{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:34:56Z","timestamp":1791153296376,"version":"4.1.0"},"reference-count":119,"publisher":"Impact Journals, LLC","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2014,6,30]]},"DOI":"10.18632\/oncotarget.1934","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T23:39:30Z","timestamp":1442360370000},"page":"3956-3969","source":"Crossref","is-referenced-by-count":97,"title":["An updated overview of HPV-associated head and neck carcinomas"],"prefix":"10.18632","volume":"5","author":[{"given":"Apostolos","family":"Zaravinos","sequence":"first","affiliation":[{"name":"Molecular Medicine Research Center and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, 1678 Nicosia, Cyprus"},{"name":"Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, 14145 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: from basic studies to clinical application","volume":"2","author":"zur Hausen","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A review of human carcinogens--Part B: biological agents","volume":"10","author":"Cogliano","year":"2009","journal-title":"Lancet Oncol"},{"key":"3","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s12253-008-9032-1","article-title":"K-ras mutation, HPV infection and smoking or alcohol abuse positively correlate with esophageal squamous carcinoma","volume":"14","author":"Spandidos","year":"2008","journal-title":"Pathol Oncol Res"},{"key":"4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5301\/JBM.2011.8737","article-title":"HPV, KRAS mutations, alcohol consumption and tobacco smoking effects on esophageal squamous-cell carcinoma carcinogenesis","volume":"27","author":"Spandidos","year":"2012","journal-title":"Int J Biol Markers"},{"key":"5","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1007\/s13277-013-1419-2","article-title":"Detection and genotype analysis of human papillomavirus in non-small cell lung cancer patients","volume":"35","author":"Sourvinos","year":"2014","journal-title":"Tumour Biol"},{"key":"6","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/jmv.21534","article-title":"Prevalence of human papilloma virus and human herpes virus types 1-7 in human nasal polyposis","volume":"81","author":"Spandidos","year":"2009","journal-title":"J Med Virol"},{"key":"7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2133.2009.09480.x","article-title":"Viral DNA detection and RAS mutations in actinic keratosis and nonmelanoma skin cancers","volume":"162","author":"Spandidos","year":"2010","journal-title":"Br J Dermatol"},{"key":"8","doi-asserted-by":"crossref","unstructured":"Ragin, Obikoya-Malomo, Kim, Chen, Flores-Obando, Gibbs, Koriyama, Aguayo, Koshiol, Caporaso, Carpagnano, Ciotti, Dosaka-Akita, Fukayama, Goto, Spandidos, Gorgoulis, Heideman, van Boerdonk, Hiroshima, Iwakawa, Kastrinakis, Kinoshita, Akiba, Landi, Eugene Liu, Wang, Mehra, Khuri, Lim, Owonikoko, Ramalingam, Sarchianaki, Syrjanen, Tsao, Sykes, Hee, Yokota, Zaravinos, Taioli. HPV-Associated Lung Cancers: an International Pooled Analysis. Carcinogenesis. 2014.","DOI":"10.1093\/carcin\/bgu038"},{"key":"9","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/nrc2961","article-title":"Why do viruses cause cancer? Highlights of the first century of human tumour virology","volume":"10","author":"Chang","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000275612","article-title":"Human papilloma virus (HPV) antigens in lesions of laryngeal squamous cell carcinomas","volume":"44","author":"Pyrhonen","year":"1982","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0020-7292(83)90015-2","article-title":"Morphological and immunohistochemical evidence of human papilloma virus (HPV) involvement in the dysplastic lesions of the uterine cervix","volume":"21","author":"Yliskoski","year":"1983","journal-title":"Int J Gynaecol Obstet"},{"key":"12","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S1473-3099(10)70190-0","article-title":"Factors affecting transmission of mucosal human papillomavirus","volume":"10","author":"van de Wijgert","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"13","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3201\/eid1406.0706162","article-title":"Transmission of human papillomavirus in heterosexual couples","volume":"14","author":"Goodman","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/jnci\/djq562","article-title":"Human papillomavirus testing in the prevention of cervical cancer","volume":"103","author":"Castle","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"15","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/lary.23298","article-title":"Human papillomavirus DNA strongly correlates with a poorer prognosis in oral cavity carcinoma","volume":"122","author":"Saussez","year":"2012","journal-title":"Laryngoscope"},{"key":"16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ejca.2009.12.014","article-title":"Estimates of cancer incidence and mortality in Europe in 2008","volume":"46","author":"Steliarova-Foucher","year":"2010","journal-title":"Eur J Cancer"},{"key":"17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3322\/caac.20138","article-title":"Cancer statistics, 2012","volume":"62","author":"Jemal","year":"2012","journal-title":"CA Cancer J Clin"},{"key":"18","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1093\/carcin\/bgt223","article-title":"The molecular features of tongue epithelium treated with the carcinogen 4-nitroquinoline-1-oxide and alcohol as a model for HNSCC","volume":"34","author":"Gudas","year":"2013","journal-title":"Carcinogenesis"},{"key":"19","unstructured":"World Health Organization. IARC monographs on the evaluation of carcinogenic risks to humans: volume 100B-Biological Agents. A review of human carcinogens. Lyon, International Agency for Research on Cancer 2012."},{"key":"20","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"Gillison","year":"2011","journal-title":"J Clin Oncol"},{"key":"21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1600-0463.2010.02624.x","article-title":"The role of human papillomavirus in head and neck cancer","volume":"118","author":"von Buchwald","year":"2010","journal-title":"Apmis"},{"key":"22","doi-asserted-by":"crossref","first-page":"c1439","DOI":"10.1136\/bmj.c1439","article-title":"Oropharyngeal carcinoma related to human papillomavirus","volume":"340","author":"Ang","year":"2010","journal-title":"Bmj"},{"key":"23","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1016\/j.vaccine.2010.02.098","article-title":"Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets","volume":"28","author":"Rose","year":"2010","journal-title":"Vaccine"},{"key":"24","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ijc.24339","article-title":"Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?","volume":"125","author":"Dalianis","year":"2009","journal-title":"Int J Cancer"},{"key":"25","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/jcp.2003.008656","article-title":"HPV infections tonsillar carcinoma","volume":"57","author":"Syrjanen","year":"2004","journal-title":"J Clin Pathol"},{"key":"26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1601-0825.2005.01112.x","article-title":"HPV and other risk factors of oral cavity\/oropharyngeal cancer in the Czech Republic","volume":"11","author":"Hamsikova","year":"2005","journal-title":"Oral Dis"},{"key":"27","first-page":"1157","article-title":"HPV infection in squamous cell carcinomas arising from different mucosal sites of the head and neck region","volume":"108","author":"Paludetti","year":"2013","journal-title":"Is p16 immunohistochemistry a reliable surrogate marker? Br J Cancer"},{"key":"28","first-page":"783","article-title":"Detection of human papillomavirus DNA in laryngeal squamous cell carcinoma by polymerase chain reaction","volume":"32A","author":"Maurizi","year":"1996","journal-title":"Eur J Cancer"},{"key":"29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/hed.10097","article-title":"Human papillomavirus infection and cyclin D1 gene amplification in laryngeal squamous cell carcinoma: biologic function and clinical significance","volume":"24","author":"Maurizi","year":"2002","journal-title":"Head Neck"},{"key":"30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12253-010-9288-0","article-title":"Vaccination against human papilloma virus (HPV): epidemiological evidence of HPV in non-genital cancers","volume":"17","author":"Spandidos","year":"2011","journal-title":"Pathol Oncol Res"},{"key":"31","first-page":"561","article-title":"Presence of HPV in head and neck tumours: high prevalence in tonsillar localization","volume":"23","author":"Vigili","year":"2004","journal-title":"J Exp Clin Cancer Res"},{"key":"32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/ijc.11381","article-title":"Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck","volume":"107","author":"Aaltonen","year":"2003","journal-title":"Int J Cancer"},{"key":"33","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/ijc.26500","article-title":"Characteristics and survival of head and neck cancer by HPV status: a cancer registry-based study","volume":"131","author":"Kato","year":"2012","journal-title":"Int J Cancer"},{"key":"34","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1016\/j.clon.2011.05.007","article-title":"Clinically significant human papilloma virus in squamous cell carcinoma of the head and neck in UK practice","volume":"24","author":"Gilbert","year":"2012","journal-title":"Clin Oncol. (R Coll Radiol)"},{"key":"35","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1002\/hed.21650","article-title":"Association of p16(INK4a) overexpression with improved outcomes in young patients with squamous cell cancers of the oral tongue","volume":"33","author":"Kimple","year":"2011","journal-title":"Head Neck"},{"key":"36","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1208130","article-title":"The mutational landscape of head and neck squamous cell carcinoma","volume":"333","author":"Grandis","year":"2011","journal-title":"Science"},{"key":"37","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jcp.55.4.244","article-title":"The causal relation between human papillomavirus and cervical cancer","volume":"55","author":"Shah","year":"2002","journal-title":"J Clin Pathol"},{"key":"38","first-page":"229","article-title":"HPV status in head and neck tumors","volume":"206","author":"Petersen","year":"2010","journal-title":"Pathology -ResearchandPractice"},{"key":"39","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1111\/cas.12009","article-title":"Prognostic value of human papillomavirus and squamous cell carcinoma antigen in head and neck squamous cell carcinoma","volume":"103","author":"Suzuki","year":"2012","journal-title":"Cancer Sci"},{"key":"40","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/ijc.11381","article-title":"Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck","volume":"107","author":"Aaltonen","year":"2003","journal-title":"Int J Cancer"},{"key":"41","first-page":"673","article-title":"Metastatic oropharyngeal squamous cell carcinoma in cervical lymph nodes associated to HPV infection type 16 and 45; clinical, morphological and molecular study of two cases","volume":"149","author":"Ortiz-Hidalgo","year":"2013","journal-title":"Gac Med Mex"},{"key":"42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12038-009-0013-7","article-title":"Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis","volume":"34","author":"Parihar","year":"2009","journal-title":"J Biosci"},{"key":"43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0168-1702(02)00190-9","article-title":"Human papillomavirus immortalization and transformation functions","volume":"89","author":"Howley","year":"2002","journal-title":"Virus Res"},{"issue":"2006 Suppl","key":"44","doi-asserted-by":"crossref","first-page":"40470","DOI":"10.1155\/IDOG\/2006\/40470","article-title":"Epidemiology and natural history of human papillomavirus infections in the female genital tract","author":"Ault","year":"2006","journal-title":"Infect Dis Obstet Gynecol"},{"key":"45","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4161\/cc.6.9.4211","article-title":"p53: guardian of the genome and policeman of the oncogenes","volume":"6","author":"Serrano","year":"2007","journal-title":"Cell Cycle"},{"key":"46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.canlet.2009.11.015","article-title":"HMGB2 stabilizes p53 by interfering with E6\/E6AP-mediated p53 degradation in human papillomavirus-positive HeLa cells","volume":"292","author":"Choi","year":"2010","journal-title":"Cancer Lett"},{"key":"47","doi-asserted-by":"crossref","first-page":"3120","DOI":"10.1128\/JVI.02004-10","article-title":"Regulation of the human papillomavirus type 18 E6\/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD","volume":"85","author":"Banks","year":"2011","journal-title":"J Virol"},{"key":"48","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nrc950","article-title":"The retinoblastoma tumour suppressor in development and cancer","volume":"2","author":"Harlow","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"49","first-page":"897","article-title":"The Rb family of cell cycle regulatory factors: clinical implications","volume":"17","author":"Giordano","year":"2000","journal-title":"Int J Oncol"},{"key":"50","first-page":"2488","article-title":"Genetic progression model for head and neck cancer: implications for field cancerization","volume":"56","author":"Sidransky","year":"1996","journal-title":"Cancer Res"},{"key":"51","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.anl.2008.10.011","article-title":"High-risk human papillomavirus (HPV) is not associated with p53 and bcl-2 expression in oral squamous cell carcinomas","volume":"36","author":"Costa Ade","year":"2009","journal-title":"Auris Nasus Larynx"},{"key":"52","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.ijrobp.2008.12.088","article-title":"Oropharyngeal squamous cell carcinoma treated with radiotherapy or radiochemotherapy: prognostic role of TP53 and HPV status","volume":"75","author":"Olmi","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"53","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1158\/0008-5472.CAN-11-3277","article-title":"Biomarkers of HPV in head and neck squamous cell carcinoma","volume":"72","author":"Kelsey","year":"2012","journal-title":"Cancer Res"},{"key":"54","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1002\/ijc.22355","article-title":"Combined analysis of HPV-DNA, p16 and EGFR expression to predict prognosis in oropharyngeal cancer","volume":"120","author":"Klussmann","year":"2007","journal-title":"Int J Cancer"},{"key":"55","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/172460080902400401","article-title":"Molecular detection methods of human papillomavirus (HPV)","volume":"24","author":"Spandidos","year":"2009","journal-title":"Int J Biol Markers"},{"key":"56","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/ijc.24911","article-title":"Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma","volume":"126","author":"Wasylyk","year":"2010","journal-title":"Int J Cancer"},{"key":"57","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/archoto.2008.540","article-title":"Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices","volume":"135","author":"Chen","year":"2009","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"58","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1002\/hed.23087","article-title":"Prevalence predictive role of p16 and epidermal growth factor receptor in surgically treated oropharyngeal and oral cavity cancer","volume":"35","author":"Worden","year":"2013","journal-title":"Head Neck"},{"key":"59","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1365-2133.2009.09079.x","article-title":"Deregulation of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in basal cell carcinoma","volume":"160","author":"Spandidos","year":"2009","journal-title":"Br J Dermatol"},{"key":"60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.canlet.2008.01.042","article-title":"Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis","volume":"264","author":"Spandidos","year":"2008","journal-title":"Cancer Lett"},{"key":"61","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1200\/JCO.2004.00.3335","article-title":"Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis","volume":"24","author":"Psyrri","year":"2006","journal-title":"J Clin Oncol"},{"key":"62","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/PAS.0b013e3182116a45","article-title":"Isolating p16-positive\/HPV-negative oropharyngeal cancer: an effort worth making","volume":"35","author":"Pilotti","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"63","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1200\/JCO.2008.20.2853","article-title":"Overgaard: Effect of HPV-Associated p16INK4A Expression on Response to Radiotherapy and Survival in Squamous Cell Carcinoma of the Head and Neck","volume":"27","author":"Overgaard","year":"2009","journal-title":"J Clin Oncol"},{"key":"64","first-page":"32360","article-title":"Phase I study of panitumumab + chemoradiotherapy (CRT) for head and neck cancer (HNC)","volume":"26","author":"Haddad","year":"2008","journal-title":"Proc Am Soc Clin Oncol"},{"key":"65","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.oraloncology.2012.05.022","article-title":"HPV status in patients with head and neck of carcinoma of unknown primary site: HPV, tobacco smoking, and outcome","volume":"48","author":"Hoffmann","year":"2012","journal-title":"Oral Oncol"},{"key":"66","doi-asserted-by":"crossref","first-page":"5630","DOI":"10.1200\/JCO.2005.04.6136","article-title":"High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma","volume":"24","author":"Pilotti","year":"2006","journal-title":"J Clin Oncol"},{"key":"67","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/hed.20977","article-title":"Cell cycle and viral and immunologic profiles of head and neck squamous cell carcinoma as predictable variables of tumor progression","volume":"31","author":"Landolfo","year":"2009","journal-title":"Head Neck"},{"key":"68","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/annonc\/mdr006","article-title":"Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial","volume":"22","author":"Cullen","year":"2011","journal-title":"Ann Oncol"},{"key":"69","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1200\/JCO.2010.29.2904","article-title":"Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02. 02 phase III trial","volume":"28","author":"McArthur","year":"2010","journal-title":"J Clin Oncol"},{"key":"70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1758-3284-2-15","article-title":"Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)","volume":"2","author":"Tsao","year":"2010","journal-title":"Head Neck Oncol"},{"key":"71","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/ijc.22851","article-title":"Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: review and meta-analysis","volume":"121","author":"Taioli","year":"2007","journal-title":"Int J Cancer"},{"key":"72","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.oraloncology.2012.06.019","article-title":"Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis","volume":"48","author":"Anderson","year":"2012","journal-title":"Oral Oncol"},{"key":"73","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1093\/annonc\/mdr544","article-title":"Tumor stage, human papillomavirus and smoking status affect the survival of patients with oropharyngeal cancer: an Italian validation study","volume":"23","author":"Licitra","year":"2012","journal-title":"Ann Oncol"},{"key":"74","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Gillison","year":"2010","journal-title":"N Engl J Med"},{"key":"75","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00405-012-2086-4","article-title":"Human papillomavirus and oropharyngeal squamous cell carcinoma: what the clinician should know","volume":"270","author":"Ferlito","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"76","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/sj.onc.1205214","article-title":"Involvement of intact HPV16 E6\/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control","volume":"21","author":"Bosch","year":"2002","journal-title":"Oncogene"},{"key":"77","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2982","article-title":"The molecular biology of head and neck cancer","volume":"11","author":"Brakenhoff","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"78","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.imbio.2011.11.005","article-title":"Decreased levels of alternative costimulatory receptors OX40 and 4-1BB characterise T cells from head and neck cancer patients","volume":"217","author":"Dumitriu","year":"2012","journal-title":"Immunobiology"},{"key":"79","first-page":"2553","article-title":"Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance","volume":"8","author":"Whiteside","year":"2002","journal-title":"Clin Cancer Res"},{"key":"80","first-page":"2136","article-title":"The number of intratumoral dendritic cells and zeta-chain expression in T cells as prognostic and survival biomarkers in patients with oral carcinoma","volume":"91","author":"Whiteside","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"81","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1158\/0008-5472.CAN-12-2606","article-title":"PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer","volume":"73","author":"Tartour","year":"2013","journal-title":"Cancer Res"},{"key":"82","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1003466","article-title":"Improved survival with ipilimumab in patients with metastatic melanoma","volume":"363","author":"Urba","year":"2010","journal-title":"N Engl J Med"},{"key":"83","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1084\/jem.20082492","article-title":"Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies","volume":"206","author":"Allison","year":"2009","journal-title":"J Exp Med"},{"key":"84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/cbr.2010.0902","article-title":"Cancer immunotherapy","volume":"26","author":"Dillman","year":"2011","journal-title":"Cancer Biother Radiopharm"},{"key":"85","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1200694","article-title":"Safety and activity of anti-PD-L1 antibody in patients with advanced cancer","volume":"366","author":"Wigginton","year":"2012","journal-title":"N Engl J Med"},{"key":"86","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Sznol","year":"2012","journal-title":"N Engl J Med"},{"key":"87","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/jnci\/djs033","article-title":"Therapeutic cancer vaccines: current status and moving forward","volume":"104","author":"Schlom","year":"2012","journal-title":"J Natl Cancer Inst"},{"key":"88","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1208130","article-title":"The mutational landscape of head and neck squamous cell carcinoma","volume":"333","author":"Grandis","year":"2011","journal-title":"Science"},{"key":"89","doi-asserted-by":"crossref","unstructured":"Vergati, Intrivici, Huen, Schlom, Tsang. Strategies for cancer vaccine development. J Biomed Biotechnol. 2010. 2010; pp. pii\u2013596432.","DOI":"10.1155\/2010\/596432"},{"key":"90","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1016\/j.vaccine.2009.07.005","article-title":"Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery","volume":"27","author":"Pai","year":"2009","journal-title":"Vaccine"},{"key":"91","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa0810097","article-title":"Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia","volume":"361","author":"Melief","year":"2009","journal-title":"N Engl J Med"},{"key":"92","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/hed.22004","article-title":"Induction of mage-A3 and HPV-16 immunity by Trojan vaccines in patients with head and neck carcinoma","volume":"34","author":"Strome","year":"2012","journal-title":"Head Neck Oncol"},{"key":"93","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00262-012-1322-5","article-title":"Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine","volume":"62","author":"Pai","year":"2013","journal-title":"Cancer Immunol Immunother"},{"key":"94","article-title":"Regression of high-grade cervical intraepithelial neoplasia with TG4001 targeted immunotherapy","volume":"204","author":"Bory","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"95","first-page":"542851","article-title":"Lm-LLO-based immunotherapies and HPV-associated disease","volume":"2012","author":"Rothman","year":"2012","journal-title":"J Oncol"},{"key":"96","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1016\/j.vaccine.2009.04.041","article-title":"The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix","volume":"27","author":"Rothman","year":"2009","journal-title":"Vaccine"},{"key":"97","first-page":"15s","article-title":"Phase I adjuvant trial of multi-epitope p53 vaccine for patients with squamous cell carcinoma of the head and neck (SCCHN): a preliminary report","volume":"27","author":"Ferris","year":"2009","journal-title":"J Clin Oncol"},{"key":"98","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer","volume":"349","author":"Cooper","year":"2003","journal-title":"N Engl J Med"},{"key":"99","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"van Glabbeke","year":"2004","journal-title":"N Engl J Med"},{"key":"100","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Fu","year":"2004","journal-title":"N Engl J Med"},{"key":"101","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/annonc\/mdh308","article-title":"Patterns of failure, prognostic factors and survival in locoregionally advanced head and neck cancer treated with concomitant chemoradiotherapy: A 9-year, 337-patient, multi-institutional experience","volume":"15","author":"Vokes","year":"2004","journal-title":"Ann Oncol"},{"key":"102","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1200\/JCO.2004.08.021","article-title":"Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma","volume":"22","author":"Calais","year":"2004","journal-title":"J Clin Oncol"},{"key":"103","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1080\/02841860802637757","article-title":"Comparison of predicted and clinical response to radiotherapy: A radiobiology modelling study","volume":"48","author":"Brodin","year":"2009","journal-title":"Acta Oncol"},{"key":"104","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Smejkal","year":"1953","journal-title":"Cancer"},{"key":"105","first-page":"1727","article-title":"A genetic explanation of Slaughter's concept of field cancerization: Evidence and clinical implications","volume":"63","author":"Brakenhoff","journal-title":"Cancer Res 2003"},{"key":"106","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0360-3016(89)90094-1","article-title":"Second malignancies in patients who have head and neck cancer: Incidence, effect on survival and implications based on the RTOG experience","volume":"17","author":"Cox","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"107","first-page":"200","article-title":"Tissue tolerance to reirradiation","volume":"10","author":"Ang","year":"2000","journal-title":"Vaccine"},{"key":"108","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jso.21012","article-title":"Chemotherapy in the treatment of locally advanced head and neck cancer","volume":"97","author":"Forastiere","year":"2008","journal-title":"J Surg Oncol"},{"key":"109","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.radonc.2013.03.002","article-title":"A dose escalation study with intensity modulated radiation therapy (IMRT) in T2N0, T2N1, T3N0 squamous cell carcinomas (SCC) of the oropharynx, larynx and hypopharynx using a simultaneous integrated boost (SIB) approach","volume":"106","author":"Gregoire","year":"2013","journal-title":"Radiother Oncol"},{"key":"110","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus - positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Gillison","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"111","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/annonc\/mdq060","article-title":"Strategies to promote translational research within the European Organisation for Research and Treatment of Cancer (EORTC) Head and Neck Cancer Group: a report from the Translational Research Subcommittee","volume":"21","author":"Langendijk","year":"2010","journal-title":"Ann Oncol"},{"key":"112","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S1470-2045(10)70035-8","article-title":"Do all patients with head and neck cancer benefit from radiotherapy and concurrent cetuximab?","volume":"11","author":"Overgaard","year":"2010","journal-title":"Lancet Oncol"},{"key":"113","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/hed.23209","article-title":"Definitive radiation therapy without chemotherapy for human papillomavirus-positive head and neck cancer","volume":"35","author":"Vaughan","year":"2013","journal-title":"Head Neck"},{"key":"114","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijrobp.2010.01.032","article-title":"Matched survival analysis in patients with locoregionally advanced resectable oropharyngeal carcinoma: platinum-based induction and concurrent chemoradiotherapy versus primary surgical resection","volume":"80","author":"Da Mosto","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"115","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0140-6736(06)69770-5","article-title":"Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis","volume":"368","author":"Pignon","year":"2006","journal-title":"Lancet"},{"key":"116","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","article-title":"Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis","volume":"26","author":"Ang","year":"2008","journal-title":"J Clin Oncol"},{"key":"117","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/hed.21688","article-title":"Weinstein GS. Transoral robotic surgery for oropharyngeal carcinoma and its impact on patient-reported quality of life and function","volume":"34","author":"O'Malley","year":"2012","journal-title":"Head Neck"},{"key":"118","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ijrobp.2010.07.008","article-title":"Concurrent cisplatin and radiation versus cetuximab and radiation for locally advanced head-and-neck cancer","volume":"81","author":"Lee","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"119","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1200\/JCO.2012.42.3988","article-title":"Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study","volume":"31","author":"Sire","year":"2013","journal-title":"J Clin Oncol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T04:39:34Z","timestamp":1718080774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.1934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,1]]},"references-count":119,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,6,30]]}},"alternative-id":["1934","24970795"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.1934","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,1]]}}}