{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:47:52Z","timestamp":1790477272722,"version":"4.1.0"},"reference-count":49,"publisher":"Impact Journals, LLC","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,9,26]]},"DOI":"10.18632\/oncotarget.20366","type":"journal-article","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T11:58:58Z","timestamp":1503143938000},"page":"74767-74780","source":"Crossref","is-referenced-by-count":19,"title":["Phosphorylation and degradation of \u03b1B-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis"],"prefix":"10.18632","volume":"8","author":[{"given":"Gabriel","family":"Fung","sequence":"first","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Wong","sequence":"additional","affiliation":[{"name":"Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, School of Medicine, University of California San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feaven","family":"Berhe","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir","family":"Mohamud","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Chao","family":"Xue","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Luo","sequence":"additional","affiliation":[{"name":"Centre for Heart Lung Innovation, St. Paul\u2019s Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,8,19]]},"reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"Fung, Luo, Qiu, Yang, McManus. Myocarditis. Circ Res. 2016; 118:496\u2013514.","DOI":"10.1161\/CIRCRESAHA.115.306573"},{"key":"2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/cvr\/cvp225","article-title":"Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy","volume":"85","author":"Wong","year":"2010","journal-title":"Cardiovasc Res"},{"key":"3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2008.03.025","article-title":"Protein quality control and degradation in cardiomyocytes","volume":"45","author":"Ranek","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"4","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1161\/CIRCRESAHA.116.305372","article-title":"Proteotoxicity and cardiac dysfunction","volume":"116","author":"Robbins","year":"2015","journal-title":"Circ Res"},{"key":"5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1106180","article-title":"Proteotoxicity and cardiac dysfunction\u2014Alzheimer's disease of the heart?","volume":"368","author":"Patterson","year":"2013","journal-title":"N Engl J Med"},{"key":"6","first-page":"439","article-title":"Build it up-tear it down: protein quality control in the cardiac sarcomere","volume":"81","author":"Patterson","year":"2009","journal-title":"Cardiovasc Res"},{"key":"7","doi-asserted-by":"crossref","first-page":"11056","DOI":"10.1128\/JVI.00008-10","article-title":"Proteasome activator REGgamma enhances coxsackieviral infection by facilitating p53 degradation","volume":"84","author":"Luo","year":"2010","journal-title":"J Virol"},{"key":"8","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1038\/cdd.2014.58","article-title":"Dominant-negative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection","volume":"21","author":"Luo","year":"2014","journal-title":"Cell Death Differ"},{"key":"9","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.4161\/auto.26059","article-title":"Cleavage of sequestosome 1\/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling","volume":"9","author":"Luo","year":"2013","journal-title":"Autophagy"},{"key":"10","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/cr.2011.114","article-title":"Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function","volume":"22","author":"Luo","year":"2012","journal-title":"Cell Res"},{"key":"11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/01.RES.83.2.117","article-title":"Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease","volume":"83","author":"McMillan","year":"1998","journal-title":"Circ Res"},{"key":"12","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1161\/01.CIR.96.10.3466","article-title":"Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart","volume":"96","author":"Benndorf","year":"1997","journal-title":"Circulation"},{"key":"13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1161\/01.RES.71.2.288","article-title":"Alpha B-crystallin in cardiac tissue. Association with actin and desmin filaments","volume":"71","author":"Chiesi","year":"1992","journal-title":"Circ Res"},{"key":"14","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1161\/01.RES.0000102401.77712.ED","article-title":"AlphaB-crystallin modulates protein aggregation of abnormal desmin","volume":"93","author":"Robbins","year":"2003","journal-title":"Circ Res"},{"key":"15","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1161\/01.CIR.96.12.4343","article-title":"Small heat shock proteins and protection against ischemic injury in cardiac myocytes","volume":"96","author":"Dillmann","year":"1997","journal-title":"Circulation"},{"key":"16","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1096\/fj.00-0199com","article-title":"Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion","volume":"15","author":"Das","year":"2001","journal-title":"FASEB J"},{"key":"17","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/CIRCRESAHA.108.180117","article-title":"Alpha B-crystallin suppresses pressure overload cardiac hypertrophy","volume":"103","author":"Wang","year":"2008","journal-title":"Circ Res"},{"key":"18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.yjmcc.2006.03.003","article-title":"CRYAB and HSPB2 deficiency increases myocyte mitochondrial permeability transition and mitochondrial calcium uptake","volume":"40","author":"Benjamin","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"19","doi-asserted-by":"crossref","first-page":"H847","DOI":"10.1152\/ajpheart.00715.2003","article-title":"Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model","volume":"286","author":"Glembotski","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/1765","article-title":"A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy","volume":"20","author":"Fardeau","year":"1998","journal-title":"Nat Genet"},{"key":"21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/hh1301.092688","article-title":"Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice","volume":"89","author":"Robbins","year":"2001","journal-title":"Circ Res"},{"key":"22","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1161\/CIRCULATIONAHA.105.572552","article-title":"Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy","volume":"112","author":"Robbins","year":"2005","journal-title":"Circulation"},{"key":"23","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.108.193516","article-title":"Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy","volume":"104","author":"Robbins","year":"2009","journal-title":"Circ Res"},{"key":"24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2007.06.044","article-title":"Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice","volume":"130","author":"Benjamin","year":"2007","journal-title":"Cell"},{"key":"25","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1161\/CIRCULATIONAHA.107.750232","article-title":"Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure","volume":"117","author":"Robbins","year":"2008","journal-title":"Circulation"},{"key":"26","doi-asserted-by":"crossref","first-page":"10132","DOI":"10.1073\/pnas.0401900101","article-title":"Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis","volume":"101","author":"Robbins","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"27","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1242\/jcs.110.21.2759","article-title":"AlphaB-crystallin interacts with intermediate filaments in response to stress","volume":"110","author":"Portier","year":"1997","journal-title":"J Cell Sci"},{"key":"28","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1111\/j.1349-7006.2009.01316.x","article-title":"alphaB-crystallin: a novel p53-target gene required for p53-dependent apoptosis","volume":"100","author":"Ishioka","year":"2009","journal-title":"Cancer Sci"},{"key":"29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.77.1.1-9.2003","article-title":"Ubiquitin-dependent proteolysis of cyclin D1 is associated with coxsackievirus-induced cell growth arrest","volume":"77","author":"McManus","year":"2003","journal-title":"J Virol"},{"key":"30","doi-asserted-by":"crossref","first-page":"29934","DOI":"10.1074\/jbc.272.47.29934","article-title":"Phosphorylation of alphaB-crystallin in response to various types of stress","volume":"272","author":"Kato","year":"1997","journal-title":"J Biol Chem"},{"key":"31","doi-asserted-by":"crossref","first-page":"28346","DOI":"10.1074\/jbc.273.43.28346","article-title":"Phosphorylation of alphaB-crystallin in mitotic cells and identification of enzymatic activities responsible for phosphorylation","volume":"273","author":"Saga","year":"1998","journal-title":"J Biol Chem"},{"key":"32","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Ben-Neriah","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"33","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1161\/01.CIR.96.12.4146","article-title":"A genome-based resource for molecular cardiovascular medicine: toward a compendium of cardiovascular genes","volume":"96","author":"Tsui","year":"1997","journal-title":"Circulation"},{"key":"34","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0735-1097(98)00026-6","article-title":"Restrictive cardiomyopathy, atrioventricular block and mild to subclinical myopathy in patients with desmin-immunoreactive material deposits","volume":"31","author":"Ferrans","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"35","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1161\/01.CIR.102.25.3046","article-title":"Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays","volume":"102","author":"Bond","year":"2000","journal-title":"Circulation"},{"key":"36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1006\/jmcc.2001.1513","article-title":"Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin","volume":"34","author":"Drenckhahn","year":"2002","journal-title":"J Mol Cell Cardiol"},{"key":"37","first-page":"H1457","article-title":"Ischemia-induced phosphorylation and translocation of stress protein alpha B-crystallin to Z lines of myocardium","volume":"274","author":"Drenckhahn","year":"1998","journal-title":"Am J Physiol"},{"key":"38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.RES.0000052989.83995.A5","article-title":"Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis","volume":"92","author":"Glembotski","year":"2003","journal-title":"Circ Res"},{"key":"39","doi-asserted-by":"crossref","first-page":"H1633","DOI":"10.1152\/ajpheart.01227.2008","article-title":"Kinetics of the translocation and phosphorylation of alphaB-crystallin in mouse heart mitochondria duringischemia","volume":"296","author":"Glembotski","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"40","doi-asserted-by":"crossref","first-page":"28675","DOI":"10.1074\/jbc.M403348200","article-title":"Phosphorylation of alphaB-crystallin alters chaperone function through loss of dimeric substructure","volume":"279","author":"Robinson","year":"2004","journal-title":"J Biol Chem"},{"key":"41","doi-asserted-by":"crossref","first-page":"16059","DOI":"10.1074\/jbc.C100107200","article-title":"The small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation","volume":"276","author":"Cryns","year":"2001","journal-title":"J Biol Chem"},{"key":"42","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.jtcvs.2007.06.026","article-title":"Phosphorylation and translocation of heat shock protein 27 and alphaB-crystallin in human myocardium after cardioplegia and cardiopulmonary bypass","volume":"134","author":"Sellke","year":"2007","journal-title":"J Thorac Cardiovasc Surg"},{"key":"43","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/nm737","article-title":"Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral heart disease","volume":"8","author":"Knowlton","year":"2002","journal-title":"Nat Med"},{"key":"44","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1167\/iovs.12-11571","article-title":"Antiapoptotic properties of alpha-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells","volume":"54","author":"Hinton","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"45","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1161\/01.CIR.0000165128.39715.87","article-title":"Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure","volume":"111","author":"Yan","year":"2005","journal-title":"Circulation"},{"key":"46","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/cdd.2015.58","article-title":"Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis","volume":"22","author":"Luo","year":"2015","journal-title":"Cell Death Differ"},{"key":"47","doi-asserted-by":"crossref","first-page":"e79546","DOI":"10.1371\/journal.pone.0079546","article-title":"Production of a dominant-negative fragment due to G3BP1 cleavage contributes to the disruption of mitochondria-associated protective stress granules during CVB3 infection","volume":"8","author":"Luo","year":"2013","journal-title":"PLoS One"},{"key":"48","doi-asserted-by":"crossref","first-page":"H401","DOI":"10.1152\/ajpheart.00292.2008","article-title":"Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice","volume":"295","author":"Luo","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"49","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/cmi.12473","article-title":"Dysferlin deficiency confers increased susceptibility to coxsackievirus-induced cardiomyopathy","volume":"17","author":"Luo","year":"2015","journal-title":"Cell Microbiol"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.20366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T13:47:43Z","timestamp":1659361663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.20366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,19]]},"references-count":49,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2017,9,26]]}},"alternative-id":["20366","29088822"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.20366","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,19]]}}}