{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:17:00Z","timestamp":1790223420202,"version":"4.1.0"},"reference-count":63,"publisher":"Impact Journals, LLC","issue":"54","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncotarget"],"published-print":{"date-parts":[[2017,11,3]]},"DOI":"10.18632\/oncotarget.21006","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T22:13:29Z","timestamp":1505772809000},"page":"92183-92194","source":"Crossref","is-referenced-by-count":9,"title":["Profile of differentially expressed Toll-like receptor signaling genes in the natural killer cells of patients with S\u00e9zary syndrome"],"prefix":"10.18632","volume":"8","author":[{"given":"Kelly C.G.","family":"Manfrere","sequence":"first","affiliation":[{"name":"Laboratory of Medical Investigation, LIM-56, Department of Dermatology, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina P.","family":"Torrealba","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation, LIM-56, Department of Dermatology, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis R.","family":"Miyashiro","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic, Hospital das Cl\u00ednicas, Department of Dermatology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e1talli Z.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation, LIM-56, Department of Dermatology, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio S.Y.","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation, LIM-56, Department of Dermatology, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"de M. Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation, LIM-56, Department of Dermatology, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Cury-Martins","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic, Hospital das Cl\u00ednicas, Department of Dermatology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto J.S.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation, LIM-56, Department of Dermatology, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Cutaneous Lymphoma Clinic, Hospital das Cl\u00ednicas, Department of Dermatology, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria N.","family":"Sato","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Investigation, LIM-56, Department of Dermatology, Tropical Medicine Institute of S\u00e3o Paulo, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7892","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"1","first-page":"486","article-title":"The immunopathogenesis of cutaneous T-cell lymphoma. Abnormal cytokine production by Sezary T cells","volume":"12","author":"Lessin","year":"1993","journal-title":"Arch Dermatol"},{"key":"2","first-page":"90","article-title":"Aberrant cytokine production by Sezary syndrome patients: cytokine secretion pattern resembles murine Th2 cells","volume":"9","author":"Rook","year":"1992","journal-title":"J Invest Dermatol"},{"key":"3","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1172\/JCI24826","article-title":"Immunopathogenesis and therapy of cutaneous T cell lymphoma","volume":"11","author":"Rook","year":"2005","journal-title":"J Clin Invest"},{"key":"4","first-page":"633","article-title":"The biology of human natural killer-cell subsets","volume":"2","author":"Caligiuri","year":"2001","journal-title":"Trends Immunol"},{"key":"5","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1182\/blood-2010-09-303057","article-title":"Dissecting CD56dim human NK cells","volume":"11","author":"Moretta","year":"2010","journal-title":"Blood"},{"key":"6","first-page":"1545","article-title":"Most CD8+ cells in skin lesions of CD3+ CD4+ mycosis fungoides are CD3+ T cells that lack CD11b, CD16, CD56, CD57, and human Hanukah factor mRNA","volume":"13","author":"Warnke","year":"1991","journal-title":"Am J Pathol"},{"key":"7","first-page":"1273","article-title":"Circulating natural killer lymphocytes are potential cytotoxic effectors against autologous malignant cells in sezary syndrome patients","volume":"12","author":"Bensussan","year":"2005","journal-title":"J Invest Dermatol"},{"key":"8","first-page":"2467","article-title":"Sezary syndrome. I. Specific skin-directed migration of peripheral blood lymphocytes","volume":"13","author":"Bach","year":"1983","journal-title":"J Immunol"},{"key":"9","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1067\/mjd.2001.116345","article-title":"Complete molecular remission during biologic response modifier therapy for Sezary syndrome is associated with enhanced helper T type 1 cytokine production and natural killer cell activity","volume":"4","author":"Rook","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10","first-page":"306","article-title":"Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?","volume":"1","author":"Paul","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"11","first-page":"1379","article-title":"Cultivation of adult tissues and organs outside of the body","volume":"5","author":"T Burrows","year":"1910","journal-title":"J Am Med Assoc"},{"key":"12","first-page":"734","article-title":"Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation","volume":"41","author":"Spies","year":"2002","journal-title":"Nature"},{"key":"13","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1038\/onc.2012.295","article-title":"Leukemia cell to endothelial cell communication via exosomal miRNAs","volume":"3","author":"Ohyashiki","year":"2013","journal-title":"Oncogene"},{"key":"14","doi-asserted-by":"publisher","first-page":"5305","DOI":"10.1172\/jci77440","article-title":"IL-12-producing monocytes and HLA-E control HCMV-driven NKG2C+ NK cell expansion","volume":"12","author":"Cerwenka","year":"2014","journal-title":"J Clin Invest"},{"key":"15","doi-asserted-by":"publisher","first-page":"4657","DOI":"10.4049\/jimmunol.1403080","article-title":"Impaired NK cell responses to pertussis and H1N1 influenza vaccine antigens in human cytomegalovirus-infected individuals","volume":"19","author":"Riley","year":"2015","journal-title":"J Immunol"},{"key":"16","doi-asserted-by":"publisher","first-page":"3865","DOI":"10.1182\/blood-2010-04-282301","article-title":"CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset","volume":"11","author":"Lanier","year":"2010","journal-title":"Blood"},{"key":"17","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/s00262-016-1803-z","article-title":"CD57 in human natural killer cells and T-lymphocytes","volume":"6","author":"Larbi","year":"2016","journal-title":"Cancer Immunol Immunother"},{"key":"18","doi-asserted-by":"publisher","first-page":"25700","DOI":"10.18632\/oncotarget.14878","article-title":"Emerging role of exosome-mediated intercellular communication in vascular remodeling","volume":"8","author":"Xiang","year":"2017","journal-title":"Oncotarget"},{"key":"19","first-page":"3528","article-title":"Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine","volume":"5","author":"Bryan","year":"1992","journal-title":"Cancer Res"},{"key":"20","doi-asserted-by":"publisher","first-page":"Cd003412","DOI":"10.1002\/14651858.CD003412.pub2","article-title":"Interventions for basal cell carcinoma of the skin","author":"Williams","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"21","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1111\/j.1365-2133.2005.06486.x","article-title":"Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from a randomized vehicle-controlled phase III study in Europe","volume":"15","author":"McRae","year":"2005","journal-title":"Br J Dermatol"},{"key":"22","first-page":"80","article-title":"Topical treatment with imiquimod may induce regression of facial keratoacanthoma","volume":"1","author":"Prinz","year":"2003","journal-title":"Eur J Dermatol"},{"key":"23","first-page":"413","article-title":"Successful treatment of keratoacanthoma and actinic keratoses with imiquimod 5% cream","volume":"1","author":"Fargnoli","year":"2003","journal-title":"Eur J Dermatol"},{"key":"24","first-page":"1050","article-title":"Successful treatment of actinic keratosis with imiquimod cream 5%: a report of six cases","volume":"14","author":"Christophers","year":"2001","journal-title":"Br J Dermatol"},{"key":"25","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.jaad.2003.12.010","article-title":"Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials","volume":"5","author":"Fox","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"26","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1001\/archderm.141.4.467","article-title":"Dosing with 5% imiquimod cream 3 times per week for the treatment of actinic keratosis: results of two phase 3, randomized, double-blind, parallel-group, vehicle-controlled trials","volume":"14","author":"Lee","year":"2005","journal-title":"Arch Dermatol"},{"key":"27","first-page":"555","article-title":"Topical imiquimod treatment of a cutaneous melanoma metastasis","volume":"4","author":"von den Driesch","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"28","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1365-2133.2005.06307.x","article-title":"Treatment of cutaneous metastatic melanoma with imiquimod 5% cream and the pulsed-dye laser","volume":"15","author":"Cheney","year":"2005","journal-title":"Br J Dermatol"},{"key":"29","doi-asserted-by":"publisher","first-page":"1970","DOI":"10.3109\/10428194.2011.582202","article-title":"Synergistic enhancement of cellular immune responses by the novel Toll receptor 7\/8 agonist 3M-007 and interferon-gamma: implications for therapy of cutaneous T-cell lymphoma","volume":"5","author":"Rook","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"30","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1586\/14760584.2013.811208","article-title":"The use of Toll-like receptor 7\/8 agonists as vaccine adjuvants","volume":"1","author":"Tomai","year":"2013","journal-title":"Expert Rev Vaccines"},{"key":"31","first-page":"1137","article-title":"Treatment of stage IA cutaneous T-Cell lymphoma with topical application of the immune response modifier imiquimod","volume":"13","author":"Rook","year":"2002","journal-title":"Arch Dermatol"},{"key":"32","doi-asserted-by":"publisher","first-page":"6646","DOI":"10.1073\/pnas.0631696100","article-title":"Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7","volume":"10","author":"Cottam","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"33","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/sj.onc.1210913","article-title":"TLR7 and TLR8 as targets in cancer therapy","volume":"2","author":"Schon","year":"2008","journal-title":"Oncogene"},{"key":"34","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1586\/14760584.6.5.835","article-title":"Resiquimod and other immune response modifiers as vaccine adjuvants","volume":"6","author":"Vasilakos","year":"2007","journal-title":"Expert Rev Vaccines"},{"key":"35","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1006\/cyto.1997.0239","article-title":"Induction of cytokines in cynomolgus monkeys by the immune response modifiers, imiquimod, S-27609 and S-28463","volume":"9","author":"Tomai","year":"1997","journal-title":"Cytokine"},{"key":"36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1006\/clim.1999.4804","article-title":"The imidazoquinolines, imiquimod and R-848, induce functional, but not phenotypic, maturation of human epidermal Langerhans\u2019 cells","volume":"9","author":"Gaspari","year":"2000","journal-title":"Clin Immunol"},{"key":"37","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1182\/blood-2015-02-630335","article-title":"Topical resiquimod can induce disease regression and enhance T-cell effector functions in cutaneous T-cell lymphoma","volume":"12","author":"Clark","year":"2015","journal-title":"Blood"},{"key":"38","doi-asserted-by":"publisher","first-page":"4142","DOI":"10.1182\/blood-2004-03-1190","article-title":"Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15","volume":"10","author":"Rook","year":"2004","journal-title":"Blood"},{"key":"39","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/cyto.b.20395","article-title":"CD158k\/KIR3DL2 is a useful marker for identifying neoplastic T-cells in Sezary syndrome by flow cytometry","volume":"7","author":"Vonderheid","year":"2008","journal-title":"Cytometry B Clin Cytom"},{"key":"40","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/jid.2014.286","article-title":"KIR3DL2\/CpG ODN interaction mediates Sezary syndrome malignant T cell apoptosis","volume":"13","author":"Marie-Cardine","year":"2015","journal-title":"J Invest Dermatol"},{"key":"41","doi-asserted-by":"publisher","first-page":"74592","DOI":"10.18632\/oncotarget.12816","article-title":"Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sezary syndrome","volume":"7","author":"Sato","year":"2016","journal-title":"Oncotarget"},{"key":"42","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nri.2015.9","article-title":"Natural killer cell memory in infection, inflammation and cancer","volume":"1","author":"Lanier","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"43","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jaci.2013.07.020","article-title":"Natural killer cell deficiency","volume":"13","author":"Orange","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"44","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00262-015-1720-6","article-title":"Natural killer cell immunosenescence in acute myeloid leukaemia patients: new targets for immunotherapeutic strategies?","volume":"6","author":"Tarazona","year":"2016","journal-title":"Cancer Immunol Immunother"},{"key":"45","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/immu.200390014","article-title":"Preferential apoptosis of CD56dim natural killer cell subset in patients with cancer","volume":"3","author":"Whiteside","year":"2003","journal-title":"Eur J Immunol"},{"key":"46","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1093\/brain\/awl205","article-title":"TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells","volume":"12","author":"Friese","year":"2006","journal-title":"Brain"},{"key":"47","first-page":"7335","article-title":"Elevated TGF-beta1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients","volume":"17","author":"Heo","year":"2004","journal-title":"J Immunol"},{"key":"48","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1080\/10428190802064917","article-title":"Expression of T-plastin, FoxP3 and other tumor-associated markers by leukemic T-cells of cutaneous T-cell lymphoma","volume":"4","author":"Hess","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"49","first-page":"7122","article-title":"Aberrant expression of T-plastin in Sezary cells","volume":"6","author":"Zhou","year":"2003","journal-title":"Cancer Res"},{"key":"50","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.imlet.2013.09.020","article-title":"CMV induces rapid NK cell maturation in HSCT recipients","volume":"15","author":"Moretta","year":"2013","journal-title":"Immunol Lett"},{"key":"51","doi-asserted-by":"publisher","first-page":"2132","DOI":"10.1182\/blood-2002-07-2247","article-title":"Cytomegalovirus seropositivity is significantly associated with mycosis fungoides and Sezary syndrome","volume":"10","author":"Duvic","year":"2003","journal-title":"Blood"},{"key":"52","first-page":"574","article-title":"Cytomegalovirus: its potential role in the development of cutaneous T-cell lymphoma","volume":"1","author":"Dreno","year":"2009","journal-title":"Exp Dermatol"},{"key":"53","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1600-065X.2007.00577.x","article-title":"Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease","volume":"22","author":"Beutler","year":"2007","journal-title":"Immunol Rev"},{"key":"54","doi-asserted-by":"publisher","first-page":"e22647","DOI":"10.4161\/onci.22647","article-title":"A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis","volume":"2","author":"Fulton","year":"2013","journal-title":"Oncoimmunology"},{"key":"55","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/leu.2010.66","article-title":"COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF)","volume":"2","author":"Woetmann","year":"2010","journal-title":"Leukemia"},{"key":"56","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1182\/blood-2002-11-3574","article-title":"Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study","volume":"10","author":"Piris","year":"2003","journal-title":"Blood"},{"key":"57","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0889-8588(18)30054-6","article-title":"The immunopathogenesis of cutaneous T-cell lymphoma","volume":"9","author":"Heald","year":"1995","journal-title":"Hematol Oncol Clin North Am"},{"key":"58","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/j.det.2015.05.008","article-title":"The use of interferons in the treatment of cutaneous T-cell lymphoma","volume":"3","author":"Rook","year":"2015","journal-title":"Dermatol Clin"},{"key":"59","doi-asserted-by":"publisher","first-page":"S187","DOI":"10.3816\/CLM.2008.s.015","article-title":"Novel therapies for cutaneous T-cell lymphomas","volume":"8","author":"Horwitz","year":"2008","journal-title":"Clin Lymphoma Myeloma"},{"key":"60","doi-asserted-by":"publisher","first-page":"e1052353","DOI":"10.1080\/2162402x.2015.1052353","article-title":"Natural Killer (NK)\/melanoma cell interaction induces NK-mediated release of chemotactic High Mobility Group Box-1 (HMGB1) capable of amplifying NK cell recruitment","volume":"4","author":"Mingari","year":"2015","journal-title":"Oncoimmunology"},{"key":"61","doi-asserted-by":"publisher","first-page":"6410","DOI":"10.1158\/0008-5472.can-11-1565","article-title":"IRF-1 expression is essential for natural killer cells to suppress metastasis","volume":"7","author":"Kroger","year":"2011","journal-title":"Cancer Res"},{"key":"62","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1182\/blood-2007-03-055749","article-title":"Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)","volume":"11","author":"Ranki","year":"2007","journal-title":"Blood"},{"key":"63","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"2","author":"Schmittgen","year":"2001","journal-title":"Methods"}],"container-title":["Oncotarget"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.21006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T14:49:52Z","timestamp":1597675792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.oncotarget.com\/lookup\/doi\/10.18632\/oncotarget.21006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":63,"journal-issue":{"issue":"54","published-print":{"date-parts":[[2017,11,3]]}},"alternative-id":["21006","29190907"],"URL":"https:\/\/doi.org\/10.18632\/oncotarget.21006","relation":{},"ISSN":["1949-2553"],"issn-type":[{"value":"1949-2553","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]}}}