{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:15:26Z","timestamp":1790284526992,"version":"4.1.0"},"reference-count":34,"publisher":"Impact Journals, LLC","issue":"48","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,10,13]]},"DOI":"10.18632\/oncotarget.20150","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T10:37:41Z","timestamp":1502447861000},"page":"83975-83985","source":"Crossref","is-referenced-by-count":26,"title":["DNA mismatch repair protein Mlh1 is required for tetravalent chromium intermediate-induced DNA damage"],"prefix":"10.18632","volume":"8","author":[{"given":"Timothy P.","family":"Wakeman","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, LA, USA"},{"name":"Department of Genetics, LSU Health Sciences Center, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, First Affiliated Hospital, Xi\u2019an Jiaotong University, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh S.","family":"Dalal","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Boohaker","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Southern Research Institute, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Oncology, The Southern Research Institute, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, LA, USA"},{"name":"Department of Genetics, LSU Health Sciences Center, New Orleans, LA, USA"},{"name":"Department of Oncology, The Southern Research Institute, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"issue":"533","key":"1","first-page":"3","article-title":"Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms","volume":"2003","author":"Patierno","journal-title":"Mutat Res"},{"issue":"28","key":"2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1080\/10590501.2010.504980","article-title":"Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis","volume":"2010","author":"Donehower","journal-title":"J Environ Sci C Environ Carcinog Ecotoxicol Rev"},{"issue":"188","key":"3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.cbi.2010.04.018","article-title":"Chromium genotoxicity: a double-edged sword","volume":"2010","author":"Ceryak","journal-title":"Chem Biol Interact"},{"issue":"69","key":"4","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1158\/0008-5472.CAN-08-2306","article-title":"Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers","volume":"2009","author":"Zhitkovich","journal-title":"Cancer Res"},{"issue":"554","key":"5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.mrfmmm.2004.05.006","article-title":"The ATM-SMC1 pathway is essential for activation of the chromium[VI]-induced S-phase checkpoint","volume":"2004","author":"Xu","journal-title":"Mut Res"},{"issue":"14","key":"6","first-page":"429","article-title":"Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake","volume":"1993","author":"Patierno","journal-title":"Carcinogenesis"},{"issue":"19","key":"7","first-page":"215","article-title":"The role of chromium(V) in the mechanism of chromate-induced oxidative DNA damage and cancer","volume":"2000","author":"Stearns","journal-title":"J Environ Pathol Toxicol Oncol"},{"issue":"27","key":"8","first-page":"2219","article-title":"Oxidative damage of DNA by chromium(V) complexes: relative importance of base versus sugar oxidation","volume":"1999","author":"Stroup","journal-title":"Nucleic Acids Res"},{"issue":"255","key":"9","first-page":"113","article-title":"Crystalline and water soluble Cr(4+) and Cr(5+) model compounds for chromium toxicity studies","volume":"2004","author":"Dalal","journal-title":"Mol Cell Biochem"},{"issue":"278","key":"10","doi-asserted-by":"publisher","first-page":"17885","DOI":"10.1074\/jbc.M210560200","article-title":"Chromium (VI) activates ataxia telangiectasia mutated (ATM) protein. Requirement of ATM for both apoptosis and recovery from terminal growth arrest","volume":"2003","author":"Patierno","journal-title":"J Biol Chem"},{"issue":"37","key":"11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4103\/2319-4170.125655","article-title":"The versatile functions of ATM kinase","volume":"2014","author":"Xu","journal-title":"Biomed J"},{"issue":"421","key":"12","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"2003","author":"Kastan","journal-title":"Nature"},{"issue":"416","key":"13","first-page":"159","article-title":"Chromium can reduce the mutagenic effects of benzo[a]pyrene diolepoxide in normal human fibroblasts via an oxidative stress mechanism","volume":"1998","author":"Reinhold","journal-title":"Mutat Res"},{"issue":"39","key":"14","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1002\/gcc.20005","article-title":"Distinct mechanisms lead to HPRT gene mutations in leukemic cells","volume":"2004","author":"Aplan","journal-title":"Genes Chromosomes Cancer"},{"issue":"155","key":"15","first-page":"832","article-title":"Determination of 8-oxoguanine in individual cell nucleus of gamma-irradiated mammalian cells","volume":"2001","author":"Chang","journal-title":"Radiat Res"},{"issue":"4","key":"16","first-page":"439","article-title":"MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae","volume":"1999","author":"Kolodner","journal-title":"Mol Cell"},{"issue":"16","key":"17","first-page":"467","article-title":"Induction of DNA-strand breaks in human peripheral blood lymphocytes and A549 lung cells by sodium dichromate: association with 8-oxo-2-deoxyguanosine formation and inter-individual variability","volume":"2001","author":"Chipman","journal-title":"Mutagenesis"},{"issue":"14","key":"18","first-page":"1315","article-title":"Direct oxidation of guanine and 7,8-dihydro-8-oxoguanine in DNA by a high-valent chromium complex: a possible mechanism for chromate genotoxicity","volume":"2001","author":"Martin","journal-title":"Chem Res Toxicol"},{"issue":"16","key":"19","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1091\/mbc.E04-02-0089","article-title":"Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2","volume":"2005","author":"Brown","journal-title":"Mol Biol Cell"},{"issue":"54","key":"20","first-page":"4308","article-title":"Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N\u2019-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation","volume":"1994","author":"Boland","journal-title":"Cancer Res"},{"issue":"266","key":"21","first-page":"1959","article-title":"Mismatch repair, genetic stability, and cancer","volume":"1994","author":"Modrich","journal-title":"Science"},{"issue":"7","key":"22","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1016\/j.dnarep.2008.05.007","article-title":"Chromium-mediated apoptosis: involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes","volume":"2008","author":"Lee","journal-title":"DNA Repair (Amst)"},{"issue":"7","key":"23","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.dnarep.2007.10.001","article-title":"Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-\/- HCT116 colon cancer cells","volume":"2008","author":"Lee","journal-title":"DNA Repair (Amst)"},{"issue":"2","key":"24","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s40572-015-0054-z","article-title":"Oral chromium exposure and toxicity","volume":"2015","author":"Costa","journal-title":"Curr Environ Health Rep"},{"issue":"23","key":"25","first-page":"213","article-title":"Induction of arthritis in mice and rats by potassium peroxochromate and assessment of disease activity by whole blood chemiluminescence and 99mpertechnetate-imaging","volume":"1995","author":"Weser","journal-title":"Free Radic Res"},{"issue":"160","key":"26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"2006","author":"Mazur","journal-title":"Chem Biol Interact"},{"key":"27","first-page":"231","article-title":"Generation of hydroxyl radical by chromate in biologically relevant systems: role of Cr(V) complexes versus tetraperoxochromate(V)","volume":"102","author":"Dalal","year":"1994","journal-title":"Environ Health Perspect"},{"issue":"198","key":"28","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.toxlet.2010.06.024","article-title":"Hexavalent chromium induced ROS formation, Akt, NF-kappaB, and MAPK activation, and TNF-alpha and IL-1alpha production in keratinocytes","volume":"2010","author":"Wang","journal-title":"Toxicol Lett"},{"issue":"52","key":"29","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1016\/j.freeradbiomed.2012.03.013","article-title":"The effects of chromium(VI) on the thioredoxin system: implications for redox regulation","volume":"2012","author":"Myers","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"30","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/cancers2020376","article-title":"The role of oxidative stress in carcinogenesis induced by metals and xenobiotics","volume":"2010","author":"Luch","journal-title":"Cancers (Basel)"},{"issue":"25","key":"31","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1128\/MCB.25.9.3596-3607.2005","article-title":"Mismatch repair proteins are activators of toxic responses to chromium-DNA damage","volume":"2005","author":"Zhitkovich","journal-title":"Mol Cell Biol"},{"issue":"261","key":"32","first-page":"12462","article-title":"Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N\u2019-nitro-N-nitrosoguanidine","volume":"1986","author":"Thilly","journal-title":"J Biol Chem"},{"issue":"90","key":"33","first-page":"6424","article-title":"An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair","volume":"1993","author":"Modrich","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"279","key":"34","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11010-005-8216-1","article-title":"Involvement of the p38 MAP kinase in Cr(VI)-induced growth arrest and apoptosis","volume":"2005","author":"Xu","journal-title":"Mol Cell Biochem"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.20150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T16:46:28Z","timestamp":1594831588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.20150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,10]]},"references-count":34,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2017,10,13]]}},"alternative-id":["20150","29137397"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.20150","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,10]]}}}