{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:09:25Z","timestamp":1787501365488,"version":"build-2736575974"},"reference-count":46,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2014,3,15]]},"DOI":"10.18632\/oncotarget.1789","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T16:41:35Z","timestamp":1442421695000},"page":"1290-1303","source":"Crossref","is-referenced-by-count":42,"title":["Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61\u00af cancer stem cells"],"prefix":"10.18632","volume":"5","author":[{"given":"Qingshan","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongju","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2013,2,19]]},"reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1021\/tx900343d","article-title":"Arsenic-induced carcinogenesis--oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment","volume":"23","author":"Conolly","year":"2010","journal-title":"Chemical research in toxicology"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.taap.2007.02.007","article-title":"Molecular processes in cellular arsenic metabolism","volume":"222","author":"Thomas","year":"2007","journal-title":"Toxicology and applied pharmacology"},{"issue":"5576","key":"3","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1126\/science.1072375","article-title":"Public health. Worldwide occurrences of arsenic in ground water","volume":"296","author":"Nordstrom","year":"2002","journal-title":"Science (New York, NY"},{"issue":"2","key":"4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/toxsci\/kfr188","article-title":"miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis","volume":"123","author":"Chen","year":"2011","journal-title":"Toxicol Sci"},{"issue":"1","key":"5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4161\/cc.23030","article-title":"JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic","volume":"12","author":"Chen","year":"2013","journal-title":"Cell Cycle"},{"issue":"9","key":"6","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/jnci\/djq093","article-title":"Arsenic-specific stem cell selection during malignant transformation","volume":"102","author":"Waalkes","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1289\/ehp.1204987","article-title":"Arsenic-transformed malignant prostate epithelia can convert noncontiguous normal stem cells into an oncogenic phenotype","volume":"120","author":"Waalkes","year":"2012","journal-title":"Environmental health perspectives"},{"issue":"6859","key":"8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Weissman","year":"2001","journal-title":"Nature"},{"issue":"19","key":"9","doi-asserted-by":"crossref","first-page":"9339","DOI":"10.1158\/0008-5472.CAN-06-3126","article-title":"Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells","volume":"66","author":"Wahl","year":"2006","journal-title":"Cancer research"},{"issue":"6","key":"10","doi-asserted-by":"crossref","first-page":"387","DOI":"10.18632\/oncotarget.173","article-title":"Molecular identification and targeting of colorectal cancer stem cells","volume":"1","author":"Medema","year":"2010","journal-title":"Oncotarget"},{"issue":"12","key":"11","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.18632\/oncotarget.432","article-title":"NCI's provocative questions on cancer: some answers to ignite discussion","volume":"2","author":"Blagosklonny","year":"2011","journal-title":"Oncotarget"},{"issue":"7","key":"12","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Dick","year":"1997","journal-title":"Nature medicine"},{"issue":"6464","key":"13","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/367645a0","article-title":"A cell initiating human acute myeloid leukaemia after transplantation into SCID mice","volume":"367","author":"Dick","year":"1994","journal-title":"Nature"},{"issue":"6","key":"14","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.stem.2012.05.007","article-title":"Cancer stem cells: current status and evolving complexities","volume":"10","author":"Lindeman","year":"2012","journal-title":"Cell stem cell"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ncb2717","article-title":"Cancer stem cells: The challenges ahead","volume":"15","author":"Medema","year":"2013","journal-title":"Nature cell biology"},{"issue":"12","key":"16","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1158\/0008-5472.CAN-10-0007","article-title":"Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells","volume":"70","author":"Shi","year":"2010","journal-title":"Cancer research"},{"issue":"5811","key":"17","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.1134910","article-title":"Asymmetric inheritance of mother versus daughter centrosome in stem cell division","volume":"315","author":"Fuller","year":"2007","journal-title":"Science"},{"issue":"5","key":"18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ng.127","article-title":"An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors","volume":"40","author":"Weinberg","year":"2008","journal-title":"Nature genetics"},{"issue":"3","key":"19","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ccr.2012.03.003","article-title":"Cancer stem cells: impact, heterogeneity, and uncertainty","volume":"21","author":"Morrison","year":"2012","journal-title":"Cancer cell"},{"issue":"1","key":"20","first-page":"11","article-title":"Signaling in colon cancer stem cells","volume":"7","author":"Majumdar","year":"2012","journal-title":"Journal of molecular signaling"},{"issue":"14","key":"21","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1074\/jbc.M011682200","article-title":"Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite","volume":"276","author":"Shi","year":"2001","journal-title":"The Journal of biological chemistry"},{"issue":"22","key":"22","first-page":"7689","article-title":"Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic","volume":"63","author":"Shi","year":"2003","journal-title":"Cancer research"},{"issue":"12","key":"23","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1172\/JCI37156","article-title":"Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation","volume":"118","author":"Wagner","year":"2008","journal-title":"J Clin Invest"},{"issue":"3","key":"24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients","volume":"123","author":"Szallasi","year":"2010","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.envres.2008.04.001","article-title":"Arsenic in drinking water and lung cancer: a systematic review","volume":"108","author":"Alberg","year":"2008","journal-title":"Environ Res"},{"issue":"10","key":"26","doi-asserted-by":"crossref","first-page":"e25886","DOI":"10.1371\/journal.pone.0025886","article-title":"Association of arsenic exposure with lung cancer incidence rates in the United States","volume":"6","author":"Guo","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/toxsci\/kfs199","article-title":"JNK-Dependent Stat3 Phosphorylation Contributes to Akt Activation in Response to Arsenic Exposure","volume":"129","author":"Chen","year":"2012","journal-title":"Toxicol Sci"},{"issue":"1","key":"28","doi-asserted-by":"crossref","DOI":"10.4161\/cc.23030","article-title":"JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic","volume":"12","author":"Chen","year":"2013","journal-title":"Cell Cycle"},{"issue":"20","key":"29","doi-asserted-by":"crossref","first-page":"8278","DOI":"10.1158\/0008-5472.CAN-08-2099","article-title":"Arsenic exposure in utero exacerbates skin cancer response in adulthood with contemporaneous distortion of tumor stem cell dynamics","volume":"68","author":"Diwan","year":"2008","journal-title":"Cancer research"},{"issue":"1","key":"30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/toxsci\/kfr282","article-title":"Overabundance of putative cancer stem cells in human skin keratinocyte cells malignantly transformed by arsenic","volume":"125","author":"Waalkes","year":"2012","journal-title":"Toxicol Sci"},{"issue":"1","key":"31","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1289\/ehp.0901059","article-title":"Arsenic exposure transforms human epithelial stem\/progenitor cells into a cancer stem-like phenotype","volume":"118","author":"Waalkes","year":"2010","journal-title":"Environmental health perspectives"},{"key":"32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1021\/tx3004054","article-title":"Chronic Exposure of Renal Stem Cells to Inorganic Arsenic Induces a Cancer Phenotype","volume":"26","author":"Waalkes","year":"2013","journal-title":"Chem Res Toxicol"},{"issue":"1","key":"33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/toxsci\/kfq315","article-title":"Carcinogenic effects of \u201cwhole-life\u201d exposure to inorganic arsenic in CD1 mice","volume":"119","author":"Waalkes","year":"2011","journal-title":"Toxicol Sci"},{"issue":"11","key":"34","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1593\/neo.05472","article-title":"The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells","volume":"7","author":"Kleer","year":"2005","journal-title":"Neoplasia"},{"issue":"1","key":"35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ccr.2010.10.035","article-title":"EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-beta-catenin signaling","volume":"19","author":"Hung","year":"2011","journal-title":"Cancer Cell"},{"issue":"24","key":"36","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1038\/emboj.2011.436","article-title":"Human pluripotent stem cells decouple respiration from energy production","volume":"30","author":"Cantley","year":"2011","journal-title":"The EMBO journal"},{"issue":"9","key":"37","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4331\/wjbc.v2.i9.202","article-title":"p53 in stem cells","volume":"2","author":"Blattner","year":"2011","journal-title":"World J Biol Chem"},{"issue":"2","key":"38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cmet.2011.06.011","article-title":"Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming","volume":"14","author":"Terzic","year":"2011","journal-title":"Cell metabolism"},{"issue":"2","key":"39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cmet.2011.07.003","article-title":"Anaerobicizing into pluripotency","volume":"14","author":"Izpisua Belmonte","year":"2011","journal-title":"Cell metabolism"},{"issue":"2","key":"40","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cell.2012.09.021","article-title":"Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat","volume":"151","author":"Knauf","year":"2012","journal-title":"Cell"},{"issue":"10","key":"41","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1074\/jbc.M109.035584","article-title":"Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition","volume":"285","author":"Zong","year":"2010","journal-title":"J Biol Chem"},{"issue":"19","key":"42","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1158\/0008-5472.CAN-08-1949","article-title":"The mammary progenitor marker CD61\/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis","volume":"68","author":"Visvader","year":"2008","journal-title":"Cancer research"},{"issue":"11","key":"43","first-page":"960","article-title":"Cytometric and biochemical characterization of human breast cancer cells reveals heterogeneous myoepithelial phenotypes","volume":"81","author":"Veneziani","year":"2012","journal-title":"Cytometry Part A : the journal of the International Society for Analytical Cytology"},{"issue":"6","key":"44","doi-asserted-by":"crossref","first-page":"A378","DOI":"10.1289\/ehp.113-a378","article-title":"Arsenic: in search of an antidote to a global poison","volume":"113","author":"Mead","year":"2005","journal-title":"Environmental health perspectives"},{"issue":"7485","key":"45","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nature12968","article-title":"Stimulus-triggered fate conversion of somatic cells into pluripotency","volume":"505","author":"Vacanti","year":"2014","journal-title":"Nature"},{"issue":"7485","key":"46","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature12969","article-title":"Bidirectional developmental potential in reprogrammed cells with acquired pluripotency","volume":"505","author":"Wakayama","year":"2014","journal-title":"Nature"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T07:36:32Z","timestamp":1599550592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,19]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,3,15]]}},"alternative-id":["1789","24675390"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.1789","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,19]]}}}