{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:04:53Z","timestamp":1790431493371,"version":"4.1.0"},"reference-count":33,"publisher":"Impact Journals, LLC","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,6,13]]},"DOI":"10.18632\/oncotarget.17387","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T11:36:18Z","timestamp":1493033778000},"page":"39640-39648","source":"Crossref","is-referenced-by-count":26,"title":["Pantoprazole blocks the JAK2\/STAT3 pathway to alleviate skeletal muscle wasting in cancer cachexia by inhibiting inflammatory response"],"prefix":"10.18632","volume":"8","author":[{"given":"Dunwei","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Chongqing Three Gorges Central Hospital, Chongqing 404000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Suining Municipal Central Hospital, Suining, Sichuan 629000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongpeng","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,4,24]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Ottery","year":"2011","journal-title":"Lancet Oncol"},{"key":"2","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.biocel.2013.05.032","article-title":"Muscle wasting in cancer","volume":"45","author":"Fearon","year":"2013","journal-title":"Int J Biochem Cell Biol"},{"key":"3","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.biopha.2013.08.005","article-title":"Malnutrition, anorexia and cachexia in cancer patients: a mini-review on pathogenesis and treatment","volume":"67","author":"Carpi","year":"2013","journal-title":"Biomed Pharmacother"},{"key":"4","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.bbrc.2009.12.123","article-title":"Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia","volume":"391","author":"Zimmers","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"5","first-page":"359","article-title":"Acute-phase response proteins are related to cachexia and accelerated angiogenesis in gastroesophageal cancers","volume":"46","author":"Gamian","year":"2008","journal-title":"Clin Chem Lab Med"},{"key":"6","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3892\/or_00000328","article-title":"Pro-inflammatory cytokine release by peripheral blood mononuclear cells from patients with advanced pancreatic cancer: relationship to acute phase response and survival","volume":"21","author":"Ross","year":"2009","journal-title":"Oncol Rep"},{"key":"7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4149\/neo_2009_01_56","article-title":"Tumor necrosis factor alpha and interferon gamma genes polymorphisms and serum levels in pancreatic adenocarcinoma","volume":"56","author":"Malecka-Panas","year":"2009","journal-title":"Neoplasma"},{"key":"8","doi-asserted-by":"crossref","first-page":"E410","DOI":"10.1152\/ajpendo.00039.2012","article-title":"JAK\/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia","volume":"303","author":"Zimmers","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/JES.0b013e3181f44f11","article-title":"Interleukin 6 as a key regulator of muscle mass during cachexia","volume":"38","author":"Baltgalvis","year":"2010","journal-title":"Exerc Sport Sci Rev"},{"key":"10","first-page":"855","article-title":"Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue","volume":"27","author":"Lopez-Soriano","year":"2005","journal-title":"Int J Oncol"},{"key":"11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1056\/NEJMra1202117","article-title":"JAKs and STATs in immunity, immunodeficiency, and cancer","volume":"368","author":"Staudt","year":"2013","journal-title":"N Engl J Med"},{"key":"12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.semcdb.2016.02.009","article-title":"STAT3 in the systemic inflammation of cancer cachexia","volume":"54","author":"Bonetto","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"13","doi-asserted-by":"crossref","first-page":"11177","DOI":"10.1074\/jbc.M115.641514","article-title":"Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia","volume":"290","author":"Mitch","year":"2015","journal-title":"J Biol Chem"},{"key":"14","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1007\/s10620-009-0951-9","article-title":"Potential anti-inflammatory effects of proton pump inhibitors: a review and discussion of the clinical implications","volume":"54","author":"Spechler","year":"2009","journal-title":"Dig Dis Sci"},{"key":"15","doi-asserted-by":"publisher","first-page":"22460","DOI":"10.18632\/oncotarget.7984","article-title":"Pantoprazole, an FDA-approved proton-pump inhibitor, suppresses colorectal cancer growth by targeting T-cell-originated protein kinase","volume":"7","author":"Duan","year":"2016","journal-title":"Oncotarget"},{"key":"16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1242\/dmm.008839","article-title":"Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia","volume":"5","author":"Lynch","year":"2012","journal-title":"Dis Model Mech"},{"key":"17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.phrs.2015.05.010","article-title":"Skeletal muscle atrophy: potential therapeutic agents and their mechanisms of action","volume":"99","author":"Mittal","year":"2015","journal-title":"Pharmacol Res"},{"key":"18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijcard.2012.09.213","article-title":"Cachexia as major underestimated unmet medical need: facts and numbers","volume":"161","author":"Anker","year":"2012","journal-title":"Int J Cardiol"},{"key":"19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2015.11.002","article-title":"Protein breakdown in cancer cachexia","volume":"54","author":"Sandri","year":"2016","journal-title":"Semin Cell Dev Biol"},{"key":"20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s00011-006-6056-4","article-title":"Molecular mechanisms involved in anti-inflammatory effects of proton pump inhibitors","volume":"55","author":"Yoshikawa","year":"2006","journal-title":"Inflamm Res"},{"key":"21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejphar.2004.12.042","article-title":"The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells","volume":"509","author":"Sasaki","year":"2005","journal-title":"Eur J Pharmacol"},{"key":"22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3164\/jcbn.08-267","article-title":"Lansoprazole, a Proton Pump Inhibitor, Suppresses Production of Tumor Necrosis Factor-alpha and Interleukin-1beta Induced by Lipopolysaccharide and Helicobacter Pylori Bacterial Components in Human Monocytic Cells via Inhibition of Activation of Nuclear Factor-kappaB and Extracellular Signal-Regulated Kinase","volume":"45","author":"Arakawa","year":"2009","journal-title":"J Clin Biochem Nutr"},{"key":"23","doi-asserted-by":"crossref","first-page":"19976","DOI":"10.1074\/jbc.M115.638411","article-title":"A key role for leukemia inhibitory factor in C26 cancer cachexia","volume":"290","author":"Jackman","year":"2015","journal-title":"J Biol Chem"},{"key":"24","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/jcp.24580","article-title":"Pancreatic cancer-induced cachexia is Jak2-dependent in mice","volume":"229","author":"Iovanna","year":"2014","journal-title":"J Cell Physiol"},{"key":"25","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1002\/glia.21157","article-title":"Proton pump inhibitors reduce interferon-gamma-induced neurotoxicity and STAT3 phosphorylation of human astrocytes","volume":"59","author":"McGeer","year":"2011","journal-title":"Glia"},{"key":"26","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.intimp.2013.07.021","article-title":"Proton pump inhibitor selectively suppresses proliferation and restores the chemosensitivity of gastric cancer cells by inhibiting STAT3 signaling pathway","volume":"17","author":"Zou","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"27","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"DeChiara","year":"2001","journal-title":"Science"},{"key":"28","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.251541198","article-title":"Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy","volume":"98","author":"Goldberg","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"29","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.3892\/or.2015.3845","article-title":"Muscle-specific E3 ubiquitin ligases are involved in muscle atrophy of cancer cachexia: an in vitro and in vivo study","volume":"33","author":"Wu","year":"2015","journal-title":"Oncol Rep"},{"key":"30","first-page":"805","article-title":"Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia","volume":"22","author":"Adrian","year":"2007","journal-title":"Histol Histopathol"},{"key":"31","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1002\/jcb.24122","article-title":"Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases\/mTOR\/HIF-1alpha\/P-gp and MRP1 signaling pathway in vitro and in vivo","volume":"113","author":"Zou","year":"2012","journal-title":"J Cell Biochem"},{"key":"32","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.3892\/or.2016.5118","article-title":"Aliskiren targets multiple systems to alleviate cancer cachexia","volume":"36","author":"Tang","year":"2016","journal-title":"Oncol Rep"},{"key":"33","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00432-013-1412-6","article-title":"MG132-mediated inhibition of the ubiquitin-proteasome pathway ameliorates cancer cachexia","volume":"139","author":"Jin","year":"2013","journal-title":"J Cancer Res Clin Onco"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.17387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T20:03:26Z","timestamp":1589141006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.17387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,24]]},"references-count":33,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2017,6,13]]}},"alternative-id":["17387","28489606"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.17387","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,24]]}}}