{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:25:34Z","timestamp":1783113934122,"version":"3.54.6"},"reference-count":28,"publisher":"Impact Journals, LLC","issue":"62","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,12,1]]},"DOI":"10.18632\/oncotarget.20756","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T20:59:13Z","timestamp":1504904353000},"page":"104981-104991","source":"Crossref","is-referenced-by-count":6,"title":["Parity improves anti-tumor immunity in breast cancer patients"],"prefix":"10.18632","volume":"8","author":[{"given":"Anna-Lena","family":"Krause","sequence":"first","affiliation":[{"name":"Translational Immunology Division, German Cancer Research Center (DKFZ), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schuetz","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Boudewijns","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pritsch","sequence":"additional","affiliation":[{"name":"Translational Immunology Division, German Cancer Research Center (DKFZ), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Golatta","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Rom","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Heil","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Sohn","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schneeweiss","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Beckhove","sequence":"additional","affiliation":[{"name":"Translational Immunology Division, German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"Regensburg Center for Interventional Immunology (RCI) and University Medical Center of Regensburg, Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Domschke","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Heidelberg University Hospital, National Center for Tumor Diseases (NCT), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,9,8]]},"reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/jnci\/djs505","article-title":"Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop","volume":"105","author":"Sherman","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nrc3670","article-title":"Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy","volume":"14","author":"Boon","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/86523","article-title":"Therapy of human tumors in NOD\/SCID mice with patient-derived reactivated memory T cells from bone marrow","volume":"7","author":"Umansky","year":"2001","journal-title":"Nat Med"},{"key":"4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13058-015-0541-z","article-title":"Presence of circulating Her2-reactive CD8+ T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients","volume":"17","author":"Pawelec","year":"2015","journal-title":"Breast Cancer Res"},{"key":"5","doi-asserted-by":"crossref","first-page":"8420","DOI":"10.1158\/0008-5472.CAN-09-1627","article-title":"Intratumoral cytokines and tumor cell biology determine spontaneous breast cancer-specific immune responses and their correlation to prognosis","volume":"69","author":"Sohn","year":"2009","journal-title":"Cancer Res"},{"key":"6","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1200\/JCO.2010.30.5037","article-title":"Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer","volume":"29","author":"Green","year":"2011","journal-title":"J Clin Oncol"},{"key":"7","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1200\/JCO.2006.05.9584","article-title":"Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse","volume":"24","author":"Banham","year":"2006","journal-title":"J Clin Oncol"},{"key":"8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00262-011-1106-3","article-title":"Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome","volume":"61","author":"Schuetz","year":"2012","journal-title":"Cancer Immunol Immunother"},{"key":"9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00262-004-0560-6","article-title":"A listing of human tumor antigens recognized by T cells: March 2004 update","volume":"54","author":"Parmiani","year":"2005","journal-title":"Cancer Immunol Immunother"},{"key":"10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/jcp.2011.089433","article-title":"Epidermal growth factor receptor status in early stage breast cancer is associated with cellular proliferation but not cross-talk","volume":"64","author":"Shousha","year":"2011","journal-title":"J Clin Pathol"},{"key":"11","doi-asserted-by":"crossref","first-page":"7716","DOI":"10.1158\/0008-5472.CAN-05-2363","article-title":"Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes","volume":"66","author":"Vlodavsky","year":"2006","journal-title":"Cancer Res"},{"key":"12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.18632\/oncoscience.4","article-title":"Expression of Cancer\/Testis genes in ductal carcinoma in situ and benign lesions of the breast","volume":"1","author":"Neville","year":"2014","journal-title":"Oncoscience"},{"key":"13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/ijc.2910280105","article-title":"Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers","volume":"28","author":"Millis","year":"1981","journal-title":"Int J Cancer"},{"key":"14","first-page":"15","article-title":"Expression of cancer-testis (CT) antigens in placenta","volume":"7","author":"Vogel","year":"2007","journal-title":"Cancer Immun"},{"key":"15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-065X.1995.tb00077.x","article-title":"MUC-1 epithelial tumor mucin-based immunity and cancer vaccines","volume":"145","author":"Barratt-Boyes","year":"1995","journal-title":"Immunol Rev"},{"key":"16","first-page":"2257","article-title":"Does pregnancy immunize against breast cancer?","volume":"55","author":"Longenecker","year":"1995","journal-title":"Cancer Res"},{"key":"17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri3361","article-title":"Mechanisms of T cell tolerance towards the allogeneic fetus","volume":"13","author":"Erlebacher","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1159\/000226973","article-title":"Pregnancy-induced cytotoxicity of splenocytes against mammary tumor cells in rats","volume":"48","author":"Sinha","year":"1991","journal-title":"Oncology"},{"key":"19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF01744946","article-title":"Inhibition of mammary tumorigenesis in virgin rats by adoptive transfer of splenocytes from parous donors","volume":"33","author":"Sinha","year":"1991","journal-title":"Cancer Immunol Immunother"},{"key":"20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-1-4614-2251-8_11","article-title":"Cellular immunity in breast milk: implications for postnatal transmission of HIV-1 to the infant","volume":"743","author":"Kourtis","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"21","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1002\/ijc.29181","article-title":"Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression","volume":"136","author":"Schedin","year":"2015","journal-title":"Int J Cancer"},{"key":"22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1080\/02841860701233443","article-title":"Intratumoral FOXP3 expression in infiltrating breast carcinoma: its association with clinicopathologic parameters and angiogenesis","volume":"46","author":"Arora","year":"2007","journal-title":"Acta Oncol"},{"key":"23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.anndiagpath.2010.07.010","article-title":"Inhibitor of differentiation is overexpressed with progression of benign to malignant lesions and related with carcinoembryonic antigen-related cell adhesion molecule 1 distribution in mammary glands","volume":"15","author":"Zhou","year":"2011","journal-title":"Ann Diagn Pathol"},{"key":"24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1349-7006.2010.01779.x","article-title":"Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer","volume":"102","author":"Katano","year":"2011","journal-title":"Cancer Sci"},{"key":"25","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1242\/dev.02797","article-title":"Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia","volume":"134","author":"Lewis","year":"2007","journal-title":"Development"},{"key":"26","first-page":"3311","article-title":"Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma","volume":"119","author":"Aigner","year":"2009","journal-title":"J Clin Invest"},{"key":"27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s13277-010-0098-5","article-title":"Identification of HLA-A0201-restricted cytotoxic T lymphocyte epitope from proliferating cell nuclear antigen","volume":"32","author":"Zheng","year":"2011","journal-title":"Tumour Biol"},{"key":"28","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1158\/0008-5472.CAN-14-2717","article-title":"Breast cancer prevention: lessons to be learned from mechanisms of early pregnancy-mediated breast cancer protection","volume":"75","author":"Rochlitz","year":"2015","journal-title":"Cancer Res"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.20756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T14:35:06Z","timestamp":1589207706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.20756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,8]]},"references-count":28,"journal-issue":{"issue":"62","published-print":{"date-parts":[[2017,12,1]]}},"alternative-id":["20756","29285226"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.20756","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,8]]}}}