{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:53:09Z","timestamp":1791229989622,"version":"4.1.0"},"reference-count":48,"publisher":"Impact Journals, LLC","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2014,3,15]]},"DOI":"10.18632\/oncotarget.1831","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T20:41:35Z","timestamp":1442436095000},"page":"1212-1225","source":"Crossref","is-referenced-by-count":77,"title":["SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker"],"prefix":"10.18632","volume":"5","author":[{"given":"Vamsi K.","family":"Kolukula","sequence":"first","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetaram","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Wellstein","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga C.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Preet","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Iacobazzi","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Biotechnology and Pharmacological Sciences, University of Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"D\u2019Orazi","sequence":"additional","affiliation":[{"name":"Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena National Cancer Institute, Rome, Italy"},{"name":"Department of Medical, Oral and Biotechnological Sciences, University of Chieti, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Biotechnology and Pharmacological Sciences, University of Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Avantaggiati","sequence":"additional","affiliation":[{"name":"Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2014,3,16]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","article-title":"Blinded by the Light: The Growing Complexity of p53","volume":"137","author":"Prives","year":"2009","journal-title":"Cell"},{"key":"2","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: one name, many proteins","volume":"26","author":"Prives","year":"2012","journal-title":"Genes Dev"},{"key":"3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2641","article-title":"p53 mutations in cancer","volume":"15","author":"Vousden","year":"2013","journal-title":"Nat Cell Biol"},{"key":"4","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1101\/gad.1662908","article-title":"The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss","volume":"22","author":"Lang","year":"2008","journal-title":"Genes Dev"},{"key":"5","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2004.11.006","article-title":"Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome","volume":"119","author":"Parant","year":"2004","journal-title":"Cell"},{"key":"6","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2004.11.004","article-title":"Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome","volume":"119","author":"Bronson","year":"2004","journal-title":"Cell"},{"key":"7","first-page":"898","article-title":"Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis","volume":"7","author":"Moll","year":"2013","journal-title":"Cell Death Differ"},{"key":"8","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccr.2012.10.022","article-title":"Cell-type, dose, and mutation-type specificity dictate mutant p53 functions in vivo","volume":"22","author":"Sabapathy","year":"2012","journal-title":"Cancer Cell"},{"key":"9","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.cell.2011.12.017","article-title":"Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway","volume":"148","author":"Freed-Pastor","year":"2012","journal-title":"Cell"},{"key":"10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ccr.2006.08.013","article-title":"Gain of function of mutant p53: the mutant p53\/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation","volume":"10","author":"Piaggio","year":"2006","journal-title":"Cancer Cell"},{"key":"11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1042\/bse0470037","article-title":"Mitochondrial metabolite transport","volume":"47","author":"Pierri","year":"2010","journal-title":"Essays Biochem"},{"key":"12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.bbabio.2008.03.008","article-title":"Diseases caused by defects of mitochondrial carriers: a review","volume":"1777","author":"Palmieri","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"13","first-page":"101","article-title":"Mitochondrial and Plasma Membrane Citrate Transporters: Discovery of Selective Inhibitors and Application to Structure\/Function Analysis","volume":"2","author":"Kaplan","year":"2010","journal-title":"Mol Cell Pharmacol"},{"issue":"10","key":"14","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.18632\/oncotarget.714","article-title":"The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis","volume":"3","author":"Avantaggiati","year":"2012","journal-title":"Oncotarget"},{"key":"15","first-page":"6888","article-title":"PGC1\u03b1 promotes tumor growth by inducing gene expression programs supporting lipogenesis","volume":"21","author":"Girnun","year":"2011","journal-title":"Cancer Res"},{"key":"16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BJ20111275","article-title":"The mitochondrial citrate carrier: a new player in inflammation","volume":"438","author":"Iacobazzi","year":"2011","journal-title":"Biochem J"},{"key":"17","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.virol.2006.04.028","article-title":"Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes","volume":"354","author":"Dandekar","year":"2006","journal-title":"Virology"},{"key":"18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Lash","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"19","first-page":"D991","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"J41","author":"Soboleva","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1593\/neo.07112","article-title":"Oncomine 3.0: Genes, Pathways, and Networks in a Collection of 18,000 Cancer Gene Expression Profiles","volume":"9","author":"Chinnaiyan","year":"2007","journal-title":"Neoplasia"},{"key":"21","first-page":"401","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"5","author":"Schultz","year":"2012","journal-title":"Cancer Discov"},{"key":"22","first-page":"pl1","article-title":"Sci Signal","volume":"269","author":"Schultz","year":"2013","journal-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal"},{"key":"23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bbrc.2007.02.114","article-title":"Transcription of the mitochondrial citrate carrier gene: role of SREBP-1, upregulation by insulin and downregulation by PUFA","volume":"356","author":"Palmieri","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"24","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.4161\/cc.24128","article-title":"Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy","volume":"12","author":"Avantaggiati","year":"2013","journal-title":"Cell Cycle"},{"key":"25","first-page":"4436","article-title":"Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy","volume":"23","author":"Avantaggiati","year":"2012","journal-title":"Cell Cycle"},{"key":"26","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/jcp.22285","article-title":"Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway","volume":"225","author":"Avantaggiati","year":"2010","journal-title":"J Cell Physiol"},{"key":"27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2144\/000113999","article-title":"LASAGNA-Search: an integrated web tool for transcription factor binding site search and visualization","volume":"54","author":"Huang","year":"2013","journal-title":"Biotechniques"},{"key":"28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbrc.2009.05.030","article-title":"Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion","volume":"385","author":"Palmieri","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"29","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1124\/mol.109.058750","article-title":"Inhibitors of the mitochondrial citrate transport protein: validation of the role of substrate binding residues and discovery of the first purely competitive inhibitor","volume":"77","author":"Kaplan","year":"2010","journal-title":"Mol Pharmacol"},{"key":"30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrc1123","article-title":"Ovarian cancer: strategies for overcoming resistance to chemotherapy","volume":"3","author":"Kaye","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"31","doi-asserted-by":"crossref","first-page":"19257","DOI":"10.3390\/ijms140919257","article-title":"The consequence of oncomorphic TP53 mutations in ovarian cancer","volume":"14","author":"Leslie","year":"2013","journal-title":"Int J Mol Sci"},{"key":"32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1755-8794-2-34","article-title":"Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer","volume":"2","author":"Nephew","year":"2009","journal-title":"BMC Med Genomics"},{"key":"33","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1158\/1535-7163.MCT-04-0311","article-title":"Genome-wide transcriptional analysis of carboplatin response in chemosensitive and chemoresistant ovarian cancer cells","volume":"4","author":"Ochs","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"34","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients","volume":"123","author":"Szallasi","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"35","doi-asserted-by":"crossref","first-page":"e82241","DOI":"10.1371\/journal.pone.0082241","article-title":"Online survival analysis software to assess the prognostic value of biomarkers using transcriptomic data in non-small-cell lung cancer","volume":"8","author":"Lanczky","year":"2013","journal-title":"PLoS One"},{"key":"36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1530\/ERC-11-0329","article-title":"Implementing an online tool for genome-wide validation of survival-associated biomarkers in ovarian-cancer using microarray data of 1287 patients","volume":"19","author":"Szallasi","year":"2012","journal-title":"Endocrine-Related Cancer"},{"issue":"11","key":"37","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1093\/carcin\/bgs232","article-title":"The rebel angel: mutant p53 as the driving oncogene in breast cancer","volume":"33","author":"Giannino Del","year":"2012","journal-title":"Carcinogenesis"},{"key":"38","first-page":"583929","article-title":"TP53 Mutations in Nonsmall Cell Lung Cancer","volume":"2011","author":"Hiroyuki","year":"2011","journal-title":"J Biomed Biotechnol"},{"key":"39","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1038\/sj.onc.1206477","article-title":"Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression","volume":"22","author":"Kirschmeier","year":"2003","journal-title":"Oncogene"},{"key":"40","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/cdd.2013.9","article-title":"p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity","volume":"20","author":"Rotter","year":"2013","journal-title":"Cell Death Differ"},{"key":"41","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cell.2009.12.037","article-title":"Chewing the fat on tumor cell metabolism","volume":"140","author":"Manning","year":"2010","journal-title":"Cell"},{"key":"42","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/jmedgenet-2012-101485","article-title":"Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter","volume":"50","author":"Elpeleg","year":"2013","journal-title":"J Med Genet"},{"key":"43","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ajhg.2013.03.009","article-title":"Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria","volume":"92","author":"Nota","year":"2013","journal-title":"Am J Hum Genet"},{"issue":"5","key":"44","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbabio.2008.10.005","article-title":"The mitochondrial p53 pathway","volume":"1787","author":"Moll","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"45","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrc2715","article-title":"p53 and metabolism","volume":"9","author":"Ryan","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"46","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.4161\/cc.9.6.11035","article-title":"The AMPK-FoxO3A axis as a target for cancer treatment","volume":"9","author":"Simone","year":"2010","journal-title":"Cell Cycle"},{"issue":"6","key":"47","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nrm2190","article-title":"Stressing the role of FoxO proteins in lifespan and disease","volume":"8","author":"Burgering","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"48","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.1248627","article-title":"Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas","volume":"343","author":"Fuchs","year":"2014","journal-title":"Science"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T23:18:11Z","timestamp":1653175091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,15]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,3,15]]}},"alternative-id":["1831","24681808"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.1831","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,15]]}}}