{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:18:06Z","timestamp":1791987486241,"version":"4.4.0"},"reference-count":30,"publisher":"Impact Journals, LLC","issue":"39","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,9,12]]},"DOI":"10.18632\/oncotarget.18528","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T18:47:57Z","timestamp":1497638877000},"page":"65386-65396","source":"Crossref","is-referenced-by-count":26,"title":["Lipocalin 2 regulates intestine bacterial survival by interplaying with siderophore in a weaned piglet model of <i>Escherichia coli<\/i> infection"],"prefix":"10.18632","volume":"8","author":[{"given":"Bing-Xiu","family":"Guo","sequence":"first","affiliation":[{"name":"College of Animal Science, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University, Hangzhou, 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science, Eastern of China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hui","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University, Hangzhou, 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science, Eastern of China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Shun","family":"Gan","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University, Hangzhou, 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science, Eastern of China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Hua","family":"Du","sequence":"additional","affiliation":[{"name":"College of Animal Science, Zhejiang University, Hangzhou, 310058, China"},{"name":"Key Laboratory of Animal Nutrition and Feed Science, Eastern of China, Ministry of Agriculture, Zhejiang University, Hangzhou, 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,6,16]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"E130","DOI":"10.3390\/ijms17010130","article-title":"Iron Homeostasis in Health and Disease","volume":"17","author":"Arosio","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.chom.2013.04.010","article-title":"Iron in infection and immunity","volume":"13","author":"Skaar","year":"2013","journal-title":"Cell Host Microbe"},{"key":"3","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1111\/j.1462-5822.2010.01529.x","article-title":"The struggle for iron - a metal at the host-pathogen interface","volume":"12","author":"Weiss","year":"2010","journal-title":"Cell Microbiol"},{"key":"4","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1017\/S0007114511001152","article-title":"Glutamine supplementation improves intestinal barrier function in a weaned piglet model of Escherichia coli infection","volume":"106","author":"Field","year":"2011","journal-title":"Brit J Nutr"},{"key":"5","doi-asserted-by":"crossref","first-page":"e1000949","DOI":"10.1371\/journal.ppat.1000949","article-title":"The battle for iron between bacterial pathogens and their vertebrate hosts","volume":"6","author":"Skaar","year":"2010","journal-title":"PLoS Pathog"},{"key":"6","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1073\/pnas.0630018100","article-title":"Enterobactin: an archetype for microbial iron transport","volume":"100","author":"Kim","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/nchembio771","article-title":"How pathogenic bacteria evade mammalian sabotage in the battle for iron","volume":"2","author":"Walsh","year":"2006","journal-title":"Nat Chem Biol"},{"key":"8","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1128\/IAI.01260-09","article-title":"Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis","volume":"78","author":"Hultgren","year":"2010","journal-title":"Infect Immun"},{"key":"9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Aderem","year":"2004","journal-title":"Nature"},{"key":"10","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1073\/pnas.0510847103","article-title":"Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury","volume":"103","author":"Mak","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"11","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1128\/IAI.01719-06","article-title":"Interleukin-8 secretion in response to aferric enterobactin is potentiated by siderocalin","volume":"75","author":"Weiser","year":"2007","journal-title":"Infect Immun"},{"key":"12","doi-asserted-by":"crossref","first-page":"e1000622","DOI":"10.1371\/journal.ppat.1000622","article-title":"Mucosal lipocalin 2 has pro-inflammatory and iron-sequestering effects in response to bacterial enterobactin","volume":"5","author":"Weiser","year":"2009","journal-title":"PLoS Pathog"},{"key":"13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3329\/jhpn.v28i3.5551","article-title":"Aetiology of diarrhoea and virulence properties of diarrhoeagenic Escherichia coli among patients and healthy subjects in southeast Nigeria","volume":"28","author":"Nweze","year":"2010","journal-title":"J Health Popul Nutr"},{"key":"14","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3945\/jn.114.192120","article-title":"Dietary Dietary arginine supplementation of mice alters the microbial population and activates intestinalinnate immunity","volume":"144","author":"Wu","year":"2014","journal-title":"J Nutr"},{"key":"15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.vetmic.2014.03.025","article-title":"Enterotoxigenic Escherichia coli infection induces intestinal epithelial cell autophagy","volume":"171","author":"Yin","year":"2014","journal-title":"Vet Microbiol"},{"key":"16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/01652176.1998.9694967","article-title":"Weaning piglets as a model for studying pathophysiology of diarrhea","volume":"20","author":"Nabuurs","year":"1998","journal-title":"Vet Q"},{"key":"17","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.micro.54.1.881","article-title":"Iron metabolism in pathogenic bacteria","volume":"54","author":"Dover","year":"2000","journal-title":"Annu Rev Microbiol"},{"key":"18","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and iron regulation, 10 years later","volume":"117","author":"Ganz","year":"2011","journal-title":"Blood"},{"key":"19","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Kaplan","year":"2004","journal-title":"Science"},{"key":"20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.imbio.2006.02.004","article-title":"Iron-withholding strategy in innate immunity","volume":"211","author":"Ding","year":"2006","journal-title":"Immunobiology"},{"key":"21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2728(96)00022-9","article-title":"The ferritins: molecular properties, iron storage function and cellular regulation","volume":"1275","author":"Arosio","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"22","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1038\/ncomms8113","article-title":"Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut","volume":"6","author":"Vijay-Kumar","year":"2015","journal-title":"Nat Commun"},{"key":"23","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Ouyang","year":"2008","journal-title":"Nat Med"},{"key":"24","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.immuni.2014.01.007","article-title":"The battle in the gut","volume":"40","author":"Monack","year":"2014","journal-title":"Immunity"},{"key":"25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.immuni.2014.01.003","article-title":"The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria","volume":"40","author":"Raffatellu","year":"2014","journal-title":"Immunity"},{"key":"26","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S1097-2765(02)00708-6","article-title":"The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition","volume":"10","author":"Strong","year":"2002","journal-title":"Mol Cell"},{"key":"27","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.2527\/jas.2013-6528","article-title":"Changes in gut microbial populations, intestinal morphology, expression of tight junction proteins, and cytokine production between two pig breeds after challenge with Escherichia coli K88: A comparative study","volume":"91","author":"Wang","year":"2013","journal-title":"J Anim Sci"},{"key":"28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12011-015-0295-6","article-title":"Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin","volume":"167","author":"Du","year":"2015","journal-title":"Biol Trace Elem Res"},{"key":"29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C-T method","volume":"3","author":"Livak","year":"2008","journal-title":"Nat Protoc"},{"key":"30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0003-2697(87)90612-9","article-title":"Universal Chemical-Assay for the Detection and Determination of Siderophores","volume":"160","author":"Neilands","year":"1987","journal-title":"Anal Biochem"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.18528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T10:33:51Z","timestamp":1589193231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.18528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,16]]},"references-count":30,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2017,9,12]]}},"alternative-id":["18528","29029438"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.18528","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,16]]}}}