"32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/humu.20601","article-title":"Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumours (MPNSTs)","volume":"29","author":"Mautner","year":"2008","journal-title":"Hum Mutat"},{"key":"33","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","article-title":"Specific association of human telomere activity with immortal cells and culture","volume":"266","author":"Shay","year":"1994","journal-title":"Science"},{"key":"34","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/346866a0","article-title":"Telomere reduction in human colorectal carcinoma and with ageing","volume":"346","author":"Allshire","year":"1990","journal-title":"Nature"},{"key":"35","first-page":"222","article-title":"The association between telomere length and cancer risk in population studied","volume":"6","author":"Jin","year":"2016","journal-title":"Sci Rep"},{"key":"36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.lungcan.2007.11.001","article-title":"Telomere shortening is associated with poor prognosis and telomerase activity correlates with DNA repair impairment in non-small cell lung cancer","volume":"60","author":"Iniesta","year":"2008","journal-title":"Lung Cancer"},{"key":"37","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/jnci\/djt191","article-title":"Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability","volume":"105","author":"Baird","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/pros.22755","article-title":"Telomere length as a risk factor for hereditary prostate cancer","volume":"74","author":"Meeker","year":"2014","journal-title":"Prostate"},{"key":"39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/carcin\/bgr248","article-title":"Telomere length variation in normal epithelial cells adjacent to tumor: potential biomarker for breast cancer local recurrence","volume":"33","author":"Zheng","year":"2012","journal-title":"Carcinogenesis"},{"key":"40","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1158\/1055-9965.EPI-11-0867","article-title":"Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk","volume":"21","author":"Cramer","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00439-015-1563-4","article-title":"Telomere length and common disease: study design and analytical challenges","volume":"134","author":"Pooley","year":"2015","journal-title":"Hum Genetics"},{"key":"42","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11060-014-1553-8","article-title":"TERT promoter mutations and BRAF mutations are rare in sporadic, and TERT promoter mutations are absent in NF1-related malignant peripheral nerve sheath tumours","volume":"120","author":"Verdijk","year":"2014","journal-title":"J Neurooncol"},{"key":"43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1479-7364-6-18","article-title":"Molecular Heterogeneity in Malignant Peripheral Nerve Sheath Tumors (MPNSTs) Associated with Neurofibromatosis Type 1 (NF1)","volume":"6","author":"Upadhyaya","year":"2012","journal-title":"Hum Genomics"},{"key":"44","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"366","author":"Begum","year":"2012","journal-title":"N Engl J Med"},{"key":"45","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2141.2011.09022.x","article-title":"Telomere dysfunction and its role in haematological cancer","volume":"156","author":"Baird","year":"2012","journal-title":"Br J Haematol"},{"key":"46","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ng1409","article-title":"In situ analyses of genome instability in breast cancer","volume":"36","author":"Garbe","year":"2004","journal-title":"Nat Genet"},{"key":"47","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/B:JOMG.0000048775.04140.92","article-title":"Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation?","volume":"9","author":"Argani","year":"2004","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"48","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.2217\/fon.10.135","article-title":"Shortened telomeres: a driving force behind leukemia?","volume":"6","author":"Baird","year":"2010","journal-title":"Future Oncology"},{"key":"49","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(01)00245-8","article-title":"NF1 tumor suppressor gene function: narrowing the GAP","volume":"104","author":"Jacks","year":"2001","journal-title":"Cell"},{"key":"50","first-page":"187984","article-title":"Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A\/p16 inactivation","volume":"155","author":"Louis","year":"1999","journal-title":"Am J Pathol"},{"key":"51","first-page":"4132","article-title":"p15INK4b, p14ARF, and p16INK4a inactivation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors","volume":"9","author":"Pilotti","year":"2003","journal-title":"Clin Cancer Res"},{"key":"52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.nbd.2004.01.006","article-title":"Genetic and phenotypic characterisation of tumour cells derived from malignant peripheral nerve sheath tumours of neurofibromatosis type-1 patients","volume":"16","author":"Kluwe","year":"2004","journal-title":"Neurobiol Dis"},{"key":"53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/01.pai.0000143787.80564.f5","article-title":"Loss of p16 (INK4A) expression is associated with allelic imbalance\/loss of heterozygosity of chromosome 9p21 in microdissected malignant peripheral nerve sheath tumors","volume":"14","author":"Kay","year":"2006","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"54","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/gcc.2870100405","article-title":"TP53 mutations are frequent in malignant NF1 tumors","volume":"10","author":"Glover","year":"1994","journal-title":"Genes Chrom Cancer"},{"key":"55","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/NEN.0b013e3181c55d55","article-title":"TP53 mutation analysis of malignant peripheral nerve sheath tumors","volume":"69","author":"Kros","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"key":"56","first-page":"345","article-title":"Chromosome 17 abnormalities and TP53 mutations in adult soft tissue sarcomas","volume":"145","author":"Cordon-Cardo","year":"1994","journal-title":"Am J Pathol"},{"key":"57","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3109\/10715762.2011.571685","article-title":"The dual role of p53: DNA protection and antioxidant","volume":"45","author":"Vina","year":"2011","journal-title":"Free Radic Res"},{"key":"58","first-page":"172","volume-title":"Pathology and Genetics of Tumours of the Nervous system","author":"Cavenee","year":"2000"},{"key":"59","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1101\/gad.439107","article-title":"The nature of telomere fusion and a definition of the critical telomere length in human cells","volume":"21","author":"Baird","year":"2007","journal-title":"Genes Dev"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T19:55:16Z","timestamp":1589140516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.16981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,9]]},"references-count":59,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2017,6,20]]}},"alternative-id":["16981","28454108"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.16981","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,9]]}}}