{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:11:25Z","timestamp":1768291885849,"version":"3.49.0"},"reference-count":47,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,6,13]]},"DOI":"10.18632\/oncotarget.17166","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T20:11:54Z","timestamp":1492459914000},"page":"38990-39000","source":"Crossref","is-referenced-by-count":8,"title":["Antineoplastic effects of CPPTL via the ROS\/JNK pathway in acute myeloid leukemia"],"prefix":"10.18632","volume":"8","author":[{"given":"Hui-Er","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hui","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Hui","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Dai","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"7892","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMoa1010222","article-title":"Cytarabine dose for acute myeloid leukemia","volume":"364","author":"Schaafsma","year":"2011","journal-title":"N Engl J Med"},{"key":"2","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1182\/blood-2013-12-544957","article-title":"Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation","volume":"123","author":"Rollig","year":"2014","journal-title":"Blood"},{"key":"3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajh.20739","article-title":"Predictable prognostic factor of CD56 expression in patients with acute myeloid leukemia with t(8: 21) after high dose cytarabine or allogeneic hematopoietic stem cell transplantation","volume":"82","author":"Kim","year":"2007","journal-title":"Am J Hematol"},{"key":"4","doi-asserted-by":"crossref","first-page":"16010","DOI":"10.1038\/nrdp.2016.10","article-title":"Acute myeloid leukaemia","volume":"2","author":"Linch","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"5","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1016\/S0140-6736(10)62105-8","article-title":"Complete remission and early death after intensive chemotherapy in patients aged 60 years or older with acute myeloid leukaemia: a web-based application for prediction of outcomes","volume":"376","author":"Koschmieder","year":"2010","journal-title":"The Lancet"},{"key":"6","first-page":"34","article-title":"Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007","volume":"119","author":"Morton","year":"2011","journal-title":"Blood"},{"key":"7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2008.04.041","article-title":"Function of reactive oxygen species during animal development: Passive or active?","volume":"320","author":"Castro-Obreg\u00f3n","year":"2008","journal-title":"Dev Biol"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Zhang, Wang, Vikash, Ye, Wu, Liu, Dong. ROS and ROS-Mediated Cellular Signaling. Oxid Med Cell Longev. 2016; 2016:1\u201318.","DOI":"10.1155\/2016\/4350965"},{"key":"9","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1016\/j.bbamcr.2016.09.012","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"1863","author":"Averill-Bates","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10","first-page":"187","article-title":"Methyl jasmonate induces apoptosis and pro-apoptotic autophagy via the ROS pathway in human non-small cell lung cancer","volume":"6","author":"Liu","year":"2016","journal-title":"Am J Cancer Res"},{"key":"11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.redox.2016.09.006","article-title":"Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer","volume":"10","author":"Ji","year":"2016","journal-title":"Redox Biol"},{"key":"12","doi-asserted-by":"publisher","first-page":"63870","DOI":"10.18632\/oncotarget.11563","article-title":"Curcumin potentiates antitumor activity of cisplatin in bladder Curcumin potentiates antitumor activity of cisplatin in bladder","volume":"7","author":"Jeong","year":"2016","journal-title":"Oncotarget"},{"key":"13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.canlet.2015.04.027","article-title":"Nelfinavir, an HIV protease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mitochondrial pathway","volume":"364","author":"Jiang","year":"2015","journal-title":"Cancer Lett"},{"key":"14","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1080\/15548627.2016.1192751","article-title":"Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint","volume":"12","author":"Wang","year":"2016","journal-title":"Autophagy"},{"key":"15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1182\/blood-2006-03-013128","article-title":"NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells","volume":"110","author":"Chandra","year":"2007","journal-title":"Blood"},{"key":"16","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1182\/blood-2006-05-024679","article-title":"MEK blockade converts AML differentiating response to retinoids into extensive apoptosis","volume":"109","author":"Tafuri","year":"2007","journal-title":"Blood"},{"key":"17","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1126\/science.281.5381.1305","article-title":"Death receptors: signaling and modulation","volume":"281","author":"Dixit","year":"1998","journal-title":"Science"},{"key":"18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(94)90372-7","article-title":"The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death","volume":"76","author":"Goodwin","year":"1994","journal-title":"Cell"},{"key":"19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.cellbio.15.1.269","article-title":"Biochemical pathways of caspase activation during apoptosis","volume":"15","author":"Wang","year":"1999","journal-title":"Annu Rev Cell Dev Biol"},{"key":"20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Korsmeyer","year":"2004","journal-title":"Cell"},{"key":"21","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(95)90541-3","article-title":"Yama\/CPP32\u03b2, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase","volume":"81","author":"Dixit","year":"1995","journal-title":"Cell"},{"key":"22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/376037a0","article-title":"Identification and inhibition of the ICE\/CED-3 protease necessary for mammalian apoptosis","volume":"376","author":"Smulson","year":"1995","journal-title":"Nature"},{"key":"23","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.1021\/jo401606q","article-title":"Protection-group-free semisyntheses of parthenolide and its cyclopropyl analogue","volume":"78","author":"Chen","year":"2013","journal-title":"J Org Chem"},{"key":"24","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1038\/bcj.2016.50","article-title":"\u2018Acute myeloid leukemia: a comprehensive review and 2016 update'","volume":"6","author":"Abdul-Hay","year":"2016","journal-title":"Blood Cancer J"},{"key":"25","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1182\/blood-2013-01-480228","article-title":"Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation","volume":"121","author":"Borthakur","year":"2013","journal-title":"Blood"},{"key":"26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4143\/crt.2014.249","article-title":"Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors","volume":"47","author":"Bang","year":"2015","journal-title":"Cancer Res Treat"},{"key":"27","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1182\/blood-2010-04-280123","article-title":"Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor","volume":"117","author":"Tweardy","year":"2011","journal-title":"Blood"},{"key":"28","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1234769","article-title":"Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation","volume":"340","author":"Artin","year":"2013","journal-title":"Science"},{"key":"29","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S1470-2045(14)70281-5","article-title":"Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials","volume":"15","author":"Chilton","year":"2014","journal-title":"Lancet Oncol"},{"key":"30","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/leu.2015.52","article-title":"CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia","volume":"29","author":"Gill","year":"2015","journal-title":"Leukemia"},{"key":"31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri3423","article-title":"Beyond oxidative stress: an immunologist's guide to reactive oxygen species","volume":"13","author":"Cunningham-Bussel","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"32","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2015.10.001","article-title":"Mitochondrial ROS Signaling in Organismal Homeostasis","volume":"163","author":"Horvath","year":"2015","journal-title":"Cell"},{"key":"33","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ccr.2006.08.015","article-title":"Reactive oxygen species in cancer cells: Live by the sword, die by the sword","volume":"10","author":"Schumacker","year":"2006","journal-title":"Cancer Cell"},{"key":"34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Huang","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"35","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1038\/onc.2008.301","article-title":"JNK signaling in apoptosis","volume":"27","author":"Reddy","year":"2008","journal-title":"Oncogene"},{"key":"36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.canlet.2013.11.019","article-title":"p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents","volume":"344","author":"Pan","year":"2014","journal-title":"Cancer Lett"},{"key":"37","doi-asserted-by":"publisher","first-page":"490","DOI":"10.18632\/oncotarget.13448","article-title":"New bipyridine gold(III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status","volume":"8","author":"Isab","year":"2017","journal-title":"Oncotarget"},{"key":"38","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/leu.2016.96","article-title":"A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells","volume":"30","author":"Anderson","year":"2016","journal-title":"Leukemia"},{"key":"39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1182\/blood-2006-10-050260","article-title":"Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance","volume":"110","author":"Cleveland","year":"2007","journal-title":"Blood"},{"key":"40","first-page":"13","article-title":"Reactive oxygen species in eradicating acute myeloid leukemic stem cells","volume":"1","author":"Wang","year":"2014","journal-title":"Stem Cell Investig"},{"key":"41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2012.12.013","article-title":"BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells","volume":"12","author":"Becker","year":"2013","journal-title":"Cell Stem Cell"},{"key":"42","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1182\/blood-2010-07-294827","article-title":"The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML","volume":"118","author":"Chng","year":"2011","journal-title":"Blood"},{"key":"43","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.1302352110","article-title":"Preferential eradication of acute myelogenous leukemia stem cells by fenretinide","volume":"110","author":"Chen","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"44","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1182\/blood-2007-05-088815","article-title":"Rapid and selective death of leukemia stem and progenitor cells induced by the compound 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione (TDZD-8)","volume":"110","author":"Jordan","year":"2007","journal-title":"Blood"},{"key":"45","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1182\/blood-2004-10-4135","article-title":"The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells","volume":"105","author":"Jordan","year":"2005","journal-title":"Blood"},{"key":"46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13045-016-0327-5","article-title":"Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells","volume":"9","author":"Zhang","year":"2016","journal-title":"J Hematol Oncol"},{"key":"47","doi-asserted-by":"publisher","first-page":"65012","DOI":"10.18632\/oncotarget.11342","article-title":"Antineoplastic effects and mechanisms of micheliolide in actue myelogenous leukemia stem cells","volume":"7","author":"Gao","year":"2016","journal-title":"Oncotarget"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.17166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T20:01:40Z","timestamp":1589140900000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.17166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":47,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2017,6,13]]}},"alternative-id":["17166","28473664"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.17166","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]}}}