{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:32:29Z","timestamp":1790839949445,"version":"4.1.0"},"reference-count":212,"publisher":"Impact Journals, LLC","issue":"41","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,9,19]]},"DOI":"10.18632\/oncotarget.19772","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T21:17:13Z","timestamp":1501622233000},"page":"71292-71316","source":"Crossref","is-referenced-by-count":56,"title":["miR-708-5p: a microRNA with emerging roles in cancer"],"prefix":"10.18632","volume":"8","author":[{"given":"Nicholas J.","family":"Monteleone","sequence":"first","affiliation":[{"name":"Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers Biomedical and Health Sciences, and the School of Graduate Studies, Health Sciences Campus - Newark, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol S.","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers Biomedical and Health Sciences, and the School of Graduate Studies, Health Sciences Campus - Newark, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,8,1]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrm3611","article-title":"Diversifying microRNA sequence and function","volume":"14","author":"Zamore","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.it.2008.04.004","article-title":"microRNAs and the immune response","volume":"29","author":"Lindsay","year":"2008","journal-title":"Trends Immunol"},{"key":"5","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Ambros","year":"1993","journal-title":"Cell"},{"key":"6","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Ruvkun","year":"2000","journal-title":"Nature"},{"key":"7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2011.03.009","article-title":"MicroRNA history: discovery, recent applications, and next frontiers","volume":"717","author":"Calin","year":"2011","journal-title":"Mutat Res"},{"key":"8","doi-asserted-by":"crossref","first-page":"D239","DOI":"10.1093\/nar\/gkv1258","article-title":"miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database","volume":"44","author":"Jian","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"9","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1186\/gb-2014-15-4-r57","article-title":"Evidence for the biogenesis of more than 1,000 novel human microRNAs","volume":"15","author":"Estivill","year":"2014","journal-title":"Genome Biol"},{"key":"10","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1101\/gad.1884710","article-title":"Mammalian microRNAs: experimental evaluation of novel and previously annotated genes","volume":"24","author":"Nusbaum","year":"2010","journal-title":"Genes Dev"},{"key":"11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrg3965","article-title":"Towards a molecular understanding of microRNA-mediated gene silencing","volume":"16","author":"Izaurralde","year":"2015","journal-title":"Nat Rev Genet"},{"key":"12","doi-asserted-by":"crossref","unstructured":"Lee, Kim, Han, Yeom, Lee, Baek, Kim. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004; 23:4051\u201360.","DOI":"10.1038\/sj.emboj.7600385"},{"key":"13","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1261\/rna.7135204","article-title":"Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs","volume":"10","author":"Cullen","year":"2004","journal-title":"RNA"},{"key":"14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Kim","year":"2003","journal-title":"Nature"},{"key":"15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrm3838","article-title":"Regulation of microRNA biogenesis","volume":"15","author":"Kim","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.40","article-title":"miRNA*: a passenger stranded in RNA-induced silencing complex?","volume":"20","author":"Kuchenbauer","year":"2010","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"17","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00018-007-7355-9","article-title":"Functional aspects of animal microRNAs","volume":"65","author":"Williams","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1261\/rna.1399509","article-title":"Deadenylation is a widespread effect of miRNA regulation","volume":"15","author":"Izaurralde","year":"2009","journal-title":"RNA"},{"key":"19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","article-title":"Prediction of mammalian microRNA targets","volume":"115","author":"Burge","year":"2003","journal-title":"Cell"},{"key":"20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrc1840","article-title":"Oncomirs - microRNAs with a role in cancer","volume":"6","author":"Slack","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"microRNAs as oncogenes and tumor suppressors","volume":"302","author":"Anderson","year":"2007","journal-title":"Dev Biol"},{"key":"22","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1261\/rna.044149.113","article-title":"Regulation of COX-2 expression by miR-146a in lung cancer cells","volume":"20","author":"Lutz","year":"2014","journal-title":"RNA"},{"key":"23","doi-asserted-by":"crossref","first-page":"e60317","DOI":"10.1371\/journal.pone.0060317","article-title":"miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells","volume":"8","author":"De Greve","year":"2013","journal-title":"PLoS One"},{"key":"24","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1093\/carcin\/bgu175","article-title":"Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status","volume":"35","author":"Troester","year":"2014","journal-title":"Carcinogenesis"},{"key":"25","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1634\/stemcells.2008-0356","article-title":"MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries","volume":"26","author":"Radich","year":"2008","journal-title":"Stem Cells"},{"key":"26","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1128\/JVI.01689-08","article-title":"Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas","volume":"83","author":"Meister","year":"2009","journal-title":"J Virol"},{"key":"27","doi-asserted-by":"crossref","first-page":"e9685","DOI":"10.1371\/journal.pone.0009685","article-title":"Characterization of the Melanoma miRNAome by Deep Sequencing","volume":"5","author":"Hayward","year":"2010","journal-title":"PLoS One"},{"key":"28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1741-7007-8-58","article-title":"Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls","volume":"8","author":"Lui","year":"2010","journal-title":"BMC Biol"},{"key":"29","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.immuni.2010.05.009","article-title":"Regulation of microRNA expression and abundance during lymphopoiesis","volume":"32","author":"Dubois","year":"2010","journal-title":"Immunity"},{"key":"30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1101\/gr.140269.112","article-title":"Birth and expression evolution of mammalian microRNA genes","volume":"23","author":"Kaessmann","year":"2013","journal-title":"Genome Res"},{"key":"31","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.201010055","article-title":"A CHOP-regulated microRNA controls rhodopsin expression","volume":"192","author":"Walter","year":"2011","journal-title":"J Cell Biol"},{"key":"32","doi-asserted-by":"crossref","first-page":"e44066","DOI":"10.1371\/journal.pone.0044066","article-title":"Cigarette smoking decreases global microRNA expression in human alveolar macrophages","volume":"7","author":"Monick","year":"2012","journal-title":"PLoS One"},{"key":"33","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/ijc.29491","article-title":"Epigenetic silencing of miR-708 enhances NF-kappaB signaling in chronic lymphocytic leukemia","volume":"137","author":"Plass","year":"2015","journal-title":"Int J Cancer"},{"key":"34","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1099\/jmm.0.067959-0","article-title":"MicroRNA expression in mice infected with seasonal H1N1, swine H1N1 or highly pathogenic H5N1","volume":"63","author":"Long","year":"2014","journal-title":"J Med Microbiol"},{"key":"35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12931-014-0107-0","article-title":"MicroRNA-708 regulates CD38 expression through signaling pathways JNK MAP kinase and PTEN\/AKT in human airway smooth muscle cells","volume":"15","author":"Kannan","year":"2014","journal-title":"Respir Res"},{"key":"36","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.1158\/0008-5472.CAN-06-0561","article-title":"Patterns of known and novel small RNAs in human cervical cancer","volume":"67","author":"Fire","year":"2007","journal-title":"Cancer Res"},{"key":"37","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.cell.2007.04.040","article-title":"A mammalian microRNA expression atlas based on small RNA library sequencing","volume":"129","author":"Hermida","year":"2007","journal-title":"Cell"},{"key":"38","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.molcel.2007.09.028","article-title":"Mammalian mirtron genes","volume":"28","author":"Lai","year":"2007","journal-title":"Mol Cell"},{"key":"39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cell.2007.06.028","article-title":"The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila","volume":"130","author":"Lai","year":"2007","journal-title":"Cell"},{"key":"40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature05983","article-title":"Intronic microRNA precursors that bypass Drosha processing","volume":"448","author":"Bartel","year":"2007","journal-title":"Nature"},{"key":"41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.ydbio.2005.11.038","article-title":"Teneurins: a conserved family of transmembrane proteins involved in intercellular signaling during development","volume":"290","author":"Chiquet-Ehrismann","year":"2006","journal-title":"Dev Biol"},{"key":"42","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.semcdb.2014.08.007","article-title":"The teneurins: new players in the generation of visual topography","volume":"35","author":"Sawatari","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"43","doi-asserted-by":"crossref","first-page":"e0177244","DOI":"10.1371\/journal.pone.0177244","article-title":"Expression of teneurins is associated with tumor differentiation and patient survival in ovarian cancer","volume":"12","author":"Ziegler","year":"2017","journal-title":"PLoS One"},{"key":"44","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1038\/ncomms6917","article-title":"Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B","volume":"6","author":"Wang","year":"2015","journal-title":"Nat Commun"},{"key":"45","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/bit.23282","article-title":"A review of the mammalian unfolded protein response","volume":"108","author":"Varner","year":"2011","journal-title":"Biotechnol Bioeng"},{"key":"46","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Samali","year":"2006","journal-title":"EMBO Rep"},{"key":"47","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jaci.2013.09.007","article-title":"The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease","volume":"132","author":"Cidlowski","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"48","article-title":"The Ensembl gene annotation system","volume":"2016","author":"Kokocinski","year":"2016","journal-title":"Database (Oxford)."},{"key":"49","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1158\/0008-5472.CAN-11-2575","article-title":"The dark side of E2F1: in transit beyond apoptosis","volume":"72","author":"Putzer","year":"2012","journal-title":"Cancer Res"},{"key":"50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MCB.19.1.1","article-title":"c-Myc target genes involved in cell growth, apoptosis, and metabolism","volume":"19","author":"Dang","year":"1999","journal-title":"Mol Cell Biol"},{"key":"51","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2407-9-52","article-title":"Loss of full length CtBP1 expression enhances the invasive potential of human melanoma","volume":"9","author":"Bosserhoff","year":"2009","journal-title":"BMC Cancer"},{"key":"52","first-page":"481","article-title":"CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1","volume":"3","author":"Grossman","year":"2012","journal-title":"Genes Cancer"},{"key":"53","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ccr.2012.11.019","article-title":"Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration","volume":"23","author":"Mittal","year":"2013","journal-title":"Cancer Cell"},{"key":"54","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1158\/0008-5472.CAN-12-0803","article-title":"Extensive promoter DNA hypermethylation and hypomethylation is associated with aberrant microRNA expression in chronic lymphocytic leukemia","volume":"72","author":"Wendtner","year":"2012","journal-title":"Cancer Res"},{"key":"55","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Consortium","year":"2012","journal-title":"Nature"},{"key":"56","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1017\/S1462399409001033","article-title":"CCAAT\/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases","volume":"11","author":"Zahnow","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"57","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/j.1471-4159.2006.03957.x","article-title":"C\/EBPbeta couples dopamine signalling to substance P precursor gene expression in striatal neurones","volume":"98","author":"Cardinaux","year":"2006","journal-title":"J Neurochem"},{"key":"58","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0169-328X(02)00419-9","article-title":"Synergistic activation of the human choline acetyltransferase gene by c-Myb and C\/EBPbeta","volume":"106","author":"Quirin-Stricker","year":"2002","journal-title":"Brain Res Mol Brain Res"},{"key":"59","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1182\/blood.V79.2.460.460","article-title":"Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6","volume":"79","author":"Kishimoto","year":"1992","journal-title":"Blood"},{"key":"60","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.4049\/jimmunol.155.11.5273","article-title":"Nuclear factor-IL6 activates the human IL-4 promoter in T cells","volume":"155","author":"Li-Weber","year":"1995","journal-title":"J Immunol"},{"key":"61","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.4049\/jimmunol.163.5.2674","article-title":"A composite C\/EBP binding site is essential for the activity of the promoter of the IL-3\/IL-5\/granulocyte-macrophage colony-stimulating factor receptor beta c gene","volume":"163","author":"de Groot","year":"1999","journal-title":"J Immunol"},{"key":"62","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1128\/MCB.20.3.912-918.2000","article-title":"Tumor necrosis factor alpha inhibits type I collagen synthesis through repressive CCAAT\/enhancer-binding proteins","volume":"20","author":"Ramirez","year":"2000","journal-title":"Mol Cell Biol"},{"key":"63","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/MCB.00939-10","article-title":"Selective abrogation of BiP\/GRP78 blunts activation of NF-kappaB through the ATF6 branch of the UPR: involvement of C\/EBPbeta and mTOR-dependent dephosphorylation of Akt","volume":"31","author":"Kitamura","year":"2011","journal-title":"Mol Cell Biol"},{"key":"64","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrg3663","article-title":"CTCF: an architectural protein bridging genome topology and function","volume":"15","author":"Corces","year":"2014","journal-title":"Nat Rev Genet"},{"key":"65","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrc3743","article-title":"Cohesin in cancer: chromosome segregation and beyond","volume":"14","author":"Losada","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"66","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nrc3932","article-title":"MicroRNA biogenesis pathways in cancer","volume":"15","author":"Gregory","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"67","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrg3853","article-title":"Competition between target sites of regulators shapes post-transcriptional gene regulation","volume":"16","author":"Rajewsky","year":"2015","journal-title":"Nat Rev Genet"},{"key":"68","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.biolcel.2004.05.002","article-title":"Post-transcriptional regulation in cancer","volume":"96","author":"Hartley","year":"2004","journal-title":"Biol Cell"},{"key":"69","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/leu.2008.286","article-title":"Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia","volume":"23","author":"den Boer","year":"2009","journal-title":"Leukemia"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1088\/2057-1739\/1\/2\/025002","article-title":"Uncovering low-dimensional, miR-based signatures of acute myeloid and lymphoblastic leukemias with a machine-learning-driven network approach","volume":"1","author":"Losert","year":"2015","journal-title":"Converg Sci Phys Oncol"},{"key":"71","first-page":"967585","article-title":"Prospective evaluation of whole genome microRNA expression profiling in childhood acute lymphoblastic leukemia","volume":"2014","author":"Cogulu","year":"2014","journal-title":"Biomed Res Int"},{"key":"72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/pbc.25222","article-title":"MiR-708-5p is differentially expressed in childhood acute lymphoblastic leukemia but not strongly associated to clinical features","volume":"62","author":"Tone","year":"2015","journal-title":"Pediatr Blood Cancer"},{"key":"73","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1093\/hmg\/ddr428","article-title":"A set of miRNAs that involve in the pathways of drug resistance and leukemic stem-cell differentiation is associated with the risk of relapse and glucocorticoid response in childhood ALL","volume":"20","author":"Chen","year":"2011","journal-title":"Hum Mol Genet"},{"key":"74","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2007.02.001","article-title":"Foxo3a is essential for maintenance of the hematopoietic stem cell pool","volume":"1","author":"Nakauchi","year":"2007","journal-title":"Cell Stem Cell"},{"key":"75","doi-asserted-by":"publisher","first-page":"995","DOI":"10.18632\/oncotarget.953","article-title":"Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa","volume":"4","author":"Obexer","year":"2013","journal-title":"Oncotarget"},{"key":"76","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cell.2007.01.003","article-title":"FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress","volume":"128","author":"DePinho","year":"2007","journal-title":"Cell"},{"key":"77","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1128\/MCB.01265-07","article-title":"The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase\/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression","volume":"28","author":"Lam","year":"2008","journal-title":"Mol Cell Biol"},{"key":"78","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nature08734","article-title":"TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia","volume":"463","author":"Hirao","year":"2010","journal-title":"Nature"},{"key":"79","doi-asserted-by":"crossref","first-page":"e2014073","DOI":"10.4084\/mjhid.2014.073","article-title":"Diagnosis and subclassification of acute lymphoblastic leukemia","volume":"6","author":"Bassan","year":"2014","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"80","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1158\/0008-5472.CAN-16-0359","article-title":"OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer","volume":"76","author":"Slack","year":"2016","journal-title":"Cancer Res"},{"key":"81","unstructured":"National Institutes of Health US. N.C.I. SEER Cancer Statistics Review, 1975-2011. 2011. https:\/\/seer.cancer.gov\/archive\/csr\/1975_2011\/."},{"key":"82","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/sj.leu.2402339","article-title":"CD38 expression is an important prognostic marker in chronic lymphocytic leukaemia","volume":"16","author":"Duhrsen","year":"2002","journal-title":"Leukemia"},{"key":"83","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.4049\/jimmunol.164.4.2200","article-title":"Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells","volume":"164","author":"Schattner","year":"2000","journal-title":"J Immunol"},{"key":"84","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1182\/blood-2011-09-379966","article-title":"Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia","volume":"119","author":"Fama","year":"2012","journal-title":"Blood"},{"key":"85","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1182\/blood-2011-07-370122","article-title":"Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis","volume":"119","author":"Staudt","year":"2012","journal-title":"Blood"},{"key":"86","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0003-3995(02)01122-X","article-title":"TPA stimulation culture for improved detection of t(11;14)(q13;q32) in mantle cell lymphoma","volume":"45","author":"Lai","year":"2002","journal-title":"Ann Genet"},{"key":"87","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0002-9440(10)65399-0","article-title":"Detection of translocation t(11;14)(q13;q32) in mantle cell lymphoma by fluorescencehybridization","volume":"154","author":"Avet-Loiseau","year":"1999","journal-title":"Am J Pathol"},{"key":"88","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1073\/pnas.1019557108","article-title":"MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia","volume":"108","author":"Galas","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"89","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10555-009-9188-5","article-title":"MicroRNA function in cancer: oncogene or a tumor suppressor?","volume":"28","author":"Alahari","year":"2009","journal-title":"Cancer Metastasis Rev"},{"key":"90","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.eururo.2005.04.005","article-title":"Adjuvant chemotherapy in invasive bladder cancer: a systematic review and meta-analysis of individual patient data Advanced Bladder Cancer (ABC) Meta-analysis Collaboration","volume":"48","author":"Advanced Bladder Cancer (ABC) Meta-analysis Collaboration","year":"2005","journal-title":"Eur Urol"},{"key":"91","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.eururo.2005.04.006","article-title":"Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data advanced bladder cancer (ABC) meta-analysis collaboration","volume":"48","author":"Advanced Bladder Cancer (ABC) Meta-analysis Collaboration","year":"2005","journal-title":"Eur Urol"},{"key":"92","first-page":"905","article-title":"Differential miRNA expression profiles in bladder urothelial carcinomas","volume":"11","author":"Li","year":"2010","journal-title":"Asian Pac J Cancer Prev"},{"key":"93","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The Genotype-Tissue Expression (GTEx) project","volume":"45","author":"Consortium","year":"2013","journal-title":"Nat Genet"},{"key":"94","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00432-013-1392-6","article-title":"miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2","volume":"139","author":"Hong","year":"2013","journal-title":"J Cancer Res Clin Oncol"},{"key":"95","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1038\/onc.2009.173","article-title":"Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase","volume":"28","author":"Villunger","year":"2009","journal-title":"Oncogene"},{"key":"96","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/cdd.2008.170","article-title":"The enigma of caspase-2: the laymen\u2019s view","volume":"16","author":"Villunger","year":"2009","journal-title":"Cell Death Differ"},{"key":"97","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1475-2867-13-42","article-title":"Caspase-2 is involved in cell death induction by taxanes in breast cancer cells","volume":"13","author":"Kovar","year":"2013","journal-title":"Cancer Cell Int"},{"key":"98","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3892\/ol.2014.2328","article-title":"Regulatory roles of microRNA-708 and microRNA-31 in proliferation, apoptosis and invasion of colorectal cancer cells","volume":"8","author":"Yang","year":"2014","journal-title":"Oncol Lett"},{"key":"99","doi-asserted-by":"crossref","first-page":"e33663","DOI":"10.1371\/journal.pone.0033663","article-title":"Mirna expression profiles identify drivers in colorectal and pancreatic cancers","volume":"7","author":"Carella","year":"2012","journal-title":"PLoS One"},{"key":"100","first-page":"827","article-title":"Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors","volume":"381","author":"Barbacid","year":"2000","journal-title":"Biol Chem"},{"key":"101","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1101\/gad.851100","article-title":"Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors","volume":"14","author":"Pavletich","year":"2000","journal-title":"Genes Dev"},{"key":"102","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Lundberg","year":"2015","journal-title":"Science"},{"key":"103","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1158\/1055-9965.EPI-11-0662","article-title":"Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin","volume":"21","author":"Abdel-Rahman","year":"2012","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"104","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/ibd.21359","article-title":"Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation","volume":"17","author":"Harris","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"105","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000113489","article-title":"Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer","volume":"72","author":"Vyzula","year":"2007","journal-title":"Oncology"},{"key":"106","doi-asserted-by":"crossref","first-page":"e18501","DOI":"10.1371\/journal.pone.0018501","article-title":"Differential expression of microRNAs in tumors from chronically inflamed or genetic (APC(Min\/+)) models of colon cancer","volume":"6","author":"Thompson","year":"2011","journal-title":"PLoS One"},{"key":"107","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/stem.530","article-title":"Neuronatin promotes neural lineage in ESCs via Ca(2+) signaling","volume":"28","author":"Sun","year":"2010","journal-title":"Stem Cells"},{"key":"108","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1242\/jcs.01481","article-title":"MAP kinases and cell migration","volume":"117","author":"Schaller","year":"2004","journal-title":"J Cell Sci"},{"key":"109","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ccr.2008.12.019","article-title":"Orai1 and STIM1 are critical for breast tumor cell migration and metastasis","volume":"15","author":"Huang","year":"2009","journal-title":"Cancer Cell"},{"key":"110","doi-asserted-by":"crossref","first-page":"19965","DOI":"10.1074\/jbc.273.32.19965","article-title":"ATP-stimulated activation of the mitogen-activated protein kinases through ionotrophic P2X2 purinoreceptors in PC12 cells. Difference in purinoreceptor sensitivity in two PC12 cell lines","volume":"273","author":"Landreth","year":"1998","journal-title":"J Biol Chem"},{"key":"111","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1038\/bjc.2014.113","article-title":"Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c","volume":"110","author":"Borgen","year":"2014","journal-title":"Br J Cancer"},{"key":"112","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/gb-2005-6-6-223","article-title":"The B7 family of immune-regulatory ligands","volume":"6","author":"Carreno","year":"2005","journal-title":"Genome Biol"},{"key":"113","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/eji.200839028","article-title":"B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction","volume":"39","author":"Steinberger","year":"2009","journal-title":"Eur J Immunol"},{"key":"114","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3892\/mmr.2012.1158","article-title":"B7-H3 expression in ductal and lobular breast cancer and its association with IL-10","volume":"7","author":"Sun","year":"2013","journal-title":"Mol Med Rep"},{"key":"115","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1097\/SLA.0b013e3181f1939d","article-title":"B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis","volume":"252","author":"Hoon","year":"2010","journal-title":"Ann Surg"},{"key":"116","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.juro.2011.04.103","article-title":"B7-H3 over expression in prostate cancer promotes tumor cell progression","volume":"186","author":"Hou","year":"2011","journal-title":"J Urol"},{"key":"117","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1002\/cam4.623","article-title":"miR-708\/LSD1 axis regulates the proliferation and invasion of breast cancer cells","volume":"5","author":"Cheng","year":"2016","journal-title":"Cancer Med"},{"key":"118","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.bbagrm.2013.05.002","article-title":"The histone LSD1 demethylase in stemness and cancer transcription programs","volume":"1829","author":"Majello","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"119","first-page":"5","article-title":"Maternal LSD1\/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation","author":"Heard","year":"2016","journal-title":"Elife"},{"key":"120","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5435\/00124635-201002000-00004","article-title":"Ewing sarcoma family of tumors","volume":"18","author":"Cheng","year":"2010","journal-title":"J Am Acad Orthop Surg"},{"key":"121","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/jcp.56.2.96","article-title":"Ewing\u2019s sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities","volume":"56","author":"Burchill","year":"2003","journal-title":"J Clin Pathol"},{"key":"122","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1128\/MCB.13.12.7393","article-title":"The Ewing\u2019s sarcoma EWS\/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1","volume":"13","author":"Denny","year":"1993","journal-title":"Mol Cell Biol"},{"key":"123","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1073\/pnas.90.12.5752","article-title":"Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation","volume":"90","author":"Denny","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"124","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1172\/JCI119152","article-title":"EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing\u2019s sarcoma and primitive neuroectodermal tumor cells","volume":"99","author":"Iwamoto","year":"1997","journal-title":"J Clin Invest"},{"key":"125","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1158\/1078-0432.CCR-06-0609","article-title":"Combined transcriptional and translational targeting of EWS\/FLI-1 in Ewing\u2019s sarcoma","volume":"12","author":"Notario","year":"2006","journal-title":"Clin Cancer Res"},{"key":"126","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nature07849","article-title":"Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions","volume":"458","author":"Rosenfeld","year":"2009","journal-title":"Nature"},{"key":"127","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0002-9440(10)61166-2","article-title":"Gene expression in Wilms\u2019 tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition","volume":"160","author":"Tycko","year":"2002","journal-title":"Am J Pathol"},{"key":"128","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1158\/0008-5472.CAN-06-3755","article-title":"Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival","volume":"67","author":"Ford","year":"2007","journal-title":"Cancer Res"},{"key":"129","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1242\/dev.01773","article-title":"Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo","volume":"132","author":"Maire","year":"2005","journal-title":"Development"},{"key":"130","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1242\/dev.00536","article-title":"Six1 is required for the early organogenesis of mammalian kidney","volume":"130","author":"Silvius","year":"2003","journal-title":"Development"},{"key":"131","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1158\/1541-7786.MCR-12-0086","article-title":"EWS\/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance","volume":"10","author":"Ford","year":"2012","journal-title":"Mol Cancer Res"},{"key":"132","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0092-8674(91)90105-8","article-title":"Oncogenic conversion of transcription factors by chromosomal translocations","volume":"66","author":"Cleary","year":"1991","journal-title":"Cell"},{"key":"133","first-page":"44","article-title":"Chromosomal translocations highlighted in Primitive Neuroectodermal Tumors (PNET) and Ewing sarcoma","volume":"3","author":"Trancau","journal-title":"J Med Life. 2014; 7 Spec No"},{"key":"134","first-page":"3250","article-title":"GADD153\/CHOP, a DNA damage-inducible protein, reduced CAAT\/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells","volume":"56","author":"Friedman","year":"1996","journal-title":"Cancer Res"},{"key":"135","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.nurt.2010.07.006","article-title":"Functions of astrocytes and their potential as therapeutic targets","volume":"7","author":"Nedergaard","year":"2010","journal-title":"Neurotherapeutics"},{"key":"136","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00401-009-0601-5","article-title":"Oligodendrocytes: biology and pathology","volume":"119","author":"Lassmann","year":"2010","journal-title":"Acta Neuropathol"},{"key":"137","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3892\/or.2013.2526","article-title":"miR-708 acts as a tumor suppressor in human glioblastoma cells","volume":"30","author":"Qiu","year":"2013","journal-title":"Oncol Rep"},{"key":"138","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrc2812","article-title":"PARP inhibition: PARP1 and beyond","volume":"10","author":"Poirier","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"139","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9440(10)61714-2","article-title":"AKT1\/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells","volume":"159","author":"Cheng","year":"2001","journal-title":"Am J Pathol"},{"key":"140","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nrc3090","article-title":"Cyclin D as a therapeutic target in cancer","volume":"11","author":"Sutherland","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"141","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4036","article-title":"Targeting EZH2 in cancer","volume":"22","author":"Roberts","year":"2016","journal-title":"Nat Med"},{"key":"142","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3892\/or_00000358","article-title":"Patterns of MMP-2 and MMP-9 expression in human cancer cell lines","volume":"21","author":"Niedzwiecki","year":"2009","journal-title":"Oncol Rep"},{"key":"143","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0960-9822(97)70094-0","article-title":"Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein","volume":"7","author":"Marshall","year":"1997","journal-title":"Curr Biol"},{"key":"144","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.molcel.2011.02.020","article-title":"Activation of the PIK3CA\/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis","volume":"42","author":"Sansom","year":"2011","journal-title":"Mol Cell"},{"key":"145","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrfmmm.2008.07.010","article-title":"Roles of the EZH2 histone methyltransferase in cancer epigenetics","volume":"647","author":"Lange","year":"2008","journal-title":"Mutat Res"},{"key":"146","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4254\/wjh.v7.i8.1020","article-title":"Hepatocellular carcinoma: From diagnosis to treatment","volume":"7","author":"Menon","year":"2015","journal-title":"World J Hepatol"},{"key":"147","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biopha.2015.05.010","article-title":"MicroRNA-708 is downregulated in hepatocellular carcinoma and suppresses tumor invasion and migration","volume":"73","author":"Liu","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"148","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.3748\/wjg.v18.i38.5442","article-title":"Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma","volume":"18","author":"Qi","year":"2012","journal-title":"World J Gastroenterol"},{"key":"149","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/mc.22483","article-title":"beta-ionone modulates the expression of miRNAs and genes involved in the metastatic phenotype of microdissected persistent preneoplastic lesions in rats submitted to hepatocarcinogenesis","volume":"56","author":"Moreno","year":"2017","journal-title":"Mol Carcinog"},{"key":"150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0167-4838(99)00279-4","article-title":"Tissue inhibitors of metalloproteinases: evolution, structure and function","volume":"1477","author":"Nagase","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"151","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1038\/onc.2011.411","article-title":"MTSS, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma","volume":"31","author":"Guan","year":"2012","journal-title":"Oncogene"},{"key":"152","doi-asserted-by":"crossref","first-page":"4098","DOI":"10.1038\/onc.2014.339","article-title":"TIMP3 controls cell fate to confer hepatocellular carcinoma resistance","volume":"34","author":"Khokha","year":"2015","journal-title":"Oncogene"},{"key":"153","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13046-016-0361-8","article-title":"Elevated MTSS1 expression associated with metastasis and poor prognosis of residual hepatitis B-related hepatocellular carcinoma","volume":"35","author":"Huang","year":"2016","journal-title":"J Exp Clin Cancer Res"},{"key":"154","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0140-6736(09)61338-6","article-title":"Ovarian cancer","volume":"374","author":"Markman","year":"2009","journal-title":"Lancet"},{"key":"155","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1056\/NEJMra041842","article-title":"Cancer of the ovary","volume":"351","author":"Cannistra","year":"2004","journal-title":"N Engl J Med"},{"key":"156","first-page":"1345","article-title":"Cell cycle arrest by glucocorticoids may protect normal tissue and solid tumors from cancer therapy","volume":"6","author":"Herr","year":"2007","journal-title":"Cancer Biol Ther"},{"key":"157","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02171708","article-title":"Glucocorticoids in cancer therapy","volume":"4","author":"Coleman","year":"1992","journal-title":"Biotherapy"},{"key":"158","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ceb.2009.06.004","article-title":"Control of cell adhesion dynamics by Rap1 signaling","volume":"21","author":"Van Aelst","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"159","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrm1229","article-title":"Ras GTPases: integrins\u2019 friends or foes?","volume":"4","author":"Ginsberg","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"160","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1158\/0008-5472.CAN-12-0540","article-title":"miRNA-708 control of CD44(+) prostate cancer-initiating cells","volume":"72","author":"Dahiya","year":"2012","journal-title":"Cancer Res"},{"key":"161","first-page":"37","article-title":"The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene","volume":"64","author":"Anstee","year":"1988","journal-title":"Immunology"},{"key":"162","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/sj.onc.1209327","article-title":"Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells","volume":"25","author":"Tang","year":"2006","journal-title":"Oncogene"},{"key":"163","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.5966\/sctm.2015-0048","article-title":"Concise Review: Emerging Role of CD44 in Cancer Stem Cells: A Promising Biomarker and Therapeutic Target","volume":"4","author":"Wei","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"164","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1038\/oncsis.2015.18","article-title":"Metformin induces ER stress-dependent apoptosis through miR-708-5p\/NNAT pathway in prostate cancer","volume":"4","author":"Li","year":"2015","journal-title":"Oncogenesis"},{"key":"165","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1038\/onc.2016.440","article-title":"Inhibition of KPNA4 attenuates prostate cancer metastasis","volume":"36","author":"Li","year":"2017","journal-title":"Oncogene"},{"key":"166","doi-asserted-by":"crossref","first-page":"e68247","DOI":"10.1371\/journal.pone.0068247","article-title":"The Drosophila importin-alpha3 is required for nuclear import of notchand it displays synergistic effects with notch receptor on cell proliferation","volume":"8","author":"Mukherjee","year":"2013","journal-title":"PLoS One"},{"key":"167","doi-asserted-by":"publisher","first-page":"40247","DOI":"10.18632\/oncotarget.5377","article-title":"ERbeta regulation of NF-kB activation in prostate cancer is mediated by HIF-1","volume":"6","author":"Mercurio","year":"2015","journal-title":"Oncotarget"},{"key":"168","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s10875-012-9696-x","article-title":"Calcitriol decreases expression of importin alpha3 and attenuates RelA translocation in human bronchial smooth muscle cells","volume":"32","author":"Agrawal","year":"2012","journal-title":"J Clin Immunol"},{"key":"169","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.immuni.2014.06.010","article-title":"Tumor-associated macrophages: from mechanisms to therapy","volume":"41","author":"Pollard","year":"2014","journal-title":"Immunity"},{"key":"170","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1158\/1535-7163.MCT-14-0451","article-title":"Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer","volume":"13","author":"Gupta","year":"2014","journal-title":"Mol Cancer Ther"},{"key":"171","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.eururo.2014.04.027","article-title":"Metformin use and prostate cancer risk","volume":"66","author":"Sorensen","year":"2014","journal-title":"Eur Urol"},{"key":"172","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nrurol.2014.136","article-title":"Prostate cancer: metformin-the new wonder drug?","volume":"11","author":"Clyne","year":"2014","journal-title":"Nat Rev Urol"},{"key":"173","first-page":"57","article-title":"Metformin in cancer prevention and therapy","volume":"2","author":"Drzewoski","year":"2014","journal-title":"Ann Transl Med"},{"key":"174","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbrc.2005.12.007","article-title":"PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells","volume":"340","author":"Nomura","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"175","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1158\/0008-5472.CAN-11-0073","article-title":"MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells","volume":"71","author":"Dahiya","year":"2011","journal-title":"Cancer Res"},{"key":"176","doi-asserted-by":"publisher","first-page":"31832","DOI":"10.18632\/oncotarget.7149","article-title":"Inhibition of c-FLIPL expression by miRNA-708 increases the sensitivity of renal cancer cells to anti-cancer drugs","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"177","doi-asserted-by":"crossref","first-page":"6566","DOI":"10.1093\/nar\/gki965","article-title":"SIP1\/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions","volume":"33","author":"Berx","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"178","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/stem.1035","article-title":"Role of BMI1, a stem cell factor, in cancer recurrence and chemoresistance: preclinical and clinical evidences","volume":"30","author":"Saleem","year":"2012","journal-title":"Stem Cells"},{"key":"179","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1158\/1535-7163.MCT-05-0375","article-title":"Survivin, a cancer target with an emerging role in normal adult tissues","volume":"5","author":"Pelus","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"180","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.3390\/cancers3021639","article-title":"Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy","volume":"3","author":"Pollok","year":"2011","journal-title":"Cancers (Basel)"},{"issue":"suppl 6","key":"181","article-title":"Roles of c-FLIP in Apoptosis, Necroptosis, and Autophagy","author":"Safa","year":"2013","journal-title":"J Carcinog Mutagen"},{"key":"182","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Vandenabeele","year":"2015","journal-title":"Nature"},{"key":"183","unstructured":"American Cancer Society. Cancer facts & figures. Atlanta, GA: American Cancer Society. https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/cancer-facts-figures-2016.html."},{"key":"184","unstructured":"World Health Organization. The top 10 Causes of Death. 2014. http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en\/index4.html."},{"key":"185","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/jnci\/djq495","article-title":"Projections of the cost of cancer care in the United States: 2010-2020","volume":"103","author":"Brown","year":"2011","journal-title":"J Natl Cancer Inst"},{"key":"186","unstructured":"Howlader, Noone, Krapcho, Neyman, Aminou, Waldron, Altekruse, Kosary, Ruhl, Tatalovich, Cho, Mariotto, Eisner, et al. 2012 Lung Cancer Facts. Lung Cancer Alliance, 2012. http:\/\/www.lungcanceralliance.org\/assets\/docs\/media\/LCA%20Funding%20Fact%20Sheet%202012.pdf."},{"key":"187","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/tc.2007.022582","article-title":"Comparison of aspects of smoking among the four histological types of lung cancer","volume":"17","author":"Colditz","year":"2008","journal-title":"Tob Control"},{"key":"188","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/modpathol.2011.92","article-title":"Immunohistochemical algorithm for differentiation of lung adenocarcinoma and squamous cell carcinoma based on large series of whole-tissue sections with validation in small specimens","volume":"24","author":"Moreira","year":"2011","journal-title":"Mod Pathol"},{"key":"189","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1158\/0008-5472.CAN-09-3153","article-title":"Evaluation of microRNA expression profiles that may predict recurrence of localized stage I non-small cell lung cancer after surgical resection","volume":"70","author":"Yendamuri","year":"2010","journal-title":"Cancer Res"},{"key":"190","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/modpathol.2010.111","article-title":"Early detection of squamous cell lung cancer in sputum by a panel of microRNA markers","volume":"23","author":"Jiang","year":"2010","journal-title":"Mod Pathol"},{"key":"191","doi-asserted-by":"crossref","first-page":"e90524","DOI":"10.1371\/journal.pone.0090524","article-title":"MicroRNA-dependent regulation of transcription in non-small cell lung cancer","volume":"9","author":"Ferrer","year":"2014","journal-title":"PLoS One"},{"key":"192","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1158\/1078-0432.CCR-11-2857","article-title":"Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers","volume":"18","author":"Yang","year":"2012","journal-title":"Clin Cancer Res"},{"key":"193","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.18632\/oncotarget.6594","article-title":"MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer","volume":"7","author":"Luo","year":"2016","journal-title":"Oncotarget"},{"key":"194","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1242\/dev.094789","article-title":"Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development","volume":"140","author":"Murry","year":"2013","journal-title":"Development"},{"key":"195","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1158\/0008-5472.CAN-14-3828","article-title":"Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS","volume":"75","author":"Han","year":"2015","journal-title":"Cancer Res"},{"key":"196","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/35060032","article-title":"Cytoplasmic localization of p21Cip1\/WAF1 by Akt-induced phosphorylation in HER-2\/neu-overexpressing cells","volume":"3","author":"Hung","year":"2001","journal-title":"Nat Cell Biol"},{"key":"197","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1172\/JCI31405","article-title":"Immune surveillance of tumors","volume":"117","author":"Smyth","year":"2007","journal-title":"J Clin Invest"},{"key":"198","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ijc.23487","article-title":"Cancer risk in people infected with human immunodeficiency virus in the United States","volume":"123","author":"Goedert","year":"2008","journal-title":"Int J Cancer"},{"key":"199","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nri1995","article-title":"Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment","volume":"7","author":"Pardoll","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"200","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fonc.2016.00121","article-title":"MicroRNA Targeting to Modulate Tumor Microenvironment","volume":"6","author":"Prakash","year":"2016","journal-title":"Front Oncol"},{"key":"201","first-page":"3969","article-title":"microRNA Expression in Prospectively Collected Blood as a Potential Biomarker of Breast Cancer Risk in the BCFR","volume":"35","author":"Santella","year":"2015","journal-title":"Anticancer Res"},{"key":"202","doi-asserted-by":"crossref","first-page":"12823","DOI":"10.1074\/jbc.M114.565473","article-title":"A microRNA processing defect in smokers\u2019 macrophages is linked to SUMOylation of the endonuclease DICER","volume":"289","author":"Monick","year":"2014","journal-title":"J Biol Chem"},{"key":"203","doi-asserted-by":"crossref","first-page":"14273","DOI":"10.1038\/srep14273","article-title":"Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression","volume":"5","author":"Yang","year":"2015","journal-title":"Sci Rep"},{"key":"204","doi-asserted-by":"crossref","first-page":"16945","DOI":"10.3390\/ijms131216945","article-title":"Oxidative stress mediated-alterations of the microRNA expression profile in mouse hippocampal neurons","volume":"13","author":"Zhang","year":"2012","journal-title":"Int J Mol Sci"},{"key":"205","first-page":"17","article-title":"Neonatal Heart-Enriched miR-708 Promotes Differentiation of Cardiac Progenitor Cells in Rats","author":"Yu","year":"2016","journal-title":"Int J Mol Sci"},{"key":"206","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1182\/blood-2008-06-165985","article-title":"miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets","volume":"116","author":"Constantinescu","year":"2010","journal-title":"Blood"},{"key":"207","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1172\/JCI83361","article-title":"MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension","volume":"126","author":"Lawrie","year":"2016","journal-title":"J Clin Invest"},{"key":"208","doi-asserted-by":"crossref","first-page":"e0150842","DOI":"10.1371\/journal.pone.0150842","article-title":"MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells","volume":"11","author":"Kannan","year":"2016","journal-title":"PLoS One"},{"key":"209","doi-asserted-by":"crossref","first-page":"e678","DOI":"10.1038\/tp.2015.159","article-title":"Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder","volume":"5","author":"Schumacher","year":"2015","journal-title":"Transl Psychiatry"},{"key":"210","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/bdi.12448","article-title":"Genetic variation in the miR-708 gene and its binding targets in bipolar disorder","volume":"18","author":"McQuillin","year":"2016","journal-title":"Bipolar Disord"},{"key":"211","doi-asserted-by":"crossref","first-page":"e76051","DOI":"10.1371\/journal.pone.0076051","article-title":"Alterations in miRNA levels in the dentate gyrus in epileptic rats","volume":"8","author":"Lukasiuk","year":"2013","journal-title":"PLoS One"},{"key":"212","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1002\/emmm.201201974","article-title":"Alteration of the microRNA network during the progression of Alzheimer\u2019s disease","volume":"5","author":"Ayoubi","year":"2013","journal-title":"EMBO Mol Med"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.19772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T20:14:58Z","timestamp":1692908098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.19772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,1]]},"references-count":212,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2017,9,19]]}},"alternative-id":["19772","29050362"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.19772","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,1]]}}}