{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:22:32Z","timestamp":1790400152701,"version":"4.1.0"},"reference-count":44,"publisher":"Impact Journals, LLC","issue":"28","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,7,11]]},"DOI":"10.18632\/oncotarget.17567","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T20:59:34Z","timestamp":1493758774000},"page":"45484-45495","source":"Crossref","is-referenced-by-count":48,"title":["ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells"],"prefix":"10.18632","volume":"8","author":[{"given":"Takayuki","family":"Hojo","sequence":"first","affiliation":[{"name":"Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan"},{"name":"Department of Dental Anesthesiology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nako","family":"Maishi","sequence":"additional","affiliation":[{"name":"Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alam Mohammad","family":"Towfik","sequence":"additional","affiliation":[{"name":"Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan"},{"name":"Department of Dental Radiology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritaka","family":"Ohga","sequence":"additional","affiliation":[{"name":"Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan"},{"name":"Department of Oral Diagnosis and Medicine, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Shindoh","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Biology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Minowa","sequence":"additional","affiliation":[{"name":"Department of Dental Radiology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Dental Anesthesiology, Hokkaido University Graduate School of Dental Medicine, Sapporo 060-8586, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Hida","sequence":"additional","affiliation":[{"name":"Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.4161\/cc.5.16.3018","article-title":"Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch","volume":"5","author":"Folkman","year":"2006","journal-title":"Cell Cycle"},{"key":"2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc1093","article-title":"Tumorigenesis and the angiogenic switch","volume":"3","author":"Benjamin","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"4","first-page":"L1057","article-title":"Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction","volume":"277","author":"Gewertz","year":"1999","journal-title":"Am J Physiol"},{"key":"5","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/cdd.2009.49","article-title":"Superoxide is the major reactive oxygen species regulating autophagy","volume":"16","author":"Gibson","year":"2009","journal-title":"Cell Death Differ"},{"key":"6","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Huang","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2008.02.044","article-title":"Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy","volume":"266","author":"Nakamura","year":"2008","journal-title":"Cancer Lett"},{"key":"8","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Mak","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.bbrc.2010.03.089","article-title":"Isolated tumor endothelial cells maintain specific character during long-term culture","volume":"394","author":"Hida","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1440-1827.2012.02792.x","article-title":"CXCR7: a novel tumor endothelial marker in renal cell carcinoma","volume":"62","author":"Hida","year":"2012","journal-title":"Pathol Int"},{"key":"11","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/j.1349-7006.2012.02261.x","article-title":"Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner","volume":"103","author":"Hida","year":"2012","journal-title":"Cancer Sci"},{"key":"12","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/bjc.2012.59","article-title":"Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells","volume":"106","author":"Kaga","year":"2012","journal-title":"Br J Cancer"},{"key":"13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/pin.12031","article-title":"The F-prostaglandin receptor is a novel marker for tumor endothelial cells in renal cell carcinoma","volume":"63","author":"Hida","year":"2013","journal-title":"Pathol Int"},{"key":"14","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1038\/bjc.2013.535","article-title":"Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis","volume":"109","author":"Nonomura","year":"2013","journal-title":"Br J Cancer"},{"key":"15","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/cas.12549","article-title":"Suprabasin as a novel tumor endothelial cell marker","volume":"105","author":"Hida","year":"2014","journal-title":"Cancer Sci"},{"key":"16","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1002\/ijc.29655","article-title":"CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property","volume":"137","author":"Hida","year":"2015","journal-title":"Int J Cancer"},{"key":"17","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.ajpath.2011.11.029","article-title":"Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment","volume":"180","author":"Hida","year":"2012","journal-title":"Am J Pathol"},{"key":"18","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.ajpath.2011.11.035","article-title":"Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high- and low-metastatic tumors","volume":"180","author":"Nonomura","year":"2012","journal-title":"Am J Pathol"},{"key":"19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ajpath.2014.10.017","article-title":"Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel","volume":"185","author":"Hida","year":"2015","journal-title":"Am J Pathol"},{"key":"20","doi-asserted-by":"crossref","first-page":"8249","DOI":"10.1158\/0008-5472.CAN-04-1567","article-title":"Tumor-associated endothelial cells with cytogenetic abnormalities","volume":"64","author":"Klagsbrun","year":"2004","journal-title":"Cancer Res"},{"key":"21","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.2353\/ajpath.2009.090202","article-title":"Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors","volume":"175","author":"Klagsbrun","year":"2009","journal-title":"Am J Pathol"},{"key":"22","doi-asserted-by":"crossref","first-page":"e80349","DOI":"10.1371\/journal.pone.0080349","article-title":"Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment","volume":"8","author":"Hida","year":"2013","journal-title":"PLoS One"},{"key":"23","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/nm.2846","article-title":"Pathological neoangiogenesis depends on oxidative stress regulation by ATM","volume":"18","author":"Kubota","year":"2012","journal-title":"Nat Med"},{"key":"24","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1177\/38.11.2212616","article-title":"Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues","volume":"38","author":"Robey","year":"1990","journal-title":"J Histochem Cytochem"},{"key":"25","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1111\/febs.12145","article-title":"Biological interplay between proteoglycans and their innate immune receptors in inflammation","volume":"280","author":"Schaefer","year":"2013","journal-title":"FEBS J"},{"key":"26","doi-asserted-by":"crossref","first-page":"35237","DOI":"10.1074\/jbc.R114.619304","article-title":"Complexity of danger: the diverse nature of damage-associated molecular patterns","volume":"289","author":"Schaefer","year":"2014","journal-title":"J Biol Chem"},{"key":"27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri2215","article-title":"How dying cells alert the immune system to danger","volume":"8","author":"Rock","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"28","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.freeradbiomed.2010.01.006","article-title":"Linking oxidative stress to inflammation: Toll-like receptors","volume":"48","author":"Billiar","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"29","doi-asserted-by":"crossref","first-page":"28039","DOI":"10.1038\/srep28039","article-title":"Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan","volume":"6","author":"Hida","year":"2016","journal-title":"Sci Rep"},{"key":"30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10238-011-0155-4","article-title":"Up-regulated biglycan expression correlates with the malignancy in human colorectal cancers","volume":"12","author":"Xing","year":"2012","journal-title":"Clin Exp Med"},{"key":"31","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1258\/ebm.2011.011124","article-title":"Biglycan expression correlates with aggressiveness and poor prognosis of gastric cancer","volume":"236","author":"Peng","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"key":"32","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.1128\/MCB.00630-07","article-title":"Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2","volume":"27","author":"Zhang","year":"2007","journal-title":"Mol Cell Biol"},{"key":"33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/MCB.26.1.221-229.2006","article-title":"Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1","volume":"26","author":"Yamamoto","year":"2006","journal-title":"Mol Cell Biol"},{"key":"34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.molcel.2006.01.013","article-title":"Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer","volume":"21","author":"Yamamoto","year":"2006","journal-title":"Mol Cell"},{"key":"35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-12-420117-0.00008-6","article-title":"Role of the Keap1-Nrf2 pathway in cancer","volume":"122","author":"Levonen","year":"2014","journal-title":"Adv Cancer Res"},{"key":"36","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1038\/onc.2010.118","article-title":"Increased cell migration and plasticity in Nrf2-deficient cancer cell lines","volume":"29","author":"Freeman","year":"2010","journal-title":"Oncogene"},{"key":"37","doi-asserted-by":"crossref","first-page":"e93265","DOI":"10.1371\/journal.pone.0093265","article-title":"Inhibitory role of the KEAP1-NRF2 pathway in TGFbeta1-stimulated renal epithelial transition to fibroblastic cells: a modulatory effect on SMAD signaling","volume":"9","author":"Kwak","year":"2014","journal-title":"PLoS One"},{"key":"38","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1089\/ars.2013.5219","article-title":"Nrf2 regulates angiogenesis: effect on endothelial cells, bone marrow-derived proangiogenic cells and hind limb ischemia","volume":"20","author":"Loboda","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-5793(94)01368-B","article-title":"Persistent oxidative stress in cancer","volume":"358","author":"Hiai","year":"1995","journal-title":"FEBS Lett"},{"key":"40","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/cas.12394","article-title":"Identification of novel targets for antiangiogenic therapy by comparing the gene expressions of tumor and normal endothelial cells","volume":"105","author":"Hida","year":"2014","journal-title":"Cancer Sci"},{"key":"41","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1074\/jbc.M300035200","article-title":"Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling","volume":"278","author":"Kalthoff","year":"2003","journal-title":"J Biol Chem"},{"key":"42","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Zhang","year":"2003","journal-title":"Nature"},{"key":"43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbalip.2010.11.011","article-title":"Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1\/2 activation in 3T3-L1 adipocytes","volume":"1811","author":"Nakayama","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"44","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mito.2012.08.002","article-title":"Redox regulation of cancer cell migration and invasion","volume":"13","author":"Yap","year":"2013","journal-title":"Mitochondrion"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.17567","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T20:31:01Z","timestamp":1589142661000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.17567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,2]]},"references-count":44,"journal-issue":{"issue":"28","published-print":{"date-parts":[[2017,7,11]]}},"alternative-id":["17567","28525375"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.17567","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,2]]}}}